Apoptosis in Daudi Human B Cells in Response to Benzo[a]pyrene and Benzo[a]pyrene-7,8-dihydrodiol

Toxicology and Applied Pharmacology

Volumn 151, Issue 2, 1998, Pages 367-376

  Salas, Virginia M ^a   Burchiel, Scott W ^a  

^a UNIVERSITY OF NEW MEXICO   (United States)

Author keywords

Apoptosis; Calcium; Daudi cells; Immunotoxicity; Polycyclic aromatic hydrocarbons

Indexed keywords

7,8 DIHYDRO 7,8 DIHYDROXYBENZO[A]PYRENE; ATRIAL NATRIURETIC FACTOR; BAX PROTEIN, HUMAN; BENZO(A)PYRENE 7,8 DIHYDRODIOL; BENZO(A)PYRENE 7,8-DIHYDRODIOL; BENZO[A]PYRENE; BENZO[A]PYRENE 7,8 DIHYDRODIOL 9,10 OXIDE; DNA FRAGMENT; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; ONCOPROTEIN; PARP1 PROTEIN, HUMAN; PROTEIN; PROTEIN BAX; PROTEIN BCL 2;

APOPTOSIS; ARTICLE; B LYMPHOCYTE; BIOSYNTHESIS; CELL LINE; DRUG EFFECT; HUMAN; METABOLISM;

7,8-DIHYDRO-7,8-DIHYDROXYBENZO(A)PYRENE 9,10-OXIDE; APOPTOSIS; ATRIAL NATRIURETIC FACTOR; B-LYMPHOCYTES; BCL-2-ASSOCIATED X PROTEIN; BENZO(A)PYRENE; CELL LINE; DIHYDROXYDIHYDROBENZOPYRENES; DNA FRAGMENTATION; HUMANS; POLY(ADP-RIBOSE) POLYMERASES; PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2;

EID: 0032138169     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1998.8455     Document Type: Article

References (52)

1. Bargou, R. C., Bommert, D., Weinmann, P., Daniel, P. T., Wagener, C., Mapara, M. Y., and Dorken, B. (1995). Induction of Bax-α protein precedes apoptosis in a human B lymphoma cell line: potential role of the bcl-2 gene family in surface IgM-mediated apoptosis. Eur. J. Immunol. 25, 770-775.
2. Bauer, E., Zuyu, G., Ueng, Y., Bell, L., Zeldin, D., and Guengerich, P. (1995). Oxidation of benzo[a]pyrene by recombinant human cytochrome P450 enzymes. Chem. Res. Toxicol. 8, 136-142.
3. Bonetti, B., Pohl, J., Gao, Y. L., and Raine, C. S. (1997). Cell death during autoimmune demyelination: Effector but not target cells are eliminated by apoptosis. J. Immunol. 159, 5733-5741.
4. Burchiel, S. W., Davis, D. P., Ray, S. D., Archuleta, M. M., Thilsted, J. P., and Corcoran, G. B. (1992). DMBA-induced cytotoxicity in lymphoid and nonlymphoid organs of B6C3F1 mice: Relation of cell death to target cell intracellular calcium and DNA damage. Toxicol. Appl. Pharmacol. 113, 126-132.
5. Burchiel, S. W., Davis, D. A. P., Ray, S. D., and Barton, S. L. (1993). DMBA induces programmed cell death (apoptosis) in the A20.1 murine B cell lymphoma. Fundam. Appl. Toxicol. 21, 120-124.
6. Cherney, B. W., Bhatia, K. G., Sgadari, C., Gutierrez, M. I., Mostowski, H., Pike, S. E., Gupta, G., Magrath, I. T., and Tosato, G. (1997). Role of the p53 tumor supressor gene in the tumorigenicity of Burkitt's lymphoma cells. Cancer Res. 57, 2508-2515.
7. Cohen, J. J., Duke, R. C., Fadok, V. A., and Sellins, K. S. (1992). Apoptosis and programmed cell death in immunity. Annu. Rev. Immunol. 10, 267-293.
8. Davila, D. R., Krieger, J. A., Yeh, A. A., and Burchiel, S. W. (1995a). Immunotoxicity of polycyclic aromatic hydrocarbons in human peripheral blood lymphocytes: Structure-activity relationships. Toxicologist 15(1), 38.
9. 2+-associated signaling pathways in the immunotoxicity of polycyclic aromatic hydrocarbons. J. Toxicol. Environ. Health 45, 101-126.
10. Del Peso, L., Gonzales-Garcia, M., Page, C., Herrera, R., and Nunez, G. (1997). Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. Science 278, 687-689.
11. Donehower, L. A., and Bradley, A. (1993) The tumor suppressor p53. Biochim. Biophys. Acta 1155, 181-205.
12. Egle, A., Villunger, A., Marschitz, I., Kos, M., Hittmair, A., Lukas, P., Grunewald, K. and Greil, R. (1997). Expression of Apo-1/Fas (CD95), Bcl-2, Bax and Bcl-x in myeloma cell lines: Relationship between responsiveness to anti-Fas mab and functional p53 status. Br. J. Haematol. 97, 418-428.
13. Gorczyca, W., Gong, J., and Darzynkiewicz, S. (1993). Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidal transferase and nick translation assays. Cancer Res. 53, 1945-1951.
14. Gottschalk, A. R., Boise, L. H., Thompson, C. B., and Quintans, J. (1994). Identification of immunosupressant-induced apoptosis in murine B cell lines and its prevention by bcl-x but not bcl-2. Proc. Natl. Acad. Sci. USA 91, 7350-7354.
15. Hardin, J. A., Hinoshita, F., and Sherr, D. H. (1992). Mechanisms by which benzo[a]pyrene, and environmental carcinogen, supresses B cell lymphopoiesis. Toxicol. Appl. Pharmacol. 117, 155-164.
16. Henderson, S., Rowe, M., Gregory, C., Croom-Carter, D., Wang, F., Longnecker, R., Kieff, E., and Rickinson, A. (1991). Induction of bcl-2 expression by Epstein-Barr virus latent membrane protein 1 protects infected B cells from programmed cell death. Cell 65, 1107-1115.
17. Kahn, A. A., Soloski, M. J., Sharp, A. H., Schilling, G., Sabatini, D. M., Li, S.-H., Ross, C. A., and Snyder, S. H. (1996). Lymphocyte apoptosis: Mediation by increased type 3 inositol 1,4,5-triphosphate receptor. Science 273, 503-507.
18. Kawabata, T. T., and White, K. L. (1987). Suppression of the in vitro humoral immune response of mouse splenocytes by benzo[a]pyrene metabolites and inhibition of benzo[a]pyrene-induced immunosuppression by α-naphthoflavone. Cancer Res. 47, 2317-2322.
19. Knox, K. A., Finney, M., Milner, A. E., Gregory, C. D., Wakelam, M. J. O., Michell, R. H., and Gordon, J. (1992). Second-messenger pathways involved in the regulation of survival in germinal-center B cells and in Burkitt lymphoma lines. Int. J. Cancer 52, 959-966.
20. Ladics, G. S., Kawabata, T. T., and White, K. L. (1991). Suppression of the in vitro humoral immune response of mouse splenocytes by 7,12-dimethylbenz[a]anthracene metabolites and inhibition of immunosuppression by α-naphthoflavone. Toxicol. Appl. Pharmacol. 110, 31-34.
21. Ladics, G. S., Kawabata, T. T., Munson, A. E., and White, K. L. (1992). Evaluation of murine splenic cell type metabolism of benzo(a)pyrene and functionality in vitro following repeated in vivo exposure to benzo(a)pyrene. Toxicol. Appl. Pharmacol. 116, 258-266.
22. 2+ fluxes. Proc. Natl. Acad. Sci. USA 91, 6569-6573.
23. Li, X.-K., Shinomaya, S., Kakefuda, T., Amemiya, H., and Suzuk, S. (1997). Induction of lymphocyte apoptosis by a novel immumosuppressant FTY720: Relation with FAS, BCL-2 and BAX expression. Transplant Proc. 29(1-2), 1267-1280.
24. Lindahl, T., Satoh, M. S., Poirier, G. G., and Klungland. (1995). Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks. Trends Biochem. Sci. 20, 405-411.
25. Liu, J. J. D., Farmer, J., Lane, W. S., Friedman, J., Weissman, I., and Schreiber, S. L. (1991). Calcineurin is a common target of cyclophilin-cyclosporin-A and FKBP-FK506 complexes. Cell 66, 807-815.
26. Liu, X., Sou, H., Slaughter, C., and Wang, X. (1997). DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis. Cell 89, 175-184.
27. 2+. Oncogene 13, 2259-2265.
28. McConkey, D. J., and Orrenius, S. (1997). The role of calcium in the regulation of apoptosis. Biochem. Biophys. Res. Commun. 239, 357-366.
29. Merchant, M., Arellano, L., and Safe, S. (1990). The mechanism of action of α-naphthoflavone as an inhibitor of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced CYP1A1 gene expression. Arch. Biochem. Biophys. 281, 84-89.
30. Mounho, B. J., Davila, D. R., and Burchiel, S. W. (1997). Characterization of intracellular calcium responses produced by polycyclic aromatic hydrocarbons in surface marker-defined human peripheral blood mononuclear cells. Toxicol. Appl. Pharmacol. 145, 323-330.
31. Mounho, B., and Burchiel, S. W. (1998). Alterations in human B cell calcium homeostasis by polycyclic aromatic hydrocarbons: Possible associations with cytochrome P450 metabolism and increased protein tyrosine phosphorylation. Toxicol. Appl. Pharmacol. 149, 80-89.
32. Nagata, S. (1997). Apoptosis by death factor. Cell 88, 355-365.
33. Ohnimus, H., Heinkelein, M., and Jassoy, C. (1997). Apoptotic cell death upon contact of CD4+ T lymphocytes with HIV glycoprotein-expressing cells is mediated by caspases but bypasses CD95 (Fas/Apo-1) and TNF Receptor 1. J. Immunol. 159, 5246-5252.
34. Okano, P., Miller, H. N., Robinson, R. C., and Gelboin, H. V. (1979). Comparison of benzo(a)pyrene and (-)-trans-7,8-dihydrobenzo(a)pyrene metabolism in human blood monocytes and lymphocytes. Cancer Res. 39, 3184-3193.
35. Orrenius, S. (1995). Apoptosis: Molecular mechanisms and implications for human disease. J. Intern. Med. 237, 529-536.
36. Osorio, L. M., De Santiago, A., Aguilar-Santelises, M., Mellstedt, H., and Jondal, M. (1997). CD6 ligation modulates the Bcl-2/Bax ratio and protects chronic lymphocytic leukemia B cells from apoptosis induced by anti-IgM. Blood 89, 2833-2841.
37. Patel, T., Gores, G. J., and Kaufman, S. H. (1996). The role of proteases during apoptosis. Exp. Cell. Res. 212, 367-373.
38. Ramet, M., Castren, K., Jarvinen, K., Pekkala, K., Turpeeniemi-Hujanen, T., Soini, Y., Paakko, P., and Vahakangas, K. (1995). p53 protein expression is correlated with benzo[a]pyrene-DNA adducts in carcinoma cell lines. Carcinogenesis. 16, 2117-2124.
39. Reed, J. C., Zha, H., Aime-Sempe, C., Takayama, S., and Wang, H. G. (1996). Structure-function analysis of Bcl-2 family proteins. In Mechanisms of Lymphocyte Activation and Immune Regulation VI. (Gupta and Cohen, Eds.), pp. 99-112. Plenum Press, New York.
40. Santavenere, E., Di Pietro, R., Centurione, M. A., Di Domenicantonio, L., Tribiani, O., and Rana, R. A. (1996). Synergistic regulatory effects of TNFα, IL-1α and IFNα on the growth and differentiation of Daudi lymphoma cells. Cell Biol. Int. 20, 335-338.
41. Schmidt, J. V., and Bradfield, C. A. (1996). Ah receptor signaling pathways. Annu. Rev. Cell Dev. Biol. 12, 55-89.
42. Sediak, T. W., Oltavai, Z. N., Yang, E., Wang, K., Boise, L. H., Thompson, C. B., and Korsmeyer, S. J. (1995). Multiple Bcl-2 family members demonstrate selective dimerization with Bax. Proc. Natl. Acad. Sci. USA 92, 7834-7838.
43. Selvakumaran, M., Lin, H., Miyashita, T., Wang, H., Stanislow, K., Reed, J. C., Hofman, B., and Lieberman, D. (1994). Immediate early up-regulation of bax expression by p53 but not TGFβ: A paradigm for distinct apoptotic pathways. Oncogene 9, 1791-1798.
44. Shimada, T., Martin, M. V., Pruess-Schwarts, D. Marnett, L. J., and Guengerich, P. (1989). Roles of individual human cytochrome P-450 enzymes in the bioactivation of benzo(a)pyrene, 7,8-dihydrobenzo(a)pyrene, and other dihydrodiol derivatives of polycyclic aromatic hydrocarbons. Cancer Res. 49, 6304-6312.
45. Strasser, A., Harris, A. W., Jacks, T., and Cory, S. (1994). DNA damage can induce apoptosis in proliferating lymphoid cells via p5 3-independent mechanisms inhibitable by Bcl-2. Cell 79, 329-339.
46. Thottala, J., and Marks, A. R. (1997). T cells deficient in inositol 1,4,5- triphosphate receptor are resistant to apoptosis. Mol. Cell. Biol. 17, 3005-3012.
47. Thakker, D. R., Tagi, H., Lu, A. Y. H., Levin, W., Conney, A. H., and Jerina, D. M. (1976). Metabolism of benzo[a]pyrene: conversion of (±)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene to highly mutagenic 7,8-diol-9,10-epoxides. Proc. Natl. Acad. Sci. USA 73, 3381-3385.
48. Vairo, G., Innes, K. M., and Adams, J. M. (1996). Bcl-2 has a cell cycle inhibitory function separable from its enhancement of cell survival. Oncogene 13, 1511-1519.
49. Waithe, W. I., Michaud, M., Harper, P. A., Okey, A. B., and Anderson, A. (1991). The ah receptor, cytochrome P4501A1 mRNA induction, and aryl hydrocarbon hydroxylase in a human lymphoblastoid cell line. Biochem. Pharmacol. 41, 85-92.
50. Whitlock, J. P., Cooper, H. L., and Gelboin, H. V. (1972). Aryl hydrocarbon (benzopyrene) hydroxylase is stimulated in human lymphocytes by mitogens and benz(a)anthracene. Science 177, 618-619.
51. Wyllie, A. H. (1980). Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature 284, 555-556.
52. Yamaguchi, K., Matulka, R. A., Schneider, A. M., Toselli, P., Trombino, A. F., Yang, S., Hafer, L. J., Mann, K. K., Tao, X.-J., Tilly, J. L., Near, R. I., and Sherr, D. H. (1997). Induction of preB cell apoptosis by 7,12-dimethylbenz-[a]anthracene in long-term primary murine bone marrow cultures. Toxicol. Appl. Pharmacol. 147, 190-203.