Chromatin alterations in leukocytes of first-episode schizophrenic patients

Ultrastructural Pathology

Volumn 34, Issue 3, 2010, Pages 106-116

  Kloukina Pantazidou, Ismini ^a   Havaki, Sophia ^a   Chrysanthou Piterou, Margarita ^a,b   Kontaxakis, Vassilis P ^b   Papadimitriou, George N ^b   Issidorides, Marietta R ^a,b  

^a Theodor Theohari Cozzika Foundation   (Greece)

^b NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS   (Greece)

Author keywords

Ammoniacal silver reaction (ASR); Chromatin; Histones; Leukocytes; Phosphotungstic acid hematoxylin (PTAH); Schizophrenia; Ultrastructure

Indexed keywords

ARGININE; BIOLOGICAL MARKER; LYSINE;

ADOLESCENT; ADULT; BLOOD; CELL NUCLEUS; CHEMISTRY; CHROMATIN; CONFERENCE PAPER; FEMALE; HUMAN; IMAGE PROCESSING; LEUKOCYTE; MALE; METHODOLOGY; MIDDLE AGED; NEUTROPHIL; SCHIZOPHRENIA; SILVER STAINING; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURE;

ADOLESCENT; ADULT; ARGININE; BIOLOGICAL MARKERS; CELL NUCLEUS; CHROMATIN; FEMALE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; LEUKOCYTES; LYSINE; MALE; MICROSCOPY, ELECTRON, TRANSMISSION; MIDDLE AGED; NEUTROPHILS; SCHIZOPHRENIA; SILVER STAINING; YOUNG ADULT;

EID: 77952286736     PISSN: 01913123     EISSN: 15210758     Source Type: Journal    
DOI: 10.3109/01913121003644781     Document Type: Conference Paper

References (33)

1. Issidorides MR, Stefanis CN, Varsou E, Katsorchis T. Altered chromatin ultrastructure in neutrophils of schizophrenics. Nature. 1975;258:612-614.
2. Kamp HV. Nuclear changes in the white blood cells of patients with schizophrenic reaction: a preliminary report. J Neuropsychiatry. 1962;4:1-3.
3. Fessel WJ, Hirata-Hibi M. Abnormal leukocytes in schizophrenia. Arch Gen Psychiatry. 1963;9:601-613.
4. Kokai M, Morita Y, Fukuda H, Hatotani N. Immunophenotypic studies on atypical lymphocytes in psychiatric patients. Psychiatry Res. 1998;77:105-112.
5. Kornberg RD, Lorch Y. Twenty-five years of the nucleosome, fundamental particle of the eukaryote chromosome. Cell. 1999;98:285-294.
6. Richmond TJ, Davey CA. The structure of DNA in the nucleosome core. Nature. 2003;423:145-150.
7. Schalch T, Duda S, Sargent DF, Richmond TJ. X-ray structure of a tetranucleosome and its implications for the chromatin fibre. Nature. 2005;436:138-141.
8. Kan PY, Lu X, Hansen JC, Hayes JJ. The H3 tail domain participates in multiple interactions during folding and selfassociation of nucleosome arrays. Mol Cell Biol. 2007;27:2084-2091.
9. Zlatanova J, van Holde K. The linker histones and chromatin structure: new twists. Prog Nucleic Acid Res Mol Biol. 1996;52:217-259.
10. Widom J. Chromatin structure: linking structure to function with histone H1. Curr Biol. 1998;8:R788-791.
11. Shilatifard A. Chromatin modifications by methylation and ubiquitination: implications in the regulation of gene expression. Annu Rev Biochem. 2006;75:243-269.
12. Kouzarides T. Chromatin modifications and their function. Cell. 2007;128:693-705.
13. Li B, Carey M, Workman JL. The role of chromatin during transcription. Cell. 2007;128:707-719.
14. Strahl BD, Allis CD. The language of covalent histone modifications. Nature. 2000;403:41-45.
15. Jenuwein T, Allis CD. Translating the histone code. Science. 2001;293:1074-1080.
16. Petronis A. Human morbid genetics revisited: relevance of epigenetics. Trends Genet. 2001;17:142-146.
17. Black MM, Ansley HR. Histone specificity revealed by ammoniacal silver staining. J Histochem Cytochem. 1966;14:177-181.
18. MacRae EK, Meetz GD. Electron microscopy of the ammoniacal silver reaction for histones in the erythropoietic cells of the chick. J Cell Biol. 1970;45:235-245.
19. Terner JY. Phosphotungstic acid-hematoxylin, reactivity in vitro. J Histochem Cytochem. 1966;14:345-351.
20. Stefanis CN, Issidorides MR. Histochemical changes in the blood cells of schizophrenic patients under pimozide treatment. Biol Psychiatry. 1976;11:53-68.
21. Issidorides MR, Katsorchis T. Dispersed and compact chromatin demonstrated with a new EM method: phosphotungstic acid hematoxylin block-staining. Histochemistry. 1981;73:21-31.
22. Kay SR. Positive-negative symptom assessment in schizophrenia: psychometric issues and scale comparison. Psychiatr Q. 1990; 61:163-168.
23. Addington D, Addington J, Maticka-Tyndale E. Assessing depression in schizophrenia: the Calgary Depression Scale. Br J Psychiatry Suppl. 1993;22:39-44.
24. Watanabe I, Donahue S, Hoggatt N. Method for electron microscopic studies of circulating human leukocytes and observations on their fine structure. J Ultrastruct Res. 1967;20:366-382.
25. Ganguli R, Brar JS, Chengappa KNR, et al. Mitogen-stimulated interleukin-2 production in never-medicated, first-episode schizophrenic patients. Arch Gen Psychiat. 1995;52:668-672.
26. Muller N, Riedel M, Gruber R, Ackenheil M, Schwartz MJ. The immune system and schizophrenia. An intergrative view. Ann N Y Acad Sci. 2000;917:456-467.
27. Strous RD, Shoenfeld Y. Schizophrenia, autoimmunity and immune system dysregulation: a comprehensive model updated and revisited. J Autoimmun. 2006;Sep;27:71-80.
28. Issidorides MR, Zioudrou C, Lykouras E, Stefanis CN. Druginduced changes in chromatin ultrastructure and nuclear basic proteins of the neutrophils of chronic schizophrenics. Prog Neuropsychopharmacol. 1978;2:79-85.
29. Gilbert N, Ramsahoye B. The relationship between chromatin structure and transcriptional activity in mammalian genomes. Brief Funct Genomic Proteomic. 2005;4:129-142.
30. Baehner RL. Normal neutrophil structure and function. In: Hoffman R, Benz EJ, Shattil SJ, et al, eds. Hematology Basic Principles and Practice. New York: Churchill Livingstone; 2000: 667-686.
31. Levenson JM, Sweatt JD. Epigenetic mechanisms: a common theme in vertebrate and invertebrate memory formation. Cell Mol Life Sci. 2006;63:1009-1016.
32. Abdolmaleky HM, Zhou JR, Thiagalingam S, Smith CL. Epigenetic and pharmacoepigenomic studies of major psychoses and potentials for therapeutics. Pharmacogenomics. 2008;9: 1809-1823.
33. Oh G, Petronis A. Environmental studies of schizophrenia through the prism of epigenetics. Schizophr Bull. 2008;34: 1122-1129.