EphrinB2 is the entry receptor for Nipah virus, an emergent deadly paramyxovirus

Nature

Volumn 436, Issue 7049, 2005, Pages 401-405

  Negrete, Oscar A ^a   Levroney, Ernest L ^a   Aguilar, Hector C ^a   Bertolotti Ciarlet, Andrea ^b   Nazarian, Ronen ^a   Tajyar, Sara ^a   Lee, Benhur ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; DRUG THERAPY; ENZYME KINETICS; PATHOLOGY; PATIENT TREATMENT; PROTEINS;

CELL TYPES; HUMAN-TO-HUMAN TRANSMISSION; PATHOBIOLOGY; THERAPEUTICS;

VIRUSES;

EPHRIN B2; GLYCOPROTEIN; HYBRID PROTEIN; PROTEIN TYROSINE KINASE; VIRUS FUSION PROTEIN; VIRUS RECEPTOR;

MEDICINE;

ANIMAL TISSUE; ARTICLE; BRAIN CELL; CONTROLLED STUDY; EMBRYO; ENDOTHELIUM CELL; NERVE CELL; NIPAH VIRUS; NONHUMAN; NUCLEOTIDE SEQUENCE; PARAMYXOVIRUS; PRIORITY JOURNAL; RAT; VIRUS ENVELOPE; ANIMAL; CELL LINE; CHEMISTRY; GENETICS; HUMAN; MEMBRANE FUSION; METABOLISM; MOLECULAR WEIGHT; PATHOGENICITY; PHYSIOLOGY; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; RABBIT; SOLUBILITY; SPRAGUE DAWLEY RAT;

ANIMALIA; NIPAH VIRUS; PARAMYXOVIRIDAE;

ANIMALS; CELL LINE; EPHRIN-B2; GLYCOPROTEINS; HUMANS; MEMBRANE FUSION; MOLECULAR WEIGHT; NIPAH VIRUS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, VIRUS; SOLUBILITY; VIRAL FUSION PROTEINS;

EID: 22944445501     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature03838     Document Type: Article

References (27)

1. Hsu, V. P. et al. Nipah virus encephalitis reemergence, Bangladesh. Emerg. Infect. Dis. 10, 2082-2087 (2004).
2. The International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDRB). Person-to-person transmission of Nipah virus during outbreak in Faridpur District. Health Sci. Bull. 2, 5-9 (2004).
3. Poliakov, A., Cotrina, M. & Wilkinson, D. G. Diverse roles of eph receptors and ephrins in the regulation of cell migration and tissue assembly. Dev. Cell 7, 465-480 (2004).
4. Palmer, A. & Klein, R. Multiple roles of ephrins in morphogenesis, neuronal networking, and brain function. Genes Dev. 17, 1429-1450 (2003).
5. Wong, K. T. et al. Nipah virus infection: pathology and pathogenesis of an emerging paramyxoviral zoonosis. Am. J. Pathol. 161, 2153-2167 (2002).
6. Chua, K. B. et al. Nipah virus: a recently emergent deadly paramyxovirus. Science 288, 1432-1435 (2000).
7. Harcourt, B. H. et al. Molecular characterization of Nipah virus, a newly emergent paramyxovirus. Virology 271, 334-349 (2000).
8. Parashar, U. D. et al. Case-control study of risk factors for human infection with a new zoonotic paramyxovirus, Nipah virus, during a 1998-1999 outbreak of severe encephalitis in Malaysia. J. Infect. Dis. 181, 1755-1759 (2000).
9. Lam, S. K. Nipah virus-a potential agent of bioterrorism? Antiviral Res. 57, 113-119 (2003).
10. Field, H. et al. The natural history of Hendra and Nipah viruses. Microbes Infect. 3, 307-314 (2001).
11. Wong, K. T. et al. A golden hamster model for human acute Nipah virus infection. Am. J. Pathol. 163, 2127-2137 (2003).
12. Hooper, P., Zaki, S., Daniels, P. & Middleton, D. Comparative pathology of the diseases caused by Hendra and Nipah viruses. Microbes Infect. 3, 315-322 (2001).
13. Bossart, K. N. et al. Membrane fusion tropism and heterotypic functional activities of the Nipah virus and Hendra virus envelope glycoproteins. J. Virol. 76, 11186-11198 (2002).
14. Tamin, A. et al. Functional properties of the fusion and attachment glycoproteins of Nipah virus. Virology 296, 190-200 (2002).
15. Guillaume, V. et al. Nipah virus: vaccination and passive protection studies in a hamster model. J. Virol. 78, 834-840 (2004).
16. Gale, N. W. et al. Ephrin-B2 selectively marks arterial vessels and neovascularization sites in the adult, with expression in both endothelial and smooth-muscle cells. Dev. Biol. 230, 151-160 (2001).
17. Shin, D. et al. Expression of ephrinB2 identifies a stable genetic difference between arterial and venous vascular smooth muscle as well as endothelial cells, and marks subsets of microvessels at sites of adult neovascularization. Dev. Biol. 230, 139-150 (2001).
18. Rucker, J. et al. Cell-cell fusion assay to study role of chemokine receptors in human immunodeficiency virus type 1 entry. Methods Enzymol. 288, 118-133 (1997).
19. Bossart, K. N. & Broder, C. C. Viral glycoprotein-mediated cell fusion assays using vaccinia virus vectors. Methods Mol. Biol. 269, 309-332 (2004).
20. Takada, A. et al. A system for functional analysis of Ebola virus glycoprotein. Proc. Natl Acad. Sci. USA 94, 14764-14769 (1997).
21. Esko, J. D., Stewart, T. E. & Taylor, W. H. Animal cell mutants defective in glycosaminoglycan biosynthesis. Proc. Natl Acad. Sci. USA 82, 3197-3201 (1985).
22. Liu, J. & Thorp, S. C. Cell surface heparan sulfate and its roles in assisting viral infections. Med. Res. Rev. 22, 1-25 (2002).
23. Kullander, K. & Klein, R. Mechanisms and functions of Eph and ephrin signalling. Nature Rev. Mol. Cell Biol. 3, 475-486 (2002).
24. Noren, N. K., Lu, M., Freeman, A. L., Koolpe, M. & Pasquale, E. B. Interplay between EphB4 on tumour cells and vascular ephrin-B2 regulates tumour growth. Proc. Natl Acad. Sci. USA 101, 5583-5588 (2004).
25. Estus, S. et al. Aggregated amyloid-beta protein induces cortical neuronal apoptosis and concomitant "apoptotic" pattern of gene induction. J. Neurosci. 17, 7736-7745 (1997).
26. Shao, R. & Guo, X. Human microvascular endothelial cells immortalized with human telomerase catalytic protein: a model for the study of in vitro angiogenesis. Biochem. Biophys. Res. Commun. 321, 788-794 (2004).
27. Tollefsen, S. et al. DNA injection in combination with electroporation: a novel method for vaccination of farmed ruminants. Scand. J. Immunol. 57, 229-238 (2003).