Muscle endurance in elderly nursing home residents is related to fatigue perception, mobility, and circulating tumor necrosis factor-alpha, interleukin-6, and heat shock protein 70

Journal of the American Geriatrics Society

Volumn 56, Issue 3, 2008, Pages 389-396

  Bautmans, Ivan ^a,b   Njemini, Rose ^a   Predom, Heidi ^a   Lemper, Jean Claude ^b,c   Mets, Tony ^a,b  

^a VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^b UNIVERSITY HOSPITAL BRUSSELS   (Belgium)

^c Foundation for Psychogeriatrics   (Belgium)

Author keywords

Cytokines; Elderly; Heat shock protein; Muscle endurance; Nursing homes

Indexed keywords

HEAT SHOCK PROTEIN 70; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

AGED; ANTHROPOMETRY; ARTICLE; BODY COMPOSITION; COMORBIDITY; CYTOKINE RELEASE; ELDERLY MOBILITY SCALE; ENDURANCE; ENZYME LINKED IMMUNOSORBENT ASSAY; FATIGUE; FEMALE; GRIP STRENGTH; HUMAN; INFLAMMATION; MAJOR CLINICAL STUDY; MALE; MOBILITY TIREDNESS SCALE; MUSCLE EXERCISE; NURSING HOME PATIENT; PHYSICAL MOBILITY; QUALITY OF LIFE; QUESTIONNAIRE; SELF CONCEPT; STATISTICAL ANALYSIS; TINETTI TEST; VISUAL ANALOG SCALE;

AGED; AGED, 80 AND OVER; FEMALE; FRAIL ELDERLY; GAIT; HSP70 HEAT-SHOCK PROTEINS; HUMANS; INTERLEUKIN-6; MALE; MOBILITY LIMITATION; MUSCLE FATIGUE; MUSCULOSKELETAL EQUILIBRIUM; NURSING HOMES; PHYSICAL ENDURANCE; SELF CONCEPT; TUMOR NECROSIS FACTOR-ALPHA;

EID: 40149083730     PISSN: 00028614     EISSN: 15325415     Source Type: Journal    
DOI: 10.1111/j.1532-5415.2007.01571.x     Document Type: Article

References (46)

1. Fried LP, Tangen CM, Walston J et al. Frailty in older adults: Evidence for a phenotype. J Gerontol A Biol Sci Med Sci 2001 56A : M146 M157.
2. Walston J, Hadley EC, Ferrucci L et al. Research Agenda for frailty in older adults: Toward a better understanding of physiology and etiology: summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older Adults. J Am Geriatr Soc 2006 54 : 991 1001.
3. Liao S, Ferrell BA. Fatigue in an older population. J Am Geriatr Soc 2000 48 : 426 430.
4. Peeters P, Mets T. The 6-minute walk as an appropriate exercise test in elderly patients with chronic heart failure. J Gerontol A Biol Sci Med Sci 1996 51A : M147 M151.
5. Bautmans I, Njemini R, Lambert M et al. Circulating acute phase mediators and skeletal muscle performance in hospitalized geriatric patients. J Gerontol A Biol Sci Med Sci 2005 60 : 361 367.
6. Bautmans I, Mets T. A fatigue resistance test for elderly persons based upon grip strength: Reliability and comparison with healthy young subjects. Aging Clin Exp Res 2005 17 : 217 222.
7. Mets T, Bautmans I, Njemini R et al. The influence of celecoxib on muscle fatigue resistance and mobility in elderly patients with inflammation. Am J Geriatr Pharmacother 2004 2 : 230 238.
8. Bautmans I, Gorus E, Njemini R et al. Handgrip performance in relation to self-perceived fatigue, physical functioning and circulating IL-6 in elderly persons without inflammation. BMC Geriatr 2007 7 : 5.
9. Gabay C, Kushner I. Acute-phase proteins and other systemic responses to inflammation. N Engl J Med 1999 340 : 448 454.
10. Delves PJ, Roitt IM. The immune system. Second of two parts. N Engl J Med 2000 343 : 108 117.
11. Kotler DP. Cachexia. Ann Intern Med 2000 133 : 622 634.
12. Roubenoff R. The pathophysiology of wasting in the elderly. J Nutr 1999 129 : 256S 259S.
13. Kushner I. Semantics, inflammation, cytokines and common sense. Cytokine Growth Factor Rev 1998 9 : 191 196.
14. Tilg H, Dinarello CA, Mier JW. IL-6 and APPs: Anti-inflammatory and immunosuppressive mediators. Immunol Today 1997 18 : 428 432.
15. Pedersen BK, Steensberg A, Schjerling P. Muscle-derived interleukin-6: Possible biological effects. J Physiol 2001 536 : 329 337.
16. Bruunsgaard H. Physical activity and modulation of systemic low-level inflammation. J Leukoc Biol 2005 78 : 819 835.
17. Njemini R, Lambert M, Demanet C et al. The induction of heat shock protein 70 in peripheral mononuclear blood cells in elderly patients: A role for inflammatory markers. Hum Immunol 2003 64 : 575 585.
18. Njemini R, Demanet C, Mets T. Inflammatory status as an important determinant of heat shock protein 70 serum concentrations during aging. Biogerontology 2004 5 : 31 38.
19. Njemini R, Lambert M, Demanet C et al. Elevated serum heat-shock protein 70 levels in patients with acute infection: Use of an optimized enzyme-linked immunosorbent assay. Scand J Immunol 2003 58 : 664 669.
20. Febbraio MA, Steensberg A, Fischer CP et al. IL-6 activates HSP72 gene expression in human skeletal muscle. Biochem Biophys Res Commun 2002 296 : 1264 1266.
21. Liu Y, Lormes W, Baur C et al. Human skeletal muscle HSP70 response to physical training depends on exercise intensity. Int J Sports Med 2000 21 : 351 355.
22. Johnson AD, Tytell M. Exogenous HSP70 becomes cell associated, but not internalized, by stressed arterial smooth muscle cells. In Vitro Cell Dev Biol Anim 1993 29A : 807 812.
23. Robinson MB, Tidwell JL, Gould T et al. Extracellular heat shock protein 70: A critical component for motoneuron survival. J Neurosci 2005 25 : 9735 9745.
24. Terry DF, Wyszynski DF, Nolan VG et al. Serum heat shock protein 70 level as a biomarker of exceptional longevity. Mech Ageing Dev 2006 127 : 862 868.
25. Katz S, Ford AB, Moskowitz RW et al. Studies of illness in the aged. The index of ADL: A standardized measure of biological and psychosocial function. JAMA 1963 185 : 914 919.
26. Folstein M, Folstein S, McHugh P. "Mini-mental state" a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975 12 : 189 198.
27. Bautmans I, Njemini R, Vasseur S et al. Biochemical changes in response to intensive resistance exercise training in the elderly. Gerontology 2005 51 : 253 265.
28. Martin AD, Spenst LF, Drinkwater DT et al. Anthropometric estimation of muscle mass in men. Med Sci Sports Exerc 1990 22 : 729 733.
29. Avlund K, Kreiner S, Schultz-Larsen K. Construct validation and the Rasch model: Functional ability of healthy elderly people. Scand J Soc Med 1993 21 : 233 246.
30. WHO. WHOQOL-100: The 100 Questions with response scales. [on-line]. Available at : Accessed November 27, 2004.
31. Tinetti ME. Performance-oriented assessment of mobility problems in elderly patients. J Am Geriatr Soc 1986 34 : 119 126.
32. Smith R. Validation and reliability of the elderly mobility scale. Physiotherapy 1994 80 : 744 747.
33. Kirkwood B. Essentials of Medical Statistics, 2nd Ed. Oxford : Blackwell Sciences Ltd, 2003.
34. Ronti T, Lupattelli G, Mannarino E. The endocrine function of adipose tissue: An update. Clin Endocrinol 2006 64 : 355 365.
35. Merkies IS, Schmitz PI, Samijn JP et al. Assessing grip strength in healthy individuals and patients with immune-mediated polyneuropathies. Muscle Nerve 2000 23 : 1393 1401.
36. Lauretani F, Russo CR, Bandinelli S et al. Age-associated changes in skeletal muscles and their effect on mobility: An operational diagnosis of sarcopenia. J Appl Physiol 2003 95 : 1851 1860.
37. Marcell TJ. Review article: Sarcopenia: causes, consequences, and preventions. J Gerontol A Biol Sci Med Sci 2003 58A : M911 M916.
38. Schaap LA, Pluijm SMF, Deeg DJH et al. Inflammatory markers and loss of muscle mass (sarcopenia) and strength. Am J Med 2006 119 : 526.e9 526.e17.
39. Zoico E, Roubenoff R. The role of cytokines in regulating protein metabolism and muscle function. Nutr Rev 2002 60 : 39 51.
40. Mooradian AD, Reed RL, Osterweil D et al. Detectable serum levels of tumor necrosis factor alpha may predict early mortality in elderly institutionalized patients. J Am Geriatr Soc 1991 39 : 891 894.
41. Bruunsgaard H, Bjerregaard E, Schroll M et al. Muscle strength after resistance training is inversely correlated with baseline levels of soluble tumor necrosis factor receptors in the oldest old. J Am Geriatr Soc 2004 52 : 237 241.
42. Bruunsgaard H, Ladelund S, Pedersen AN et al. Predicting death from tumour necrosis factor-alpha and interleukin-6 in 80-year-old people. Clin Exp Immunol 2003 132 : 24 31.
43. Febbraio MA, Pedersen BK. Muscle-derived interleukin-6: Mechanisms for activation and possible biological roles. FASEB J 2002 16 : 1335 1347.
44. Febbraio MA, Hiscock N, Sacchetti M et al. Interleukin-6 is a novel factor mediating glucose homeostasis during skeletal muscle contraction. Diabetes 2004 53 : 1643 1648.
45. Asea A. Stress proteins and initiation of immune response: Chaperokine activity of hsp72. Exerc Immunol Rev 2005 11 : 34 45.
46. Franceschi C, Capri M, Monti D et al. Inflammaging and anti-inflammaging: A systemic perspective on aging and longevity emerged from studies in humans. Mech of Ageing Dev 2007 128 : 92 105.