Activation of opioid μ receptors in caudal medullary raphe region inhibits the ventilatory response to hypercapnia in anesthetized rats

Anesthesiology

Volumn 107, Issue 2, 2007, Pages 288-297

  Zhang, Zhenxiong ^b   Xu, Fadi ^a   Zhang, Cancan ^b   Liang, Xiaomin ^b  

^a LOVELACE RESPIRATORY RESEARCH INSTITUTE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CARBON DIOXIDE; DEXTRO PHENYLALANYLCYSTEINYLTYROSYL DEXTRO TRYPTOPHYLARGINYLTHREONYLPENICILLAMINYLTHREONINAMIDE 2,7 DISULFIDE; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; MU OPIATE RECEPTOR; MU OPIATE RECEPTOR AGONIST; MU OPIATE RECEPTOR ANTAGONIST;

ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN REGION; BREATHING RATE; CONTROLLED STUDY; END TIDAL CARBON DIOXIDE TENSION; HYPERCAPNIA; LUNG MINUTE VOLUME; LUNG VENTILATION; MALE; MEDULLA OBLONGATA; NONHUMAN; PRIORITY JOURNAL; RAT; RESPIRATORY FUNCTION; TIDAL VOLUME;

ANALGESICS, OPIOID; ANESTHESIA; ANIMALS; CARBON DIOXIDE; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; HYPERCAPNIA; MALE; MEDULLA OBLONGATA; NARCOTIC ANTAGONISTS; PEPTIDES; RAPHE NUCLEI; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID, MU; RESPIRATORY PHYSIOLOGY; TIME FACTORS;

EID: 34547592980     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/01.anes.0000270760.46821.67     Document Type: Article

References (61)

1. McCrimmon DR, Alheid GF: On the opiate trail of respiratory depression. Am J Physiol Regul Integr Comp Physiol 2003; 285:R1274-5
2. Jaffe JH, Martin WR: Opioid agonists and antagonists, Goodman and Gilman's The Pharmacological Basis of Therapeutics. Edited by Gilman AG, Rall TW, Nies AS, Taylor P. New York, Pergamon, 1990, pp 485-521
3. Gutstein HB, Akil H. Opioid analgesics, Goodman & Gilman's The Pharmacological Basis of Therapeutics 10th Edition. Edited by Hardman JG, Limbird LE, Goodman AG. New York McGraw-Hill, 2001, pp 569-619.
4. Shook JE, Watkins WD, Camporesi EM: Differential roles of opioid receptors in respiration, respiratory disease, and opiate-induced respiratory depression. Am Rev Respir Dis 1990; 142:895-909
5. Yeadon M, Kitchen I: Opioids and respiration. Prog Neurobiol 1989; 33:1-16
6. Putnam RW, Filosa JA, Ritucci NA: Cellular mechanisms involved in CO(2) and acid signaling in chemosensitive neurons. Am J Physiol Cell Physiol 2004; 287:C1493-526
7. Hurle MA, Mediavilla A, Florez J: Differential respiratory patterns induced by opioids applied to the ventral medullary and dorsal pontine surfaces of cats. Neuropharmacology 1985; 24:597-606
8. Santiago TV, Edelman NH: Opioids and breathing. J Appl Physiol 1985; 59:1675-85
9. Bourke DL, Warley A: The steady-state and rebreathing methods compared during morphine administration in humans. J Physiol 1989; 419:509-17
10. Weil JV, McCullough RE, Kline JS, Sodal IE: Diminished ventilatory response to hypoxia and hypercapnia after morphine in normal man. N Engl J Med 1975; 292:1103-6
11. Vivian JA, Kishioka S, Butelman ER, Broadbear J, Lee KO, Woods JH: Analgesic, respiratory and heart rate effects of cannabinoid and opioid agonists in rhesus monkeys: Antagonist effects of SR 141716A. J Pharmacol Exp Ther 1998; 286:697-703
12. Romberg R, Sarton E, Teppema L, Matthes HW, Kieffer BL, Dahan A: Comparison of morphine-6-glucuronide and morphine on respiratory depressant and antinociceptive responses in wild type and mu-opioid receptor deficient mice. Br J Anaesth 2003; 91:862-70
13. Eager KR, Robinson BJ, Galletly DC, Miller JH: Endogenous opioid modulation of hypercapnic-stimulated respiration in the rat. Respir Physiol 1994; 96:13-24
14. Kelly HW: Drug-induced pulmonary diseases, Pharmacotherapy: A Pathophysiological Approach. Edited by Dipiro JT, Talbert RL, Hayes PE, Yee GC, Posey LM. Norwalk, Appleton & Lange, 1993, pp 482-93
15. Dahan A, Sarton E, Teppema L, Olievier C, Nieuwenhuijs D, Matthes HW, Kieffer BL: Anesthetic potency and influence of morphine and sevoflurane on respiration in μ-opioid receptor knockout mice. ANESTHESIOLOGY 2001; 94:824-32
16. Su YF, McNutt RW, Chang KJ: Delta-opioid ligands reverse alfentanil-induced respiratory depression but not antinociception. J Pharmacol Exp Ther 1998; 287:815-23
17. Matthes HW, Smadja C, Valverde O, Vonesch JL, Foutz AS, Boudinot E, Denavit-Saubie M, Severini C, Negri L, Roques BP, Maldonado R, Kieffer BL: Activity of the delta-opioid receptor is partially reduced, whereas activity of the kappa-receptor is maintained in mice lacking the mu-receptor. J Neurosci 1998; 18:7285-95
18. Matthes HW, Maldonado R, Simonin F, Valverde O, Slowe S, Kitchen I, Befort K, Dierich A, Le Meur, M Dolle P, Tzavara E, Hanoune J, Roques BP, Kieffer BL: Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid-receptor gene. Nature 1996; 383:819-23
19. Christrup LL: Morphine metabolites. Acta Anaesthesiol Scand 1997; 41:116-22
20. Pasternak GW, Bodnar RJ, Clark JA, Inturrisi CE: Morphine-6-glucuronide, a potent mu agonist. Life Sci 1987; 41:2845-9
21. Morin-Surun MP, Boudinot E, Gacel G, Champagnat J, Roques BP, Denavit-Saubie M,: Different effects of mu and delta opiate agonists on respiration. Eur J Pharmacol 1984; 98:235-40
22. Yeadon M, Kitchen I: Multiple opioid receptors mediate the respiratory depressant effects of fentanyl-like drugs in the rat. Gen Pharmacol 1990; 21:655-64
23. Narita M, Tseng LF: Evidence for the existence of the beta-endorphinsensitive "epsilon-opioid receptor" in the brain: The mechanisms of epsilon-mediated antinociception. Jpn J Pharmacol 1998; 76:233-53
24. Bernard DG, Li A, Nattie EE: Evidence for central chemoreception in the midline raphe. J Appl Physiol 1996; 80:108-15
25. Nattie EE, Li A: CO2 dialysis in the medullary raphe of the rat increases ventilation in sleep. J Appl Physiol 2001; 90:1247-57
26. Nattie EE, Li A, Richerson G, Lappi DA: Medullary serotonergic neurones and adjacent neurones that express neurokinin-1 receptors are both involved in chemoreception in vivo. J Physiol 2004; 556:235-53
27. Taylor NC, Li A, Nattie EE: Medullary serotonergic neurones modulate the ventilatory response to hypercapnia, but not hypoxia in conscious rats. J Physiol 2005; 566:543-57
28. Wang W, Pizzonia JH, Richerson GB: Chemosensitivity of rat medullary raphe neurones in primary tissue culture. J Physiol 1998; 511(pt 2):433-50
29. Wang W, Tiwari JK, Bradley SR, Zaykin RV, Richerson GB: Acidosis-stimulated neurons of the medullary raphe are serotonergic. J Neurophysiol 2001; 85:2224-35
30. Pete G, Mack SO, Haxhiu MA, Walbaum S, Gauda EB: CO(2)-induced c-Fos expression in brainstem preprotachykinin mRNA containing neurons. Respir Physiol Neurobiol 2002; 130:265-74
31. Connelly CA, Ellenberger HH, Feldman JL: Are there serotonergic projections from raphe and retrotrapezoid nuclei to the ventral respiratory group in the rat? Neurosci Lett 1989; 105:34-40
32. Voss MD, De Castro, D Lipski J, Pilowsky PM, Jiang C: Serotonin immunoreactive boutons form close appositions with respiratory neurons of the dorsal respiratory group in the cat. J Comp Neurol 1990; 295:208-18
33. Zhan WZ, Ellenberger HH, Feldman JL: Monoaminergic and GABAergic terminations in phrenic nucleus of rat identified by immunohistochemical labeling. Neuroscience 1989; 31:105-13
34. Ding YQ, Kaneko T, Nomura S, Mizuno N: Immunohistochemical localization of mu-opioid receptors in the central nervous system of the rat. J Comp Neurol 1996; 367:375-402
35. Paxinos G, Watson C: The Rat Brain in Stereotaxic Coordinates, 4th edition. San Diego, a division of Harcourt Brace, 1998, pp 56-69
36. Haji A, Takeda R: Effects of a kappa-receptor agonist U-50488 on bulbar respiratory neurons and its antagonistic action against the mu receptor-induced respiratory depression in decerebrate cats. Jpn J Pharmacol 2001; 87:333-7
37. Nason MW Jr, Mason P: Medullary raphe neurons facilitate brown adipose tissue activation. J Neurosci 2006; 26:1190-8
38. Hurley RW, Hammond DL: Contribution of endogenous enkephalins to the enhanced analgesic effects of supraspinal mu opioid receptor agonists after inflammatory injury. J Neurosci 2001; 21:2536-45
39. Szeto HH, Lovelace JL, Fridland G, Soong Y, Fasolo J, Wu D, Desiderio DM, Schiller PW: In vivo pharmacokinetics of selective mu-opioid peptide agonists. J Pharmacol Exp Ther 2001; 298:57-61
40. Dahan A, DeGoede J, Berkenbosch A, Olievier IC: The influence of oxygen on the ventilatory response to carbon dioxide in man. J Physiol 1990; 428:485-99
41. Wang R, Xu F, Zhuang J, Zhang C: Carotid sinus nerve is involved in cardiorespiratory responses to intracarotid injection of capsaicin in the rat. J Appl Physiol 2006; 100:60-6
42. Howard RS, Sears TA: The effects of opiates on the respiratory activity of thoracic motoneurones in the anaesthetized and decerebrate rabbit. J Physiol 1991; 437:181-99
43. Ling GS, Spiegel K, Lockhart SH, Pasternak GW: Separation of opioid analgesia from respiratory depression: Evidence for different receptor mechanisms. J Pharmacol Exp Ther 1985; 232:149-55
44. Ferguson LM, Drummond GB: Acute effects of fentanyl on breathing pattern in anaesthetized subjects. Br J Anaesth 2006; 96:384-90
45. Camporesi EM, Nielsen CH, Bromage PR, Durant PA: Ventilatory CO2 sensitivity after intravenous and epidural morphine in volunteers. Anesth Analg 1983; 62:633-40
46. Modalen AO, Quiding H, Frey J, Westman L, Lindahl S: A novel molecule with peripheral opioid properties: The effects on hypercarbic and hypoxic ventilation at steady-state compared with morphine and placebo. Anesth Analg 2006; 102:104-9
47. Baekey DM, Morris KF, Nuding SC, Segers LS, Lindsey BG, Shannon R: Medullary raphe neuron activity is altered during fictive cough in the decerebrate cat. J Appl Physiol 2003; 94:93-100
48. Hosogai M, Matsuo S: Inspiratory neurons with decrementing firing pattern in raphe nuclei of feline medulla. Auton Neurosci 2002; 99:13-7
49. Hall WD, Degenhardt LJ, Lynskey MT: Opioid overdose mortality in Australia, 1964-1997: Birth-cohort trends. Med J Aust 1999; 171:34-7
50. Kinney HC, Belliveau RA, Trachtenberg FL, Rava LA, Paterson DS: The development of the medullary serotonergic system in early human life. Auton Neurosci 2007; 132:81-102
51. Kinney HC, Filiano JJ, White WF: Medullary serotonergic network deficiency in the sudden infant death syndrome: Review of a 15-year study of a single dataset. J Neuropathol Exp Neurol 2001; 60:228-47
52. Panigrahy A, Filiano J, Sleeper LA, Mandell F, Valdes-Dapena M, Krous HF, Rava LA, Foley E, White WF, Kinney HC: Decreased serotonergic receptor binding in rhombic lip-derived regions of the medulla oblongata in the sudden infant death syndrome. J Neuropathol Exp Neurol 2000; 59:377-84
53. Champion HC, Zadina JE, Kastin AJ, Hackler L, Ge LJ, Kadowitz PJ: Endomorphin 1 and 2, endogenous ligands for the mu-opioid receptor, decrease cardiac output, and total peripheral resistance in the rat. Peptides 1997; 18:1393-7
54. Xia Y, Haddad GG: Ontogeny and distribution of opioid receptors in the rat brainstem. Brain Res 1991; 549:181-93
55. Greenwald MK: Effects of opioid dependence and tobacco use on ventilatory response to progressive hypercapnia. Pharmacol Biochem Behav 2004; 77:39-47
56. Tafil-Klawe M, Klawe JJ, Sikorski W, Drzewiecka B: Reflex respiratory responses to progressive hyperoxic hypercapnia and normocapnic hypoxia in normocapnic and hypercapnic obstructive sleep apnea patients. J Physiol Pharmacol 2004; 55 (suppl 3):135-8
57. Suzuki S, Watanuki Y, Yoshiike Y, Okubo T: Effects of fenoterol on ventilatory response to hypercapnia and hypoxia in patients with chronic obstructive pulmonary disease. Thorax 1997; 52:125-9
58. Cicero TJ, Nock B, Meyer ER: Gender-related differences in the antinociceptive properties of morphine. J Pharmacol Exp Ther 1996; 279:767-73
59. Baamonde AI, Hidalgo Andres-Trelles FA: Sex-related differences in the effects of morphine and stress on visceral pain. Neuropharmacology 1989; 28:967-70
60. Kavaliers M, Innes DG: Developmental changes in opiate-induced analgesia in deer mice: Sex and population differences. Brain Res 1990; 516:326-31
61. Sarton E, Olofsen E, Romberg R, den Hartigh J, Kest B, Nieuwenhuijs D, Burm A, Teppema L, Dahan A: Sex differences in morphine analgesia: An experimental study in healthy volunteers. ANESTHESIOLOGY 2000; 93:1245-54