Neurosteroid dehydroepiandrosterone sulphate inhibits persistent sodium currents in rat medial prefrontal cortex via activation of sigma-1 receptors

Experimental Neurology

Volumn 210, Issue 1, 2008, Pages 128-136

  Cheng, Zheng Xiang ^a   Lan, Dan Mei ^a   Wu, Pei Ying ^a   Zhu, Yan Hua ^a   Dong, Yi ^a   Ma, Lan ^a   Zheng, Ping ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Chemical inhibition of mitochondria; Dehydroepiandrosterone sulphate; Excitability; Gi protein; Medial prefrontal cortex; Neurosteroid; Persistent sodium currents; Protein kinase C; Sigma 1 receptors; Whole cell patch clamp

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; HALOPERIDOL; PRASTERONE SULFATE; PROTEIN KINASE C; SIGMA 1 OPIATE RECEPTOR; SODIUM; SODIUM CYANIDE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG INHIBITION; EXCITABILITY; MEMBRANE POTENTIAL; NONHUMAN; PATCH CLAMP; PREFRONTAL CORTEX; PRIORITY JOURNAL; RAT; SODIUM CURRENT; WHOLE CELL;

ANALYSIS OF VARIANCE; ANIMALS; ANIMALS, NEWBORN; DEHYDROEPIANDROSTERONE SULFATE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ENZYME INHIBITORS; MEMBRANE POTENTIALS; NEURAL INHIBITION; NEURONS; PATCH-CLAMP TECHNIQUES; PHENYLACETATES; PREFRONTAL CORTEX; PYRROLIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, SIGMA; SODIUM CHANNELS;

EID: 39149108182     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2007.10.004     Document Type: Article

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