Plasma levels of protoporphyrin IX in humans after oral administration of 5-aminolevulinic acid

Journal of Photochemistry and Photobiology B: Biology

Volumn 37, Issue 1-2, 1997, Pages 151-153

  Webber, John ^a   Kessel, David ^a   Fromm, David ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Aminolevulinic acid; Pharmacokinetics; Photodynamic therapy; Protoporphyrin IX

Indexed keywords

AMINOLEVULINIC ACID; PHOTOSENSITIZING AGENT; PROTOPORPHYRIN;

ADULT; AGED; ARTICLE; CASE REPORT; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG HALF LIFE; DRUG METABOLISM; HUMAN; MALE; ORAL DRUG ADMINISTRATION; PHOTODYNAMIC THERAPY; PHOTOSENSITIZATION; PRIORITY JOURNAL; SKIN SENSITIZATION;

ADMINISTRATION, ORAL; AGED; AMINOLEVULINIC ACID; HUMANS; MALE; MIDDLE AGED; PHOTOSENSITIZING AGENTS; PROTOPORPHYRINS; SPECTROMETRY, FLUORESCENCE;

EID: 0031022485     PISSN: 10111344     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1011-1344(96)07348-4     Document Type: Article

References (17)

1. [1] Z. Malik and H. Lugaci, Destruction of erythroleukaemic cells by photoactivation of endogenous porphyrins, Br. J. Cancer, 56 (1987) 589-595.
2. [2] Z. Malik, B. Ehrenberg and A. Faraggi, Inactivation of erythrocytic, lymphocytic and myelocytic leukemic cells by photoexcitation of endogenous porphyrins, J. Photochem. Photobiol. B: Biol., 4 (1989) 195-205.
3. [3] J.C. Kennedy and R.H. Pettier, Endogenous protoporphyrin IX, a clinically useful photosensitizer for photodynamic therapy, J. Photochem. Photobiol. B: Biol., 14 (1992) 275-292.
4. [4] J.C. Kennedy and R.H. Pettier, Using δ-aminolevulinic acid in cancer therapy, ACS Symposium Series, 559 (1994) 291-302.
5. [5] H.A. Dailey and A. Smith, Differential interaction of porphyrins used in photoradiation therapy with ferrochelatase, Biochem. J., 223 (1984) 441-445.
6. [6] N. Schoenfeld, O. Epstein, M. Lahav, R. Mamet, M. Shaklai and A. Atsmon, The heme biosynthetic pathway in lymphocytes of patients with malignant lymphoproliferative disorders, Cancer Lett., 43 (1988) 43-48.
7. [7] M.M.H. Ell-Sharabasy, A.M. El-Waseef, M.M. Hafez and S.A. Salim, Porphyrin metabolism in some malignant diseases, Br. J. Cancer, 65 (1992) 409-412.
8. [8] J.H.P. Wilson, R. van Hillegersberg, J.W.O. van den Berg, W.J. Kort and O.T. Terpsta, Photodynamic therapy for gastrointestinal tumors, Scand. J. Gastroenterol., 26 Suppl., 188 (1991) 20-25.
9. [9] D.X.G. Divans, J.C. Kennedy and R.H. Pettier, Phototoxic damage to sebaceous glands and hair follicles of mice after systemic administration of 5-aminolevulinic acid correlates with localized protoporphyrin IX fluorescence, Am. J. Pathol., 136 (1990) 891-897.
10. [10] C.S. Loh, J. Bedwell, A.J. MacRobert, N. Krasner, D. Phillips and S.G. Bown, Photodynamic therapy of the normal rat stomach: a comparative study between disulfonated aluminium phthalocyanine and 5-aminolaevulinic acid, Br. J. Cancer, 66 (1992) 452-462.
11. [11] J. Bedwell, A.J. MacRobert, D. Phillips and S.G. Bown, Fluorescence distribution and photodynamic effect of ALA-induced PP in the DMH rat colonic tumour model, Br. J. Cancer, 65 (1992) 818-824.
12. [12] S.R. Edwards, B.C. Shanley and J.A. Reynoldson, Neuropharmacology of delta-aminolaevulinic acid-I. Effect of acute administration in rodents, Neuropharmacol., 23 (1984) 477-481.
13. [13] C.S. Loh, A.J. MacRobert, J. Bedwell, J. Regula, N. Krasner and S.G. Bown, Oral versus intravenous administration of 5-aminolaevulinic acid for photodynamic therapy, Br. J. Cancer, 68 (1993) 41-51.
14. [14] L. Gossner, R. Sroka, E.G. Hahn and C. Eli, Photodynamic therapy: successful destruction of gastrointestinal cancer after oral administration of aminolevulinic acid, Gastroint. 1 Endo., 41 (1995) 55-58.
15. [15] B.W. Henderson, L. Vaughan, D.A. Bellnier, H. van Leengoed, P.G. Johnson and A.R. Oseroff, Photosensitization of murine tumor, vasculature and skin by 5-aminolevulinic acid-induced porphyrin, Photochem. Photobiol., 62 (1995) 780-789.
16. [16] J. Regula, A.J. MacRobert, A. Gorchein, G.A. Buonaccorsi, S.M. Thorpe, G.M. Spencer, A.R.W. Hatfield and S.G. Bown, Photosensitisation and photodynamic therapy of oesophageal, duodenal and colorectal tumours using 5 aminolaevulinic acid induced protoporphyrin IX-a pilot study, Gut, 36 (1995) 67-75.
17. [17] P. Mustajoki, K. Timonen, A, Gorchein, A.M. Seppalainen, E. Matikamen and R. Tenhunen, Sustained high plasma 5-aminolaevulinic acid concentration in a volunteer: no porphyric symptoms, Europ. J. Clin. Invest., 22 (1992) 407-411.