Changes in tumor hypoxia induced by mild temperature hyperthermia as assessed by dual-tracer immunohistochemistry

Radiotherapy and Oncology

Volumn 88, Issue 2, 2008, Pages 269-276

  Sun, Xiaorong ^a,b   Li, Xiao Feng ^a   Russell, James ^a   Xing, Ligang ^a   Urano, Muneyasu ^a   Li, Gloria C ^a   Humm, John L ^a   Ling, C Clifton ^a,c  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b SHANDONG CANCER HOSPITAL AND INSTITUTE   (China)

^c VARIAN MEDICAL SYSTEMS   (United States)

Author keywords

Blood flow; EF5; Hypoxia; Mild temperature hyperthermia; Pimonidazole

Indexed keywords

2 (2 NITRO 1H IMIDAZOL 1 YL) N (2,2,3,3,3 PENTAFLUOROPROPYL)ACETAMIDE; CD31 ANTIGEN; PIMONIDAZOLE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL; CANCER CELL CULTURE; COLORECTAL CANCER; CONTROLLED STUDY; DRUG BINDING; DRUG DISTRIBUTION; FEMALE; HEATING; HUMAN; HUMAN CELL; HYPERTHERMIA; HYPOXIA; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; STAINING; TISSUE OXYGENATION; TISSUE PERFUSION;

ADENOCARCINOMA; ANALYSIS OF VARIANCE; ANIMALS; CELL HYPOXIA; COLORECTAL NEOPLASMS; ETANIDAZOLE; FEMALE; HYDROCARBONS, FLUORINATED; HYPERTHERMIA, INDUCED; IMMUNOHISTOCHEMISTRY; MICE; NITROIMIDAZOLES; OXYGEN; RADIATION-SENSITIZING AGENTS; TRANSPLANTATION, HETEROLOGOUS;

EID: 49149130796     PISSN: 01678140     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.radonc.2008.05.015     Document Type: Article

References (30)

1. Harris A.L. Hypoxia - a key regulatory factor in tumour growth. Nat Rev 2 (2002) 38-47
2. Hockel M., and Vaupe P. Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects. J Natl Cancer Inst 93 (2001) 266-276
3. Vaupel P. Tumor microenvironmental physiology and its implications for radiation oncology. Sem Radiat Oncol 14 (2004) 198-206
4. Brizel D.M., Scully S.P., Harrelson J.M., et al. Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma. Cancer Res 56 (1996) 941-943
5. Reinhold H.S., and Endrich B. Tumour microcirculation as a target for hyperthermia. Int J Hyperthermia 2 (1986) 111-137
6. Hall E.J., and Roizin-Towle L. Biological effects of heat. Cancer Res 44 (1984) 4708s-4713s
7. Vernon C.C., Hand J.W., Field S.B., et al. Radiotherapy with or without hyperthermia in the treatment of superficial localized breast cancer: results from five randomized controlled trials. International Collaborative Hyperthermia Group. Int J Radiat Oncol Biol Phys 35 (1996) 731-744
8. van der Zee J., Gonzalez Gonzalez D., van Rhoon G.C., van Dijk J.D., van Putten W.L., and Hart A.A. Comparison of radiotherapy alone with radiotherapy plus hyperthermia in locally advanced pelvic tumours: a prospective, randomised, multicentre trial. Dutch Deep Hyperthermia Group. Lancet 355 (2000) 1119-1125
9. Harima Y., Nagata K., Harima K., Ostapenko V.V., Tanaka Y., and Sawada S. A randomized clinical trial of radiation therapy versus thermoradiotherapy in stage IIIB cervical carcinoma. Int J Hyperthermia 17 (2001) 97-105
10. van der Zee J., and van Rhoon G.C. Cervical cancer: radiotherapy and hyperthermia. Int J Hyperthermia 22 (2006) 229-234
11. Song C.W., Park H., and Griffin R.J. Improvement of tumor oxygenation by mild hyperthermia. Radiat Res 155 (2001) 515-528
12. Shakil A., Osborn J.L., and Song C.W. Changes in oxygenation status and blood flow in a rat tumor model by mild temperature hyperthermia. Int J Radiat Oncol Biol Phys 43 (1999) 859-865
13. Vujaskovic Z., Poulson J.M., Gaskin A.A., et al. Temperature-dependent changes in physiologic parameters of spontaneous canine soft tissue sarcomas after combined radiotherapy and hyperthermia treatment. Int J Radiat Oncol Biol Phys 46 (2000) 179-185
14. Brizel D.M., Scully S.P., Harrelson J.M., et al. Radiation therapy and hyperthermia improve the oxygenation of human soft tissue sarcomas. Cancer Res 56 (1996) 5347-5350
15. 2 measurement of breast cancer reoxygenation after neoadjuvant chemotherapy and hyperthermia treatment. Int J Hyperthermia 19 (2003) 498-506
16. Ljungkvist A.S., Bussink J., Kaanders J.H., and van der Kogel A.J. Dynamics of tumor hypoxia measured with bioreductive hypoxic cell markers. Radiat Res 167 (2007) 127-145
17. Ljungkvist A.S., Bussink J., Kaanders J.H., et al. Hypoxic cell turnover in different solid tumor lines. Int J Radiat Oncol Biol Phys 62 (2005) 1157-1168
18. Ljungkvist A.S., Bussink J., Rijken P.F., Raleigh J.A., Denekamp J., and Van Der Kogel A.J. Changes in tumor hypoxia measured with a double hypoxic marker technique. Int J Radiat Oncol Biol Phys 48 (2000) 1529-1538
19. Ljungkvist A.S., Bussink J., Kaanders J.H., Wiedenmann N.E., Vlasman R., and van der Kogel A.J. Dynamics of hypoxia, proliferation and apoptosis after irradiation in a murine tumor model. Radiat Res 165 (2006) 326-336
20. Lord E.M., Harwell L., and Koch C.J. Detection of hypoxic cells by monoclonal antibody recognizing 2-nitroimidazole adducts. Cancer Res 53 (1993) 5721-5726
21. Kleiter M.M., Thrall D.E., Malarkey D.E., et al. A comparison of oral and intravenous pimonidazole in canine tumors using intravenous CCI-103F as a control hypoxia marker. Int J Radiat Oncol Biol Phys 64 (2006) 592-602
22. Urano M., Gerweck L.E., Epstein R., Cunningham M., and Suit H.D. Response of a spontaneous murine tumor to hyperthermia: factors which modify the thermal response in vivo. Radiat Res 83 (1980) 312-322
23. Shin K.H., Diaz-Gonzalez J.A., Russell J., et al. Detecting changes in tumor hypoxia with carbonic anhydrase IX and pimonidazole. Cancer Biol Ther 6 (2007) 70-75
24. Li X.F., Carlin S., Urano M., Russell J., Ling C.C., and O'Donoghue J.A. Visualization of hypoxia in microscopic tumors by immunofluorescent microscopy. Cancer Res 67 (2007) 7646-7653
25. Song C.W., Shakil A., Osborn J.L., and Iwata K. Tumour oxygenation is increased by hyperthermia at mild temperatures. Int J Hyperthermia 12 (1996) 367-373
26. Horsman M.R., and Overgaard J. Can mild hyperthermia improve tumour oxygenation?. Int J Hyperthermia 13 (1997) 141-147
27. Okajima K., Griffin R.J., Iwata K., Shakil A., and Song C.W. Tumor oxygenation after mild-temperature hyperthermia in combination with carbogen breathing: dependence on heat dose and tumor type. Radiat Res 149 (1998) 294-299
28. Thrall D.E., Larue S.M., Pruitt A.F., Case B., and Dewhirst M.W. Changes in tumour oxygenation during fractionated hyperthermia and radiation therapy in spontaneous canine sarcomas. Int J Hyperthermia 22 (2006) 365-373
29. Song C.W. Modification of blood flow. In: Molls M., and Vauple P. (Eds). Blood perfusion and microenvironment of human tumors (1998), Springer-Verlag, Berlin 193-207
30. Song C.W., Park H.J., Lee C.K., and Griffin R. Implications of increased tumor blood flow and oxygenation caused by mild temperature hyperthermia in tumor treatment. Int J Hyperthermia 21 (2005) 761-767