Blood chromatin as a biosensor of the epigenetic milieu: A tool for studies in living psychiatric patients

Epigenomics

Volumn 4, Issue 5, 2012, Pages 551-559

  Sharma, Rajiv P ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

blood; brain; chromatin; histone; lymphocyte; neuron; PBMC; remodeling; schizophrenia

Indexed keywords

HEMOGLOBIN A1C; MESSENGER RNA; VALPROIC ACID;

BIOSENSOR; BRAIN FUNCTION; CHROMATIN; CHROMATIN DEPOSITION; CHROMATIN MODIFICATION; DIABETES MELLITUS; EPIGENETICS; GENE NETWORK; GENETIC PARAMETERS; GENETIC TRANSCRIPTION; GLUCOSE BLOOD LEVEL; HUMAN; MENTAL PATIENT; MONOZYGOTIC TWINS; NUCLEOSOME; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN GLYCOSYLATION; REVIEW;

BIOLOGICAL MARKERS; BRAIN; CELL NUCLEUS; CHROMATIN; CHROMATIN ASSEMBLY AND DISASSEMBLY; CYTODIAGNOSIS; EPIGENESIS, GENETIC; GENE REGULATORY NETWORKS; HISTONES; HUMANS; LEUKOCYTES, MONONUCLEAR; MENTAL DISORDERS; NEURONS; PROMOTER REGIONS, GENETIC; RNA, MESSENGER; TRANSCRIPTION, GENETIC;

EID: 84868524269     PISSN: 17501911     EISSN: 1750192X     Source Type: Journal    
DOI: 10.2217/epi.12.46     Document Type: Review

References (57)

1. Sims RJ 3rd, Nishioka K, Reinberg D. Hist one lysine methylation: A signature for chromatin function. Trends Genet. 19(11), 629-639 (2003). (Pubitemid 37338383)
2. Gavin DP, Kartan S, Chase KA, Jayaraman S, Sharma RP. Hist one deacetylase inhibitors and candidate gene expression: An in vivo and in vitro approach to studying chromatin remodeling in a clinical population. J. Psychiatr. Res. 43(9), 870-876 (2009).
3. Gavin DP, Rosen C, Chase KA, Grayson DR, Sharma RP. Dimethylated lysine 9 of hist one 3 is elevated in schizophrenia and exhibits a divergent response to hist one deacetylase inhibitors in lymphocyte cultures. J. Psychiatr. Neurosci. 34(3), 232-237 (2009).
4. Gavin DP, Kartan S, Chase KA, Grayson DR, Sharma RP. Reduced baseline acetylated hist one 3 levels, and a blunted response to HDAC inhibition in lymphocyte cultures from schizophrenia subjects. Schizophr. Res. 103(1-3), 330-332 (2008).
5. Sharma RP, Rosen C, Kartan S et al. Valproic acid and chromatin remodeling in schizophrenia and bipolar disorder: Preliminary results from a clinical population. Schizophr. Res. 88(1-3), 227-231 (2006).
6. Wang Z, Zang C, Rosenfeld JA et al. Combinatorial patterns of hist one acetylations and methylations in the human genome. Nat. Genet. 40(7), 897-903 (2008). (Pubitemid 351913645)
7. Barski A, Cuddapah S, Cui K et al. High-Resolution profiling of hist one methylations in the human genome. Cell 129(4), 823-837 (2007). (Pubitemid 46802390)
8. Maze I, Covington HE 3rd, Dietz DM et al. Essential role of the hist one methyltransferase G9a in cocaine-induced plasticity. Science 327(5962), 213-216 (2010).
9. Schaefer A, Sampath SC, Intrator A et al. Control of cognition and adaptive behavior by the GLP/G9a epigenetic suppressor complex. Neuron 64(5), 678-691 (2009).
10. Sharma RP, Gavin DP, Chase KA. Heterochromatin as an incubator for pathology and treatment non-Response: Implication for neuropsychiatric illness. Pharmacogenomics J. doi:10.1038/tpj.2011.64 (2012) (Epub ahead of print).
11. Rahman I, Marwick J, Kirkham P. Redox modulation of chromatin remodeling: Impact on hist one acetylation and deacetylation, NF-kB and pro-inflammatory gene expression. Biochem. Pharmacol. 68(6), 1255-1267 (2004). (Pubitemid 39094292)
12. Takizawa N, Watanabe K, Nouno K, Kobayashi N, Nagata K. Association of functional influenza viral proteins and RNAs with nuclear chromatin and sub-Chromatin structure. Microbes Infect. 8(3), 823-833 (2006).
13. Jones DR, Divecha N. Linking lipids to chromatin. Curr. Opin Genet. Dev. 14(2), 196-202 (2004). (Pubitemid 38520148)
14. Tsankova N, Renthal W, Kumar A, Nestler EJ. Epigenetic regulation in psychiatric disorders. Nat. Rev. Neurosci. 8(5), 355-367 (2007). (Pubitemid 46652469)
15. Pandey SC, Ugale R, Zhang H, Tang L, Prakash A. Brain chromatin remodeling: A novel mechanism of alcoholism. J. Neurosci. 28(14), 3729-3737 (2008).
16. Levine A, Huang Y, Drisaldi B et al. Molecular mechanism for a gateway drug: Epigenetic changes initiated by nicotine prime gene expression by cocaine. Sci. Transl Med. 3(107), 107ra109 (2011).
17. Aoyagi S, Archer TK. Dynamic hist one acetylation/deacetylation with progesterOne receptor-mediated transcription. Mol. Endocrinol. 21(4), 843-856 (2007). (Pubitemid 46984726)
18. Sun JM, Chen HY, Davie Jr. Effect of estradiol on hist one acetylation dynamics in human breast cancer cells. J. Biol. Chem. 276(52), 49435-49442 (2001).
19. McKenna NJ, O'Malley BW. Combinatorial control of gene expression by nuclear receptors and coregulators. Cell 108(4), 465-474 (2002). (Pubitemid 34260872)
20. Sharma RP. Schizophrenia, epigenetics and ligand-activated nuclear receptors: A framework for chromatin therapeutics. Schizophr. Res. 72(2-3), 79-90 (2005). (Pubitemid 39550980)
21. Kirillova GP, Hrutkay RJ, Shurin MR et al. Dopamine receptors in human lymphocytes: Radioligand binding and quantitative RT-PCR assays. J. Neurosci. Methods 174(2), 272-280 (2008).
22. Vile JM, Strange PG. High-affinity binding sites for neuroleptic drugs in human peripheral blood lymphocytes and their relation to dopamine receptors. A long-standing controversy. Biochem. Pharmacol. 49(6), 747-753 (1995).
23. Vetoshkin AV, Fomenko AM, Zozulia AA. Lymphocyte serotonin receptors: A radioreceptor study. Biull. Eksp Biol. Med. 94(7), 52-53 (1982). (Pubitemid 12012818)
24. Kohm AP, Sanders VM. Norepinephrine: A messenger from the brain to the immune system. Immunol. Today 21(11), 539-542 (2000).
25. Marazziti D, Catena Dell'osso M et al. Alterations of the dopamine transporter in resting lymphocytes of patients with different psychotic disorders. Psychiatry Res. 175(1-2), 54-57 (2010).
26. Fujii T, Takada-Takatori Y, Kawashima K. Basic and clinical aspects of non-Neuronal acetylcholine: Expression of an independent, non-Neuronal cholinergic system in lymphocytes and its clinical significance in immunotherapy. J. Pharmacol. Sci. 106(2), 186-192 (2008). (Pubitemid 351366336)
27. Mehrishi JN, Mills IH. Opiate receptors on lymphocytes and platelets in man. Clin. Immunol. Immunopathol. 27(2), 240-249 (1983). (Pubitemid 13127260)
28. Guidotti A, Dong E, Kundakovic M et al. Characterization of the action of antipsychotic subtypes on valproate-induced chromatin remodeling. Trends Pharmacol. Sci. 30(2), 55-60 (2009).
29. Fischer A, Sananbenesi F, Wang X, Dobbin M, Tsai LH. Recovery of learning and memory is associated with chromatin remodelling. Nature 447(7141), 178-182 (2007). (Pubitemid 46763080)
30. Korzus E, Rosenfeld MG, Mayford M. CBP hist one acetyltransferase activity is a critical compOnent of memory consolidation. Neuron 42(6), 961-972 (2004). (Pubitemid 38798234)
31. Hsieh J, Gage FH. Epigenetic control of neural stem cell fate. Curr. Opin Genet. Dev. 14(5), 461-469 (2004). (Pubitemid 39360292)
32. Martinowich K, Hattori D, Wu H et al. DNA methylation-Related chromatin remodeling in activity-dependent BDNF gene regulation. Science 302(5646), 890-893 (2003). (Pubitemid 37339633)
33. Caron H, van Schaik B, van der Mee M et al. The human transcriptome map: Clustering of highly expressed genes in chromosomal domains. Science 291(5507), 1289-1292 (2001).
34. Versteeg R, van Schaik BD, van Batenburg MF et al. The human transcriptome map reveals extremes in gene density, intron length, GC content, and repeat pattern for domains of highly and weakly expressed genes. Genome Res. 13(9), 1998-2004 (2003). (Pubitemid 37161757)
35. Middleton FA, Pato CN, Gentile KL et al. Gene expression analysis of peripheral blood leukocytes from discordant sib-Pairs with schizophrenia and bipolar disorder reveals points of convergence between genetic and functional genomic approaches. Am. J. Med. Genet. B Neuropsychiatr. Genet. 136B(1), 12-25 (2005). (Pubitemid 40917523)
36. Sullivan PF, Fan C, Perou CM. Evaluating the comparability of gene expression in blood and brain. Am. J. Med. Genet. B Neuropsychiatr. Genet. 141B(3), 261-268 (2006).
37. Guidotti A, Auta J, Chen Y et al. Epigenetic GABAergic targets in schizophrenia and bipolar disorder. Neuropharmacology 60(7-8), 1007-1016 (2011).
38. Cheung I, Shulha HP, Jiang Y et al. Developmental regulation and individual differences of neuronal H3K4me3 epigenomes in the prefrontal cortex. Proc. Natl Acad. Sci. USA 107(19), 8824-8829 (2010).
39. Wen B, Wu H, Shinkai Y, Irizarry RA, Feinberg AP. Large hist one H3 lysine 9 dimethylated chromatin blocks distinguish differentiated from embryonic stem cells. Nat. Genet. 41(2), 246-250 (2009).
40. Lee SA, Tsao TT, Yang KC et al. Construction and analysis of the protein-Protein interaction networks for schizophrenia, bipolar disorder, and major depression. BMC Bioinformatics 12(SUPPL13), S20 (2011).
41. Shelton RC, Claiborne J, Sidoryk-Wegrzynowicz M et al. Altered expression of genes involved in inflammation and apoptosis in frontal cortex in major depression. Mol. Psychiatry 16(7), 751-762 (2011).
42. Garbett K, Gal-Chis R, Gaszner G, Lewis DA, Mirnics K. Transcriptome alterations in the prefrontal cortex of subjects with schizophrenia who committed suicide. Neuropsychopharmacol. Hung. 10(1), 9-14 (2008).
43. Arion D, Unger T, Lewis DA, Levitt P, Mirnics K. Molecular evidence for increased expression of genes related to immune and chaperOne function in the prefrontal cortex in schizophrenia. Biol. Psychiatry 62(7), 711-721 (2007). (Pubitemid 47374650)
44. Tang B, Capitao C, Dean B, Thomas EA. Differential age- And disease-Related effects on the expression of genes related to the arachidonic acid signaling pathway in schizophrenia. Psychiatry Res. 196(2-3), 201-206 (2012).
45. Issidorides MR, Stefanis CN, Varsou E, Katsorchis T. Altered chromatin ultrastructure in neutrophils of schizophrenics. Nature 258(5536), 612-614 (1975).
46. Stefanis CN, Issidorides MR. Histochemical changes in the blood cells of schizophrenic patients under pimozide treatment. Biol. Psychiatry 11(1), 53-68 (1976).
47. Kosower NS, Gerad L, Goldstein M et al. Constitutive heterochromatin of chromosome 1 and Duffy blood group alleles in schizophrenia. Am. J. Med. Genet. 60(2), 133-138 (1995).
48. Kloukina-Pantazidou I, Havaki S, Chrysanthou-Piterou M et al. Chromatin alterations in leukocytes of first-episode schizophrenic patients. Ultrastruct. Pathol. 34(3), 106-116 (2010).
49. Fraga MF, Ballestar E, Paz MF et al. Epigenetic differences arise during the lifetime of monozygotic twins. Proc. Natl Acad. Sci. USA 102(30), 10604-10609 (2005). (Pubitemid 41061601)
50. Mill J, Dempster E, Caspi A et al. Evidence for monozygotic twin (MZ) discordance in methylation level at two CpG sites in the promoter region of the catechol-O-methyltransferase (COMT) gene. Am. J. Med. Genet. B Neuropsychiatr. Genet. 141B(4), 421-425 (2006). (Pubitemid 43872897)
51. Kuratomi G, Iwamoto K, Bundo M et al. Aberrant DNA methylation associated with bipolar disorder identified from discordant monozygotic twins. Mol. Psychiatry 13(4), 429-441 (2008). (Pubitemid 351399814)
52. Petronis A, Gottesman II, Kan P et al. Monozygotic twins exhibit numerous epigenetic differences: Clues to twin discordance? Schizophr. Bull. 29(1), 169-178 (2003). (Pubitemid 36871068)
53. Tsujita T, Niikawa N, Yamashita H et al. Genomic discordance between monozygotic twins discordant for schizophrenia. Am. J. Psychiatry 155(3), 422-424 (1998). (Pubitemid 28114903)
54. de Ruijter AJ, van Gennip AH, Caron HN, Kemp S, van Kuilenburg AB. Hist one deacetylases (HDACs): Characterization of the classical HDAC family. Biochem. J. 370(3), 737-749 (2003). (Pubitemid 36399066)
55. Dangond F, Gullans SR. Differential expression of human hist one deacetylase mRNAs in response to immune cell apoptosis induction by trichostatin A and butyrate. Biochem. Biophys. Res. Commun. 247(3), 833-837 (1998). (Pubitemid 28418477)
56. Migliore M, Shepherd GM. Opinion: An integrated approach to classifying neuronal phenotypes. Nat. Rev. Neurosci. 6(10), 810-818 (2005). (Pubitemid 41679243)
57. Rohlfing CL, Wiedmeyer HM, Little RR, England JD, Tennill A, Goldstein DE. Defining the relationship between plasma glucose and HbA(1c): Analysis of glucose profiles and HbA(1c) in the Diabetes Control and Complications Trial. Diabetes Care 25(2), 275-278 (2002). (Pubitemid 41079621)