Gene expression analysis of peripheral blood leukocytes from discordant sib-pairs with schizophrenia and bipolar disorder reveals points of convergence between genetic and functional genomic approaches

American Journal of Medical Genetics - Neuropsychiatric Genetics

Volumn 136 B, Issue 1, 2005, Pages 12-25

  Middleton, Frank A ^a,b   Pato, Carlos N ^a,b,c,d   Gentile, Karen L ^a,b   McGann, Lindsay ^a,b   Brown, Andrea M ^a,b   Trauzzi, Marco ^a,b   Diab, Heba ^a,b   Morley, Christopher P ^a,b   Medeiros, Helena ^a,b   Macedo, Antonio ^e   Azevedo, M Helena ^e   Pato, Michele T ^a,b,c,d  

^a SUNY UPSTATE MEDICAL UNIVERSITY   (United States)

^b State University of New York Upstate Medical University: College of Medicine   (United States)

^c GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

^e UNIVERSITY OF COIMBRA   (Portugal)

Author keywords

GeneChip; Microarray; RNA; White blood cell

Indexed keywords

ARTICLE; BIPOLAR DISORDER; CHROMOSOME 5Q; CHROMOSOME 6Q; CYTOGENETICS; GENE EXPRESSION; GENE MAPPING; GENETIC ANALYSIS; GENETIC LINKAGE; HUMAN; LEUKOCYTE; NEUROPSYCHIATRY; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ANALYSIS; RNA TRANSCRIPTION; SCHIZOPHRENIA; TWIN DISCORDANCE;

ADULT; ANALYSIS OF VARIANCE; BIPOLAR DISORDER; CHROMOSOME MAPPING; FAMILY HEALTH; FEMALE; GENE EXPRESSION PROFILING; GENOMICS; HAPLOTYPES; HUMANS; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POLYMORPHISM, SINGLE NUCLEOTIDE; REPRODUCIBILITY OF RESULTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SCHIZOPHRENIA; SIBLINGS; VARIATION (GENETICS);

EID: 21444436743     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.30171     Document Type: Article

References (15)

1. Falls DL. 2003. Neuregulins: Functions, forms, and signaling strategies. Exp Cell Res 284(1):14-30.
2. Gilladoga AD, Edelhoff S, Blackwood EM, Eisenman RN, Disteche CM. 1992. Mapping of MAX to human chromosome 14 and mouse chromosome 12 by in situ hybridization. Oncogene 7(6):1249-1251.
3. Irizarry RA, Bolstad BM, Collin F, Cope LM, Hobbs B, Speed TP. 2003. Summaries of Affymetrix GeneChip probe level data. Nucleic Acids Res 31(4):e15.
4. Johnson MW, Miyata H, Vinters HV. 2002. Ezrin and moesin expression within the developing human cerebrum and tuberous sclerosis-associated cortical tubers. Acta Neuropathol (Berl) 104:188-196.
5. Middleton FA, Mimics K, Pierri JN, Lewis DA, Levitt P. 2002. Gene expression profiling reveals alterations of specific metabolic pathways in schizophrenia. J Neurosci 22(7):2718-2729.
6. Middleton FA, Ramos EJ, Xu Y, Diab H, Zhao X, Das UN, Meguid M. 2004a. Application of genomic technologies: DNA microarrays and metabolic profiling of obesity in the hypothalamus and in subcutaneous fat. Nutrition 20:14-25.
7. Middleton FA, Pato MT, Gentile KL, Morley CP, Zhao X, Eisener AF, et al. 2004b. Genomewide linkage analysis of bipolar disorder by use of a high-density single-nucleotide-Polymorphism (SNP)genotyping assay. A comparison with microsatellite marker assays and finding of significant linkage to chromosome 6q22. Am J Hum Genet 74:886-897.
8. Mimics K, Middleton FA, Marquez AM, Lewis DA, Levitt P. 2000. Molecular characterization of schizophrenia revealed by microarray analysis of gene expression in prefrontal cortex. Neuron 28:53-67.
9. Pato CN, Pato MT, Kirby A, Petryshen TL, Medeiros H, Carvalho C, Macedo A, Dourado A, Coelho I, Valente J, Scares MJ, Ferreira CP, Lei M, Verner A, Hudson TJ, Morley CP, Kennedy JL, Azevedo MH, Daly MJ, Sklar P. 2004. Genome-wide scan in Portuguese Island families implicates multiple loci in bipolar disorder: Fine mapping adds support on chromosomes 6 and 11. Am J Med Genet 127B(1):30-34.
10. Petryshen TL, Middleton FA, Kirby A, Aldinger KA, Purcell S, Tahl AR, Morley CP, McGann L, Gentile KL, Rockwell GN, Medeiros HM, Carvalho C, Macedo A, Dourado A, Valente J, Ferreira CP, Patterson NJ, Azevedo MH, Daly MJ, Pato CN, Pato MT, Sklar P. 2005. Support for involvement of neuregulin 1 in schizophrenia pathophysiology. Mol Psychiatry 10:328.
11. Sklar P, Pato MT, Kirby A, Petryshen TL, Medeiros H, Carvalho C, Macedo A, Dourado A, Coelho I, Valente J, Soares MJ, Ferreira CP, Lei M, Verner A, Hudson TJ, Morley CP, Kennedy JL, Azevedo MH, Lander E, Daly MJ, Pato CN. 2004. Genome-wide scan in Portuguese Island families identifies 5q31-5q35 as a susceptibility locus for schizophrenia and psychosis. Mol Psychiatry 9:213-218.
12. Stoeckman AK, Ma L, Towle HC. 2004. Mix is the functional heteromeric partner of the carbohydrate response element-binding protein in glucose regulation of lipogenic enzyme genes. J Biol Chem 279:15662-15669.
13. Vawter MP, Ferran E, Galke B, Cooper K, Bunney WE, Byerley W. 2004. Microarray screening of lymphocyte gene expression differences in a multiplex schizophrenia pedigree. Schizophr Res 67:41-52.
14. Wagner AJ, LeBeau MM, Diaz MO, Hay N. 1992. Expression, regulation, and chromosaomal localization of the Max gene. Proc Natl Acad Sci 89(7):3111-3115.
15. Yeoh EJ, Ross ME, Shurtleff SA, Williams WK, Patel D, Mahfouz R, Behm FG, Raimondi SC, Relling MV, Patel A, Cheng C, Campana D, Wilkins D, Zhou X, Li J, Liu H, Pui CH, Evans WE, Naeve C, Wong L, Downing JR. 2002. Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling. Cancer Cell 1:133-143.