Ligand migration in the gaseous insulin-CB7 Complex - A cautionary tale about the use of ECD-MS for ligand binding site determination

Journal of the American Society for Mass Spectrometry

Volumn 23, Issue 11, 2012, Pages 1911-1920

  Heath, Brittany L ^a   Jockusch, Rebecca A ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

Cucurbituril; Electron capture dissociation; Fourier transform ion cyclotron resonance mass spectrometry; Insulin; Ion activation; Ligand binding site determination

Indexed keywords

CUCURBITURILS; ELECTRON CAPTURE DISSOCIATION; FOURIER-TRANSFORM ION CYCLOTRON RESONANCE MASS SPECTROMETRY; ION ACTIVATION; LIGAND-BINDING SITES;

AMINO ACIDS; BINDING ENERGY; BINDING SITES; COMPLEXATION; DISSOCIATION; ELECTROSPRAY IONIZATION; EXPERIMENTS; IONS; LIGANDS; MASS SPECTROMETRY;

INSULIN;

CUCURBIT 7 PROTEIN; INSULIN; PHENYLALANINE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CHEMICAL INTERACTION; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ELECTRON CAPTURE DETECTION; ELECTROSPRAY; FOURIER TRANSFORM MASS SPECTROMETRY; GAS; ION CYCLOTRON RESONANCE MASS SPECTROMETRY; LIGAND BINDING; MASS SPECTROMETER; MASS SPECTROMETRY; NONHUMAN; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN TRANSPORT;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; BINDING, COMPETITIVE; BRIDGED COMPOUNDS; CATTLE; IMIDAZOLES; INSULIN; MASS SPECTROMETRY; MOLECULAR SEQUENCE DATA; PHENYLALANINE; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN INTERACTION MAPPING; REPRODUCIBILITY OF RESULTS;

BOVINAE;

EID: 84868242023     PISSN: 10440305     EISSN: 18791123     Source Type: Journal    
DOI: 10.1007/s13361-012-0470-3     Document Type: Article

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