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Volumn 3, Issue 1, 2009, Pages 33-38

Panobinostat (LBH589): A novel pan-deacetylase inhibitor with activity in T cell lymphoma

Author keywords

[No Author keywords available]

Indexed keywords

BORTEZOMIB; LENALIDOMIDE; MELPHALAN; PANOBINOSTAT; ROMIDEPSIN; STEROID; THALIDOMIDE; VORINOSTAT;

EID: 69749111046     PISSN: 19707339     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper
Times cited : (25)

References (23)
  • 1
    • 0033566302 scopus 로고    scopus 로고
    • Chromatin remodeling and leukemia: New therapeutic paradigms
    • Redner RL, Wang J, Liu JM. Chromatin remodeling and leukemia: new therapeutic paradigms. Blood 1999;94:417-428 (Pubitemid 29323855)
    • (1999) Blood , vol.94 , Issue.2 , pp. 417-428
    • Redner, R.L.1    Wang, J.2    Liu, J.M.3
  • 2
    • 34547897023 scopus 로고    scopus 로고
    • Histone deacetylases and cancer
    • Glozak MA, Seto E. Histone deacetylases and cancer. Oncogene 2007;26:5420-5432
    • (2007) Oncogene , vol.26 , pp. 5420-5432
    • Glozak, M.A.1    Seto, E.2
  • 3
    • 33748451151 scopus 로고    scopus 로고
    • Anticancer activities of histone deacetylase inhibitors
    • DOI 10.1038/nrd2133, PII NRD2133
    • Bolden JE, Peart MJ, Johnstone RW. Anticancer activities of histone deacetylase inhibitors. Nat Rev Drug Discov 2006;5:769-784 (Pubitemid 44348499)
    • (2006) Nature Reviews Drug Discovery , vol.5 , Issue.9 , pp. 769-784
    • Bolden, J.E.1    Peart, M.J.2    Johnstone, R.W.3
  • 4
    • 35848933227 scopus 로고    scopus 로고
    • Epigenetic targets in hematological malignancies: Combination therapies with HDACis and demethylating agents
    • DOI 10.1586/14737140.7.10.1439
    • Bishton M, Kenealy M, Johnstone R, Rasheed W, Prince HM. Epigenetic targets in hematological malignancies: combination therapies with HDACis and demethylating agents. Expert Rev Anticancer Ther 2007;7:1439-1449 (Pubitemid 351826909)
    • (2007) Expert Review of Anticancer Therapy , vol.7 , Issue.10 , pp. 1439-1449
    • Bishton, M.1    Kenealy, M.2    Johnstone, R.3    Rasheed, W.4    Prince, H.M.5
  • 5
    • 21244467166 scopus 로고    scopus 로고
    • Epigenetic and chromatin modifiers as targeted therapy of hematologic malignancies
    • DOI 10.1200/JCO.2005.16.600
    • Bhalla KN. Epigenetic and chromatin modifiers as targeted therapy of hematologic malignancies. J Clin Oncol 2005;23:3971-3993 (Pubitemid 46218700)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.17 , pp. 3971-3993
    • Bhalla, K.N.1
  • 8
    • 33751172982 scopus 로고    scopus 로고
    • Aggresome induction by proteasome inhibitor bortezomib and alpha-tubulin hyperacetylation by tubulin deacetylase (TDAC) inhibitor LBH589 are synergistic in myeloma cells
    • DOI 10.1182/blood-2006-04-016055
    • Catley L, Weisberg E, Kiziltepe T, Tai YT, Hideshima T, Neri P, et al. Aggresome induction by proteasome inhibitor bortezomib and alpha-tubulin hyperacetylation by tubulin deacetylase (TDAC) inhibitor LBH589 are synergistic in myeloma cells. Blood 2006;108:3441-3449 (Pubitemid 44776885)
    • (2006) Blood , vol.108 , Issue.10 , pp. 3441-3449
    • Catley, L.1    Weisberg, E.2    Kiziltepe, T.3    Tai, Y.-T.4    Hideshima, T.5    Neri, P.6    Tassone, P.7    Atadja, P.8    Chauhan, D.9    Munshi, N.C.10    Anderson, K.C.11
  • 9
    • 69749092177 scopus 로고    scopus 로고
    • Efficacy of Panobinostat (LBH589) in CTCL Cell Lines and a Murine Xenograft Model: Defining Molecular Pathways of Panobinostat Activity in CTCL
    • Shao W, Growney JD, Feng Y, O'Connor G, Pu M, Yao Y-M, et al. Efficacy of Panobinostat (LBH589) in CTCL Cell Lines and a Murine Xenograft Model: Defining Molecular Pathways of Panobinostat Activity in CTCL. ASH Annual Meeting Abstracts 2007;110:1375.
    • (2007) ASH Annual Meeting Abstracts , vol.110 , pp. 1375
    • Shao, W.1    Growney, J.D.2    Feng, Y.3    O'Connor, G.4    Pu, M.5    Yao, Y.-M.6
  • 10
    • 85097913069 scopus 로고    scopus 로고
    • Efficacy of Panobinostat (LBH589) in Multiple Myeloma Cell Lines and in Vivo Mouse Model: Tumor-Specific Cytotoxicity and Protection of Bone Integrity in Multiple Myeloma
    • Growney JD, Atadja P, Shao W, Wang Y, Pu M, Firestone B, et al. Efficacy of Panobinostat (LBH589) in Multiple Myeloma Cell Lines and In Vivo Mouse Model: Tumor-Specific Cytotoxicity and Protection of Bone Integrity in Multiple Myeloma. ASH Annual Meeting Abstracts 2007;110:1510.
    • (2007) ASH Annual Meeting Abstracts , vol.110 , pp. 1510
    • Growney, J.D.1    Atadja, P.2    Shao, W.3    Wang, Y.4    Pu, M.5    Firestone, B.6
  • 11
    • 69749091923 scopus 로고    scopus 로고
    • Potent anticancer activity of panobinostat (LBH589) in small-cell lung cancer in both in vitro and in vivo tumor models
    • Abstract 86
    • Atadja P, Shao W, Wang Y, Growney JD, Cheng J, Kowal C, et al. Potent anticancer activity of panobinostat (LBH589) in small-cell lung cancer in both in vitro and in vivo tumor models. Ann oncol 2008; viii50. Abstract 86.
    • (2008) Ann Oncol
    • Atadja, P.1    Shao, W.2    Wang, Y.3    Growney, J.D.4    Cheng, J.5    Kowal, C.6
  • 13
    • 38349187877 scopus 로고    scopus 로고
    • Clinically relevant QTc prolongation is not associated with current dose schedules of LBH589 (panobinostat)
    • discussion 333-334
    • Zhang L, Lebwohl D, Masson E, Laird G, Cooper MR, Prince HM. Clinically relevant QTc prolongation is not associated with current dose schedules of LBH589 (panobinostat). J Clin Oncol 2008;26:332-3; discussion 333-334
    • (2008) J Clin Oncol , vol.26 , pp. 332-333
    • Zhang, L.1    Lebwohl, D.2    Masson, E.3    Laird, G.4    Cooper, M.R.5    Prince, H.M.6
  • 15
    • 43049088775 scopus 로고    scopus 로고
    • Phase I study of oral LBH589, a novel deacetylase (DAC) inhibitor in advanced solid tumors and non-hodgkin's lymphoma
    • Prince HM, George D, Patnaik A, Mita M, Dugan M, Butterfoss D, et al. Phase I study of oral LBH589, a novel deacetylase (DAC) inhibitor in advanced solid tumors and non-hodgkin's lymphoma. J Clin Oncol (Meeting Abstracts) 2007;25(18-suppl):3500.
    • (2007) J Clin Oncol (Meeting Abstracts) , vol.25 , Issue.18 SUPPL. , pp. 3500
    • Prince, H.M.1    George, D.2    Patnaik, A.3    Mita, M.4    Dugan, M.5    Butterfoss, D.6
  • 16
    • 51649126841 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor panobinostat induces clinical responses with associated alterations in gene expression profiles in cutaneous T-cell lymphoma
    • Ellis L, Pan Y, Smyth GK, George DJ, McCormack C, Williams-Truax R, et al. Histone deacetylase inhibitor panobinostat induces clinical responses with associated alterations in gene expression profiles in cutaneous T-cell lymphoma. Clin Cancer Res 2008;14:4500-4510
    • (2008) Clin Cancer Res , vol.14 , pp. 4500-4510
    • Ellis, L.1    Pan, Y.2    Smyth, G.K.3    George, D.J.4    McCormack, C.5    Williams-Truax, R.6
  • 20
    • 69749094850 scopus 로고    scopus 로고
    • Final clinical results of a Phase 2 NCI multicenter study of romidepsin in recurrent cutaneous T-cell lymphoma (molecular analyses included)
    • Bates S, Piekarz R, Wright J, Frye R, Figg WD, Sr., Allen SL, et al. Final clinical results of a Phase 2 NCI multicenter study of romidepsin in recurrent cutaneous T-cell lymphoma (molecular analyses included). ASH Annual Meeting Abstracts 2008;112:1568.
    • (2008) ASH Annual Meeting Abstracts , vol.112 , pp. 1568
    • Bates, S.1    Piekarz, R.2    Wright, J.3    Frye, R.4    Figg Sr., W.D.5    Allen, S.L.6
  • 21
    • 67449109154 scopus 로고    scopus 로고
    • Phase IA/II Study of Oral Panobinostat (LBH589), a Novel Pan- Deacetylase Inhibitor (DACi) demonstrating Efficacy in Patients with Advanced Hematologic Malignancies
    • Ottmann OG, Spencer A, Prince HM, Bhalla KN, Fischer T, Liu A, et al. Phase IA/II Study of Oral Panobinostat (LBH589), a Novel Pan- Deacetylase Inhibitor (DACi) demonstrating Efficacy in Patients with Advanced Hematologic Malignancies. ASH Annual Meeting Abstracts 2008;112:958.
    • (2008) ASH Annual Meeting Abstracts , vol.112 , pp. 958
    • Ottmann, O.G.1    Spencer, A.2    Prince, H.M.3    Bhalla, K.N.4    Fischer, T.5    Liu, A.6
  • 22
    • 67449125357 scopus 로고    scopus 로고
    • A Phase II Study of Oral Panobinostat (LBH589) in Adult Patients with Advanced Refractory Multiple Myeloma
    • Wolf JL, Siegel D, Matous J, Lonial S, Goldschmidt H, Schmitt S, et al. A Phase II Study of Oral Panobinostat (LBH589) in Adult Patients with Advanced Refractory Multiple Myeloma. ASH Annual Meeting Abstracts 2008;112:2774.
    • (2008) ASH Annual Meeting Abstracts , vol.112 , pp. 2774
    • Wolf, J.L.1    Siegel, D.2    Matous, J.3    Lonial, S.4    Goldschmidt, H.5    Schmitt, S.6
  • 23
    • 67449140087 scopus 로고    scopus 로고
    • A Phase IB, Multicenter, Open-Label, Dose-Escalation Study of Oral Panobinostat (LBH589) and I.V. Bortezomib in Patients with Relapsed Multiple Myeloma
    • Siegel Dd, Sezer O, San Miguel JF, Mateos M-V, Prosser I, Cavo M, et al. A Phase IB, Multicenter, Open-Label, Dose-Escalation Study of Oral Panobinostat (LBH589) and I.V. Bortezomib in Patients with Relapsed Multiple Myeloma. ASH Annual Meeting Abstracts 2008;112: 2781.
    • (2008) ASH Annual Meeting Abstracts , vol.112 , pp. 2781
    • Siegel, Dd.1    Sezer, O.2    San Miguel, J.F.3    Mateos, M.-V.4    Prosser, I.5    Cavo, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.