Sigma-1 Receptor Agonists Directly Inhibit NaV1.2/1.4 Channels

PLoS ONE

Volumn 7, Issue 11, 2012, Pages

  Gao, Xiao Fei ^a   Yao, Jin Jing ^a   He, Yan Lin ^a   Hu, Changlong ^a   Mei, Yan Ai ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

1 PHENYLCYCLOHEXANECARBOXYLIC ACID 2 MORPHOLINOETHYL ESTER; 1,3 DI O TOLYLGUANIDINE; CYCLIC AMP DEPENDENT PROTEIN KINASE; DEXTROMETHORPHAN; GUANINE NUCLEOTIDE BINDING PROTEIN; N ALLYLNORMETAZOCINE; OPIATE AGONIST; PHENYLALANINE; PROTEIN KINASE C; SIGMA 1 OPIATE RECEPTOR; SIGMA 1 OPIATE RECEPTOR AGONIST; SODIUM CHANNEL NAV1.2; SODIUM CHANNEL NAV1.4; TYROSINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL STRAIN COS7; CELL STRAIN HEK293; CHANNEL GATING; CONCENTRATION RESPONSE; CONTROLLED STUDY; GRANULE CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; POINT MUTATION; PROTEIN DOMAIN; RAT; SITE DIRECTED MUTAGENESIS; SODIUM CURRENT;

ANIMALS; CERCOPITHECUS AETHIOPS; COS CELLS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DEXTROMETHORPHAN; GTP-BINDING PROTEINS; GUANIDINES; HEK293 CELLS; HUMANS; ION CHANNEL GATING; LIDOCAINE; MUSCLE PROTEINS; MUTAGENESIS, SITE-DIRECTED; MUTANT PROTEINS; MUTATION; NAV1.2 VOLTAGE-GATED SODIUM CHANNEL; NEURONS; PHENAZOCINE; PROTEIN KINASE C; PROTEIN KINASE INHIBITORS; RATS; RECEPTORS, SIGMA; SIGNAL TRANSDUCTION; SODIUM CHANNELS; TRANSFECTION;

EID: 84868348858     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0049384     Document Type: Article

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