NFAT1 C-Terminal Domains Are Necessary but Not Sufficient for Inducing Cell Death

PLoS ONE

Volumn 7, Issue 10, 2012, Pages

  Faget, Douglas V ^a   Lucena, Pedro I ^a   Robbs, Bruno K ^a   Viola, João P B ^a  

^a INSTITUTO NACIONAL DE CÂNCER   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

HYBRID PROTEIN; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR NFAT1; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; APOPTOSIS; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL CYCLE ARREST; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL TRANSFORMATION; CONTROLLED STUDY; DNA FRAGMENTATION; EXPRESSION VECTOR; FIBROBLAST; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; PHENOTYPE; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN; SEQUENCE HOMOLOGY; TRANSACTIVATION;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; DNA PRIMERS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; GENTIAN VIOLET; MICE; MULTIGENE FAMILY; NFATC TRANSCRIPTION FACTORS; NIH 3T3 CELLS; PLASMIDS; PROTEIN STRUCTURE, TERTIARY; TRANS-ACTIVATORS;

EID: 84868135815     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0047868     Document Type: Article

References (43)

1. Macian F, (2005) NFAT proteins: key regulators of T-cell development and function. Nat Rev Immunol 5: 472-484.
2. Rao A, Luo C, Hogan PG, (1997) Transcription factors of the NFAT family: regulation and function. Annu Rev Immunol 15: 707-747.
3. Luo C, Burgeon E, Rao A, (1996) Mechanisms of transactivation by nuclear factor of activated T cells-1. J Exp Med 184: 141-147.
4. Muller MR, Rao A, (2010) NFAT, immunity and cancer: a transcription factor comes of age. Nat Rev Immunol 10: 645-656.
5. Horsley V, Pavlath GK, (2002) NFAT: ubiquitous regulator of cell differentiation and adaptation. J Cell Biol 156: 771-774.
6. Baksh S, Widlund HR, Frazer-Abel AA, Du J, Fosmire S, et al. (2002) NFATc2-mediated repression of cyclin-dependent kinase 4 expression. Mol Cell 10: 1071-1081.
7. Caetano MS, Vieira-de-Abreu A, Teixeira LK, Werneck MB, Barcinski MA, et al. (2002) NFATC2 transcription factor regulates cell cycle progression during lymphocyte activation: evidence of its involvement in the control of cyclin gene expression. FASEB J 16: 1940-1942.
8. Carvalho LD, Teixeira LK, Carrossini N, Caldeira AT, Ansel KM, et al. (2007) The NFAT1 transcription factor is a repressor of cyclin A2 gene expression. Cell Cycle 6: 1789-1795.
9. McCaffrey PG, Goldfeld AE, Rao A, (1994) The role of NFATp in cyclosporin A-sensitive tumor necrosis factor-alpha gene transcription. J Biol Chem 269: 30445-30450.
10. Latinis KM, Norian LA, Eliason SL, Koretzky GA, (1997) Two NFAT transcription factor binding sites participate in the regulation of CD95 (Fas) ligand expression in activated human T cells. J Biol Chem 272: 31427-31434.
11. Youn HD, Chatila TA, Liu JO, (2000) Integration of calcineurin and MEF2 signals by the coactivator p300 during T-cell apoptosis. EMBO J 19: 4323-4331.
12. Hoey T, Sun YL, Williamson K, Xu X, (1995) Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins. Immunity 2: 461-472.
13. Park J, Takeuchi A, Sharma S, (1996) Characterization of a new isoform of the NFAT (nuclear factor of activated T cells) gene family member NFATc. J Biol Chem 271: 20914-20921.
14. Xanthoudakis S, Viola JP, Shaw KT, Luo C, Wallace JD, et al. (1996) An enhanced immune response in mice lacking the transcription factor NFAT1. Science 272: 892-895.
15. Hodge MR, Ranger AM, Charles de la Brousse F, Hoey T, Grusby MJ, et al. (1996) Hyperproliferation and dysregulation of IL-4 expression in NF-ATp-deficient mice. Immunity 4: 397-405.
16. Schuh K, Kneitz B, Heyer J, Bommhardt U, Jankevics E, et al. (1998) Retarded thymic involution and massive germinal center formation in NF-ATp-deficient mice. Eur J Immunol 28: 2456-2466.
17. de la Pompa JL, Timmerman LA, Takimoto H, Yoshida H, Elia AJ, et al. (1998) Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum. Nature 392: 182-186.
18. Ranger AM, Grusby MJ, Hodge MR, Gravallese EM, de la Brousse FC, et al. (1998) The transcription factor NF-ATc is essential for cardiac valve formation. Nature 392: 186-190.
19. Ranger AM, Hodge MR, Gravallese EM, Oukka M, Davidson L, et al. (1998) Delayed lymphoid repopulation with defects in IL-4-driven responses produced by inactivation of NF-ATc. Immunity 8: 125-134.
20. Robbs BK, Cruz AL, Werneck MB, Mognol GP, Viola JP, (2008) Dual roles for NFAT transcription factor genes as oncogenes and tumor suppressors. Mol Cell Biol 28: 7168-7181.
21. Neal JW, Clipstone NA, (2003) A constitutively active NFATc1 mutant induces a transformed phenotype in 3T3-L1 fibroblasts. J Biol Chem 278: 17246-17254.
22. Teixeira LK, Fonseca BP, Vieira-de-Abreu A, Barboza BA, Robbs BK, et al. (2005) IFN-gamma production by CD8+ T cells depends on NFAT1 transcription factor and regulates Th differentiation. J Immunol 175: 5931-5939.
23. Jain J, Burgeon E, Badalian TM, Hogan PG, Rao A, (1995) A similar DNA-binding motif in NFAT family proteins and the Rel homology region. J Biol Chem 270: 4138-4145.
24. Ho AM, Jain J, Rao A, Hogan PG, (1994) Expression of the transcription factor NFATp in a neuronal cell line and in the murine nervous system. J Biol Chem 269: 28181-28186.
25. Wang DZ, McCaffrey PG, Rao A, (1995) The cyclosporin-sensitive transcription factor NFATp is expressed in several classes of cells in the immune system. Ann N Y Acad Sci 766: 182-194.
26. Okamura H, Aramburu J, Garcia-Rodriguez C, Viola JP, Raghavan A, et al. (2000) Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity. Mol Cell 6: 539-550.
27. Kaminuma O, Kitamura F, Kitamura N, Hiroi T, Miyoshi H, et al. (2008) Differential contribution of NFATc2 and NFATc1 to TNF-alpha gene expression in T cells. J Immunol 180: 319-326.
28. Carneiro FR, Ramalho-Oliveira R, Mognol GP, Viola JP, (2011) Interferon regulatory factor 2 binding protein 2 is a new NFAT1 partner and represses its transcriptional activity. Mol Cell Biol 31: 2889-2901.
29. Tamm I, Kikuchi T, (1991) Activation of signal transduction pathways protects quiescent Balb/c-3T3 fibroblasts against death due to serum deprivation. J Cell Physiol 148: 85-95.
30. Macian F, Lopez-Rodriguez C, Rao A, (2001) Partners in transcription: NFAT and AP-1. Oncogene 20: 2476-2489.
31. Nguyen TN, Kim LJ, Walters RD, Drullinger LF, Lively TN, et al. (2010) The C-terminal region of human NFATc2 binds cJun to synergistically activate interleukin-2 transcription. Mol Immunol 47: 2314-2322.
32. Garcia-Rodriguez C, Rao A, (1998) Nuclear factor of activated T cells (NFAT)-dependent transactivation regulated by the coactivators p300/CREB-binding protein (CBP). J Exp Med 187: 2031-2036.
33. Liu ZG, Smith SW, McLaughlin KA, Schwartz LM, Osborne BA, (1994) Apoptotic signals delivered through the T-cell receptor of a T-cell hybrid require the immediate-early gene nur77. Nature 367: 281-284.
34. Yu H, Kumar SM, Fang D, Acs G, Xu X, (2007) Nuclear orphan receptor TR3/Nur77 mediates melanoma cell apoptosis. Cancer Biol Ther 6: 405-412.
35. Yang H, Bushue N, Bu P, Wan YJ, (2010) Induction and intracellular localization of Nur77 dictate fenretinide-induced apoptosis of human liver cancer cells. Biochem Pharmacol 79: 948-954.
36. Lin B, Kolluri SK, Lin F, Liu W, Han YH, et al. (2004) Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3. Cell 116: 527-540.
37. Wang Q, Ji Y, Wang X, Evers BM, (2000) Isolation and molecular characterization of the 5′-upstream region of the human TRAIL gene. Biochem Biophys Res Commun 276: 466-471.
38. Mariani SM, Krammer PH, (1998) Surface expression of TRAIL/Apo-2 ligand in activated mouse T and B cells. Eur J Immunol 28: 1492-1498.
39. Ettinger R, Panka DJ, Wang JK, Stanger BZ, Ju ST, et al. (1995) Fas ligand-mediated cytotoxicity is directly responsible for apoptosis of normal CD4+ T cells responding to a bacterial superantigen. J Immunol 154: 4302-4308.
40. Holtz-Heppelmann CJ, Algeciras A, Badley AD, Paya CV, (1998) Transcriptional regulation of the human FasL promoter-enhancer region. J Biol Chem 273: 4416-4423.
41. Hanahan D, Weinberg RA, (2000) The hallmarks of cancer. Cell 100: 57-70.
42. Mancini M, Toker A, (2009) NFAT proteins: emerging roles in cancer progression. Nat Rev Cancer 9: 810-820.
43. Ranger AM, Gerstenfeld LC, Wang J, Kon T, Bae H, et al. (2000) The nuclear factor of activated T cells (NFAT) transcription factor NFATp (NFATc2) is a repressor of chondrogenesis. J Exp Med 191: 9-22.