Hypoxia targeted bifunctional suicide gene expression enhances radiotherapy in vitro and in vivo

Radiotherapy and Oncology

Volumn 105, Issue 1, 2012, Pages 57-63

  Sun, Xiaorong ^a,b   Xing, Ligang ^b,c   Deng, Xuelong ^b   Hsiao, Hung Tsung ^b   Manami, Akiko ^b   Koutcher, Jason A ^b   Clifton Ling, C ^b   Li, Gloria C ^b  

^a SHANDONG UNIVERSITY   (China)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c SHANDONG CANCER HOSPITAL AND INSTITUTE   (China)

Author keywords

5 Flurocytosine; Cytosine deaminase; Hypoxia; Radiosensitization; Uracil phosphoribosyltransferase

Indexed keywords

5 FLUROCYTOSINE; ANTINEOPLASTIC AGENT; CYTOSINE DEAMINASE; FLUOROURACIL; PIMONIDAZOLE; PLASMID VECTOR; PRODRUG; UNCLASSIFIED DRUG; URACIL PHOSPHORIBOSYLTRANSFERASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL; CANCER CHEMOTHERAPY; CANCER CONTROL; CANCER GENE THERAPY; CANCER RADIOTHERAPY; CELL ASSAY; CELL HYPOXIA; CHEMORADIOTHERAPY; CONTROLLED STUDY; CYTOTOXICITY; DRUG SENSITIVITY; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; FUSION GENE; GENE EXPRESSION; GENETIC TRANSFECTION; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; RADIOSENSITIZATION; RAT; STAINING; SUICIDE GENE; TISSUE SECTION; TUMOR REGRESSION; TUMOR VOLUME; TUMOR XENOGRAFT; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CELL HYPOXIA; CELL LINE, TUMOR; COLONY-FORMING UNITS ASSAY; CYTOSINE DEAMINASE; FLOW CYTOMETRY; FLUCYTOSINE; GENE EXPRESSION; GENES, TRANSGENIC, SUICIDE; GENETIC THERAPY; MICE; MICROSCOPY, FLUORESCENCE; NEOPLASMS, EXPERIMENTAL; PENTOSYLTRANSFERASES; PLASMIDS; RADIATION TOLERANCE; TUMOR CELLS, CULTURED;

EID: 84868374271     PISSN: 01678140     EISSN: 18790887     Source Type: Journal    
DOI: 10.1016/j.radonc.2012.07.011     Document Type: Article

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