Multiphoton excitation fluorescence microscopy of 5-aminolevulinic acid induced fluorescence in experimental gliomas

Lasers in Surgery and Medicine

Volumn 40, Issue 4, 2008, Pages 273-281

  Kantelhardt, Sven Rainer ^a   Diddens, Heike ^c   Leppert, Jan ^b   Rohde, Veit ^a   Hüttmann, Gereon ^c   Giese, Alf ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^c UNIVERSITY OF LÜBECK   (Germany)

Author keywords

5 ALA; Extent of resection; Glioma; Multiphoton excitation fluorescence microscopy

Indexed keywords

AMINOLEVULINIC ACID; PROTOPORPHYRIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOFLUORESCENCE; BRAIN; CONTROLLED STUDY; CYTOPLASM; EXCITATION; FILTER; GLIOMA; HUMAN; HUMAN CELL; IMAGING SYSTEM; MOUSE; MULTIPHOTON MICROSCOPY; NONHUMAN; PRIORITY JOURNAL; TUMOR CELL;

AMINOLEVULINIC ACID; ANIMALS; BRAIN NEOPLASMS; CELL LINE, TUMOR; GLIOMA; HUMANS; MICE; MICROSCOPY, FLUORESCENCE, MULTIPHOTON; PHOTOSENSITIZING AGENTS; PROTOPORPHYRINS;

EID: 43049151449     PISSN: 01968092     EISSN: 10969101     Source Type: Journal    
DOI: 10.1002/lsm.20623     Document Type: Article

References (33)

1. Uehlinger P, Zellweger M, Wagnieres G, Juillerat-Jeanneret L, van den Bergh H, Lange N. 5-Aminolevulinic acid and its derivatives: Physical chemical properties and protoporphyrin IX formation in cultured cells. J Photochem Photobiol B 2000;54(1):72-80.
2. Hebeda KM, Saarnak AE, Olivo M, Sterenborg HJ, Wolbers JG. 5-Aminolevulinic acid induced endogenous porphyrin fluorescence in 9L and C6 brain tumours and in the normal rat brain. Acta Neurochir (Wien) 1998;140(5):503-512.
3. Stummer W, Novotny A, Stepp H, Goetz C, Bise K, Reulen HJ. Fluorescence-guided resection of glioblastoma multiforme by using 5-aminolevulinic acid-induced porphyrins: A prospective study in 52 consecutive patients. J Neurosurg 2000;93:1003-1013.
4. Stummer W, Stocker S, Novotny A, Heimann A, Sauer O, Kempski O, Plesnila N, Wietzorrek J, Reulen HJ. In vitro and in vivo porphyrin accumulation by C6 glioma cells after exposure to 5-aminolevulinic acid. J Photochem Photobiol B 1998;45(2-3):160-169.
5. Stummer W, Stocker S, Wagner S, Stepp H, Fritsch C, Goetz C, Goetz AE, Kiefmann R, Reulen HJ. Intraoperative detection of malignant gliomas by 5-aminolevulinic acid-induced porphyrin fluorescence. Neurosurgery 1998;42(3):518-525.
6. Angell-Petersen E, Spetalen S, Madsen SJ, Sun CH, Peng Q, Carper SW, Sioud M, Hirschberg H. Influence of light fluence rate on the effects of photodymamic therapy in an orthotopic rat glioma model. J Neurosurg 2006;104(1):109-117.
7. Stummer W, Stepp H, Moller G, Ehrhardt A, Leonhard M, Reulen HJ. Technical principles for protoporphyrin-IX-fluorescence guided microsurgical resection of malignant glioma tissue. Acta Neurochir (Wien) 1998;140(10):995- 1000.
8. Bogaards A, Varma A, Collens SP, Lin A, Giles A, Yang VX, Bilbao JM, Lilge LD, Muller PJ, Wilson BC. Increased brain tumor resection using fluorescence image guidance in a preclinical model. Lasers Surg Med 2004;35(3):181-190.
9. Utsuki S, Oka H, Sato S, Shimizu S, Suzuki S, Tanizaki Y, Kondo K, Miyajima Y, Fujii K. Histological examination of false positive tissue resection using 5-aminolevulinic acid-induced fluorescence guidance. Neurol Med Chir (Tokyo) 2007;47(5):210-213; discussion 213-214.
10. Stummer W, Pichlmeier U, Meinel T, Wiestler OD, Zanella F, Reulen HJ, ALA-Glioma Study Group. Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: A randomised controlled multicentre phase III trial. Lancet Oncol 2006;7(5):392-401.
11. Filbeck T, Roessler W, Knuechel R, Straub M, Kiel HJ, Wieland WF. Clinical results of the transurethreal resection and evaluation of superficial bladder carcinomas by means of fluorescence diagnosis after intravesical instillation of 5-aminolevulinic acid. J Endourol 1999;13(2):117-121.
12. Kriegmair M, Baumgartner R, Knuchel R, Stepp H, Hofstadter F, Hofstetter A. Detection of early bladder cancer by 5-aminolevulinic acid induced porphyrin fluorescence. J Urol 1996;155(1):105-109.
13. Riedl CR, Plas E, Pfluger H. Fluorescence detection of bladder tumors with 5-amino-levulinic acid. J Endourol 1999;13(10):755-759.
14. Leunig A, Betz CS, Mehlmann M, Stepp H, Arbogast S, Grevers G, Baumgartner R. A pilot series demonstrating fluorescence staining of laryngeal papilloma using 5-amino-levulinic acid. Laryngoscope 2000;110:1783-1785.
15. Wang I, Clemente LP, Pratas RM, Cardoso E, Clemente MP, Montan S, Svanberg S, Svanberg K. Fluorescence diagnostics and kinetic studies in the head and neck region utilizing low-dose delta-aminolevulinic acid sensitization. Cancer Lett 1999;135:11-19.
16. Baumgartner R, Huber RM, Schulz H, Stepp H, Rick K, Gamarra F, Leberig A, Roth C. Inhalation of 5-aminolevulinic acid: A new technique for fluorescence detection of early stage lung cancer. J Photochem Photobiol B 1996;36:169-174.
17. Hillemanns P, Weingandt H, Baumgartner R, Diebold J, Xiang W, Stepp H. Photodetection of cervical intraepithelial neoplasia using 5-aminolevulinic acid-induced porphyrin fluorescence. Cancer 2000;88:2275-2282.
18. Malik E, Berg C, Meyhofer-Malik A, Buchweitz O, Moubayed P, Diedrich K. Fluorescence diagnosis of endometriosis using 5-aminolevulinic acid. Surg Endosc 2000;14:452-455.
19. Löning M, Diddens H, Kupker W, Diedrich K, Hüttmann G. Laparoscopic fluorescence detection of ovarian carcinoma metastases using 5-aminolevulinic acid-induced protoporphyrin IX. Cancer 2004;100:1650-1656.
20. Löning M, Diddens H, Holl-Ulrich K, Löning U, Küpker W, Diedrich K, Hüttmann G. Fluorescence staining of human ovarian cancer tissue following application of 5-aminolevulinic acid: Fluorescence microscopy studies. Lasers Surg Med 2006;38:549-554.
21. Messmann H. 5-Aminolevulinic acid-induced protoporphyrin IX for the detection of gastrointestinal dysplasia. Gastrointest Endosc Clin N Am 2000;10:497-512.
22. Ackermann G, Abels C, Karrer S, Baumler W, Landthaler M, Szeimies RM. Fluorescence-assisted biopsy of basal cell carcinomas. Hautarzt 2000;51:920-924.
23. Leppert J, Krajewski J, Kantelhardt SR, Schlaffer S, Petkus N, Reusche E, Huttmann G, Giese A. Multiphoton excitation of autofluorescence for microscopy of glioma tissue. Neurosurgery 2006;58(4):759-767.
24. König K. Multiphoton microscopy in life sciences. J Microsc 2000;200(Pt 2):83-104.
25. Kantelhardt SR, Leppert J, Krajewski J, Petkus N, Reusche E, Tronnier VM, Huttmann G, Giese A. Imaging of brain and brain tumor specimens by time-resolved multiphoton excitation microscopy ex vivo. Neuro-oncol 2007;2:103-112.
26. Becker W, Bergmann A, König K, Tirlapur U. Picosecond fluorescence lifetime microscopy by TCSP imaging. Proc SPIE 2001;4262:414-419.
27. Novotny A, Xiang J, Stummer W, Teuscher NS, Smith DE, Keep RF. Mechanisms of 5-aminolevulinic acid uptake at the choroid plexus. J Neurochem 2000;75:321-328.
28. Kendall CA, McCloskey K, Stone N, Barr H, Greenhalgh D. Multiphoton imaging in the detection of malignancy in the oesophagus. In: Wilson T, editor. Confocal, multiphoton, and nonlinear microscopic imaging: Proceedings of SPIE Vol. 5139. Wilson T, Ed. 2003. pp. 51-55.
29. Ganesan S, Elangovan M, Periasamy A. Kinetics and comparison of δ-aminolevulinic-acid-induced endogenous protoporphyrin-IX in single cell by steady state and multiphoton fluorescence imaging. In: Periasamy A, So PT, editors. Multiphoton microscopy in the biomedical sciences; proceedings of SPIE Vol. 4262. Periasamy A, So PTC, Eds. 2001. 263-267.
30. Kim D, Kim KH, Yazdanfar S, So PTC. High-speed handheld multiphoton multifoci microscopy. Multiphoton microscopy in the biomedical science IV, at Biomedical Optics 2001,San Jose, CA. SPIE Proc 2004;5323:267-272.
31. König K, Ehlers A, Riemann I, Schenkl S, Buckle R, Kaatz M. Clinical two-photon microendoscopy. Microsc Res Tech 2007;70:398-402.
32. Böhringer HJ, Boller D, Leppert J, Knopp U, Lankenau E, Reusche E, Hüttmann G, Giese A. Time domain and spectral domain optical coherence tomography in the analysis of brain tumor tissue. Laser Surg Med 2006;38:588-597.
33. Böhringer HJ, Lankenau E, Rohde V, Hüttmann G, Giese A. Optical coherence tomography or experimental neuroendoscopy. Minim Invasive Neurosurg 2006;49:269-275.