Aminolevulinic acid (ALA)-protoporphyrin IX fluorescence guided tumour resection. Part 2: Theoretical, biochemical and practical aspects

Journal of Clinical Neuroscience

Volumn 19, Issue 12, 2012, Pages 1611-1616

  Colditz, Michael J ^a   Leyen, Karin Van ^b   Jeffree, Rosalind L ^a  

^a ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

^b Neurosurgery Department   (Switzerland)

Author keywords

Aminolevulinic acid (ALA); Fluorescence guided resection; Gliolan; Glioma; Protoporphyrin IX

Indexed keywords

AMINOLEVULINIC ACID; BEVACIZUMAB; DEXAMETHASONE; PROTOPORPHYRIN;

BLOOD BRAIN BARRIER; BRAIN SURGERY; BRAIN TUMOR; CANCER SURGERY; DRUG BLOOD LEVEL; FLUORESCENCE; FLUORESCENCE MICROSCOPY; GLIOMA; HEME SYNTHESIS; HUMAN; HYPOTENSION; LIVER FUNCTION TEST; MENINGIOMA; MITOCHONDRION; NAUSEA; OPTIMAL DRUG DOSE; PHOTODYNAMIC THERAPY; PRIORITY JOURNAL; REVIEW; SIDE EFFECT; SUNBURN; SURGICAL ANATOMY; SWELLING; TISSUE DISTRIBUTION; TUMOR LOCALIZATION; VOMITING;

AMINOLEVULINIC ACID; BRAIN NEOPLASMS; FLUORESCENT DYES; GLIOMA; HUMANS; NEUROSURGICAL PROCEDURES; PHOTOSENSITIZING AGENTS; PROTOPORPHYRINS; SURGERY, COMPUTER-ASSISTED;

EID: 84868302839     PISSN: 09675868     EISSN: 15322653     Source Type: Journal    
DOI: 10.1016/j.jocn.2012.03.013     Document Type: Review

References (63)

1. M.J. McGirt, K.L. Chaichana, and M. Gathinji Independent association of extent of resection with survival in patients with malignant brain astrocytoma J Neurosurg 110 2009 156 162
2. M.J. Colditz, and R.L. Jeffree Aminolevulinic acid (ALA)-protoporphyrin IX fluorescence guided tumour resection. Part 1: Clinical, radiological and pathological studies J Clin Neurosci 19 2012 1471 1474
3. M. Ishizuka, F. Abe, and Y. Sano Novel development of 5-aminolevurinic acid (ALA) in cancer diagnoses and therapy Int Immunopharmacol 11 2011 358 365
4. B. Krammer, and K. Plaetzer ALA and its clinical impact, from bench to bedside Photochem Photobiol Sci 7 2008 283 289
5. Q. Peng, T. Warloe, and K. Berg 5-Aminolevulinic acid-based photodynamic therapy. Clinical research and future challenges Cancer 79 1997 2282 2308
6. B.W. Pogue, S. Gibbs-Strauss, and P.A. Valdes Review of neurosurgical fluorescence imaging methodologies IEEE J Sel Top Quantum Electron 16 2010 493 505
7. L. Teng, M. Nakada, and S.G. Zhao Silencing of ferrochelatase enhances 5-aminolevulinic acid-based fluorescence and photodynamic therapy efficacy Br J Cancer 104 2011 798 807
8. H. Munakata, J.-Y. Sun, and K. Yoshida Role of the heme regulatory motif in the heme-mediated inhibition of mitochondrial import of 5-aminolevulinate synthase J Biochem (Tokyo) 136 2004 233 238
9. J.C. Kennedy, and R.H. Pottier Endogenous protoporphyrin IX, a clinically useful photosensitizer for photodynamic therapy J Photochem Photobiol B 14 1992 275 292
10. F.B. McGillion, G.G. Thompson, and A. Goldberg Tissue uptake of δ-aminolaevulinic acid Biochem Pharmacol 24 1975 299 301
11. European Medicines Agency. Gliolan Scientific Discussion. 2007 [21st July, 2011]; Available from: < http://www.ema.europa.eu/ema/index.jsp?curl= pages/medicines/human/medicines/000744/human-med-000807.jsp&murl=menus/ medicines/medicines.jsp&mid=WC0b01ac058001d124 >.
12. A. Johansson, G. Palte, and O. Schnell 5-Aminolevulinic acid-induced protoporphyrin IX levels in tissue of human malignant brain tumors Photochem Photobiol 86 2010 1373 1378
13. J. van den Boogert, R. van Hillegersberg, and F.W. de Rooij 5-Aminolaevulinic acid-induced protoporphyrin IX accumulation in tissues: pharmacokinetics after oral or intravenous administration J Photochem Photobiol B 44 1998 29 38
14. W. Stummer, H.J. Reulen, and T. Meinel Extent of resection and survival in glioblastoma multiforme: identification of and adjustment for bias Neurosurgery 62 2008 564 576 discussion-76
15. W. Stummer, H. Stepp, and G. Moller Technical principles for protoporphyrin-IX-fluorescence guided microsurgical resection of malignant glioma tissue Acta Neurochir (Wien) 140 1998 995 1000
16. K.M. Hebeda, A.E. Saarnak, and M. Olivo 5-Aminolevulinic acid induced endogenous porphyrin fluorescence in 9L and C6 brain tumours and in the normal rat brain Acta Neurochir (Wien) 140 1998 503 512 discussion 12-3
17. T.R. Walters, T.J. Gribble, and H.C. Schwartz Synthesis of haem in normal and leukaemic leucocytes Nature 197 1963 1213 1214
18. K. Takahashi, N. Ikeda, and N. Nonoguchi Enhanced expression of coproporphyrinogen oxidase in malignant brain tumors: CPOX expression and 5-ALA-induced fluorescence Neuro Oncol 13 2011 1234 1243
19. L. Wyld, M.W. Reed, and N.J. Brown The influence of hypoxia and pH on aminolaevulinic acid-induced photodynamic therapy in bladder cancer cells in vitro Br J Cancer 77 1998 1621 1627
20. L. Wyld, M. Tomlinson, and M.W. Reed Aminolaevulinic acid-induced photodynamic therapy: cellular responses to glucose starvation Br J Cancer 86 2002 1343 1347
21. I. Georgakoudi, P.C. Keng, and T.H. Foster Hypoxia significantly reduces aminolaevulinic acid-induced protoporphyrin IX synthesis in EMT6 cells Br J Cancer 79 1999 1372 1377
22. R. Diez Valle, S. Tejada Solis, and M.A. Idoate Gastearena Surgery guided by 5-aminolevulinic fluorescence in glioblastoma: volumetric analysis of extent of resection in single-center experience J Neurooncol 102 2011 105 113
23. Idoate MA, Diez Valle R, Echeveste J, et al. Pathological characterization of the glioblastoma border as shown during surgery using 5-aminolevulinic acid-induced fluorescence. Neuropathology 2011;31:575-82.
24. H. Fukuda, S. Paredes, and A.M. Batlle Tumour-localizing properties of porphyrins. In vivo studies using free and liposome encapsulated aminolevulinic acid Comp Biochem Physiol [B] 102 1992 433 436
25. P. Steinbach, H. Weingandt, and R. Baumgartner Cellular fluorescence of the endogenous photosensitizer protoporphyrin IX following exposure to 5-aminolevulinic acid Photochem Photobiol 62 1995 887 895
26. H. Stepp, T. Beck, and T. Pongratz ALA and malignant glioma: fluorescence-guided resection and photodynamic treatment J Environ Pathol Toxicol Oncol 26 2007 157 164
27. S.M. Ocheltree, H. Shen, and Y. Hu Role of PEPT2 in the choroid plexus uptake of glycylsarcosine and 5-aminolevulinic acid: studies in wild-type and null mice Pharm Res 21 2004 1680 1685
28. Y. Hu, H. Shen, and R.F. Keep Peptide transporter 2 (PEPT2) expression in brain protects against 5-aminolevulinic acid neurotoxicity J Neurochem 103 2007 2058 2065
29. M. Zimmermann, and A.C. Stan PepT2 transporter protein expression in human neoplastic glial cells and mediation of fluorescently tagged dipeptide derivative beta-Ala-Lys-Nepsilon-7-amino-4-methyl-coumarin-3-acetic acid accumulation J Neurosurg 112 2010 1005 1014
30. S.R. Ennis, A. Novotny, and J. Xiang Transport of 5-aminolevulinic acid between blood and brain Brain Res 959 2003 226 234
31. S.L. Gibson, J.J. Havens, and T.H. Foster Time-dependent intracellular accumulation of delta-aminolevulinic acid, induction of porphyrin synthesis and subsequent phototoxicity Photochem Photobiol 65 1997 416 421
32. Moretti M. Bermudez, Garcia S. Correa, and C. Perotti Delta-ainolevulinic acid transport in murine mammary adenocarcinoma cells is mediated by beta transporters Br J Cancer 87 2002 471 474
33. S. Bulnes, J. Bilbao, and J.V. Lafuente Microvascular adaptive changes in experimental endogenous brain gliomas Histol Histopathol 24 2009 693 706
34. S.W. Schneider, T. Ludwig, and L. Tatenhorst Glioblastoma cells release factors that disrupt blood-brain barrier features Acta Neuropathol (Berl) 107 2004 272 276
35. A. Johansson, G. Palte, and O. Schnell 5-Aminolevulinic acid-induced protoporphyrin IX levels in tissue of human malignant brain tumors Photochem Photobiol 86 2010 1373 1378
36. R. Ishihara, Y. Katayama, and T. Watanabe Quantitative spectroscopic analysis of 5-aminolevulinic acid-induced protoporphyrin IX fluorescence intensity in diffusely infiltrating astrocytomas Neurol Med Chir (Tokyo) 47 2007 53 57
37. J.C. Tonn, and W. Stummer Fluorescence-guided resection of malignant gliomas using 5-aminolevulinic acid: practical use, risks, and pitfalls Clin Neurosurg 55 2008 20 26
38. W. Stummer, H. Stepp, and G. Möller Technical principles for protoporphyrin-IX-fluorescence guided microsurgical resection of malignant glioma tissue Acta Neurochir (Wien) 140 1998 995 1000
39. W. Stummer, S. Stocker, and S. Wagner Intraoperative detection of malignant gliomas by 5-aminolevulinic acid-induced porphyrins fluorescence Neurosurgery 42 1998 518 525
40. W. Stummer, A. Novotny, and H. Stepp Fluorescence-guided resection of glioblastoma multiforme by using 5-aminolevulinic acid-induced porphyrins: a prospective study in 52 consecutive patients J Neurosurg 93 2000 1003 1013
41. G.C. Feigl, R. Ritz, and M. Moraes Resection of malignant brain tumors in eloquent cortical areas: a new multimodal approach combining 5-aminolevulinic acid and intraoperative monitoring J Neurosurg 113 2010 352 357
42. W. Stummer, U. Pichlmeier, and T. Meinel Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial Lancet Oncol 7 2006 392 401
43. G. Widhalm, S. Wolfsberger, and G. Minchev 5-Aminolevulinic acid is a promising marker for detection of anaplastic foci in diffusely infiltrating gliomas with nonsignificant contrast enhancement Cancer 116 2010 1545 1552
44. M. Hefti, G. von Campe, and M. Moschopulos 5-aminolevulinic acid induced protoporphyrin IX fluorescence in high-grade glioma surgery: a one-year experience at a single institution Swiss Med Wkly 138 2008 180 185
45. J. Webber, D. Kessel, and D. Fromm Side effects and photosensitization of human tissues after aminolevulinic acid J Surg Res 68 1997 31 37
46. J. Webber, D. Kessel, and D. Fromm Plasma levels of protoporphyrin IX in humans after oral administration of 5-aminolevulinic acid J Photochem Photobiol B 37 1997 151 153
47. R. Ackroyd, N. Brown, and D. Vernon 5-Aminolevulinic acid photosensitization of dysplastic Barrett's esophagus: a pharmacokinetic study Photochem Photobiol 70 1999 656 662
48. C.J. Kelty, R. Ackroyd, and N.J. Brown Comparison of high- vs low-dose 5-aminolevulinic acid for photodynamic therapy of Barrett's esophagus Surg Endosc 18 2004 452 458
49. European Medicines Agency. Gliolan. 2007 [29th July, 2011]; Available from: < http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/ medicines/000744/human-med-000807.jsp&murl=menus/medicines/medicines. jsp&mid=WC0b01ac058001d124 >.
50. A.K. Sinha, S. Anand, and B.J. Ortel Methotrexate used in combination with aminolaevulinic acid for photodynamic killing of prostate cancer cells Br J Cancer 95 2006 485 495
51. S. Anand, G. Honari, and T. Hasan Low-dose methotrexate enhances aminolevulinate-based photodynamic therapy in skin carcinoma cells in vitro and in vivo Clin Cancer Res 15 2009 3333 3343
52. D.W. Roberts, P.A. Valdes, and B.T. Harris Coregistered fluorescence-enhanced tumor resection of malignant glioma: relationships between delta-aminolevulinic acid-induced protoporphyrin IX fluorescence, magnetic resonance imaging enhancement, and neuropathological parameters J Neurosurg 114 2011 595 603
53. Specialised Therapeutics Australia. Specialised Therapeutics to License Brain Tumour Visualisation Drug Gliolan® in Australia & NZ. 2011 [15th, July, 2011]; Available from: < http://www.specialisedtherapeutics.com.au/ index.php?q=specialised-therapeutics-to-license-brain-tumour-visualisation-drug- gliolan-in-australia-and-nz.html >.
54. US National Institutes of Health. Clinical Trials. 2011 [14th November, 2011]; Available from: < http://clinicaltrials.gov/ct2/results?term= levulan+AND+glioma >.
55. European Medicines Agency. Gliolan - EPAR Summary for the public. 2011 [29th July, 2011]; Available from: < http://www.ema.europa.eu/ema/index.jsp? curl=pages/medicines/human/medicines/000744/human-med-000807.jsp&murl=menus/ medicines/medicines.jsp&jsenabled=true >.
56. R. Ritz, G.C. Feigl, and M.U. Schuhmann Use of 5-ALA fluorescence guided endoscopic biopsy of a deep-seated primary malignant brain tumor J Neurosurg 114 2011 1410 1413
57. Y. Tamura, T. Kuroiwa, and Y. Kajimoto Endoscopic identification and biopsy sampling of an intraventricular malignant glioma using a 5-aminolevulinic acid-induced protoporphyrin IX fluorescence imaging system. Technical note J Neurosurg 106 2007 507 510
58. S.R. Kantelhardt, H. Diddens, and J. Leppert Multiphoton excitation fluorescence microscopy of 5-aminolevulinic acid induced fluorescence in experimental gliomas Lasers Surg Med 40 2008 273 281
59. K. Bekelis, P.A. Valdes, and K. Erkmen Quantitative and qualitative 5-aminolevulinic acid-induced protoporphyrin IX fluorescence in skull base meningiomas Neurosurg Focus 30 2011 E8
60. S. Utsuki, H. Oka, and Y. Miyajima Auditory alert system for fluorescence-guided resection of gliomas Neurol Med Chir (Tokyo) 48 2008 95 97
61. H. Liao, M. Noguchi, and T. Maruyama An integrated diagnosis and therapeutic system using intra-operative 5-aminolevulinic-acid-induced fluorescence guided robotic laser ablation for precision neurosurgery Med Image Anal 16 2010 754 766
62. G. Hennig, H. Stepp, and A. Johansson Photobleaching-based method to individualize irradiation time during interstitial 5-aminolevulinic acid photodynamic therapy Photodiagnosis Photodyn Ther 8 2011 275 281
63. G. Berkovitch-Luria, M. Weitman, and A. Nudelman Multifunctional 5-aminolevulinic acid prodrugs activating diverse cell-death pathways Invest New Drugs 30 2012 1028 1038