Identification of functionally distinct TRAF proinflammatory and phosphatidylinositol 3-kinase/mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (PI3K/MEK) transforming activities emanating from RET/PTC fusion oncoprotein

Journal of Biological Chemistry

Volumn 287, Issue 6, 2012, Pages 3691-3703

  Wixted, Josephine H F ^a,b   Rothstein, Jay L ^c   Eisenlohr, Laurence C ^b  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLULAR TRANSFORMATION; CYTOKINE PRODUCTION; CYTOKINE SECRETIONS; ONCOPROTEINS; PHOSPHATIDYLINOSITOL; PROINFLAMMATORY; PROTEIN KINASE; SIGNAL-REGULATED KINASE; THYROID CARCINOMA; THYROID TUMORS; TRANSFORMATION EFFICIENCY; TRANSFORMING ACTIVITY;

ONCOGENIC VIRUSES; TUMORS;

ENZYMES;

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE 1; MONOCYTE CHEMOTACTIC PROTEIN 1; ONCOPROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; RET PTC FUSION ONCOPROTEIN; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL TRANSFORMATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; HUMAN; HUMAN CELL; INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; THYROID FOLLICULAR CARCINOMA;

ANIMALS; CELL LINE, TUMOR; HUMANS; INFLAMMATION; MAP KINASE SIGNALING SYSTEM; MICE; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; NIH 3T3 CELLS; ONCOGENE PROTEINS, FUSION; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEIN-TYROSINE KINASES; RATS; THYROID NEOPLASMS; TNF RECEPTOR-ASSOCIATED FACTOR 2; TNF RECEPTOR-ASSOCIATED FACTOR 3;

EID: 84856731682     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.322677     Document Type: Article

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