Characterization of the interaction between astrocytes and encephalitogenic lymphocytes during the development of experimental autoimmune encephalitomyelitis (EAE) in mice

Clinical and Experimental Immunology

Volumn 170, Issue 3, 2012, Pages 254-265

  Yang, J F ^a   Tao, H Q ^b   Liu, Y M ^a   Zhan, X X ^a   Liu, Y ^a   Wang, X Y ^a   Wang, J H ^a   Mu, L L ^a   Yang, L L ^a   Gao, Z M ^a   Kong, Q F ^a   Wang, G Y ^a   Han, J H ^a   Sun, B ^a   Li, H L ^a,c  

^a HARBIN MEDICAL UNIVERSITY   (China)

^b THE SECOND AFFILIATED HOSPITAL OF HARBIN MEDICAL UNIVERSITY   (China)

^c BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

Author keywords

Astrocyte; Experimental autoimmune encephalitomyelitis; IL 27; MHC II; Multiple sclerosis

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 17; INTERLEUKIN 27; INTERLEUKIN 4; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; NEUTRALIZING ANTIBODY; TRANSFORMING GROWTH FACTOR BETA;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CELL INTERACTION; CELL PROLIFERATION; CYTOKINE RELEASE; ENCEPHALITOGENIC LYMPHOCYTE; FEMALE; IMMUNIZATION; IN VITRO STUDY; LYMPHOCYTE; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPINAL CORD;

ANIMALS; ASTROCYTES; CELL COMMUNICATION; COCULTURE TECHNIQUES; CYTOKINES; DISEASE MODELS, ANIMAL; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; EPITOPES; FEMALE; GENE EXPRESSION REGULATION; GENES, MHC CLASS II; INTERFERON-GAMMA; INTERLEUKINS; LYMPHOCYTE ACTIVATION; LYMPHOCYTES; MICE; MICE, INBRED C57BL; MYELIN-OLIGODENDROCYTE GLYCOPROTEIN; PEPTIDE FRAGMENTS; SPINAL CORD;

EID: 84868236917     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2012.04661.x     Document Type: Article

References (56)

1. Linker RA, Lee DH. Models of autoimmune demyelination in the central nervous system: on the way to translational medicine. Exp Transl Stroke Med 2009; 1:5.
2. McFarland HF, Martin R. Multiple sclerosis: a complicated picture of autoimmunity. Nat Immunol 2007; 8:913-919.
3. Recks MS, Addicks K, Kuerten S. Spinal cord histopathology of MOG peptide 35-55-induced experimental autoimmune encephalomyelitis is time- and score-dependent. Neurosci Lett 2011; 494:227-231.
4. Sospedra M, Martin R. Immunology of multiple sclerosis. Annu Rev Immunol 2005; 23:683-747.
5. Aranami T, Yamamura T. Th17 cells and autoimmune encephalomyelitis (EAE/MS). Allergol Int 2008; 57:115-120.
6. Leipe J, Grunke M, Dechant C etal. Th17 cells in autoimmune arthritis. Arthritis Rheum 2010; 62:2876-2885.
7. Mu L, Sun B, Kong Q etal. Disequilibrium of T helper type 1, 2 and 17 cells and regulatory T cells during the development of experimental autoimmune myasthenia gravis. Immunology 2009; 128 (Suppl.):e826-836.
8. Mayne CG, Spanier JA, Relland LM, Williams CB, Hayes CE. 1, 25-Dihydroxyvitamin D3 acts directly on the T lymphocyte vitamin D receptor to inhibit experimental autoimmune encephalomyelitis. Eur J Immunol 2011; 41:822-832.
9. Axtell RC, de Jong BA, Boniface K etal. T helper type 1 and 17 cells determine efficacy of interferon-beta in multiple sclerosis and experimental encephalomyelitis. Nat Med 2010; 16:406-412.
10. Jang E, Cho ML, Oh HJ, Youn J. Deficiency of foxp3 regulatory T cells exacerbates autoimmune arthritis by altering the synovial proportions of CD4 T cells and dendritic cells. Immune Netw 2011; 11:299-306.
11. Abbott NJ, Ronnback L, Hansson E. Astrocyte-endothelial interactions at the blood-brain barrier. Nat Rev Neurosci 2006; 7:41-53.
12. Sofroniew MV, Vinters HV. Astrocytes: biology and pathology. Acta Neuropathol 2010; 119:7-35.
13. Schwaninger M, Sallmann S, Petersen N etal. Bradykinin induces interleukin-6 expression in astrocytes through activation of nuclear factor-kappaB. J Neurochem 1999; 73:1461-1466.
14. Didier N, Romero IA, Creminon C, Wijkhuisen A, Grassi J, Mabondzo A. Secretion of interleukin-1beta by astrocytes mediates endothelin-1 and tumour necrosis factor-alpha effects on human brain microvascular endothelial cell permeability. J Neurochem 2003; 86:246-254.
15. Dong Y, Benveniste EN. Immune function of astrocytes. Glia 2001; 36:180-190.
16. Nair A, Frederick TJ, Miller SD. Astrocytes in multiple sclerosis: a product of their environment. Cell Mol Life Sci 2008; 65:2702-2720.
17. Saikali P, Antel JP, Pittet CL, Newcombe J, Arbour N. Contribution of astrocyte-derived IL-15 to CD8 T cell effector functions in multiple sclerosis. J Immunol 2010; 185:5693-5703.
18. Argaw AT, Asp L, Zhang J etal. Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS inflammatory disease. J Clin Invest 2012; 122:2454-2468.
19. Carpentier PA, Begolka WS, Olson JK, Elhofy A, Karpus WJ, Miller SD. Differential activation of astrocytes by innate and adaptive immune stimuli. Glia 2005; 49:360-374.
20. Meinl E, Aloisi F, Ertl B etal. Multiple sclerosis. Immunomodulatory effects of human astrocytes on T cells. Brain 1994; 117 (Pt 6):1323-1332.
21. Aloisi F, Penna G, Cerase J, Menendez Iglesias B, Adorini L. IL-12 production by central nervous system microglia is inhibited by astrocytes. J Immunol 1997; 159:1604-1612.
22. Aloisi F, Ria F, Adorini L. Regulation of T-cell responses by CNS antigen-presenting cells: different roles for microglia and astrocytes. Immunol Today 2000; 21:141-147.
23. Xu J, Racke MK, Drew PD. Peroxisome proliferator-activated receptor-alpha agonist fenofibrate regulates IL-12 family cytokine expression in the CNS: relevance to multiple sclerosis. J Neurochem 2007; 103:1801-1810.
24. Xu J, Drew PD. Peroxisome proliferator-activated receptor-gamma agonists suppress the production of IL-12 family cytokines by activated glia. J Immunol 2007; 178:1904-1913.
25. Pflanz S, Timans JC, Cheung J etal. IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells. Immunity 2002; 16:779-790.
26. Owaki T, Asakawa M, Kamiya S etal. IL-27 suppresses CD28-mediated [correction of medicated] IL-2 production through suppressor of cytokine signaling 3. J Immunol 2006; 176:2773-2780.
27. Fitzgerald DC, Ciric B, Touil T etal. Suppressive effect of IL-27 on encephalitogenic Th17 cells and the effector phase of experimental autoimmune encephalomyelitis. J Immunol 2007; 179:3268-3275.
28. Stumhofer JS, Laurence A, Wilson EH etal. Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system. Nat Immunol 2006; 7:937-945.
29. Batten M, Li J, Yi S etal. Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells. Nat Immunol 2006; 7:929-936.
30. Guo X, Nakamura K, Kohyama K etal. Inhibition of glial cell activation ameliorates the severity of experimental autoimmune encephalomyelitis. Neurosci Res 2007; 59:457-466.
31. Constantinescu CS, Tani M, Ransohoff RM etal. Astrocytes as antigen-presenting cells: expression of IL-12/IL-23. J Neurochem 2005; 95:331-340.
32. Miljkovic D, Momcilovic M, Stojanovic I, Stosic-Grujicic S, Ramic Z, Mostarica-Stojkovic M. Astrocytes stimulate interleukin-17 and interferon-gamma production in vitro. J Neurosci Res 2007; 85:3598-3606.
33. Kang Z, Altuntas CZ, Gulen MF etal. Astrocyte-restricted ablation of interleukin-17-induced Act1-mediated signaling ameliorates autoimmune encephalomyelitis. Immunity 2010; 32:414-425.
34. Wang ZW, Wang P, Lin FH etal. Early-life exposure to lipopolysaccharide reduces the severity of experimental autoimmune encephalomyelitis in adulthood and correlated with increased urine corticosterone and apoptotic CD4+ T cells. Neuroscience 2011; 193:283-290.
35. Zhou Y, Sonobe Y, Akahori T etal. IL-9 promotes Th17 cell migration into the central nervous system via CC chemokine ligand-20 produced by astrocytes. J Immunol 2011; 186:4415-4421.
36. Fraczek LA, Martin CB, Martin BK. c-Jun and c-Fos regulate the complement factor H promoter in murine astrocytes. Mol Immunol 2011; 49:201-210.
37. Bender H, Wiesinger MY, Nordhoff C etal. Interleukin-27 displays interferon-gamma-like functions in human hepatoma cells and hepatocytes. Hepatology 2009; 50:585-591.
38. Yang XO, Panopoulos AD, Nurieva R etal. STAT3 regulates cytokine-mediated generation of inflammatory helper T cells. J Biol Chem 2007; 282:9358-9363.
39. Sonobe Y, Yawata I, Kawanokuchi J, Takeuchi H, Mizuno T, Suzumura A. Production of IL-27 and other IL-12 family cytokines by microglia and their subpopulations. Brain Res 2005; 1040:202-207.
40. Pai RK, Askew D, Boom WH, Harding CV. Regulation of class II MHC expression in APCs: roles of types I, III, and IV class II transactivator. J Immunol 2002; 169:1326-1333.
41. Chastain EM, Duncan DS, Rodgers JM, Miller SD. The role of antigen presenting cells in multiple sclerosis. Biochim Biophys Acta 2010; 1812:265-274.
42. Gimsa U, ØRen A, Pandiyan P etal. Astrocytes protect the CNS: antigen-specific T helper cell responses are inhibited by astrocyte-induced upregulation of CTLA-4 (CD152). J Mol Med (Berl) 2004; 82:364-372.
43. Trajkovic V, Vuckovic O, Stosic-Grujicic S etal. Astrocyte-induced regulatory T cells mitigate CNS autoimmunity. Glia 2004; 47:168-179.
44. Lee YS, Amadi-Obi A, Yu CR, Egwuagu CE. Retinal cells suppress intraocular inflammation (uveitis) through production of interleukin-27 and interleukin-10. Immunology 2011; 132:492-502.
45. Wang J, Wang G, Sun B etal. Interleukin-27 suppresses experimental autoimmune encephalomyelitis during bone marrow stromal cell treatment. J Autoimmun 2008; 30:222-229.
46. Sweeney CM, Lonergan R, Basdeo SA etal. IL-27 mediates the response to IFN-beta therapy in multiple sclerosis patients by inhibiting Th17 cells. Brain Behav Immun 2011; 25:1170-1181.
47. Guo B, Chang EY, Cheng G. The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice. J Clin Invest 2008; 118:1680-1690.
48. Kleinschnitz C, Meuth SG, Kieseier BC, Wiendl H. Immunotherapeutic approaches in MS: update on pathophysiology and emerging agents or strategies 2006. Endocr Metab Immune Disord Drug Targets 2007; 7:35-63.
49. Schroder K, Hertzog PJ, Ravasi T, Hume DA. Interferon-gamma: an overview of signals, mechanisms and functions. J Leukoc Biol 2004; 75:163-189.
50. De Keyser J, Laureys G, Demol F, Wilczak N, Mostert J, Clinckers R. Astrocytes as potential targets to suppress inflammatory demyelinating lesions in multiple sclerosis. Neurochem Int 2010; 57:446-450.
51. Sun D, Newman TA, Perry VH, Weller RO. Cytokine-induced enhancement of autoimmune inflammation in the brain and spinal cord: implications for multiple sclerosis. Neuropathol Appl Neurobiol 2004; 30:374-384.
52. Stoll G, Muller S, Schmidt B etal. Localization of interferon-gamma and Ia-antigen in T cell line-mediated experimental autoimmune encephalomyelitis. Am J Pathol 1993; 142:1866-1875.
53. Crocker SJ, Whitmire JK, Frausto RF etal. Persistent macrophage/microglial activation and myelin disruption after experimental autoimmune encephalomyelitis in tissue inhibitor of metalloproteinase-1-deficient mice. Am J Pathol 2006; 169:2104-2116.
54. Fitzgerald DC, Zhang GX, El-Behi M etal. Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells. Nat Immunol 2007; 8:1372-1379.
55. Lee E, Chanamara S, Pleasure D, Soulika AM. IFN-gamma signaling in the central nervous system controls the course of experimental autoimmune encephalomyelitis independently of the localization and composition of inflammatory foci. J Neuroinflammation 2012; 9:7.
56. Merkler D, Boscke R, Schmelting B etal. Differential macrophage/microglia activation in neocortical EAE lesions in the marmoset monkey. Brain Pathol 2006; 16:117-123.