Pontine μ-opioid receptors mediate bradypnea caused by intravenous remifentanil infusions at clinically relevant concentrations in dogs

Journal of Neurophysiology

Volumn 108, Issue 9, 2012, Pages 2430-2441

  Prkic, Ivana ^a,b   Mustapic, Sanda ^a,b   Radocaj, Tomislav ^a,b   Stucke, Astrid G ^a,b,c   Stuth, Eckehard A E ^a,b,c   Hopp, Francis A ^a,b   Dean, Caron ^a,b   Zuperku, Edward J ^a,b  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b Affairs Medical Center   (United States)

^c Children's Hospital of Wisconsin   (United States)

Author keywords

Control of breathing; Opioids; Pons; Respiratory depression

Indexed keywords

ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; MU OPIATE RECEPTOR; NALOXONE; REMIFENTANIL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRADYPNEA; BREATHING RATE; CONTINUOUS INFUSION; CONTROLLED STUDY; DRUG EFFECT; EXPERIMENTAL DOG; HISTOPATHOLOGY; INFERIOR COLLICULUS; MICROINJECTION; NONHUMAN; PONS; PONTINE NUCLEUS; PRIORITY JOURNAL; SUPERIOR CEREBELLAR PEDUNCLE;

ANALGESICS, OPIOID; ANESTHETICS, INTRAVENOUS; ANIMALS; BRAIN MAPPING; DIAPHRAGM; DOGS; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; HYPEROXIA; INFUSIONS, INTRAVENOUS; NALOXONE; NARCOTIC ANTAGONISTS; PHRENIC NERVE; PIPERIDINES; PONS; RECEPTORS, OPIOID, MU; RESPIRATORY RATE;

EID: 84868322892     PISSN: 00223077     EISSN: 15221598     Source Type: Journal    
DOI: 10.1152/jn.00185.2012     Document Type: Article

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