Henipavirus receptor usage and tropism

Current Topics in Microbiology and Immunology

Volumn 359, Issue , 2012, Pages 59-78

  Pernet, Olivier ^a   Wang, Yao E ^a   Lee, Benhur ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPHRIN B2; EPHRIN B3; VIRUS RECEPTOR;

BIOLOGICAL WARFARE; CLINICAL FEATURE; HENDRA VIRUS; HENDRA VIRUS INFECTION; HENIPAVIRUS; HENIPAVIRUS INFECTION; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR BIOLOGY; MORTALITY; NIPAH VIRUS; NIPAH VIRUS INFECTION; NONHUMAN; PARAMYXOVIRUS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REGULATORY MECHANISM; REVIEW; SYMPTOM; VIRAL RESPIRATORY TRACT INFECTION; VIRAL TROPISM; VIRUS ATTACHMENT; VIRUS CELL INTERACTION; VIRUS CLASSIFICATION; VIRUS ENCEPHALITIS; VIRUS ENTRY; VIRUS PARTICLE; VIRUS VIRULENCE;

ANIMALS; BLOOD VESSELS; BRAIN; ENDOTHELIAL CELLS; EPHRIN-B2; EPHRIN-B3; HENDRA VIRUS; HENIPAVIRUS INFECTIONS; HUMANS; MODELS, MOLECULAR; NIPAH VIRUS; RECEPTORS, VIRUS; VIRAL FUSION PROTEINS; VIRAL TROPISM; VIRUS INTERNALIZATION;

ANIMALIA; HENDRA VIRUS; HENIPAVIRUS; PARAMYXOVIRIDAE;

EID: 84868310649     PISSN: 0070217X     EISSN: None     Source Type: Book Series    
DOI: 10.1007/82-2012-222     Document Type: Review

References (118)

1. Adams RH, Wilkinson GA, Weiss C, Diella F, Gale NW et al (1999) Roles of ephrinb ligands and ephb receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis. Genes Dev 13:295-306 (Pubitemid 29095801)
2. Aguilar HC, Lee B (2011) Emerging Paramyxoviruses: molecular mechanisms and antiviral strategies. Expert Rev Mol Med 13:e6
3. Bennett BD, Zeigler FC, Gu Q, Fendly B, Goddard AD et al (1995) Molecular cloning of a ligand for the eph-related receptor protein-tyrosine kinase htk. Proc Natl Acad Sci USA 92:1866-1870
4. Benson MD, Romero MI, Lush ME, Lu QR, Henkemeyer M et al (2005) Ephrin-b3 is a myelin-based inhibitor of neurite outgrowth. Proc Natl Acad Sci USA 102:10694-10699 (Pubitemid 41061616)
5. Bergemann AD, Cheng HJ, Brambilla R, Klein R, Flanagan JG (1995) Elf-2, a new member of the eph ligand family, is segmentally expressed in mouse embryos in the region of the hindbrain and newly forming somites. Mol Cell Biol 15:4921-4929
6. Bergemann AD, Zhang L, Chiang MK, Brambilla R, Klein R et al (1998) Ephrin-B3, a ligand for the receptor EphB3, expressed at the midline of the developing neural tube. Oncogene 16:471-480 (Pubitemid 28062074)
7. Bishop KA, Hickey AC, Khetawat D, Patch JR, Bossart KN et al (2008) Residues in the stalk domain of the Hendra virus g glycoprotein modulate conformational changes associated with receptor binding. J Virol 82:11398-11409
8. Bonaparte MI, Dimitrov AS, Bossart KN, Crameri G, Mungall BA et al (2005) Ephrin-b2 ligand is a functional receptor for Hendra virus and Nipah virus. Proc Natl Acad Sci USA 102:10652-10657 (Pubitemid 41061609)
9. Bossart KN, Crameri G, Dimitrov AS, Mungall BA, Feng Y et al (2005) Receptor binding, fusion inhibition, and induction of cross-reactive neutralizing antibodies by a soluble g glycoprotein of Hendra virus. J Virol 79:6690-6702 (Pubitemid 40677300)
10. Bossart KN, Geisbert TW, Feldmann H, Zhu Z, Feldmann F et al (2011) A neutralizing human monoclonal antibody protects African green monkeys from Hendra virus challenge. Sci Transl Med 3:105ra103
11. Bossart KN, Tachedjian M, McEachern JA, Crameri G, Zhu Z et al (2008) Functional studies of host-specific ephrin-b ligands as Henipavirus receptors. Virology 372:357-371 (Pubitemid 351284563)
12. Bossart KN, Wang LF, Eaton BT, Broder CC (2001) Functional expression and membrane fusion tropism of the envelope glycoproteins of Hendra virus. Virology 290:121-135 (Pubitemid 33111883)
13. Bossart KN, Zhu Z, Middleton D, Klippel J, Crameri G et al (2009) A neutralizing human monoclonal antibody protects against lethal disease in a new ferret model of acute Nipah virus infection. PLoS Pathog 5:e1000642
14. Bowden TA, Aricescu AR, Gilbert RJC, Grimes JM, Jones EY et al (2008a) Structural basis of Nipah and Hendra virus attachment to their cell-surface receptor ephrin-B2. Nat Struct Mol Biol 15:567-572 (Pubitemid 351799140)
15. Bowden TA, Crispin M, Harvey DJ, Aricescu AR, Grimes JM et al (2008b) Crystal structure and carbohydrate analysis of Nipah virus attachment glycoprotein: a template for antiviral and vaccine design. J Virol 82:11628-11636
16. Bowden TA, Crispin M, Harvey DJ, Jones EY, Stuart DI (2010a) Dimeric architecture of the Hendra virus attachment glycoprotein: evidence for a conserved mode of assembly. J Virol 84:6208-6217
17. Bowden TA, Crispin M, Jones EY, Stuart DI (2010b) Shared paramyxoviral glycoprotein architecture is adapted for diverse attachment strategies. Biochem Soc Trans 38:1349-1355
18. Bucci C, Lütcke A, Steele-Mortimer O, Olkkonen VM, Dupree P et al (1995) Co-operative regulation of endocytosis by three rab5 isoforms. FEBS Lett 366:65-71
19. *ephrinB2 protein-protein interaction and receptor specificity. J Biol Chem 281:28185-28192 (Pubitemid 44414532)
20. Chua KB (2010) Epidemiology, surveillance and control of Nipah virus infections in Malaysia. Malays J Pathol 32:69-73
21. Chua KB, Goh KJ, Wong KT, Kamarulzaman A, Tan PS et al (1999) Fatal encephalitis due to Nipah virus among pig-farmers in Malaysia. Lancet 354:1257-1259 (Pubitemid 29469355)
22. Cowan CA, Henkemeyer M (2001) The sh2/sh3 adaptor grb4 transduces B-ephrin reverse signals. Nature 413:174-179 (Pubitemid 32867879)
23. Crimeen-Irwin B, Ellis S, Christiansen D, Ludford-Menting MJ, Milland J et al (2003) Ligand binding determines whether cd46 is internalized by clathrin-coated pits or macropinocytosis. J Biol Chem 278:46927-46937 (Pubitemid 37452275)
24. Edwards CM, Mundy GR (2008) Eph receptors and ephrin signaling pathways: a role in bone homeostasis. Int J Med Sci 5:263-272
25. Eph Nomenclature Committee (1997) Unified nomenclature for eph family receptors and their ligands, the ephrins. Eph nomenclature committee. Cell 90:403-404
26. Erbar S, Diederich S, Maisner A (2008) Selective receptor expression restricts Nipah virus infection of endothelial cells. Virol. J 5:142
27. Fogarty R, Halpin K, Hyatt AD, Daszak P, Mungall BA (2008) Henipavirus susceptibility to environmental variables. Virus Res 132:140-144
28. Füller T, Korff T, Kilian A, Dandekar G, Augustin HG (2003) Forward ephb4 signaling in endothelial cells controls cellular repulsion and segregation from ephrinB2 positive cells. J Cell Sci 116:2461-2470 (Pubitemid 36790128)
29. Gale NW, Baluk P, Pan L, Kwan M, Holash J et al (2001) Ephrin-B2 selectively marks arterial vessels and neovascularization sites in the adult, with expression in both endothelial and smooth-muscle cells. Dev Biol 230:151-160 (Pubitemid 32171414)
30. Geisbert TW, Daddario-DiCaprio KM, Hickey AC, Smith MA, Chan Y et al (2010) Development of an acute and highly pathogenic nonhuman primate model of Nipah virus infection. PLoS ONE 5:e10690
31. Georgakopoulos A, Litterst C, Ghersi E, Baki L, Xu C et al (2006) Metalloproteinase/presenilin1 processing of ephrinb regulates ephb-induced src phosphorylation and signaling. EMBO J 25:1242-1252
32. Georgakopoulos A, Xu J, Xu C, Mauger G, Barthet G et al (2011) Presenilin1/gamma-secretase promotes the ephb2-induced phosphorylation of ephrinB2 by regulating phosphoprotein associated with glycosphingolipid-enriched microdomains/csk binding protein. FASEB J 25:3594-3604
33. Gerety SS, Anderson DJ (2002) Cardiovascular ephrinB2 function is essential for embryonic angiogenesis. Development 129:1397-1410 (Pubitemid 34874161)
34. Goh KJ, Tan CT, Chew NK, Tan PS, Kamarulzaman A et al (2000) Clinical features of Nipah virus encephalitis among pig farmers in Malaysia. N Engl J Med 342:1229-1235 (Pubitemid 30235951)
35. Guillaume V, Aslan H, Ainouze M, Guerbois M, Wild TF et al (2006) Evidence of a potential receptor-binding site on the Nipah virus g protein (NiV-G): identification of globular head residues with a role in fusion promotion and their localization on an NiV-G structural model. J Virol 80:7546-7554 (Pubitemid 44092576)
36. Hafner C, Becker B, Landthaler M, Vogt T (2006) Expression profile of Eph receptors and ephrin ligands in human skin and downregulation of epha1 in nonmelanoma skin cancer. Mod Pathol 19:1369-1377 (Pubitemid 44423085)
37. Hasebe F, Thuy NTT, Inoue S, Yu F, Kaku Y et al (2012) Serologic evidence of Nipah virus infection in bats, Vietnam. Emerg Infect Dis 18:536-537
38. Hashiguchi T, Maenaka K, Yanagi Y (2011a) Measles virus hemagglutinin: structural insights into cell entry and measles vaccine. Front Microbiol 2:247
39. Hashiguchi T, Ose T, Kubota M, Maita N, Kamishikiryo J et al (2011b) Structure of the Measles virus hemagglutinin bound to its cellular receptor slam. Nat Struct Mol Biol 18:135-141
40. Hayman DTS, Suu-Ire R, Breed AC, McEachern JA, Wang L et al (2008) Evidence of Henipavirus infection in West African fruit bats. PLoS ONE 3:e2739
41. Hayman DTS, Wang L, Barr J, Baker KS, Suu-Ire R et al (2011) Antibodies to Henipavirus or Henipa-like viruses in domestic pigs in Ghana, West Africa. PLoS ONE 6:e25256
42. Himanen J, Saha N, Nikolov DB (2007) Cell-cell signaling via Eph receptors and ephrins. Curr Opin Cell Biol 19:534-542 (Pubitemid 350016850)
43. Holmberg J, Frisén J (2002) Ephrins are not only unattractive. Trends Neurosci 25:239-243 (Pubitemid 34327797)
44. Homaira N, Rahman M, Hossain MJ, Epstein JH, Sultana R et al (2010) Nipah virus outbreak with person-to-person transmission in a district of Bangladesh, 2007. Epidemiol Infect 138:1630-1636
45. Hooper P, Zaki S, Daniels P, Middleton D (2001) Comparative pathology of the diseases caused by Hendra and Nipah viruses. Microbes Infect 3:315-322 (Pubitemid 32385781)
46. Hooper PT, Ketterer PJ, Hyatt AD, Russell GM (1997a) Lesions of experimental equine Morbillivirus pneumonia in horses. Vet Pathol 34:312-322 (Pubitemid 127471113)
47. Hooper PT, Westbury HA, Russell GM (1997b) The lesions of experimental equine Morbillivirus disease in cats and guinea pigs. Vet Pathol 34:323-329 (Pubitemid 127471114)
48. Hsu VP, Hossain MJ, Parashar UD, Ali MM, Ksiazek TG et al (2004) Nipah virus encephalitis reemergence, Bangladesh. Emerg Infect Dis 10:2082-2087 (Pubitemid 39587329)
49. Kobayashi H, Kitamura T, Sekiguchi M, Homma MK, Kabuyama Y et al (2007) Involvement of EphB1 receptor/ephrinB2 ligand in neuropathic pain. Spine 32:1592-1598 (Pubitemid 47051841)
50. Kullander K, Croll SD, Zimmer M, Pan L, McClain J et al (2001) Ephrin-B3 is the midline barrier that prevents corticospinal tract axons from recrossing, allowing for unilateral motor control. Genes Dev 15:877-888 (Pubitemid 32295068)
51. Kunz TH, Braun de Torrez E, Bauer D, Lobova T, Fleming TH (2011) Ecosystem services provided by bats. Ann NY Acad Sci 1223:1-38
52. Lamb RA, Paterson RG, Jardetzky TS (2006) Paramyxovirus membrane fusion: lessons from the F and HN atomic structures. Virology 344:30-37 (Pubitemid 41814447)
53. Lee B (2007) Envelope-receptor interactions in Nipah virus pathobiology. Ann NY Acad Sci 1102:51-65 (Pubitemid 47084909)
54. Lee B, Ataman ZA (2011) Modes of Paramyxovirus fusion: a Henipavirus perspective. Trends Microbiol 19:389-399
55. Li Y, Wang J, Hickey AC, Zhang Y, Li Y et al (2008) Antibodies to nipah or nipah-like viruses in bats, China. Emerg Infect Dis 14:1974-1976
56. Liebl DJ, Morris CJ, Henkemeyer M, Parada LF (2003) mRNA expression of ephrins and Eph receptor tyrosine kinases in the neonatal and adult mouse central nervous system. J Neurosci Res 71:7-22 (Pubitemid 36008398)
57. Lim CC, Sitoh YY, Lee KE, Kurup A, Hui F (1999) Meningoencephalitis caused by a novel Paramyxovirus: an advanced MRI case report in an emerging disease. Singap Med J 40:356-358
58. Lim CCT, Lee WL, Leo YS, Lee KE, Chan KP et al (2003) Late clinical and magnetic resonance imaging follow up of Nipah virus infection. J Neurol Neurosurg Psychiatr 74:131-133 (Pubitemid 36069053)
59. Luby SP, Gurley ES, Hossain MJ (2009) Transmission of human infection with Nipah virus. Clin Infect Dis 49:1743-1748
60. Luby SP, Rahman M, Hossain MJ, Blum LS, Husain MM et al (2006) Foodborne transmission of Nipah virus, Bangladesh. Emerg Infect Dis 12:1888-1894 (Pubitemid 44904927)
61. Mäkinen T, Adams RH, Bailey J, Lu Q, Ziemiecki A et al (2005) PDZ interaction site in ephrinB2 is required for the remodeling of lymphatic vasculature. Genes Dev 19:397-410 (Pubitemid 40189302)
62. Marianneau P, Guillaume V, Wong T, Badmanathan M, Looi RY et al (2010) Experimental infection of squirrel monkeys with Nipah virus. Emerg Infect Dis 16:507-510
63. Maar D, Harmon B, Chu D et al (2012) Cysteines in the stalk of the Nipah virus G glycoprotein are located in a distinct subdomain critical for fusion activation. J Virol (in press)
64. Marston DJ, Dickinson S, Nobes CD (2003) Rac-dependent trans-endocytosis of ephrinbs regulates Eph-ephrin contact repulsion. Nat Cell Biol 5:879-888 (Pubitemid 37220693)
65. Massé N, Ainouze M, Néel B, Wild TF, Buckland R et al (2004) Measles virus (mv) hemagglutinin: evidence that attachment sites for mv receptors slam and CD46 overlap on the globular head. J Virol 78:9051-9063 (Pubitemid 39096516)
66. Mathieu C, Pohl C, Szecsi J, Trajkovic-Bodennec S, Devergnas S et al (2011) Nipah virus uses leukocytes for efficient dissemination within a host. J Virol 85:7863-7871
67. McFarlane R, Becker N, Field H (2011) Investigation of the climatic and environmental context of Hendra virus spillover events 1994-2010. PLoS ONE 6:e28374
68. Mercer J, Helenius A (2008) Vaccinia virus uses macropinocytosis and apoptotic mimicry to enter host cells. Science 320:531-535 (Pubitemid 351590666)
69. Meyer S, Hafner C, Guba M, Flegel S, Geissler EK et al (2005) Ephrin-B2 overexpression enhances integrin-mediated ECM-attachment and migration of B16 melanoma cells. Int J Oncol 27:1197-1206
70. Mills JN, Alim ANM, Bunning ML, Lee OB, Wagoner KD et al (2009) Nipah virus infection in dogs, Malaysia, 1999. Emerg Infect Dis 15:950-952
71. Mühlebach MD, Mateo M, Sinn PL, Prüfer S, Uhlig KM et al (2011) Adherens junction protein nectin-4 is the epithelial receptor for Measles virus. Nature 480:530-533
72. Mungall BA, Middleton D, Crameri G, Bingham J, Halpin K et al (2006) Feline model of acute Nipah virus infection and protection with a soluble glycoprotein-based subunit vaccine. J Virol 80:12293-12302 (Pubitemid 44904379)
73. Mungall BA, Middleton D, Crameri G, Halpin K, Bingham J et al (2007) Vertical transmission and fetal replication of Nipah virus in an experimentally infected cat. J Infect Dis 196:812-816 (Pubitemid 47378929)
74. Nahar N, Sultana R, Gurley ES, Hossain MJ, Luby SP (2010) Date palm sap collection: exploring opportunities to prevent nipah transmission. Ecohealth 7:196-203
75. Negrete OA, Chu D, Aguilar HC, Lee B (2007) Single amino acid changes in the nipah and Hendra virus attachment glycoproteins distinguish ephrinB2 from ephrinB3 usage. J Virol 81:10804-10814 (Pubitemid 47463353)
76. Negrete OA, Levroney EL, Aguilar HC, Bertolotti-Ciarlet A, Nazarian R et al (2005) EphrinB2 is the entry receptor for Nipah virus, an emergent deadly Paramyxovirus. Nature 436:401-405 (Pubitemid 41059050)
77. Negrete OA, Wolf MC, Aguilar HC, Enterlein S, Wang W et al (2006) Two key residues in ephrinB3 are critical for its use as an alternative receptor for Nipah virus. PLoS Pathog 2:e7
78. Noyce RS, Bondre DG, Ha MN, Lin LT, Sisson G, Tsao MS, Richardson CD (2011) Tumor cell marker PVRL4 (nectin 4) is an epithelial cell receptor for Measles virus. PLoS Pathog 7:e1002240
79. Olson JG, Rupprecht C, Rollin PE, An US, Niezgoda M et al (2002) Antibodies to nipah-like virus in bats (pteropus lylei), Cambodia. Emerg Infect Dis 8:987-988 (Pubitemid 35000822)
80. Pascall JC, Brown KD (2004) Intramembrane cleavage of ephrinB3 by the human rhomboid family protease, RHBDl2. Biochem Biophys Res Commun 317:244-252 (Pubitemid 38401991)
81. Pasquale EB (2008) Eph-ephrin bidirectional signaling in physiology and disease. Cell 133:38-52 (Pubitemid 351442996)
82. Pernet O, Pohl C, Ainouze M, Kweder H, Buckland R (2009) Nipah virus entry can occur by macropinocytosis. Virology 395:298-311
83. Pfaff D, Héroult M, Riedel M, Reiss Y, Kirmse R et al (2008) Involvement of endothelial ephrin-B2 in adhesion and transmigration of EphB-receptor-expressing monocytes. J Cell Sci 121:3842-3850
84. Pitulescu ME, Adams RH (2010) Eph/ephrin molecules - a hub for signaling and endocytosis. Genes Dev 24:2480-2492
85. Plowright RK, Field HE, Smith C, Divljan A, Palmer C et al (2008) Reproduction and nutritional stress are risk factors for Hendra virus infection in little red flying foxes (Pteropus scapulatus). Proc Biol Sci 275:861-869 (Pubitemid 351252811)
86. Radhakrishna H, Al-Awar O, Khachikian Z, Donaldson JG (1999) ARF6 requirement for Rac ruffling suggests a role for membrane trafficking in cortical actin rearrangements. J Cell Sci 112(Pt 6):855-866 (Pubitemid 29179318)
87. Rahman MA, Hossain MJ, Sultana S, Homaira N, Khan SU et al (2012) Date palm sap linked to Nipah virus outbreak in Bangladesh, 2008. Vector Borne Zoonotic Dis 12:65-72
88. Rockx B, Bossart KN, Feldmann F, Geisbert JB, Hickey AC et al (2010) A novel model of lethal Hendra virus infection in African green monkeys and the effectiveness of ribavirin treatment. J Virol 84:9831-9839
89. Saeed MF, Kolokoltsov AA, Albrecht T, Davey RA (2010) Cellular entry of Ebola virus involves uptake by a macropinocytosis-like mechanism and subsequent trafficking through early and late endosomes. PLoS Pathog 6:e1001110
90. Selvey LA, Wells RM, McCormack JG, Ansford AJ, Murray K et al (1995) Infection of humans and horses by a newly described Morbillivirus. Med J Aust 162:642-645
91. Su Z, Xu P, Ni F (2004) Single phosphorylation of TYR304 in the cytoplasmic tail of ephrin B2 confers high-affinity and bifunctional binding to both the SH2 domain of GRB4 and the PDZ domain of the PDZ-RGS3 protein. Eur J Biochem 271:1725-1736 (Pubitemid 38586304)
92. Suksanpaisan L, Susantad T, Smith DR (2009) Characterization of Dengue virus entry into HEPG2 cells. J Biomed Sci 16:17
93. Sun P, Yamamoto H, Suetsugu S, Miki H, Takenawa T et al (2003) Small GTPase Rah/Rab34 is associated with membrane ruffles and macropinosomes and promotes macropinosome formation. J Biol Chem 278:4063-4071 (Pubitemid 36801141)
94. Tan C, Chua K (2008) Nipah virus encephalitis. Curr Infect Dis Rep 10:315-320
95. Tanimura N, Imada T, Kashiwazaki Y, Sharifah SH (2006) Distribution of viral antigens and development of lesions in chicken embryos inoculated with Nipah virus. J Comp Pathol 135:74-82 (Pubitemid 44417992)
96. Tatsuo H, Ono N, Tanaka K, Yanagi Y (2000) Slam (CDW150) is a cellular receptor for Measles virus. Nature 406:893-897 (Pubitemid 30664265)
97. Vandenbroucke E, Mehta D, Minshall R, Malik AB (2008) Regulation of endothelial junctional permeability. Ann NY Acad Sci 1123:134-145 (Pubitemid 351431312)
98. Vigant F, Lee B (2011) Hendra and nipah infection: pathology, models and potential therapies. Infect Disord Drug Targets 11:315-336
99. Wacharapluesadee S, Boongird K, Wanghongsa S, Ratanasetyuth N, Supavonwong P et al (2010) A longitudinal study of the prevalence of Nipah virus in Pteropus lylei bats in Thailand: evidence for seasonal preference in disease transmission. Vector Borne Zoonotic Dis 10:183-190
100. Wang HU, Chen ZF, Anderson DJ (1998) Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4. Cell 93:741-753 (Pubitemid 28257581)
101. Weise C, Erbar S, Lamp B, Vogt C, Diederich S et al (2010) Tyrosine residues in the cytoplasmic domains affect sorting and fusion activity of the Nipah virus glycoproteins in polarized epithelial cells. J Virol 84:7634-7641
102. Wilkinson DG (2003) How attraction turns to repulsion. Nat Cell Biol 5:851-853 (Pubitemid 37220684)
103. Williamson MM, Hooper PT, Selleck PW, Westbury HA, Slocombe RF (2000) Experimental Hendra virus infectionin pregnant guinea-pigs and fruit bats (Pteropus poliocephalus). J Comp Pathol 122:201-207 (Pubitemid 30301559)
104. Williamson MM, Hooper PT, Selleck PW, Westbury HA, Slocombe RF (2001) A guinea-pig model of Hendra virus encephalitis. J Comp Pathol 124:273-279 (Pubitemid 32631562)
105. Williamson MM, Torres-Velez FJ (2010) Henipavirus: a review of laboratory animal pathology. Vet Pathol 47:871-880
106. Wong KT, Grosjean I, Brisson C, Blanquier B, Fevre-Montange M et al (2003) A golden hamster model for human acute Nipah virus infection. Am J Pathol 163:2127-2137 (Pubitemid 37310041)
107. Wong KT, Shieh W, Kumar S, Norain K, Abdullah W et al (2002) Nipah virus infection: pathology and pathogenesis of an emerging Paramyxoviral zoonosis. Am J Pathol 161:2153-2167 (Pubitemid 35434861)
108. Xu K, Rajashankar KR, Chan Y, Himanen JP, Broder CC et al (2008) Host cell recognition by the Henipaviruses: crystal structures of the nipah g attachment glycoprotein and its complex with ephrin-B3. Proc Natl Acad Sci USA 105:9953-9958
109. Yoneda M, Guillaume V, Ikeda F, Sakuma Y, Sato H et al (2006) Establishment of a Nipah virus rescue system. Proc Natl Acad Sci USA 103:16508-16513 (Pubitemid 44715226)
110. Young PL, Halpin K, Selleck PW, Field H, Gravel JL et al (1996) Serologic evidence for the presence in pteropus bats of a Paramyxovirus related to equine Morbillivirus. Emerg Infect Dis 2:239-240 (Pubitemid 126444995)
111. Yuan J, Marsh G, Khetawat D, Broder CC, Wang L et al (2011a) Mutations in the G-H loopregion of ephrin-B2 can enhance Nipah virus binding and infection. J Gen Virol 92:2142-2152
112. Yuan K, Hong T, Chen JJW, Tsai WH, Lin MT (2004) Syndecan-1 up-regulated by ephrinB2/EphB4 plays dual roles in inflammatory angiogenesis. Blood 104:1025-1033 (Pubitemid 39038022)
113. Yuan K, Jin YT, Lin MT (2000) Expression of tie-2, angiopoietin-1, angiopoietin-2, ephrinb2 and ephb4 in pyogenic granuloma of human gingiva implicates their roles in inflammatory angiogenesis. J Periodont Res 35:165-171
114. Yuan P, Leser GP, Demeler B, Lamb RA, Jardetzky TS (2008) Domain architecture and oligomerization properties of the Paramyxovirus PIV 5 hemagglutinin-neuraminidase (HN) protein. Virology 378:282-291
115. Yuan P, Swanson KA, Leser GP, Paterson RG, Lamb RA et al (2011b) Structure of the newcastle disease virus hemagglutinin-neuraminidase (HN) ectodomain reveals a four-helix bundle stalk. Proc Natl Acad Sci USA 108:14920-14925
116. Zamudio-Meza H, Castillo AM, González-Bonilla C et al (2009) Rac1 and CDC42 GTPases cross-talk regulates formation of filopodia required for Dengue virus type-2 entry into HMEC-1 cells. J Gen Virol 90(pt 12):2902-2911. Epub 2009 Aug 26
117. Zhao C, Irie N, Takada Y, Shimoda K, Miyamoto T et al (2006) Bidirectional ephrinb2-Ephb4 signaling controls bone homeostasis. Cell Metab 4:111-121 (Pubitemid 44138718)
118. Zimmer M, Palmer A, Köhler J, Klein R (2003) EphB-ephrinB bi-directional endocytosis terminates adhesion allowing contact mediated repulsion. Nat Cell Biol 5:869-878 (Pubitemid 37220692)