Biomarkers of peripheral muscle fatigue during exercise

BMC Musculoskeletal Disorders

Volumn 13, Issue , 2012, Pages

  Finsterer, Josef ^a  

^a KRANKENANSTALT RUDOLFSTIFTUNG   (Austria)

Author keywords

Biological marker; Biomarker; Exercise fatigue; Monitoring; Muscle exercise; Muscle fatigue

Indexed keywords

ADENOSINE TRIPHOSPHATE; BIOLOGICAL MARKER; CALCIUM; INTERLEUKIN 6; LACTIC ACID;

ACIDOSIS; AEROBIC METABOLISM; BIOENERGY; CIRCADIAN RHYTHM; EXERCISE TEST; GENETICS; HUMAN; IMMUNE RESPONSE; MUSCLE EXERCISE; MUSCLE FATIGUE; NONHUMAN; PERIPHERAL MUSCLE FATIGUE; REVIEW;

ADENOSINE TRIPHOSPHATE; ANIMALS; BIOLOGICAL MARKERS; ENERGY METABOLISM; EXERCISE; HUMANS; INFLAMMATION MEDIATORS; MUSCLE CONTRACTION; MUSCLE FATIGUE; MUSCLE, SKELETAL; OXIDATIVE STRESS;

EID: 84868487612     PISSN: None     EISSN: 14712474     Source Type: Journal    
DOI: 10.1186/1471-2474-13-218     Document Type: Review

References (97)

1. Methods for the assessment of peripheral muscle fatigue and its energy and metabolic determinants in COPD. Rondelli RR, Dal Corso S, Simões A, Malaguti C, J Bras Pneumol 2009 35 1125 1135 10.1590/S1806-37132009001100011 20011849
2. Neuromuscular fatigue in healthy muscle: underlying factors and adaptation mechanisms. Boyas S, Guével A, Ann Phys Rehabil Med 2011 54 88 108 21376692
3. Skeletal muscle weakness in patients with sarcoidosis and its relationship with exercise intolerance and reduced health status. Spruit MA, Thomeer MJ, Gosselink R, Troosters T, Kasran A, Debrock AJ, Demedts MG, Decramer M, Thorax 2005 60 32 38 10.1136/thx.2004.022244 15618580
4. Fatigued muscles in COPD but no finishing line in sight. Gosker HR, Schols AM, Eur Respir J 2008 31 693 694 10.1183/09031936.00015308 18378778
5. Mechanical and EMG responses of the vastus lateralis and changes in biochemical variables to isokinetic exercise in endurance and power athletes. Rainoldi A, Gazzoni M, Merletti R, Minetto MA, J Sports Sci 2008 26 321 331 18074299
6. Adaptation of skeletal muscle to increased neuromuscular activity as induced by chronic low frequency stimulation. Pette D, Scand J Rehabil Med Suppl 1994 30 7 18 7886430
7. Fatigue resistance of rat extraocular muscles does not depend on creatine kinase activity. McMullen CA, Hayess K, Andrade FH, BMC Physiol 2005 17 5 12
8. The role of exercise-induced myokines in muscle homeostasis and the defense against chronic diseases. Brandt C, Pedersen BK, J Biomed Biotechnol 2010 in press.
9. IL-6 signaling in exercise and disease. Pedersen BK, Biochem Soc Trans 2007 35 1295 7 17956334
10. Oxidative stress biomarkers responses to physical overtraining: implications for diagnosis. Margonis K, Fatouros IG, Jamurtas AZ, Nikolaidis MG, Douroudos I, Chatzinikolaou A, Mitrakou A, Mastorakos G, Papassotiriou I, Taxildaris K, Kouretas D, Free Radic Biol Med 2007 43 901 10 10.1016/j.freeradbiomed.2007.05.022 17697935
11. High-intensity exercise elicits the mobilization of senescent T lymphocytes into the peripheral blood compartment in human subjects. Simpson RJ, Florida-James GD, Cosgrove C, Whyte GP, Macrae S, Pircher H, Guy K, J Appl Physiol 2007 103 396 401 10.1152/japplphysiol.00007.2007 17379755
12. Anabolic and catabolic biomarkers as predictors of muscle strength decline: the InCHIANTI study. Stenholm S, Maggio M, Lauretani F, Bandinelli S, Ceda GP, Di Iorio A, Giallauria F, Guralnik JM, Ferrucci L, Rejuvenation Res 2010 13 3 11 10.1089/rej.2009.0891 20230273
13. Physiological types and histochemical profiles in motor units of the cat gastrocnemius. Burke RE, Levine DN, Tsairis P, Zajac FE 3rd, J Physiol 1973 234 723 48 4148752
14. The effect of intracellular pH on contractile function of intact, single fibres of mouse muscle declines with increasing temperature. Westerblad H, Bruton JD, Lännergren J, J Physiol 1997 500 193 204 9097943
15. Muscle fatigue: the cellular aspects. Fitts RH, Am J Sports Med 1996 24 suppl 9 13 8947417
16. Energy turnover in relation to slowing of contractile properties during fatiguing contractions of the human anterior tibialis muscle. Jones DA, Turner DL, McIntyre DB, Newham DJ, J Physiol 2009 587 4329 38 10.1113/jphysiol.2009. 175265 19596896
17. 31P-NMR observation of free ADP during fatiguing, repetitive contractions of murine skeletal muscle lacking AK1. Hancock CR, Brault JJ, Wiseman RW, Terjung RL, Meyer RA, Am J Physiol Cell Physiol 2005 288 1298 304 10.1152/ajpcell.00621.2004 15689408
18. AMP deamination delays muscle acidification during heavy exercise and hypoxia. Korzeniewski B, J Biol Chem 2006 281 3057 66 16314416
19. Multiple-sprint work: methodological, physiological, and experimental issues. Glaister M, Int J Sports Physiol Perform 2008 3 107 12 19193958
20. Stressed out: the skeletal muscle ryanodine receptor as a target of stress. Bellinger AM, Mongillo M, Marks AR, J Clin Invest 2008 118 445 53 10.1172/JCI34006 18246195
21. Lactate kinetics in human tissues at rest and during exercise. van Hall G, Acta Physiol (Oxf) 2010 199 499 508 10.1111/j.1748-1716.2010.02122.x
22. Lactate stress testing in 155 patients with mitochondriopathy. Finsterer J, Milvay E, Can J Neurol Sci 2002 29 49 53 11858534
23. Cardiac biomarkers, electrolytes, and other analytes in collapsed marathon runners: implications for the evaluation of runners following competition. Siegel AJ, Januzzi J, Sluss P, Lee-Lewandrowski E, Wood M, Shirey T, Lewandrowski KB, Am J Clin Pathol 2008 129 948 51 10.1309/4L0M60MGAQBCHMV7 18480012
24. Effect of age on metabolic fatigue and on indirect symptoms of skeletal muscle damage after stretch-shortening exercise. Skurvydas A, Streckis V, Mickeviciene D, Kamandulis S, Stanislovaitis A, Mamkus G, J Sports Med Phys Fitness 2006 46 431 41 16998448
25. Incremental treadmill exercise until onset of fatigue and its relationship to metabolic response and locomotion pattern. Schuback K, Essén-Gustavsson B, Persson SG, Equine Vet J Suppl 1999 30 337 41 10659279
26. Oxidative capacity of the skeletal muscle and lactic acid kinetics during exercise in normal subjects and in patients with COPD. Maltais F, Simard AA, Simard C, Jobin J, Desgagnés P, LeBlanc P, Am J Respir Crit Care Med 1996 153 288 93 8542131
27. Contraction-mediated phosphorylation of AMPK is lower in skeletal muscle of adenylate kinase-deficient mice. Hancock CR, Janssen E, Terjung RL, J Appl Physiol 2006 100 406 13 10.1152/japplphysiol.00885.2005 16195390
28. Protecting muscle ATP: positive roles for peripheral defense mechanisms-introduction. Myburgh KH, Med Sci Sports Exerc 2004 36 16 9 10.1249/01.MSS.0000106280.19491.B5 14707762
29. AMP-activated protein kinase: a key system mediating metabolic responses to exercise. Hardie DG, Med Sci Sports Exerc 2004 36 28 34 10.1249/01.MSS. 0000106171.38299.64 14707764
30. Hyperammonemia in the pediatric emergency care setting. Galal NM, Fouad HM, Saied A, Dabnon M, Pediatr Emerg Care 2010 26 888 91 10.1097/PEC. 0b013e3181fe90bc 21088638
31. Greater growth hormone and insulin response in women than in men during repeated bouts of sprint exercise. Esbjörnsson M, Norman B, Suchdev S, Viru M, Lindhgren A, Jansson E, Acta Physiol (Oxf) 2009 197 107 15 10.1111/j.1748-1716.2009.01994.x
32. The plasma ammonia response to cycle exercise in COPD. Calvert LD, Singh SJ, Greenhaff PL, Morgan MD, Steiner MC, Eur Respir J 2008 31 751 8 10.1183/09031936.00164106 18094007
33. Plasmatic markers of muscular stress in isokinetic exercise. Speranza L, Grilli A, Patruno A, Franceschelli S, Felzani G, Pesce M, Vinciguerra I, De Lutiis MA, Felaco M, J Biol Regul Homeost Agents 2007 21 21 9 18211747
34. Hyperamylasemia, specific pancreatic enzymes, and hypoxanthine during recovery from diabetic ketoacidosis. Møller-Petersen J, Andersen PT, Hjørne N, Ditzel J, Clin Chem 1985 31 2001 4 2415270
35. Purine metabolism in women with primary gout. Puig JG, Mateos FA, Miranda ME, Torres RJ, De Miguel E, Pérez De Ayala C, Gil AA, Am J Med 1994 97 332 8 10.1016/0002-9343(94)90299-2 7942934
36. May peripheral and central fatigue be correlated? Can we monitor them by means of clinical laboratory tools? Bianchi GP, Grossi G, Bargossi AM, J Sports Med Phys Fitness 1997 37 194 9 9407750
37. Reliability of different blood indices to explore the oxidative stress in response to maximal cycling and static exercises. Steinberg JG, Delliaux S, Jammes Y, Clin Physiol Funct Imaging 2006 26 106 12 10.1111/j.1475-097X.2006. 00658.x 16494601
38. Effects of acute aerobic and unaerobic exercise on blood markers of oxidative stress. Bloomer RJ, Goldfarb AH, Wideman L, McKenzie MJ, Consitt LA, J Strength Cond Res 2005 19 276 85 15903362
39. Relationship between oxidative stress in muscle tissue and weight-lifting-induced muscle damage. Uchiyama S, Tsukamoto H, Yoshimura S, Tamaki T, Pflugers Arch 2006 452 109 16 10.1007/s00424-005-0012-y 16402246
40. On the importance of fatty acid composition of membranes for aging. Hulbert AJ, J Theor Biol 2005 234 277 88 10.1016/j.jtbi.2004.11.024 15757684
41. Relationship between musculoskeletal symptoms and blood markers of oxidative stress in patients with chronic fatigue syndrome. Vecchiet J, Cipollone F, Falasca K, Mezzetti A, Pizzigallo E, Bucciarelli T, De Laurentis S, Affaitati G, De Cesare D, Giamberardino MA, Neurosci Lett 2003 335 151 4 10.1016/S0304-3940(02)01058-3 12531455
42. Blood and salivary oxidative stress biomarkers following an acute session of resistence exercise in humans. Deminice R, Sicchieri T, Payao PO, Jordao AA, Int J Sports Med 2010 31 599 603 10.1055/s-0030-1255107 20617486
43. Age-related changes in nitric oxide activity, cyclic GMP, and TBARS levels in platelets and erythrocytes reflect the oxidative status in central nervous system. Kawamoto EM, Vasconcelos AR, Degaspari S, Böhmer AE, Scavone C, Marcourakis T, Age (Dordr) 2012 in press.
44. Factors associated with gender difference in the intima-media thickness of the common carotid artery. Tan TY, Lu CH, Lin TK, Liou CW, Chuang YC, Schminke U, Clin Radiol 2009 64 1097 103 10.1016/j.crad.2009.06.009 19822243
45. Changes in blood lipid peroxidation markers and antioxidants after a single sprint unaerobic exercise. Groussard C, Rannou-Bekono F, Machefer G, Chevanne M, Vincent S, Sergent O, Cillard J, Gratas-Delamarche A, Eur J Appl Physiol 2003 89 14 20 10.1007/s00421-002-0767-1 12627300
46. Absence of myofibrillar creatine kinase and diaphragm isometric function during repetitive activation. LaBella JJ, Daood MJ, Koretsky AP, Roman BB, Sieck GC, Wieringa B, Watchko JF, J Appl Physiol 1998 84 1166 73 9516180
47. Chronic fatigue syndrome combines increased exercise-induced oxidative stress and reduced cytokine and Hsp responses. Jammes Y, Steinberg JG, Delliaux S, Brégeon F, J Intern Med 2009 266 196 206 10.1111/j.1365-2796.2009. 02079.x 19457057
48. Effects of age and caloric restriction on lipid peroxidation: measurement of oxidative stress by F2-isoprostane levels. Ward WF, Qi W, Van Remmen H, Zackert WE, Roberts LJ 2nd, Richardson A, J Gerontol A Biol Sci Med Sci 2005 60 847 51 10.1093/gerona/60.7.847 16079206
49. Regulatory factors of basal F(2)-isoprostane formation: population, age, gender and smoking habits in humans. Basu S, Helmersson J, Jarosinska D, Sällsten G, Mazzolai B, Barregård L, Free Radic Res 2009 43 85 91 10.1080/10715760802610851 19085196
50. Oxidative stress in athletes during extreme endurance exercise. Mastaloudis A, Leonard SW, Traber MG, Free Radic Biol Med 2001 31 911 22 10.1016/S0891-5849(01)00667-0 11585710
51. The human plasma proteome: history, character, and diagnostic prospects. Anderson NL, Anderson NG, Mol Cell Proteomics 2002 1 845 67 10.1074/mcp.R200007- MCP200 12488461
52. Increased protein carbonylation and decreased antioxidant status in anemic H. pylori infected patients: Effect of treatment. Rajendiran S, Zachariah B, Hamide A, Saudi J Gastroenterol 2012 18 252 6 10.4103/1319-3767.98430 22824768
53. Carbonyl formation in erythrocyte membrane proteins during aging in humans. Jha R, Rizvi SI, Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2011 155 39 42 10.5507/bp.2011.013 21475376
54. Oxidative stress and protein glycation in primary hypothyroidism. Male/female difference. Nanda N, Bobby Z, Hamide A, Clin Exp Med 2008 8 101 8 10.1007/s10238-008-0164-0 18618220
55. Age-related carbonyl stress and erythrocyte membrane protein carbonylation. Li G, Liu L, Hu H, Zhao Q, Xie F, Chen K, Liu S, Chen Y, Shi W, Yin D, Clin Hemorheol Microcirc 2010 46 305 11 21187579
56. Super-marathon race increases serum and urinary nitrotyrosine and carbonyl levels. Radák Z, Ogonovszky H, Dubecz J, Pavlik G, Sasvari M, Pucsok J, Berkes I, Csont T, Ferdinandy P, Eur J Clin Invest 2003 33 726 30 10.1046/j.1365-2362.2003.01202.x 12864784
57. Radical species in inflammation and overtraining. Tiidus PM, Can J Physiol Pharmacol 1998 76 533 8 10.1139/y98-047 9839079
58. Thiol homeostasis and supplements in physical exercise. Sen CK, Packer L, Am J Clin Nutr 2000 72 suppl 2 653S 69S 10919972
59. Glutathione, vitamin E and oxidative stress in coronary artery disease: relevance of age and gender. Cavalca V, Veglia F, Squellerio I, Marenzi G, Minardi F, De Metrio M, Cighetti G, Boccotti L, Ravagnani P, Tremoli E, Eur J Clin Invest 2009 39 267 72 10.1111/j.1365-2362.2009.02094.x 19292881
60. N-acetylcysteine inhibits muscle fatigue in humans. Reid MB, Stokić DS, Koch SM, Khawli FA, Leis AA, J Clin Invest 1994 94 2468 74 10.1172/JCI117615 7989604
61. Antioxidant status and glutathione metabolism in peripheral blood mononuclear cells from patients with chronic hepatitis C. Boya P, de la Peña A, Beloqui O, Larrea E, Conchillo M, Castelruiz Y, Civeira MP, Prieto J, J Hepatol 1999 31 808 14 10.1016/S0168-8278(99)80281-5 10580577
62. Aging-related oxidative stress in healthy humans. Mendoza- Núñez VM, Ruiz-Ramos M, Sánchez-Rodríguez MA, Retana-Ugalde R, Muñoz-Sánchez JL, Tohoku J Exp Med 2007 213 261 8 10.1620/tjem.213.261 17984623
63. Sex differences in oxidant/antioxidant balance under a chronic mild stress regime. Kamper EF, Chatzigeorgiou A, Tsimpoukidi O, Kamper M, Dalla C, Pitychoutis PM, Papadopoulou-Daifoti Z, Physiol Behav 2009 98 215 22 10.1016/j.physbeh.2009.05.011 19477190
64. Effects of tai chi training on antioxidant capacity in pre- and postmenopausal women. Palasuwan A, Suksom D, Margaritis I, Soogarun S, Rousseau AS, J Aging Res 2011 2011 234696 21584229
65. Increased blood antioxidant systems of runners in response to training load. Robertson JD, Maughan RJ, Duthie GG, Morrice PC, Clin Sci (Lond) 1991 80 611 8
66. Relation between oxidative stress markers and antioxidant endogenous defenses during exhaustive exercise. Sureda A, Tauler P, Aguiló A, Cases N, Fuentespina E, Córdova A, Tur JA, Pons A, Free Radic Res 2005 39 1317 24 10.1080/10715760500177500 16298861
67. Reference ranges of normal blood catalase activity and levels in familial hypocatalasemia in Hungary. Vitai M, Góth L, Clin Chim Acta 1997 261 35 42 10.1016/S0009-8981(97)06514-5 9187503
68. Comparison of oxidative stress and antioxidant capacity before and after running exercises in both sexes. Pepe H, Balci SS, Revan S, Akalin PP, Kurtoǧlu F, Gend Med 2009 6 587 95 10.1016/j.genm.2009.10.001 20114009
69. Influence of regular exercise on erythrocyte catalase activity in adolescents with down syndrome. Rosety-Rodríguez M, Rosety M, Ordóñez FJ, Med Clin (Barc) 2006 127 533 4 10.1157/13093724
70. Oxidative stress biomarkers in mitochondrial myopathies, basally and after cysteine donor supplementation. Mancuso M, Orsucci D, Logerfo A, Rocchi A, Petrozzi L, Nesti C, Galetta F, Santoro G, Murri L, Siciliano G, J Neurol 2010 257 774 81 10.1007/s00415-009-5409-7 19960200
71. N-acetylcysteine supplementation controls total antioxidant capacity, creatine kinase, lactate, nd tumor necrotic factor-alpha against oxidative stress induced by graded exercise in sedentary men. Leelarungrayub D, Khansuwan R, Pothongsunun P, Klaphajone J, Oxid Med Cell Longev 2011 2011 329643 21904641
72. Plasma protein oxidation and its correlation with antioxidant potential during human aging. Pandey KB, Mehdi MM, Maurya PK, Rizvi SI, Dis Markers 2010 29 31 6 20826915
73. Plasma total antioxidant capacity in an adult Hong Kong Chinese population. Woo J, Leung SS, Lam CW, Ho SC, Lam TH, Janus ED, Clin Biochem 1997 30 553 7 10.1016/S0009-9120(97)00112-4 9399024
74. Effects of an antioxidant vitamin mixture on lipid peroxidation at rest and postexercise. Kanter MM, Nolte LA, Holloszy JO, J Appl Physiol 1993 74 965 9 8458821
75. Exercise, depletion of antioxidants and antioxidant manipulation. Balakrishnan SD, Anuradha CV, Cell Biochem Funct 1998 16 269 75 10.1002/(SICI)1099-0844(1998120)16:4<269::AID-CBF797>3.0.CO;2-B 9857489
76. Does muscle-derived interleukin-6 mediate some of the beneficial effects of exercise on cancer treatment-related fatigue? Wood LJ, Nail LM, Winters KA, Oncol Nurs Forum 2009 36 519 24 10.1188/09.ONF.519-524 19726392
77. The effects of intensive, moderate and downhill treadmill running on human blood lymphocytes expressing the adhesion/activation molecules CD54 (ICAM-1), CD18 (beta2 integrin) and CD53. Simpson RJ, Florida-James GD, Whyte GP, Guy K, Eur J Appl Physiol 2006 97 109 21 10.1007/s00421-006-0146-4 16506060
78. Reference intervals for human peripheral blood lymphocyte subpopulations from 'healthy' young and aged subjects. Stulnig T, Maczek C, Böck G, Majdic O, Wick G, Int Arch Allergy Immunol 1995 108 205 10 10.1159/000237155 7580284
79. Gender specificity of altered human immune cytokine profiles in aging. Goetzl EJ, Huang MC, Kon J, Patel K, Schwartz JB, Fast K, Ferrucci L, Madara K, Taub DD, Longo DL, FASEB J 2010 24 3580 9 10.1096/fj.10-160911 20453111
80. Donor CD8 T cells and IFN-gamma are critical for sex-based differences in donor CD4 T cell engraftment and lupus-like phenotype in short-term chronic graft-versus-host disease mice. Foster AD, Soloviova K, Puliaeva I, Puliaiev M, Puliaev R, Finkelman F, Via CS, J Immunol 2011 186 6238 54 10.4049/jimmunol. 1001074 21531893
81. T-lymphocytes expressing CC chemokine receptor-5 are increased in frail older adults. De Fanis U, Wang GC, Fedarko NS, Walston JD, Casolaro V, Leng SX, J Am Geriatr Soc 2008 56 904 8 10.1111/j.1532-5415.2008.01673.x 18384587
82. Role of myokines in exercise and metabolism. Pedersen BK, Akerström TC, Nielsen AR, Fischer CP, J Appl Physiol 2007 103 1093 8 10.1152/japplphysiol. 00080.2007 17347387
83. Contraction-induced myokine production and release: is skeletal muscle an endocrine organ? Febbraio MA, Pedersen BK, Exerc Sport Sci Rev 2005 33 114 9 10.1097/00003677-200507000-00003 16006818
84. The effect of carbohydrate ingestion on the interleukin-6 response to a 90-minute run time trial. Robson-Ansley P, Barwood M, Eglin C, Ansley L, Int J Sports Physiol Perform 2009 4 186 94 19567922
85. The anti-inflammatory effect of exercise. Petersen AM, Pedersen BK, J Appl Physiol 2005 98 1154 62 10.1152/japplphysiol.00164.2004 15772055
86. Treatment with levamisole and colchicine can result in a significant reduction of IL-6, IL-8 or TNF-alpha level in patients with mucocutaneous type of Behcet's disease. Sun A, Wang YP, Chia JS, Liu BY, Chiang CP, J Oral Pathol Med 2009 38 401 5 10.1111/j.1600-0714.2009.00774.x 19434815
87. Influence of the sample collection method on salivary interleukin-6 levels in resting and post-exercise conditions. Minetto MA, Gazzoni M, Lanfranco F, Baldi M, Saba L, Pedrola R, Komi PV, Rainoldi A, Eur J Appl Physiol 2007 101 249 56 10.1007/s00421-007-0484-x 17569075
88. Elevated plasma interleukin-6 levels in trained male triathletes following an acute period of intense interval training. Robson-Ansley PJ, Blannin A, Gleeson M, Eur J Appl Physiol 2007 99 353 60 10.1007/s00421-006-0354- y 17165057
89. Muscle endurance in elderly nursing home residents is related to fatigue perception, mobility, and circulating tumor necrosis factor-, interleukin-6, and heat shock protein 70. Bautmans I, Njemini R, Predom H, Lemper JC, Mets T, J Am Geriatr Soc 2008 56 389 96 10.1111/j.1532-5415.2007.01571.x 18179479
90. Age and pro-inflammatory cytokine production: wound-healing implications for scar-formation and the timing of genital surgery in boys. Bermudez DM, Canning DA, Liechty KW, J Pediatr Urol 2011 7 324 31 10.1016/j.jpurol.2011.02. 013 21527214
91. Correlation of psycho-neuroendocrine-immune (PNI) gene expression with symptoms of acute infectious mononucleosis. Vernon SD, Nicholson A, Rajeevan M, Dimulescu I, Cameron B, Whistler T, Lloyd A, Brain Res 2006 1068 1 6 10.1016/j.brainres.2005.11.013 16376318
92. Moderate exercise increases expression for sensory, adrenergic, and immune genes in chronic fatigue syndrome patients but not in normal subjects. Light AR, White AT, Hughen RW, Light KC, J Pain 2009 10 1099 112 10.1016/j.jpain.2009.06.003 19647494
93. Interleukin-6 and its mRNA responses in exercise and recovery: relationship to muscle glycogen. Gusba JE, Wilson RJ, Robinson DL, Graham TE, Scand J Med Sci Sports 2008 18 77 85 17346285
94. Advanced oxidation protein products as a novel marker of oxidative stress in uremia. Witko-Sarsat V, Friedlander M, Capeillère-Blandin C, Nguyen-Khoa T, Nguyen AT, Zingraff J, Jungers P, Descamps-Latscha B, Kidney Int 1996 49 1304 13 10.1038/ki.1996.186 8731095
95. Unravelling the nature of postexertional malaise in myalgic encephalomyelitis/chronic fatigue syndrome: the role of elastase, complement C4a and interleukin-1beta. Nijs J, Van Oosterwijck J, Meeus M, Lambrecht L, Metzger K, Frémont M, Paul L, J Intern Med 2010 267 418 35 10.1111/j.1365-2796. 2009.02178.x 20433584
96. Stress lactate in mitochondrial myopathy under constant, unadjusted workload. Finsterer J, Milvay E, Eur J Neurol 2004 11 811 6 10.1111/j.1468-1331. 2004.00859.x 15667411
97. Cycle ergometry is not a sensitive diagnostic test for mitochondrial myopathy. Jeppesen TD, Olsen D, Vissing J, J Neurol 2003 250 293 9 10.1007/s00415-003-0993-4 12638019