A preclinical model for noninvasive imaging of hypoxia-induced gene expression; comparison with an exogenous marker of tumor hypoxia

European Journal of Nuclear Medicine and Molecular Imaging

Volumn 31, Issue 11, 2004, Pages 1530-1538

  Wen, Bixiu ^a   Burgman, Paul ^a   Zanzonico, Pat ^a   O'Donoghue, Joseph ^a   Cai, Shangde ^a   Finn, Ron ^a   Serganova, Inna ^a   Blasberg, Ronald ^a   Gelovani, Juri ^a   Li, Gloria C ^a   Ling, C Clifton ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

FMISO; Herpes simplex virus 1 thymidine kinase; Molecular imaging; Positron emission tomography; Tumor hypoxia

Indexed keywords

1 FLUORO 3 (2 NITRO 1 IMIDAZOLYL) 2 PROPANOL F 18; CELL MARKER; FIALURIDINE I 124; FLUORINE 18; GREEN FLUORESCENT PROTEIN; HYPOXIA INDUCIBLE FACTOR 1; IODINE 124; MARKER; PHOSPHORUS; THYMIDINE KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CANCER MODEL; COMPARATIVE STUDY; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; FEASIBILITY STUDY; FUSION GENE; GENE CONSTRUCT; GENE EXPRESSION; GENETIC ANALYSIS; HERPES SIMPLEX VIRUS 1; HYPOXIA; HYPOXIC CELL; IMAGE ANALYSIS; IMAGING; ISOTOPE LABELING; MOLECULE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PROMOTER REGION; RADIOACTIVITY; RAT; REGULATORY MECHANISM; REPORTER GENE; TRANSACTIVATION; TUMOR; UPREGULATION;

ADENOCARCINOMA; ANIMALS; ARABINOFURANOSYLURACIL; CELL HYPOXIA; CELL LINE, TUMOR; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; DRUG EVALUATION, PRECLINICAL; FEASIBILITY STUDIES; FLUORINE RADIOISOTOPES; GENE EXPRESSION PROFILING; HYPOXIA-INDUCIBLE FACTOR 1; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IODINE RADIOISOTOPES; MISONIDAZOLE; NUCLEAR PROTEINS; RADIOPHARMACEUTICALS; RATS; THYMIDINE KINASE; TRANSCRIPTION FACTORS; TUMOR MARKERS, BIOLOGICAL; VIRAL PROTEINS;

EID: 9944256262     PISSN: 16197070     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00259-004-1673-z     Document Type: Article

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