Indoxyl sulfate upregulates expression of ICAM-1 and MCP-1 by oxidative stress-induced NF-κB activation

American Journal of Nephrology

Volumn 31, Issue 5, 2010, Pages 435-441

  Tumur, Zohra ^a   Shimizu, Hidehisa ^a   Enomoto, Atsushi ^b   Miyazaki, Hitoshi ^c   Niwa, Toshimitsu ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b NAGOYA UNIVERSITY   (Japan)

^c UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

Endothelial cell; Indoxyl sulfate; Intercellular adhesion molecule 1; Monocyte chemotactic protein 1; Nuclear factor B

Indexed keywords

ACETYLCYSTEINE; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDICAN; INTERCELLULAR ADHESION MOLECULE 1; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; REACTIVE OXYGEN METABOLITE; SERINE; TRANSCRIPTION FACTOR RELA; ANTIOXIDANT;

ARTICLE; CARDIOVASCULAR DISEASE; CHRONIC KIDNEY DISEASE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UMBILICAL VEIN; UPREGULATION; VASCULAR ENDOTHELIUM; WESTERN BLOTTING; BIOLOGICAL MODEL; BIOSYNTHESIS; CELL CULTURE; CYTOLOGY; DOSE RESPONSE; GENE EXPRESSION REGULATION; METABOLISM; TIME;

ACETYLCYSTEINE; ANTIOXIDANTS; CELLS, CULTURED; CHEMOKINE CCL2; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; GENE EXPRESSION REGULATION; HUMANS; INDICAN; INTERCELLULAR ADHESION MOLECULE-1; MODELS, BIOLOGICAL; NF-KAPPA B; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; TIME FACTORS;

EID: 77950605070     PISSN: 02508095     EISSN: None     Source Type: Journal    
DOI: 10.1159/000299798     Document Type: Article

References (25)

1. Efstratiadis G, Tziomalos K, Mikhailidis DP, Athyros VG, Hatzitolios A: Atherogenesis in renal patients: a model of vascular disease? Curr Vasc Pharmacol 2008; 6: 93-107.
2. Schiffrin EL, Lipman ML, Mann JF: Chronic kidney disease: effects on the cardiovascular system. Circulation 2007; 116: 85-97.
3. Niwa T, Ise M: Indoxyl sulfate, a circulating uremic toxin, stimulates the progression of glomerular sclerosis. J Lab Clin Med 1994; 124: 96-104.
4. Miyazaki T Ise M Seo H Niwa T Indoxyl sulfate increases the gene expressions of Miyazaki T, Ise M, Seo H, Niwa T: Indoxyl sulfate increases the gene expressions of TGF-- 1, TIMP-1 and pro-- 1(I) collagen in uremic rat kidneys. Kidney Int 1997; 52(suppl 62):S15-S22.
5. Gelasco AK, Raymond JR: Indoxyl sulfate induces complex redox alterations in mesangial cells. Am J Physiol Renal Physiol 2006; 290:F1551-F1558.
6. Owada S, Goto S, Bannai K, Hayashi H, Nishijima F, Niwa T: Indoxyl sulfate reduces superoxide scavenging activity in the kidneys of normal and uremic rats. Am J Nephrol 2008; 28: 446-454.
7. Dou L, Jourde-Chiche N, Faure V, Cerini C, Berland Y, Dignat-George F, Brunet P: The uremic solute indoxyl sulfate induces oxidative stress in endothelial cells. J Thromb Haemost 2007; 5: 1302-1308.
8. Tumur Z, Niwa T: Indoxyl sulfate inhibits nitric oxide production and cell viability by inducing oxidative stress in vascular endothelial cells. Am J Nephrol 2009; 29: 551-557.
9. Dou L, Bertrand E, Cerini C, Faure V, Sampol J, Vanholder R, Berland Y, Brunet P: The uremic solutes p-cresol and indoxyl sulfate inhibit endothelial proliferation and wound repair. Kidney Int 2004; 65: 442-451.
10. Faure V, Dou L, Sabatier F, Cerini C, Sampol J, Berland Y, Brunet P, Dignat-George F: Elevation of circulating endothelial microparticles in patients with chronic renal failure. J Thromb Haemost 2006; 4: 566-573.
11. Shimoishi K, Anraku M, Kitamura K, Tasaki Y, Taguchi K, Hashimoto M, Fukunaga E, Maruyama T, Otagiri M: An oral adsorbent, AST-120 protects against the progression of oxidative stress by reducing the accumulation of indoxyl sulfate in the systemic circulation in renal failure. Pharm Res 2007; 24: 1283-1289.
12. Namikoshi T, Tomita N, Satoh M, Sakuta T, Kuwabara A, Kobayashi S, Higuchi Y, Nishijima F, Kashihara N: Oral adsorbent AST-120 ameliorates endothelial dysfunction independent of renal function in rats with subtotal nephrectomy. Hypertens Res 2009; 32: 194-200.
13. Taki K, Tsuruta Y, Niwa T: Indoxyl sulfate and atherosclerotic risk factors in hemodialysis patients. Am J Nephrol 2007; 27: 30-35.
14. Barreto FC, Barreto DV, Liabeuf S, Meert N, Glorieux G, Temmar M, Choukroun G, Vanholder R, Massy ZA: Serum indoxyl sulfate is associated with vascular disease and mortality in chronic kidney disease patients. Clin J Am Soc Nephrol 2009; 4: 1551-1558.
15. Libby P: Inflammation in atherosclerosis. Nature 2002; 420: 868-874.
16. Fortuño A, San José G, Moreno MU, Díez J, Zalba G: Oxidative stress and vascular remodelling. Exp Physiol 2005; 90: 457-462.
17. Yung LM, Leung FP, Yao X, Chen ZY, Huang Y: Reactive oxygen species in vascular wall. Cardiovasc Hematol Disord Drug Targets 2006; 6: 1-19.
18. De Martin R, Hoeth M, Hofer-Warbinek R, Schmid JA: The transcription factor NFkappa B and the regulation of vascular cell function. Arterioscler Thromb Vasc Biol 2000; 20:E83-E88.
19. Canty TG Jr, Boyle EM Jr, Farr A, Morgan EN, Verrier ED, Pohlman TH: Oxidative stress induces NF-kappaB nuclear translocation without degradation of IkappaBalpha. Circulation 1999; 100(suppl 19):II361-II364.
20. Ross R: Atherosclerosis-an inflammatory disease. N Engl J Med 1999; 340: 115-126.
21. Egashira K: Molecular mechanisms mediating inflammation in vascular disease: special reference to monocyte chemoattractant protein-1. Hypertension 2003; 41: 834-841.
22. Kusano KF, Nakamura K, Kusano H, Nishii N, Banba K, Ikeda T, Hashimoto K, Yamamoto M, Fujio H, Miura A, Ohta K, Morita H, Saito H, Emori T, Nakamura Y, Kusano I, Ohe T: Significance of the level of monocyte chemoattractant protein-1 in human atherosclerosis. Circ J 2004; 68: 671-676.
23. Stinghen AE, Gonçalves SM, Martines EG, Nakao LS, Riella MC, Aita CA, Pecoits-Filho R: Increased plasma and endothelial cell expression of chemokines and adhesion molecules in chronic kidney disease. Nephron Clin Pract 2009; 111:c117-c126.
24. Brand K, Page S, Rogler G, Bartsch A, Brandl R, Knuechel R, Page M, Kaltschmidt C, Baeuerle PA, Neumeier D: Activated transcription factor nuclear factor-kappa B is present in the atherosclerotic lesion. J Clin Invest 1996; 97: 1715-1722.
25. Mazor RL, Menendez IY, Ryan MA, Fiedler MA, Wong HR: Sesquiterpene lactones are potent inhibitors of interleukin 8 gene expression in cultured human respiratory epithelium. Cytokine 2000; 12: 239-245.