Fluorescence-guided resection of glioblastoma multiforme by using 5-aminolevulinic acid-induced porphyrins: A prospective study in 52 consecutive patients

Journal of Neurosurgery

Volumn 93, Issue 6, 2000, Pages 1003-1013

  Stummer, W ^a   Novotny, A ^a   Stepp, H ^a   Goetz, C ^a   Bise, K ^a   Reulen, H J ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

5 aminolevulinic acid; Fluorescence guided resection; Glioma; Porphyrin

Indexed keywords

AMINOLEVULINIC ACID; PORPHYRIN DERIVATIVE;

ADULT; AGED; ARTICLE; CANCER SURGERY; CANCER SURVIVAL; DIAGNOSTIC VALUE; FEMALE; FLUORESCENCE; GLIOBLASTOMA; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SURGICAL TECHNIQUE;

EID: 0034433453     PISSN: 00223085     EISSN: None     Source Type: Journal    
DOI: 10.3171/jns.2000.93.6.1003     Document Type: Article

References (41)

1. Early postoperative magnetic resonance imaging after resection of malignant glioma: Objective evaluation of residual tumor and its influence on regrowth and prognosis
2. Effect of the extent of surgical resection on survival and quality of life in patients with supratentorial glioblastomas and anaplastic astrocytomas
3. Radiation response and survival time in patients with glioblastoma multiforme
4. Survival after stereotactic biopsy of malignant gliomas
5. Regression models and life tables
6. Resection, biopsy, and survival in malignant glial neoplasms. A retrospective study of clinical parameters, therapy and outcome
7. The treatment of adult supratentorial high grade astrocytomas
8. Cerebral astrocytomas: Histopathologic correlation of MR and CT contrast enhancement with stereotactic biopsy
9. Does the extent of surgery make a difference in high grade malignant astrocytoma
10. Photodynamic therapy of oral cancer: Photosensitisation with systemic aminolaevulinic acid
11. 5-Aminolevulinic acid induced endogenous porphyrin fluorescence in 9L and C6 brain tumours and in the normal rat brain
12. Experimental and clinical study of glioma at surgery using fluorescent imaging by a surgical microscope after fluorescein administration
13. Non-parametric estimation for incomplete observations
14. Imaging-based stereotaxic serial biopsies in untreated intracranial glial neoplasms
15. Endogenous protoporphyrin IX, a clinically useful photosensitizer for photodynamic therapy
16. Quantitative imaging study of extent of surgical resection and prognosis of malignant astrocytomas
17. Surgical resection and radiation therapy versus biopsy and radiation therapy in the treatment of glioblastoma multiforme
18. Endogenous porphyrin distribution induced by 5-aminolaevulinic acid in the tissue layers of the gastrointestinal tract
19. Univariate and multivariate statistical analysis of high-grade gliomas: The relationship of radiation dose and other prognostic factors
20. The clinical use of fluorescein in neurosurgery. The localization of brain tumors
21. Improved surgical resection of human brain tumors. Part I. A preliminary study
22. The role of surgery in the management of supratentorial intermediate and high-grade astrocytomas in adults
23. Prognostic implications of the extent of surgical resection in patients with intracranial malignant gliomas
24. Laser-induced fluorescence: Experimental intraoperative delineation of tumor resection margins
25. The relationship between survival and the extent of the resection in patients with supratentorial malignant gliomas
26. Photosensitisation and photodynamic therapy of oesophageal, duodenal and colorectal tumours using 5 aminolaevulinic acid induced protoporphyrin IX - A pilot study
27. Multimodality management of recurrent adult malignant gliomas: Results of a phase II multiagent chemotherapy study and analysis of cytoreductive surgery
28. Treatment of patients with primary glioblastoma multiforme with standard postoperative radiotherapy and radiosurgical boost: Prognostic factors and long-term outcome
29. Influence of location and extent of surgical resection on survival of patients with glioblastoma multiforme: Results of three consecutive Radiation Therapy Oncology Group (RTOG) clinical trials
30. Large effect of age on the survival of patients with glioblastoma treated with radiotherapy and brachytherapy boost
31. Kinetics of photofrin II in perifocal brain edema
32. Technical principles for protoporphyrin-IX-fluorescence guided microsurgical resection of malignant glioma tissue
33. In vitro and in vivo porphyrin accumulation by C6 glioma cells after exposure to 5-aminolevulinic acid
34. Intraoperative detection of malignant gliomas by 5-aminolaevulinic acid-induced porphyrin fluorescence
35. The influence of the extent of surgery on the neurological function and survival in malignant glioma. A retrospective analysis in 243 patients
36. Side effects and photosensitization of human tissues after aminolevulinic acid
37. Supratentorial anaplastic gliomas in adults. The prognostic importance of extent of resection and prior low-grade glioma
38. Current neurosurgical management and the impact of the extent of resection in the treatment of malignant gliomas of childhood: A report of the Children's Cancer Group Trial No. CCG- 945
39. The prognostic importance of tumor size in malignant gliomas: A computed tomographic scan study by the Brain Tumor Cooperative Group
40. Long-term follow-up results of 175 patients with malignant glioma: Importance of radical tumour resection and postoperative adjuvant therapy with interferon, ACNU and radiation