-
1
-
-
0033566302
-
Chromatin remodeling and leukemia: New therapeutic paradigms
-
Redner RL, Wang J, Liu JM. Chromatin remodeling and leukemia: new therapeutic paradigms. Blood 1999;94:417-428 (Pubitemid 29323855)
-
(1999)
Blood
, vol.94
, Issue.2
, pp. 417-428
-
-
Redner, R.L.1
Wang, J.2
Liu, J.M.3
-
2
-
-
34547897023
-
Histone deacetylases and cancer
-
Glozak MA, Seto E. Histone deacetylases and cancer. Oncogene 2007;26:5420-5432
-
(2007)
Oncogene
, vol.26
, pp. 5420-5432
-
-
Glozak, M.A.1
Seto, E.2
-
3
-
-
33748451151
-
Anticancer activities of histone deacetylase inhibitors
-
DOI 10.1038/nrd2133, PII NRD2133
-
Bolden JE, Peart MJ, Johnstone RW. Anticancer activities of histone deacetylase inhibitors. Nat Rev Drug Discov 2006;5:769-784 (Pubitemid 44348499)
-
(2006)
Nature Reviews Drug Discovery
, vol.5
, Issue.9
, pp. 769-784
-
-
Bolden, J.E.1
Peart, M.J.2
Johnstone, R.W.3
-
4
-
-
35848933227
-
Epigenetic targets in hematological malignancies: Combination therapies with HDACis and demethylating agents
-
DOI 10.1586/14737140.7.10.1439
-
Bishton M, Kenealy M, Johnstone R, Rasheed W, Prince HM. Epigenetic targets in hematological malignancies: combination therapies with HDACis and demethylating agents. Expert Rev Anticancer Ther 2007;7:1439-1449 (Pubitemid 351826909)
-
(2007)
Expert Review of Anticancer Therapy
, vol.7
, Issue.10
, pp. 1439-1449
-
-
Bishton, M.1
Kenealy, M.2
Johnstone, R.3
Rasheed, W.4
Prince, H.M.5
-
5
-
-
21244467166
-
Epigenetic and chromatin modifiers as targeted therapy of hematologic malignancies
-
DOI 10.1200/JCO.2005.16.600
-
Bhalla KN. Epigenetic and chromatin modifiers as targeted therapy of hematologic malignancies. J Clin Oncol 2005;23:3971-3993 (Pubitemid 46218700)
-
(2005)
Journal of Clinical Oncology
, vol.23
, Issue.17
, pp. 3971-3993
-
-
Bhalla, K.N.1
-
6
-
-
69749105820
-
-
Potent anticancer activity of the pandeacetylase inhibitor panobinostat (LBH589) as a single agent in in vitro and in vivo tumor models. Poster presentation. (Abstract 6244)
-
Shao W, Growney JD, Feng Y, Wang P, Yan-Neale Y, O'Connor G, et al. Potent anticancer activity of the pandeacetylase inhibitor panobinostat (LBH589) as a single agent in in vitro and in vivo tumor models. 99th American Association Cancer Research Annual Meeting, 12-16 April, 2008, San Diego, California. Poster presentation. (Abstract 6244). 2008a
-
(2008)
99th American Association Cancer Research Annual Meeting, 12-16 April, 2008, San Diego, California
-
-
Shao, W.1
Growney, J.D.2
Feng, Y.3
Wang, P.4
Yan-Neale, Y.5
O'Connor, G.6
-
7
-
-
33745258655
-
The histone deacetylase inhibitor LBH589 is a potent antimyeloma agent that overcomes drug resistance
-
DOI 10.1158/0008-5472.CAN-05-4186
-
Maiso P, Carvajal-Vergara X, Ocio EM, Lopez-Perez R, Mateo G, Gutierrez N, et al. The histone deacetylase inhibitor LBH589 is a potent antimyeloma agent that overcomes drug resistance. Cancer Res 2006;66:5781-5789 (Pubitemid 43927132)
-
(2006)
Cancer Research
, vol.66
, Issue.11
, pp. 5781-5789
-
-
Maiso, P.1
Carvajal-Vergara, X.2
Ocio, E.M.3
Lopez-Perez, R.4
Mateo, G.5
Gutierrez, N.6
Atadja, P.7
Pandiella, A.8
San Miguel, J.F.9
-
8
-
-
33751172982
-
Aggresome induction by proteasome inhibitor bortezomib and alpha-tubulin hyperacetylation by tubulin deacetylase (TDAC) inhibitor LBH589 are synergistic in myeloma cells
-
DOI 10.1182/blood-2006-04-016055
-
Catley L, Weisberg E, Kiziltepe T, Tai YT, Hideshima T, Neri P, et al. Aggresome induction by proteasome inhibitor bortezomib and alpha-tubulin hyperacetylation by tubulin deacetylase (TDAC) inhibitor LBH589 are synergistic in myeloma cells. Blood 2006;108:3441-3449 (Pubitemid 44776885)
-
(2006)
Blood
, vol.108
, Issue.10
, pp. 3441-3449
-
-
Catley, L.1
Weisberg, E.2
Kiziltepe, T.3
Tai, Y.-T.4
Hideshima, T.5
Neri, P.6
Tassone, P.7
Atadja, P.8
Chauhan, D.9
Munshi, N.C.10
Anderson, K.C.11
-
9
-
-
69749092177
-
Efficacy of Panobinostat (LBH589) in CTCL Cell Lines and a Murine Xenograft Model: Defining Molecular Pathways of Panobinostat Activity in CTCL
-
Shao W, Growney JD, Feng Y, O'Connor G, Pu M, Yao Y-M, et al. Efficacy of Panobinostat (LBH589) in CTCL Cell Lines and a Murine Xenograft Model: Defining Molecular Pathways of Panobinostat Activity in CTCL. ASH Annual Meeting Abstracts 2007;110:1375.
-
(2007)
ASH Annual Meeting Abstracts
, vol.110
, pp. 1375
-
-
Shao, W.1
Growney, J.D.2
Feng, Y.3
O'Connor, G.4
Pu, M.5
Yao, Y.-M.6
-
10
-
-
85097913069
-
Efficacy of Panobinostat (LBH589) in Multiple Myeloma Cell Lines and in Vivo Mouse Model: Tumor-Specific Cytotoxicity and Protection of Bone Integrity in Multiple Myeloma
-
Growney JD, Atadja P, Shao W, Wang Y, Pu M, Firestone B, et al. Efficacy of Panobinostat (LBH589) in Multiple Myeloma Cell Lines and In Vivo Mouse Model: Tumor-Specific Cytotoxicity and Protection of Bone Integrity in Multiple Myeloma. ASH Annual Meeting Abstracts 2007;110:1510.
-
(2007)
ASH Annual Meeting Abstracts
, vol.110
, pp. 1510
-
-
Growney, J.D.1
Atadja, P.2
Shao, W.3
Wang, Y.4
Pu, M.5
Firestone, B.6
-
11
-
-
69749091923
-
Potent anticancer activity of panobinostat (LBH589) in small-cell lung cancer in both in vitro and in vivo tumor models
-
Abstract 86
-
Atadja P, Shao W, Wang Y, Growney JD, Cheng J, Kowal C, et al. Potent anticancer activity of panobinostat (LBH589) in small-cell lung cancer in both in vitro and in vivo tumor models. Ann oncol 2008; viii50. Abstract 86.
-
(2008)
Ann Oncol
-
-
Atadja, P.1
Shao, W.2
Wang, Y.3
Growney, J.D.4
Cheng, J.5
Kowal, C.6
-
12
-
-
33748063974
-
A phase I study of intravenous LBH589, a novel cinnamic hydroxamic acid analogue histone deacetylase inhibitor, in patients with refractory hematologic malignancies
-
DOI 10.1158/1078-0432.CCR-06-0511
-
Giles F, Fischer T, Cortes J, Garcia-Manero G, Beck J, Ravandi F, et al. Aphase I study of intravenous LBH589, a novel cinnamic hydroxamic acid analogue histone deacetylase inhibitor, in patients with refractory hematologic malignancies. Clin Cancer Res 2006;12:4628-4635 (Pubitemid 44297814)
-
(2006)
Clinical Cancer Research
, vol.12
, Issue.15
, pp. 4628-4635
-
-
Giles, F.1
Fischer, T.2
Cortes, J.3
Garcia-Manero, G.4
Beck, J.5
Ravandi, F.6
Masson, E.7
Rae, P.8
Laird, G.9
Sharma, S.10
Kantarjian, H.11
Dugan, M.12
Albitar, M.13
Bhalla, K.14
-
13
-
-
38349187877
-
Clinically relevant QTc prolongation is not associated with current dose schedules of LBH589 (panobinostat)
-
discussion 333-334
-
Zhang L, Lebwohl D, Masson E, Laird G, Cooper MR, Prince HM. Clinically relevant QTc prolongation is not associated with current dose schedules of LBH589 (panobinostat). J Clin Oncol 2008;26:332-3; discussion 333-334
-
(2008)
J Clin Oncol
, vol.26
, pp. 332-333
-
-
Zhang, L.1
Lebwohl, D.2
Masson, E.3
Laird, G.4
Cooper, M.R.5
Prince, H.M.6
-
14
-
-
69749117725
-
-
Phase I pharmacokinetic and pharmacodynamic study of once-weekly i.v. panobinostat (LBH589). Poster presentation
-
Sharma S, Vogelzang NJ, Beck J, Patnaik A, Mita M, Dugan M, et al. Phase I pharmacokinetic and pharmacodynamic study of once-weekly i.v. panobinostat (LBH589). European Cancer Conference (ECCO 14), 23-27 September 2007, Barcelona, Spain. Poster presentation.
-
European Cancer Conference (ECCO 14), 23-27 September 2007, Barcelona, Spain
-
-
Sharma, S.1
Vogelzang, N.J.2
Beck, J.3
Patnaik, A.4
Mita, M.5
Dugan, M.6
-
15
-
-
43049088775
-
Phase I study of oral LBH589, a novel deacetylase (DAC) inhibitor in advanced solid tumors and non-hodgkin's lymphoma
-
Prince HM, George D, Patnaik A, Mita M, Dugan M, Butterfoss D, et al. Phase I study of oral LBH589, a novel deacetylase (DAC) inhibitor in advanced solid tumors and non-hodgkin's lymphoma. J Clin Oncol (Meeting Abstracts) 2007;25(18-suppl):3500.
-
(2007)
J Clin Oncol (Meeting Abstracts)
, vol.25
, Issue.18 SUPPL.
, pp. 3500
-
-
Prince, H.M.1
George, D.2
Patnaik, A.3
Mita, M.4
Dugan, M.5
Butterfoss, D.6
-
16
-
-
51649126841
-
Histone deacetylase inhibitor panobinostat induces clinical responses with associated alterations in gene expression profiles in cutaneous T-cell lymphoma
-
Ellis L, Pan Y, Smyth GK, George DJ, McCormack C, Williams-Truax R, et al. Histone deacetylase inhibitor panobinostat induces clinical responses with associated alterations in gene expression profiles in cutaneous T-cell lymphoma. Clin Cancer Res 2008;14:4500-4510
-
(2008)
Clin Cancer Res
, vol.14
, pp. 4500-4510
-
-
Ellis, L.1
Pan, Y.2
Smyth, G.K.3
George, D.J.4
McCormack, C.5
Williams-Truax, R.6
-
17
-
-
67449134299
-
Phase II Trial of Oral Panobinostat (LBH589) in Patients with Refractory Cutaneous T-Cell Lymphoma (CTCL)
-
Duvic M, Becker JC, Dalle S, Vanaclocha F, Bernengo MG, Lebbe C, et al. Phase II Trial of Oral Panobinostat (LBH589) in Patients with Refractory Cutaneous T-Cell Lymphoma (CTCL). ASH Annual Meeting Abstracts 2008;112:1005.
-
(2008)
ASH Annual Meeting Abstracts
, vol.112
, pp. 1005
-
-
Duvic, M.1
Becker, J.C.2
Dalle, S.3
Vanaclocha, F.4
Bernengo, M.G.5
Lebbe, C.6
-
18
-
-
34247860871
-
Vorinostat for treatment of cutaneous manifestations of advanced primary cutaneous T-cell lymphoma
-
DOI 10.1158/1078-0432.CCR-06-2672
-
Mann BS, Johnson JR, He K, Sridhara R, Abraham S, Booth BP, et al. Vorinostat for treatment of cutaneous manifestations of advanced primary cutaneous T-cell lymphoma. Clin Cancer Res 2007;13:2318-2322 (Pubitemid 46698579)
-
(2007)
Clinical Cancer Research
, vol.13
, Issue.8
, pp. 2318-2322
-
-
Mann, B.S.1
Johnson, J.R.2
He, K.3
Sridhara, R.4
Abraham, S.5
Booth, B.P.6
Verbois, L.7
Morse, D.E.8
Jee, J.M.9
Pope, S.10
Harapanhalli, R.S.11
Dagher, R.12
Farrell, A.13
Justice, R.14
Pazdur, R.15
-
19
-
-
34547683194
-
Phase IIB multicenter trial of vorinostat in patients with persistent, progressive, or treatment refractory cutaneous t-cell lymphoma
-
DOI 10.1200/JCO.2006.10.2434
-
Olsen EA, Kim YH, Kuzel TM, Pacheco TR, Foss FM, Parker S, et al. Phase IIb multicenter trial of vorinostat in patients with persistent, progressive, or treatment refractory cutaneous T-cell lymphoma. J Clin Oncol 2007;25: 3109-3115 (Pubitemid 47218059)
-
(2007)
Journal of Clinical Oncology
, vol.25
, Issue.21
, pp. 3109-3115
-
-
Olsen, E.A.1
Kim, Y.H.2
Kuzel, T.M.3
Pacheco, T.R.4
Foss, F.M.5
Parker, S.6
Frankel, S.R.7
Chen, C.8
Ricker, J.L.9
Arduino, J.M.10
Duvic, M.11
-
20
-
-
69749094850
-
Final clinical results of a Phase 2 NCI multicenter study of romidepsin in recurrent cutaneous T-cell lymphoma (molecular analyses included)
-
Bates S, Piekarz R, Wright J, Frye R, Figg WD, Sr., Allen SL, et al. Final clinical results of a Phase 2 NCI multicenter study of romidepsin in recurrent cutaneous T-cell lymphoma (molecular analyses included). ASH Annual Meeting Abstracts 2008;112:1568.
-
(2008)
ASH Annual Meeting Abstracts
, vol.112
, pp. 1568
-
-
Bates, S.1
Piekarz, R.2
Wright, J.3
Frye, R.4
Figg Sr., W.D.5
Allen, S.L.6
-
21
-
-
67449109154
-
Phase IA/II Study of Oral Panobinostat (LBH589), a Novel Pan- Deacetylase Inhibitor (DACi) demonstrating Efficacy in Patients with Advanced Hematologic Malignancies
-
Ottmann OG, Spencer A, Prince HM, Bhalla KN, Fischer T, Liu A, et al. Phase IA/II Study of Oral Panobinostat (LBH589), a Novel Pan- Deacetylase Inhibitor (DACi) demonstrating Efficacy in Patients with Advanced Hematologic Malignancies. ASH Annual Meeting Abstracts 2008;112:958.
-
(2008)
ASH Annual Meeting Abstracts
, vol.112
, pp. 958
-
-
Ottmann, O.G.1
Spencer, A.2
Prince, H.M.3
Bhalla, K.N.4
Fischer, T.5
Liu, A.6
-
22
-
-
67449125357
-
A Phase II Study of Oral Panobinostat (LBH589) in Adult Patients with Advanced Refractory Multiple Myeloma
-
Wolf JL, Siegel D, Matous J, Lonial S, Goldschmidt H, Schmitt S, et al. A Phase II Study of Oral Panobinostat (LBH589) in Adult Patients with Advanced Refractory Multiple Myeloma. ASH Annual Meeting Abstracts 2008;112:2774.
-
(2008)
ASH Annual Meeting Abstracts
, vol.112
, pp. 2774
-
-
Wolf, J.L.1
Siegel, D.2
Matous, J.3
Lonial, S.4
Goldschmidt, H.5
Schmitt, S.6
-
23
-
-
67449140087
-
A Phase IB, Multicenter, Open-Label, Dose-Escalation Study of Oral Panobinostat (LBH589) and I.V. Bortezomib in Patients with Relapsed Multiple Myeloma
-
Siegel Dd, Sezer O, San Miguel JF, Mateos M-V, Prosser I, Cavo M, et al. A Phase IB, Multicenter, Open-Label, Dose-Escalation Study of Oral Panobinostat (LBH589) and I.V. Bortezomib in Patients with Relapsed Multiple Myeloma. ASH Annual Meeting Abstracts 2008;112: 2781.
-
(2008)
ASH Annual Meeting Abstracts
, vol.112
, pp. 2781
-
-
Siegel, Dd.1
Sezer, O.2
San Miguel, J.F.3
Mateos, M.-V.4
Prosser, I.5
Cavo, M.6
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