Research resource: Interplay between the genomic and transcriptional networks of androgen receptor and estrogen receptor α in luminal breast cancer cells

Molecular Endocrinology

Volumn 26, Issue 11, 2012, Pages 1941-1952

  Need, Eleanor F ^a   Selth, Luke A ^a   Harris, Tiffany J ^a   Birrell, Stephen N ^a   Tilley, Wayne D ^a   Buchanan, Grant ^a  

^a UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; ANDROSTANOLONE; ESTROGEN RECEPTOR ALPHA;

ARTICLE; BINDING SITE; BREAST CANCER; CANCER CELL; CANCER CELL CULTURE; CELL PROLIFERATION; CELL SURVIVAL; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; MICROARRAY ANALYSIS; MOLECULAR INTERACTION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANDROGENS; BASE SEQUENCE; BINDING SITES; BREAST NEOPLASMS; CELL LINE, TUMOR; ESTROGEN RECEPTOR ALPHA; ESTROGENS; FEMALE; GENE REGULATORY NETWORKS; GENOME, HUMAN; HUMANS; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; NUCLEOTIDE MOTIFS; PROTEIN BINDING; RECEPTORS, ANDROGEN;

EID: 84868142715     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2011-1314     Document Type: Article

References (60)

1. Jia L, Berman BP, Jariwala U, Yan X, Cogan JP, Walters A, Chen T, Buchanan G, Frenkel B, Coetzee GA 2008 Genomic androgen receptor-occupied regions with different functions, defined by histone acetylation, coregulators and transcriptional capacity. PLoSONE 3:e3645
2. Kim TH, Barrera LO, Zheng M, Qu C, Singer MA, Richmond TA, Wu Y, Green RD, Ren B 2005 A high-resolution map of active promoters in the human genome. Nature 436:876-880
3. Carroll JS, Brown M 2006 Estrogen receptor target gene: an evolving concept. Mol Endocrinol 20:1707-1714
4. Wang Q, Carroll JS, Brown M 2005 Spatial and temporal recruitment of androgen receptor and its coactivators involves chromosomal looping and polymerase tracking. Mol Cell 19:631-642
5. Cicatiello L, Mutarelli M, Grober OM, Paris O, Ferraro L, Ravo M, Tarallo R, Luo S, Schroth GP, Seifert M, Zinser C, Chiusano ML, Traini A, De Bortoli M, Weisz A 2010 Estrogen receptor α controls a gene network in luminal-like breast cancer cells comprising multiple transcription factors and microRNAs. Am J Pathol 176:2113-2130
6. Fullwood MJ, Han Y, Wei CL, Ruan X, Ruan Y 2010 Chromatin interaction analysis using paired-end tag sequencing. Curr Protoc Mol Biol 21:Unit 21.15.1-25
7. Hurtado A, Holmes KA, Geistlinger TR, Hutcheson IR, Nicholson RI, Brown M, Jiang J, Howat WJ, Ali S, Carroll JS 2008 Regulation of ERBB 2 by oestrogen receptor-PAX 2 determines response to tamoxifen. Nature 456:663-666
8. Jozwik KM, Carroll JS 2012 Pioneer factors in hormone-dependent cancers. Nat Rev Cancer 12:381-385
9. Ni M, Chen Y, Lim E, Wimberly H, Bailey ST, Imai Y, Rimm DL, Liu XS, Brown M 2011 Targeting androgen receptor in estrogen receptor-negative breast cancer. Cancer Cell 20:119-131
10. Wang Q, Li W, Zhang Y, Yuan X, Xu K, Yu J, Chen Z, Beroukhim R, Wang H, Lupien M, Wu T, Regan MM, Meyer CA, Carroll JS, Manrai AK, Jänne OA, Balk SP, Mehra R, Han B, Chinnaiyan AM, Rubin MA, True L, Fiorentino M, Fiore C, Loda M, Kantoff PW, Liu XS, Brown M 2009 Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer. Cell 138:245-256
11. Welboren WJ, van Driel MA, Janssen-Megens EM, van Heeringen SJ, Sweep FC, Span PN, Stunnenberg HG 2009 ChIP-Seq of ERα and RNA polymerase II defines genes differentially responding to ligands. EMBO J 28:1418-1428
12. Wyce A, Bai Y, Nagpal S, Thompson CC 2010 Research resource: the androgen receptor modulates expression of genes with critical roles in muscle development and function. Mol Endocrinol 24: 1665-1674
13. Bonofiglio D, Gabriele S, Aquila S, Catalano S, Gentile M, Middea E, Giordano F, Andó S 2005 Estrogen receptor α binds to peroxisome proliferator-activated receptor response element and negatively interferes with peroxisome proliferator-activated receptor γ signaling in breast cancer cells. Clin Cancer Res 11:6139-6147
14. Hua S, Kittler R, White KP 2009 Genomic antagonism between retinoic acid and estrogen signaling in breast cancer. Cell 137: 1259-1271
15. Charn TH, Liu ET, Chang EC, Lee YK, Katzenellenbogen JA, Katzenellenbogen BS 2010 Genome-wide dynamics of chromatin binding of estrogen receptors α and β: mutual restriction and competitive site selection. Mol Endocrinol 24:47-59
16. Poulin R, Simard J, Labrie C, Petitclerc L, Dumont M, Lagace L, Labrie F 1989 Down-regulation of estrogen receptors by androgens in the ZR-75-1 human breast cancer cell line. Endocrinology 125: 392-399
17. Lanzino M, De Amicis F, McPhaul MJ, Marsico S, Panno ML, Andó S 2005 Endogenous coactivator ARA 70 interacts with estrogen receptor α (ERα) and modulates the functional ERα/androgen receptor interplay in MCF-7 cells. J Biol Chem 280:20421-20430
18. Migliaccio A, Di Domenico M, Castoria G, Nanayakkara M, Lombardi M, de Falco A, Bilancio A, Varricchio L, Ciociola A, Auricchio F 2005 Steroid receptor regulation of epidermal growth factor signaling through Src in breast and prostate cancer cells: steroid antagonist action. Cancer Res 65:10585-10593
19. Carroll JS, Liu XS, Brodsky AS, Li W, Meyer CA, Szary AJ, Eeckhoute J, Shao W, Hestermann EV, Geistlinger TR, Fox EA, Silver PA, Brown M 2005 Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein Fox A 1. Cell 122:33-43
20. Peters AA, Buchanan G, Ricciardelli C, Bianco-Miotto T, Centenera MM, Harris JM, Jindal S, Segara D, Jia L, Moore NL, Henshall SM, Birrell SN, Coetzee GA, Sutherland RL, Butler LM, Tilley WD 2009 Androgen receptor inhibits estrogen receptor-α activity and is prognostic in breast cancer. Cancer Res 69:6131-6140
21. Song KH, Park YY, Park KC, Hong CY, Park JH, Shong M, Lee K, Choi HS 2004 The atypical orphan nuclear receptor DAX-1 interacts with orphan nuclear receptor Nur77 and represses its transactivation. Mol Endocrinol 18:1929-1940
22. Ting HJ, Bao BY, Hsu CL, Lee YF 2005 Androgen-receptor coregulators mediate the suppressive effect of androgen signals on vitamin D receptor activity. Endocrine 26:1-9
23. Krycer JR, Brown AJ 2011 Cross-talk between the androgen receptor and the liver X receptor: implications for cholesterol homeostasis. J Biol Chem 286:20637-20647
24. Dimitrakakis C, Bondy C 2009 Androgens and the breast. Breast Cancer Res 11:212
25. Kennedy BJ 1958 Fluoxymesterone therapy in advanced breast cancer. N Engl J Med 259:673-675
26. Ingle JN, Suman VJ, Mailliard JA, Kugler JW, Krook JE, Michalak JC, Pisansky TM, Wold LE, Donohue JH, Goetz MP, Perez EA 2006 Randomized trial of tamoxifen alone or combined with fluoxymesterone as adjuvant therapy in postmenopausal women with resected estrogen receptor positive breast cancer. North Central Cancer Treatment Group Trial 89-30-52. Breast Cancer Res Treat 98:217-222
27. Hu R, Dawood S, Holmes MD, Collins LC, Schnitt SJ, Cole K, Marotti JD, Hankinson SE, Colditz GA, Tamimi RM 2011 Androgen receptor expression and breast cancer survival in postmenopausal women. Clin Cancer Res 17:1867-1874
28. Smyth G, Gentleman R, Carey V, Dudoit S, Irizarry R, Huber W 2005 Limma: linear models for microarray data. In: Bioinformatics and Computational Biology Solutions using R and Bioconductor. New York: Springer; 397-420
29. Huber W, von Heydebreck A, Sultmann H, Poustka A, Vingron M 2002 Variance stabilization applied to microarray data calibration and to the quantification of differential expression. Bioinformatics 18 Suppl 1:S 96-S 104
30. Johnson WE, Li C, Rabinovic A 2007 Adjusting batch effects in microarray expression data using empirical Bayes methods. Biostatistics 8:118-127
31. Need EF, Scher HI, Peters AA, Moore NL, Cheong A, Ryan CJ, Wittert GA, Marshall VR, Tilley WD, Buchanan G 2009 A novel androgen receptor amino terminal region reveals two classes of amino/carboxyl interaction-deficient variants with divergent capacity to activate responsive sites in chromatin. Endocrinology 150: 2674-2682
32. Carroll JS, Meyer CA, Song J, Li W, Geistlinger TR, Eeckhoute J, Brodsky AS, Keeton EK, Fertuck KC, Hall GF, Wang Q, Bekiranov S, Sementchenko V, Fox EA, Silver PA, Gingeras TR, Liu XS, Brown M 2006 Genome-wide analysis of estrogen receptor binding sites. Nat Genet 38:1289-1297
33. Fejes AP, Robertson G, Bilenky M, Varhol R, Bainbridge M, Jones SJ 2008 FindPeaks 3.1: a tool for identifying areas of enrichment from massively parallel short-read sequencing technology. Bioinformatics 24:1729-1730
34. Hawkins RD, Hon GC, Ren B 2010 Next-generation genomics: an integrative approach. Nat Rev Genet 11:476-486
35. Goecks J, Nekrutenko A, Taylor J 2010 Galaxy: a comprehensive approach for supporting accessible, reproducible, and transparent computational research in the life sciences. Genome Biol 11:R 86
36. Ji H, Jiang H, Ma W, Johnson DS, Myers RM, WongWH 2008 An integrated software system for analyzing ChIP-chip and ChIP-seq data. Nat Biotechnol 26:1293-1300
37. Bryne JC, Valen E, Tang MH, Marstrand T, Winther O, da Piedade I, Krogh A, Lenhard B, Sandelin A 2008 JASPAR, the open access database of transcription factor-binding profiles: new content and tools in the 2008 update. Nucleic Acids Res 36:D 102-D 106
38. Engel LW, Young NA, Tralka TS, Lippman ME, O'Brien SJ, Joyce MJ 1978 Establishment and characterization of three new continuous cell lines derived from human breast carcinomas. Cancer Res 38:3352-3364
39. Zhu Y, Wang A, Liu MC, Zwart A, Lee RY, Gallagher A, Wang Y, Miller WR, Dixon JM, Clarke R 2006 Estrogen receptor α positive breast tumors and breast cancer cell lines share similarities in their transcriptome data structures. Int J Oncol 29:1581-1589
40. Wang Q, Li W, Liu XS, Carroll JS, Jänne OA, Keeton EK, Chinnaiyan AM, Pienta KJ, Brown M 2007 A hierarchical network of transcription factors governs androgen receptor-dependent prostate cancer growth. Mol Cell 27:380-392
41. Robinson JL, Macarthur S, Ross-Innes CS, Tilley WD, Neal DE, Mills IG, Carroll JS 2011 Androgen receptor driven transcription in molecular apocrine breast cancer is mediated by Fox A 1. EMBO J 30:3019-3027
42. Krum SA, Miranda-Carboni GA, Lupien M, Eeckhoute J, Carroll JS, Brown M 2008 Unique ERα cistromes control cell type-specific gene regulation. Mol Endocrinol 22:2393-2406
43. Hurtado A, Holmes KA, Ross-Innes CS, Schmidt D, Carroll JS 2011 FOXA 1 is a key determinant of estrogen receptor function and endocrine response. Nat Genet 43:27-33
44. Davis DL, Burch JB 1996 The chicken vitellogenin II gene is flanked by a GATA factor-dependent estrogen response unit. Mol Endocrinol 10:937-944
45. Lin CY, Vega VB, Thomsen JS, Zhang T, Kong SL, Xie M, Chiu KP, Lipovich L, Barnett DH, Stossi F, Yeo A, George J, Kuznetsov VA, Lee YK, Charn TH, Palanisamy N, Miller LD, Cheung E, Katzenellenbogen BS, Ruan Y, Bourque G, Wei CL, Liu ET 2007 Whole-genome cartography of estrogen receptor alpha binding sites. PLoS Genet 3:e87
46. Massie CE, Adryan B, Barbosa-Morais NL, Lynch AG, Tran MG, Neal DE, Mills IG 2007 New androgen receptor genomic targets show an interaction with the ETS 1 transcription factor. EMBORep 17:17
47. Bolton EC, So AY, Chaivorapol C, Haqq CM, Li H, Yamamoto KR 2007 Cell-and gene-specific regulation of primary target genes by the androgen receptor. Genes Dev 21:2005-2017
48. Birrell SN, Bentel JM, Hickey TE, Ricciardelli C, Weger MA, Horsfall DJ, Tilley WD 1995 Androgens induce divergent proliferative responses in human breast cancer cell lines. J Steroid Biochem Mol Biol 52:459-467
49. Doane AS, Danso M, Lal P, Donaton M, Zhang L, Hudis C, Gerald WL 2006 An estrogen receptor-negative breast cancer subset characterized by a hormonally regulated transcriptional program and response to androgen. Oncogene 25:3994-4008
50. Macedo LF, Guo Z, Tilghman SL, Sabnis GJ, Qiu Y, Brodie A 2006 Role of androgens on MCF-7 breast cancer cell growth and on the inhibitory effect of letrozole. Cancer Res 66:7775-7782
51. Søreide JA, Lea OA, Varhaug JE, Skarstein A, Kvinnsland S 1992 Androgen receptors in operable breast cancer: relation to other steroid hormone receptors, correlations to prognostic factors and predictive value for effect of adjuvant tamoxifen treatment. Eur J Surg Oncol 18:112-118
52. Mandal S, Davie JR 2007 An integrated analysis of genes and pathways exhibiting metabolic differences between estrogen receptor positive breast cancer cells. BMC Cancer 7:181
53. Takayama K, Kaneshiro K, Tsutsumi S, Horie-Inoue K, Ikeda K, Urano T, Ijichi N, Ouchi Y, Shirahige K, Aburatani H, Inoue S 2007 Identification of novel androgen response genes in prostate cancer cells by coupling chromatin immunoprecipitation and genomic microarray analysis. Oncogene 26:4453-4463
54. Valouev A, Johnson DS, Sundquist A, Medina C, Anton E, Batzoglou S, Myers RM, Sidow A 2008 Genome-wide analysis of transcription factor binding sites based on ChIP-Seq data. Nat Methods 5:829-834
55. Magnani L, Eeckhoute J, Lupien M 2011 Pioneer factors: directing transcriptional regulators within the chromatin environment. Trends Genet 27:465-474
56. Voss TC, Schiltz RL, Sung MH, Yen PM, Stamatoyannopoulos JA, Biddie SC, Johnson TA, Miranda TB, John S, Hager GL 2011 Dynamic Exchange at regulatory elements during chromatin remodeling underlies assisted loading mechanism. Cell 146:544-554
57. Ross-Innes CS, Stark R, Holmes KA, Schmidt D, Spyrou C, Russell R, Massie CE, Vowler SL, Eldridge M, Carroll JS 2010 Cooperative interaction between retinoic acid receptor-α and estrogen receptor in breast cancer. Genes Dev 24:171-182
58. Agoff SN, Swanson PE, Linden H, Hawes SE, Lawton TJ 2003 Androgen receptor expression in estrogen receptor-negative breast cancer. Immunohistochemical, clinical, and prognostic associations. Am J Clin Pathol 120:725-731
59. Buchanan G, Birrell SN, Peters AA, Bianco-Miotto T, Ramsay K, Cops EJ, Yang M, Harris JM, Simila HA, Moore NL, Bentel JM, Ricciardelli C, Horsfall DJ, Butler LM, Tilley WD 2005 Decreased androgen receptor levels and receptor function in breast cancer contribute to the failure of response to medroxyprogesterone acetate. Cancer Res 65:8487-8496
60. Crooks GE, Hon G, Chandonia JM, Brenner SE 2004 WebLogo: a sequence logo generator. Genome Res 14:1188-1190