Alcohol dependence is independently associated with sepsis, septic shock, and hospital mortality among adult intensive care unit patients

Critical Care Medicine

Volumn 35, Issue 2, 2007, Pages 345-350

  O'Brien Jr , James M ^a   Lu, Bo ^b   Ali, Naeem A ^a   Martin, Greg S ^c   Aberegg, Scott K ^a   Marsh, Clay B ^a   Lemeshow, Stanley ^b   Douglas, Ivor S ^d  

^a THE OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d DENVER HEALTH MEDICAL CENTER   (United States)

Author keywords

Alcohol withdrawal delirium; Alcohol related disorders; Alcoholism; Critical care; Sepsis; Septic; Shock

Indexed keywords

ADULT; ALCOHOL WITHDRAWAL; ALCOHOLISM; ARTICLE; CONFIDENCE INTERVAL; CONTROLLED STUDY; DATA ANALYSIS; DEMOGRAPHY; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; ERYTHROCYTE; ERYTHROCYTE TRANSFUSION; FEMALE; HOSPITAL ADMISSION; HOSPITALIZATION; HUMAN; INFECTION RATE; INTENSIVE CARE UNIT; LIVER DISEASE; MAJOR CLINICAL STUDY; MALE; MORTALITY; MULTIVARIATE ANALYSIS; PRIORITY JOURNAL; REMISSION; SEPSIS; SEPTIC SHOCK; UNITED STATES; URBAN AREA;

ADOLESCENT; ADULT; ALCOHOLISM; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; FEMALE; HOSPITAL MORTALITY; HUMANS; INTENSIVE CARE UNITS; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; SEPSIS; SHOCK, SEPTIC;

EID: 33846416218     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.CCM.0000254340.91644.B2     Document Type: Article

References (32)

1. Medical consequences of alcohol abuse. Alcohol Res Health 2000; 24:27-31
2. Mokdad AH, Marks JS, Stroup DF, et al: Actual causes of death in the United States, 2000. JAMA 2004; 291:1238-1245
3. Harwood H: Updating Estimates of the Economic Costs of Alcohol Abuse in the United States: Estimates, Update Methods and Data. Bethesda, MD, The Lewin Group for the National Institute on Alcohol Abuse and Alcoholism, 2000
4. Marik P, Mohedin B: Alcohol-related admissions to an inner city hospital intensive care unit. Alcohol Alcohol 1996; 31:393-396
5. Mostafa SM, Murthy BV: Alcohol-associated admissions to an adult intensive care unit: An audit. Eur J Anaesthesiol 2002; 19: 193-196
6. Hoyert DL, Arias E, Smith BL, et al: Deaths: Final data for 1999. Natl Vital Stat Rep 2001; 49:1-113
7. Angus DC, Linde-Zwirble WT, Lidicker J, et al: Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care. Crit Care Med 2001; 29:1303-1310
8. Martin GS, Mannino DM, Eaton S, et al: The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 2003; 348:1546-1554
9. Foreman MG, Mannino DM, Moss M: Cirrhosis as a risk factor for sepsis and death: Analysis of the National Hospital Discharge Survey. Chest 2003; 124:1016-1020
10. Witt DJ, Craven DE, McCabe WR: Bacterial infections in adult patients with the acquired immune deficiency syndrome (AIDS) and AIDS-related complex. Am J Med 1987; 82: 900-906
11. Williams MD, Braun LA, Cooper LM, et al: Hospitalized cancer patients with severe sepsis: Analysis of incidence, mortality, and associated costs of care. Crit Care 2004; 8:R291-R298
12. Groeger JS, Lucas AB, Thaler HT, et al: Infectious morbidity associated with long-term use of venous access devices in patients with cancer. Ann Intern Med 1993; 119:1168-1174
13. Raghavan M, Marik PE: Anemia, allogenic blood transfusion, and immunomodulation in the critically ill. Chest 2005; 127:295-307
14. Diaz LE, Montero A, Gonzalez-Gross M, et al: Influence of alcohol consumption on immunologic status: A review. Eur J Clin Nutr 2002; 56:S50-S53
15. Fernandez-Sola J, Junque A, Estruch R, et al: High alcohol intake as a risk and prognostic factor for community-acquired pneumonia. Arch Intern Med 1995; 155:1649-1654
16. Hudolin V: Tuberculosis and alcoholism. Ann N Y Acad Sci 1975; 252:353-364
17. Ruiz M, Ewig S, Torres A, et al: Severe community-acquired pneumonia. Risk factors and follow-up epidemiology. Am J Respir Crit Care Med 1999; 160:923-929
18. Saitz R, Ghali WA, Moskowitz MA: The impact of alcohol-related diagnoses on pneumonia outcomes. Arch Intern Med 1997; 157: 1446-1452
19. Moss M, Bucher B, Moore FA, et al: The role of chronic alcohol abuse in the development of acute respiratory distress syndrome in adults. JAMA 1996; 275:50-54
20. Moss M, Parsons PE, Steinberg KP, et al: Chronic alcohol abuse is associated with an increased incidence of acute respiratory distress syndrome and severity of multiple organ dysfunction in patients with septic shock. Crit Care Med 2003; 31:869-877
21. Hudson LD, Milberg JA, Anardi D, et al: Clinical risks for development of the acute respiratory distress syndrome. Am J Respir Crit Care Med 1995; 151:293-301
22. Deyo RA, Cherkin DC, Ciol MA: Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. J Clin Epidemiol 1992; 45:613-619
23. Laupland KB, Gregson DB, Zygun DA, et al: Severe bloodstream infections: A population-based assessment. Crit Care Med 2004; 32: 992-997
24. Rosenthal GE, Sirio CA, Shepardson LB, et al: Use of intensive care units for patients with low severity of illness. Arch Intern Med 1998; 158:1144-1151
25. Gamble L, Mason CM, Nelson S: The effects of alcohol on immunity and bacterial infection in the lung. Med Mal Infect 2006; 36: 72-77
26. Happel KI, Nelson S: Alcohol, immunosuppression, and the lung. Proc Am Thorac Soc 2005; 2:428-432
27. Pavia CS, La Mothe M, Kavanagh M: Influence of alcohol on antimicrobial immunity. Biomed Pharmacother 2004; 58:84-89
28. Szabo G: Consequences of alcohol consumption on host defence. Alcohol Alcohol 1999; 34:830-841
29. Moss M, Guidot DM, Wong-Lambertina M, et al: The effects of chronic alcohol abuse on pulmonary glutathione homeostasis. Am J Respir Crit Care Med 2000; 161:414-419
30. Guidot DM, Modelska K, Lois M, et al: Ethanol ingestion via glutathione depletion impairs alveolar epithelial barrier function in rats. Am J Physiol Lung Cell Mol Physiol 2000; 279:L127-L135
31. Dufour MC, Caces MF: Epidemiology of the medical consequences of alcohol. Alcohol Health Res World 1993; 17:265-271
32. Umbricht-Schneiter A, Santora P, Moore RD: Alcohol abuse: Comparison of two methods for assessing its prevalence and associated morbidity in hospitalized patients. Am J Med 1991; 91:110-118