Silymarin attenuates benzo(a)pyrene induced toxicity by mitigating ROS production, DNA damage and calcium mediated apoptosis in peripheral blood mononuclear cells (PBMC)

Ecotoxicology and Environmental Safety

Volumn 86, Issue , 2012, Pages 79-85

  Perumal Vijayaraman, Kiruthiga ^a   Muruganantham, Shanmuganathan ^a   Subramanian, Manickavalli ^a   Shunmugiah, Karutha Pandian ^a   Kasi, Pandima Devi ^a  

^a ALAGAPPA UNIVERSITY   (India)

Author keywords

Apoptosis; Benzo(a)pyrene; Cytochrome P450; DNA damage; PBMC; Reactive oxygen species; Silymarin

Indexed keywords

BENZO[A]PYRENE; CALCIUM; CYTOCHROME P450 1A1; CYTOCHROME P450 1B1; DNA; NITRIC OXIDE; REACTIVE OXYGEN METABOLITE; SILYMARIN;

APOPTOSIS; BLOOD; CALCIUM; CARCINOGEN; CYTOCHROME; DAMAGE; DNA; RISK FACTOR; TOXICITY;

APOPTOSIS; ARTICLE; ATOMIC ABSORPTION SPECTROMETRY; CALCIUM CELL LEVEL; CATALYSIS; CELL PROTECTION; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DNA DAMAGE; DRUG MECHANISM; ENZYME ASSAY; ENZYME INHIBITION; FLUORESCENCE MICROSCOPY; FLUOROMETRY; HUMAN; HUMAN CELL; IMMUNOTOXICITY; OXIDATIVE STRESS; PERIPHERAL BLOOD MONONUCLEAR CELL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION REGULATION;

APOPTOSIS; BENZO(A)PYRENE; CALCIUM; CELLS, CULTURED; DNA DAMAGE; ENVIRONMENTAL POLLUTANTS; HUMANS; LEUKOCYTES, MONONUCLEAR; PROTECTIVE AGENTS; REACTIVE OXYGEN SPECIES; SILYMARIN;

EID: 84868300089     PISSN: 01476513     EISSN: 10902414     Source Type: Journal    
DOI: 10.1016/j.ecoenv.2012.08.031     Document Type: Article

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