메뉴 건너뛰기




Volumn 26, Issue 11, 2012, Pages 4458-4467

Accelerated aging of the GABAergic septohippocampal pathway and decreased hippocampal rhythms in a mouse model of Alzheimer's disease

Author keywords

rhythm; J20 mice; Medial septum

Indexed keywords

AGING; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHOLINERGIC ACTIVITY; CONTROLLED STUDY; GABAERGIC TRANSMISSION; GAMMA RHYTHM; HIPPOCAMPUS; HIPPOCAMPUS THETA RHYTHM; INNERVATION; MALE; MOUSE; NERVE ENDING; NONHUMAN; PRIORITY JOURNAL; SEPTOHIPPOCAMPAL PATHWAY;

EID: 84868275692     PISSN: None     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.12-208413     Document Type: Article
Times cited : (74)

References (58)
  • 1
    • 0347914568 scopus 로고    scopus 로고
    • Human cholinergic basal forebrain: Chemoanatomy and neurologic dysfunction
    • Mufson, E. J., Ginsberg, S. D., Ikonomovic, M. D., and DeKosky, S. T. (2003) Human cholinergic basal forebrain: chemoanatomy and neurologic dysfunction. J. Chem. Neuroanat. 26, 233-242
    • (2003) J. Chem. Neuroanat. , vol.26 , pp. 233-242
    • Mufson, E.J.1    Ginsberg, S.D.2    Ikonomovic, M.D.3    DeKosky, S.T.4
  • 2
    • 0034125843 scopus 로고    scopus 로고
    • On neurodegenerative diseases, models, and treatment strategies: Lessons learned and lessons forgotten a generation following the cholinergic hypothesis
    • Bartus, R. T. (2000) On neurodegenerative diseases, models, and treatment strategies: lessons learned and lessons forgotten a generation following the cholinergic hypothesis. Exp. Neurol. 163, 495-529
    • (2000) Exp. Neurol. , vol.163 , pp. 495-529
    • Bartus, R.T.1
  • 3
    • 0020072221 scopus 로고
    • Alzheimer's disease and senile dementia: Loss of neurons in the basal forebrain
    • Whitehouse, P. J., Price, D. L., Struble, R. G., Clark, A. W., Coyle, J. T., and Delon, M. R. (1982) Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain. Science 215, 1237-1239
    • (1982) Science , vol.215 , pp. 1237-1239
    • Whitehouse, P.J.1    Price, D.L.2    Struble, R.G.3    Clark, A.W.4    Coyle, J.T.5    Delon, M.R.6
  • 4
    • 0030963566 scopus 로고    scopus 로고
    • Acetylcholine, aging, and alzheimer's disease
    • Muir, J. L. (1997) Acetylcholine, aging, and Alzheimer's disease. Pharmacol. Biochem. Behav. 56, 687-696
    • (1997) Pharmacol. Biochem. Behav. , vol.56 , pp. 687-696
    • Muir, J.L.1
  • 5
    • 79955727727 scopus 로고    scopus 로고
    • The cholinergic system in aging and neuronal degeneration
    • Schliebs, R., and Arendt, T. (2011) The cholinergic system in aging and neuronal degeneration. Behav. Brain Res. 221, 555-563
    • (2011) Behav. Brain Res. , vol.221 , pp. 555-563
    • Schliebs, R.1    Arendt, T.2
  • 6
    • 51449106987 scopus 로고    scopus 로고
    • The length of hippocampal cholinergic fibers is reduced in the aging brain
    • Ypsilanti, A. R., Girao da Cruz, M. T., Burgess, A., and Aubert, I. (2008) The length of hippocampal cholinergic fibers is reduced in the aging brain. Neurobiol. Aging 29, 1666-1679
    • (2008) Neurobiol. Aging , vol.29 , pp. 1666-1679
    • Ypsilanti, A.R.1    Girao Da Cruz, M.T.2    Burgess, A.3    Aubert, I.4
  • 7
    • 0031875257 scopus 로고    scopus 로고
    • Cholinergic strategies for alzheimer's disease
    • Winkler, J., Thal, L. J., Gage, F. H., and Fisher, L. J. (1998) Cholinergic strategies for Alzheimer's disease. J. Mol. Med. 76, 555-567
    • (1998) J. Mol. Med. , vol.76 , pp. 555-567
    • Winkler, J.1    Thal, L.J.2    Gage, F.H.3    Fisher, L.J.4
  • 8
    • 0023808226 scopus 로고
    • Gaba-containing neurons in the septum control inhibitory interneurons in the hippocampus
    • Freund, T. F., and Antal, M. (1988) GABA-containing neurons in the septum control inhibitory interneurons in the hippocampus. Nature 336, 170-173
    • (1988) Nature , vol.336 , pp. 170-173
    • Freund, T.F.1    Antal, M.2
  • 9
    • 0025102862 scopus 로고
    • Innervation of different peptide-containing neurons in the hippocampus by gabaergic septal afferents
    • Gulyas, A. I., Gorcs, T. J., and Freund, T. F. (1990) Innervation of different peptide-containing neurons in the hippocampus by GABAergic septal afferents. Neuroscience 37, 31-44
    • (1990) Neuroscience , vol.37 , pp. 31-44
    • Gulyas, A.I.1    Gorcs, T.J.2    Freund, T.F.3
  • 10
    • 1842411265 scopus 로고    scopus 로고
    • Disinhibition of rat hippocampal pyramidal cells by gabaergic afferents from the septum
    • Toth, K., Freund, T. F., and Miles, R. (1997) Disinhibition of rat hippocampal pyramidal cells by GABAergic afferents from the septum. J. Physiol. 500(Pt. 2), 463-474
    • (1997) J. Physiol. , vol.500 , Issue.PART. 2 , pp. 463-474
    • Toth, K.1    Freund, T.F.2    Miles, R.3
  • 11
    • 0030849281 scopus 로고    scopus 로고
    • Inhibitory control of gabaergic interneurons in the hippocampus
    • Freund, T. F., and Gulyas, A. I. (1997) Inhibitory control of GABAergic interneurons in the hippocampus. Can. J. Physiol. Pharmacol. 75, 479-487
    • (1997) Can. J. Physiol. Pharmacol. , Issue.75 , pp. 479-487
    • Freund, T.F.1    Gulyas, A.I.2
  • 12
    • 67649386562 scopus 로고    scopus 로고
    • Gabaergic neurons of the medial septum lead the hippocampal network during theta activity
    • Hangya, B., Borhegyi, Z., Szilagyi, N., Freund, T. F., and Varga, V. (2009) GABAergic neurons of the medial septum lead the hippocampal network during theta activity. J. Neurosci. 29, 8094-8102
    • (2009) J. Neurosci. , vol.29 , pp. 8094-8102
    • Hangya, B.1    Borhegyi, Z.2    Szilagyi, N.3    Freund, T.F.4    Varga, V.5
  • 13
    • 0037204104 scopus 로고    scopus 로고
    • Theta oscillations in the hippocampus
    • Buzsaki, G. (2002) Theta oscillations in the hippocampus. Neuron 33, 325-340
    • (2002) Neuron , vol.33 , pp. 325-340
    • Buzsaki, G.1
  • 14
    • 27644529959 scopus 로고    scopus 로고
    • Hippocampal mechanisms for the context-dependent retrieval of episodes
    • Hasselmo, M. E., and Eichenbaum, H. (2005) Hippocampal mechanisms for the context-dependent retrieval of episodes. Neural Netw. 18, 1172-1190
    • (2005) Neural Netw. , vol.18 , pp. 1172-1190
    • Hasselmo, M.E.1    Eichenbaum, H.2
  • 15
    • 27644517889 scopus 로고    scopus 로고
    • Hippocampal theta rhythm: A tag for short-term memory
    • Vertes, R. P. (2005) Hippocampal theta rhythm: a tag for short-term memory. Hippocampus 15, 923-935
    • (2005) Hippocampus , vol.15 , pp. 923-935
    • Vertes, R.P.1
  • 17
    • 77955860261 scopus 로고    scopus 로고
    • Decreased rhythmic gabaergic septal activity and memory-Associated theta oscillations after hippocampal amyloid-beta pathology in the rat
    • Villette, V., Poindessous-Jazat, F., Simon, A., Lena, C., Roullot, E., Bellessort, B., Epelbaum, J., Dutar, P., and Stephan, A. (2010) Decreased rhythmic GABAergic septal activity and memory-Associated theta oscillations after hippocampal amyloid-beta pathology in the rat. J. Neurosci. 30, 10991-11003
    • (2010) J. Neurosci. , vol.30 , pp. 10991-11003
    • Villette, V.1    Poindessous-Jazat, F.2    Simon, A.3    Lena, C.4    Roullot, E.5    Bellessort, B.6    Epelbaum, J.7    Dutar, P.8    Stephan, A.9
  • 20
    • 0033672464 scopus 로고    scopus 로고
    • Transient epileptic amnesia in dementia: A treatable unrecognized cause of episodic amnestic wandering
    • Rabinowicz, A. L., Starkstein, S. E., Leiguarda, R. C., and Coleman, A. E. (2000) Transient epileptic amnesia in dementia: a treatable unrecognized cause of episodic amnestic wandering. Alzheimer Dis. Assoc. Disord. 14, 231-233
    • (2000) Alzheimer Dis. Assoc. Disord. , vol.14 , pp. 231-233
    • Rabinowicz, A.L.1    Starkstein, S.E.2    Leiguarda, R.C.3    Coleman, A.E.4
  • 21
    • 0034213718 scopus 로고    scopus 로고
    • High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: Synaptotoxicity without plaque formation
    • Mucke, L., Masliah, E., Yu, G. Q., Mallory, M., Rockenstein, E. M., Tatsuno, G., Hu, K., Kholodenko, D., Johnson-Wood, K., and McConlogue, L. (2000) High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation. J. Neurosci. 20, 4050-4058
    • (2000) J. Neurosci. , vol.20 , pp. 4050-4058
    • Mucke, L.1    Masliah, E.2    Yu, G.Q.3    Mallory, M.4    Rockenstein, E.M.5    Tatsuno, G.6    Hu, K.7    Kholodenko, D.8    Johnson-Wood, K.9    McConlogue, L.10
  • 22
    • 0042924399 scopus 로고    scopus 로고
    • Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to alzheimer's disease-related cognitive deficits
    • Palop, J. J., Jones, B., Kekonius, L., Chin, J., Yu, G. Q., Raber, J., Masliah, E., and Mucke, L. (2003) Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer's disease-related cognitive deficits. Proc. Natl. Acad. Sci. U. S. A. 100, 9572-9577
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 9572-9577
    • Palop, J.J.1    Jones, B.2    Kekonius, L.3    Chin, J.4    Yu, G.Q.5    Raber, J.6    Masliah, E.7    Mucke, L.8
  • 23
    • 1842638722 scopus 로고    scopus 로고
    • The gabaergic septohippocampal pathway in control and reeler mice: Target specificity and termination onto reelin-expressing interneurons
    • Pascual, M., Perez-Sust, P., and Soriano, E. (2004) The GABAergic septohippocampal pathway in control and reeler mice: target specificity and termination onto Reelin-expressing interneurons. Mol. Cell. Neurosci. 25, 679-691
    • (2004) Mol. Cell. Neurosci. , vol.25 , pp. 679-691
    • Pascual, M.1    Perez-Sust, P.2    Soriano, E.3
  • 24
    • 0029997828 scopus 로고    scopus 로고
    • Expression of ngf and nt3 mrnas in hippocampal interneurons innervated by the gabaergic septohippocampal pathway
    • Rocamora, N., Pascual, M., Acsady, L., de Lecea, L., Freund, T. F., and Soriano, E. (1996) Expression of NGF and NT3 mRNAs in hippocampal interneurons innervated by the GABAergic septohippocampal pathway. J. Neurosci. 16, 3991-4004
    • (1996) J. Neurosci. , vol.16 , pp. 3991-4004
    • Rocamora, N.1    Pascual, M.2    Acsady, L.3    De Lecea, L.4    Freund, T.F.5    Soriano, E.6
  • 26
    • 32544453662 scopus 로고    scopus 로고
    • Involvement of the ca3-ca1 synapse in the acquisition of associative learning in behaving mice
    • Gruart, A., Munoz, M. D., and Delgado-Garcia, J. M. (2006) Involvement of the CA3-CA1 synapse in the acquisition of associative learning in behaving mice. J. Neurosci. 26, 1077-1087
    • (2006) J. Neurosci. , Issue.26 , pp. 1077-1087
    • Gruart, A.1    Munoz, M.D.2    Delgado-Garcia, J.M.3
  • 27
    • 0343714644 scopus 로고    scopus 로고
    • Scopolamine impairs information processing in the hippocampus and performance of a learned eyeblink response in alert cats
    • Munera, A., Gruart, A., Munoz, M. D., and Delgado-Garcia, J. M. (2000) Scopolamine impairs information processing in the hippocampus and performance of a learned eyeblink response in alert cats. Neurosci. Lett. 292, 33-36
    • (2000) Neurosci. Lett. , Issue.292 , pp. 33-36
    • Munera, A.1    Gruart, A.2    Munoz, M.D.3    Delgado-Garcia, J.M.4
  • 28
    • 16244380511 scopus 로고    scopus 로고
    • Role of class 3 semaphorins in the development and maturation of the septohippocampal pathway
    • Pascual, M., Pozas, E., and Soriano, E. (2005) Role of class 3 semaphorins in the development and maturation of the septohippocampal pathway. Hippocampus 15, 184-202
    • (2005) Hippocampus , vol.15 , pp. 184-202
    • Pascual, M.1    Pozas, E.2    Soriano, E.3
  • 29
    • 0024346318 scopus 로고
    • Degenerative changes in forebrain cholinergic nuclei correlate with cognitive impairments in aged rats
    • Fischer, W., Gage, F. H., and Bjorklund, A. (1989) Degenerative changes in forebrain cholinergic nuclei correlate with cognitive impairments in aged rats. Eur. J. Neurosci. 1, 34-45
    • (1989) Eur. J. Neurosci. , vol.1 , pp. 34-45
    • Fischer, W.1    Gage, F.2    Bjorklund, A.3
  • 30
    • 3042810397 scopus 로고    scopus 로고
    • Immunocytochemically defined interneuron populations in the hippocampus of mouse strains used in transgenic technology
    • Matyas, F., Freund, T. F., and Gulyas, A. I. (2004) Immunocytochemically defined interneuron populations in the hippocampus of mouse strains used in transgenic technology. Hippocampus 14, 460-481
    • (2004) Hippocampus , vol.14 , pp. 460-481
    • Matyas, F.1    Freund, T.F.2    Gulyas, A.I.3
  • 31
    • 0030337503 scopus 로고    scopus 로고
    • Interneurons of the hippocampus
    • Freund, T. F., and Buzsaki, G. (1996) Interneurons of the hippocampus. Hippocampus 6, 347-470
    • (1996) Hippocampus , vol.6 , pp. 347-470
    • Freund, T.F.1    Buzsaki, G.2
  • 32
    • 0024504531 scopus 로고
    • Gabaergic septohippocampal neurons contain parvalbumin
    • Freund, T. F. (1989) GABAergic septohippocampal neurons contain parvalbumin. Brain Res. 478, 375-381
    • (1989) Brain Res. , vol.478 , pp. 375-381
    • Freund, T.F.1
  • 33
    • 0019926318 scopus 로고
    • Septo-hippocampal relationships during eeg theta rhythm. Electroencephalogr
    • Gaztelu, J. M., and Buno, W., Jr. (1982) Septo-hippocampal relationships during EEG theta rhythm. Electroencephalogr. Clin. Neurophysiol. 54, 375-387
    • (1982) Clin. Neurophysiol. , vol.54 , pp. 375-387
    • Gaztelu, J.M.1    Buno Jr., W.2
  • 34
    • 0021139951 scopus 로고
    • Spatial learning and motor deficits in aged rats
    • Gage, F. H., Dunnett, S. B., and Björklund, A. (1984) Spatial learning and motor deficits in aged rats. Neurobiol. Aging 5, 43-48
    • (1984) Neurobiol. Aging , vol.5 , pp. 43-48
    • Gage, F.H.1    Dunnett, S.B.2    Björklund, A.3
  • 35
    • 1842326807 scopus 로고    scopus 로고
    • Age-related differences in an ecologically based study of route learning
    • Wilkniss, S. M., Jones, M. G., Korol, D. L., Gold, P. E., and Manning, C. A. (1997) Age-related differences in an ecologically based study of route learning. Psychol. Aging 12, 372-375
    • (1997) Psychol. Aging , vol.12 , pp. 372-375
    • Wilkniss, S.M.1    Jones, M.G.2    Korol, D.L.3    Gold, P.E.4    Manning, C.A.5
  • 36
    • 0033835539 scopus 로고    scopus 로고
    • Spatial memory and aging: Performance on a human analog of the morris water maze
    • Newman, M. C., and Kaszniak, A. W. (2000) Spatial memory and aging: performance on a human analog of the Morris water maze. Aging Neuropsychol. Cogn. 7, 86-93
    • (2000) Aging Neuropsychol. Cogn. , vol.7 , pp. 86-93
    • Newman, M.C.1    Kaszniak, A.W.2
  • 37
    • 79955090038 scopus 로고    scopus 로고
    • Septohippocampal pathways contribute to system consolidation of a spatial memory: Sequential implication of gabaergic and cholinergic neurons
    • Lecourtier, L., de Vasconcelos, A. P., Leroux, E., Cosquer, B., Geiger, K., Lithfous, S., and Cassel, J.-C. (2010) Septohippocampal pathways contribute to system consolidation of a spatial memory: sequential implication of GABAergic and cholinergic neurons. Hippocampus 21, 1277-1289
    • (2010) Hippocampus , vol.21 , pp. 1277-1289
    • Lecourtier, L.1    De Vasconcelos, A.P.2    Leroux, E.3    Cosquer, B.4    Geiger, K.5    Lithfous, S.6    Cassel, J.-C.7
  • 38
    • 0026525223 scopus 로고
    • Cholinergic cell loss and hypertrophy in the medial septal nucleus of the behaviorally characterized aged rhesus monkey
    • Stroessner-Johnson, H. M., Rapp, P. R., and Amaral, D. G. (1992) Cholinergic cell loss and hypertrophy in the medial septal nucleus of the behaviorally characterized aged rhesus monkey. J. Neurosci. 12, 1936-1944
    • (1992) J. Neurosci. , vol.12 , pp. 1936-1944
    • Stroessner-Johnson, H.M.1    Rapp, P.R.2    Amaral, D.G.3
  • 39
    • 0028947094 scopus 로고
    • Ageing: The cholinergic hypothesis of cognitive decline
    • Gallagher, M., and Colombo, P. J. (1995) Ageing: the cholinergic hypothesis of cognitive decline. Curr. Opin. Neurobiol. 5, 161-168
    • (1995) Curr. Opin. Neurobiol. , vol.5 , pp. 161-168
    • Gallagher, M.1    Colombo, P.J.2
  • 40
    • 41949104908 scopus 로고    scopus 로고
    • Early cholinergic neuronal and axonal abnormalities are present early in aging and in alzheimer disease
    • Geula, C. N. N., Nicholas, A., Wu, C. K. (2008) Early cholinergic neuronal and axonal abnormalities are present early in aging and in Alzheimer disease. J. Neuropathol. Exp. Neurol. 67, 309-318
    • (2008) J. Neuropathol. Exp. Neurol. , vol.67 , pp. 309-318
    • Geula, C.N.N.1    Nicholas, A.2    Wu, C.K.3
  • 41
    • 0036810329 scopus 로고    scopus 로고
    • Alzheimer's disease and the basal forebrain cholinergic system: Relations to î2-Amyloid peptides, cognition, and treatment strategies
    • Auld, D. S., Kornecook, T. J., Bastianetto, S. p., and Quirion, R. m. (2002) Alzheimer's disease and the basal forebrain cholinergic system: relations to Î2-Amyloid peptides, cognition, and treatment strategies. Prog. Neurobiol. 68, 209-245
    • (2002) Prog. Neurobiol. , vol.68 , pp. 209-245
    • Auld, D.S.1    Kornecook, T.J.2    Bastianetto, S.P.3    Quirion, R.4
  • 43
    • 35449007976 scopus 로고    scopus 로고
    • Gabaa receptors in aging and alzheimer's disease
    • Rissman, R. A., De Blas, A. L., and Armstrong, D. M. (2007) GABAA receptors in aging and Alzheimer's disease. J. Neurochem. 103, 1285-1292
    • (2007) J. Neurochem. , vol.103 , pp. 1285-1292
    • Rissman, R.A.1    De Blas, A.L.2    Armstrong, D.M.3
  • 44
    • 79954994735 scopus 로고    scopus 로고
    • Implications for treatment: Gabaa receptors in aging, down syndrome and alzheimer's disease
    • Rissman, R. A., and Mobley, W. C. (2011) Implications for treatment: GABAA receptors in aging, Down syndrome and Alzheimer's disease. J. Neurochem. 117, 613-622
    • (2011) J. Neurochem. , Issue.117 , pp. 613-622
    • Rissman, R.A.1    Mobley, W.C.2
  • 45
    • 0032482182 scopus 로고    scopus 로고
    • Hippocampal interneurons expressing glutamic acid decarboxylase and calcium-binding proteins decrease with aging in fischer 344 rats
    • Shetty, A. K., and Turner, D. A. (1998) Hippocampal interneurons expressing glutamic acid decarboxylase and calcium-binding proteins decrease with aging in Fischer 344 rats. J. Comp. Neurol. 394, 252-269
    • (1998) J. Comp. Neurol. , vol.394 , pp. 252-269
    • Shetty, A.K.1    Turner, D.A.2
  • 46
    • 0345269186 scopus 로고    scopus 로고
    • Rat hippocampal gabaergic molecular markers are differentially affected by ageing
    • Vela, J., Gutierrez, A., Vitorica, J., and Ruano, D. (2003) Rat hippocampal GABAergic molecular markers are differentially affected by ageing. J. Neurochem. 85, 368-377
    • (2003) J. Neurochem. , vol.85 , pp. 368-377
    • Vela, J.1    Gutierrez, A.2    Vitorica, J.3    Ruano, D.4
  • 47
    • 0030012145 scopus 로고    scopus 로고
    • Interneurons containing calretinin are specialized to control other interneurons in the rat hippocampus
    • Gulyas, A. I., Hajos, N., and Freund, T. F. (1996) Interneurons containing calretinin are specialized to control other interneurons in the rat hippocampus. J. Neurosci. 16, 3397-3411
    • (1996) J. Neurosci. , vol.16 , pp. 3397-3411
    • Gulyas, A.I.1    Hajos, N.2    Freund, T.F.3
  • 48
    • 84862101988 scopus 로고    scopus 로고
    • The origin of extracellular fields and currents-Eeg, ecog, lfp and spikes
    • Buzsaki, G., Anastassiou, C. A., and Koch, C. (2012) The origin of extracellular fields and currents-EEG, ECoG, LFP and spikes. Nat. Rev. 13, 407-420
    • (2012) Nat. Rev. , Issue.13 , pp. 407-420
    • Buzsaki, G.1    Anastassiou, C.A.2    Koch, C.3
  • 49
    • 77956815064 scopus 로고    scopus 로고
    • Neuron loss in transgenic mouse models of alzheimer's disease
    • Wirths, O., and Bayer, T. A. (2010) Neuron loss in transgenic mouse models of Alzheimer's disease. Int. J. Alzheimers Dis. 2010, 723782
    • (2010) Int. J. Alzheimers Dis. , vol.2010 , pp. 723782
    • Wirths, O.1    Bayer, T.A.2
  • 50
    • 36949016215 scopus 로고    scopus 로고
    • Alzheimer disease models and human neuropathology: Similarities and differences
    • Duyckaerts, C., Potier, M.-C., and Delatour, B. T. (2008) Alzheimer disease models and human neuropathology: similarities and differences. Acta Neuropathol. 115, 5-38
    • (2008) Acta Neuropathol. , vol.115 , pp. 5-38
    • Duyckaerts, C.1    Potier, M.-C.2    Delatour, B.T.3
  • 51
    • 0030611097 scopus 로고    scopus 로고
    • A-beta deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein v717f (pdapp) transgenic mouse
    • Irizarry, M. C., Soriano, F., McNamara, M., Page, K. J., Schenk, D., Games, D., and Hyman, B. T. (1997) A-beta deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse. J. Neurosci. 17, 7053-7059
    • (1997) J. Neurosci. , vol.17 , pp. 7053-7059
    • Irizarry, M.C.1    Soriano, F.2    McNamara, M.3    Page, K.J.4    Schenk, D.5    Games, D.6    Hyman, B.T.7
  • 54
    • 47249089923 scopus 로고    scopus 로고
    • Subfield and layer-specific depletion in calbindin-d28k, calretinin and parvalbumin immunoreactivity in the dentate gyrus of amyloid precursor protein/presenilin 1 transgenic mice
    • Popovic, M., Caballero-Bleda, M., Kadish, I., and Van Groen, T. (2008) Subfield and layer-specific depletion in calbindin-D28K, calretinin and parvalbumin immunoreactivity in the dentate gyrus of amyloid precursor protein/presenilin 1 transgenic mice. Neuroscience 155, 182-191
    • (2008) Neuroscience , vol.155 , pp. 182-191
    • Popovic, M.1    Caballero-Bleda, M.2    Kadish, I.3    Van Groen, T.4
  • 56
    • 77954132249 scopus 로고    scopus 로고
    • Amyloid-α-induced neuronal dysfunction in alzheimer's disease: From synapses toward neural networks
    • Palop, J. J., and Mucke, L. (2010) Amyloid-α-induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks. Nat. Neurosci. 13, 812-818
    • (2010) Nat. Neurosci. , Issue.13 , pp. 812-818
    • Palop, J.J.1    Mucke, L.2
  • 57
    • 0034668934 scopus 로고    scopus 로고
    • Distinct frequency preferences of different types of rat hippocampal neurones in response to oscillatory input currents
    • Pike, F. G., Goddard, R. S., Suckling, J. M., Ganter, P., Kasthuri, N., and Paulsen, O. (2000) Distinct frequency preferences of different types of rat hippocampal neurones in response to oscillatory input currents. J. Physiol. 529, 205-213
    • (2000) J. Physiol. , vol.529 , pp. 205-213
    • Pike, F.G.1    Goddard, R.S.2    Suckling, J.M.3    Ganter, P.4    Kasthuri, N.5    Paulsen, O.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.