Regulation of class II MHC expression in APCs: Roles of types I, III, and IV class II transactivator

Journal of Immunology

Volumn 169, Issue 3, 2002, Pages 1326-1333

  Pai, Rish K ^a   Askew, David ^a   Boom, W Henry ^a   Harding, Clifford V ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APC; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ANIMAL CELL; ANTIBODY PRODUCTION; ARTICLE; CELL MATURATION; DENDRITIC CELL; IMMUNE RESPONSE; INFLAMMATORY CELL; MACROPHAGE ACTIVATION; MAJOR HISTOCOMPATIBILITY COMPLEX; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN PROCESSING; PROTEIN SYNTHESIS; T LYMPHOCYTE ACTIVATION; TRANSACTIVATION;

EID: 0036681840     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.169.3.1326     Document Type: Article

References (46)

1. Regulated expression of cell surface antigens during B cell development
2. CpG DNA induces maturation of dendritic cells with distinct effects on nascent and recycling MIIC-11 antigen processing mechanisms
3. Class II major histocompatibility complex molecules of murine dendritic cells: Synthesis, sialylation of invariant chain, and antigen processing capacity are down-regulated upon culture
4. Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells
5. Coordinated events during bacteria-induced DC maturation
6. Class II transactivator: Mastering the art of major histocompatibility complex expression
7. Quantitative control of MHC class II expression by the transactivator CIITA
8. Regulation of MHC class II expression by interferon-γ mediated by the transactivator gene CIITA
9. Mice lacking the MHC class II transactivator (CIITA) show tissue-specific impairment of MHC claes II expression
10. Reduced IL-4-, lipopolysaccharide-, and IFN-γ-induced MHC class II expression in mice lacking class II transactivator due to targeted deletion of the GTP-binding domain
11. CIITA is a transcriptional coactivator that is recruited to MHC class II promoters by multiple synergistic interactions with an enhanceosome complex
12. CIITA leucine-rich repeats control nuclear localization, in vivo recruitment to the major histocompatibility complex (MHC) class II enhanceosome, and MHC class II gene transactivation
13. Transcriptional scaffold: CIITA interacts with NF-Y, RFX, and CREB to cause stereospecific regulation of the class II major histocompatibility complex promoter
14. Associations and interactions between bare lymphocyte syndrome factors
15. Expression of MHC class II molecules in different cellular and functional compartments is controlled by differential usage of multiple promoters of the transactivator CIITA
16. The bare lymphocyte syndrome and the regulation of MHC expression
17. Maturation of dendritic cells is accompanied by rapid transcriptional silencing of class II transactivator (CIITA) expression
18. Identification of distinct regions of 5′ flanking DNA that mediate constitutive. IFN-γ, STATI, and TGF-β-regulated expression of the class II transactivator gene
19. Two distinct γ interferon-inducible promoters of the major histocompatibility complex class II transactivator gene are differentially regulated by STATI, interferon regulatory factor 1, and transforming growth factor B
20. Constitutive expression of MHC class II genes in melanoma cell lines results from the transcription of class II transactivator abnormally initiated from its B cell-specific promoter
21. + T-cell activation
22. Differential selectivity of CIITA promoter activation by IFN-γ and IRF-1 in astrocytes and macrophages: CIITA promoter activation is not affected by TNF-α
23. Selective abrogation of major histocompatibility complex class II expression on extrahematopoietic cells in mice lacking promoter IV of the class II transactivator gene
24. Transformation of mouse bone marrow cells by transfection with a human oncogene related to c-myc is associated with the endogenous production of macrophage colony stimulating factor 1
25. Retinal VEGF mRNA measured by SYBR green I fluorescence: A versatile approach to quantitative PCR
26. Increased expression of la antigens on resting B cells: An additional role for B-cell growth factor
27. Regulation of the expression of multiple class II genes in murine B cells by B cell stimulatory factor 1 (BSF-1)
28. Activation of cutaneous dendritic cells by CpG-containing oligodeoxynucleotides: A role for dendritic cells in the augmentation of Th1 responses by immunostimulatory DNA
29. Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells
30. Toll-like receptor 2-dependent inhibition of macrophage class II MHC expression and antigen processing hy 19 kD lipoprotein of Mycobacterium tuberculosis
31. TNF-α suppresses IFN-γ-induced MHC class II expression in HT1080 cells hy destabilizing class II transactivator mRNA
32. Methylation of class II transactivator promoter IV: A novel mechanism of MHC class II gene control
33. Class II transactivator and class II MHC gene expression in microglia: Modulation by the cyto kines TGF-β, IL-4, IL-13 and IL-10
34. IL-1β inhibits IFN-γ-induced class II MHC expression by suppressing transcription of the class II transactivator gene
35. Downregulation of CIITA function by protein kinase a (PKA)-mediated phosphorylation: Mechanism of prostaglandin E, cyclic AMP, and PKA inhibition of class II major histocompalibility complex expression in monocytic lines
36. Mechanisms of nuclear import and export that control the subcellular localization of class II transactivator
37. IFN-γ regulation of the type IV class II transactivator promoter in astrocytes
38. High level class II transactivator induction does not occur with transient activation of the IFN-γ signaling pathway
39. IFN regulatory factor-1 plays a central role in the regulation of the expression of class I and II MHC genes in vivo
40. Activation of the MHC class II transactivator CIITA by interferon-γ requires cooperative interaction hetween Stat1 and USF-1
41. IFN-γ regulation of class II transactivator promoter IV in macrophages and microglia: Involvement of the suppressors of cytokine signaling-1 protein
42. Patterns of expression of human "la-like" antigens during the terminal stages of B cell development
43. BLIMP-1 mediates extinction of major histocompatibility class II transactivator expression in plasma cells
44. Toll-like receptors: Critical proteins linking innate and acquired immunity
45. Origin, maturation and antigen presenting function of dendritic cells
46. Antigen processing by epidermal Langerhans cells correlates with the level of biosynthesis of major histocompatibility complex class II molecules and expression of invariant chain