Arrest of spermatogenesis and defective breast development in mice lacking A-myb

Nature

Volumn 386, Issue 6626, 1997, Pages 713-717

  Toscani, Antonio ^a   Mettus, Richard V ^a   Coupland, Robert ^a   Simpkins, Henry ^a   Litvin, Judith ^a   Orth, Joanne ^a   Hatton, Kimi S ^a   Reddy, E Premkumar ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL MODEL; ARTICLE; BREAST DEVELOPMENT; BREAST MALFORMATION; CONTROLLED STUDY; DEVELOPMENTAL DISORDER; GENE EXPRESSION; GENE MUTATION; HOMOZYGOSITY; MALE INFERTILITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPERMATOGENESIS; TESTIS;

EID: 0030948537     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/386713a0     Document Type: Article

References (28)

1. Nomura, N. et al. Isolation of human cDNA clones of myb-related genes. A-myb and B-myb. Nucleic Acids Res. 16, 11075-11089 (1988).
2. Mettus, R. V. et al. Murine A-myb: evidence for differential splicing and tissue-specific expression. Oncogene 9, 3077-3086 (1994).
3. Trauth, K. et al. Mouse A-myb encodes a trans-activator and is expressed in mitotically active cells of the developing central nervous system, adult testis and B-lymphocytes. EMBO J. 13, 5994-6005 (1994).
4. Mansour, S. L., Thomas, K. R. & Capecchi, M. R. Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes. Nature 336, 348-352 (1988).
5. Amann, R. P., Johnson, L., Thompson, D. L. Jr & Pickett, B. W. Daily spermatozoal production, epididymal spermatozoal reserves and transit time of spermatozoa through the epididymis of the rhesus monkey. Biol. Reprod. 15, 586-592 (1976).
6. Mori. C. et al. Programmed cell death in the interdigital tissue of the fetal mouse limb is apoptosis with DNA fragmentation. Anat. Rec. 242, 103-110 (1995).
7. Nantel, F. et al. Spermiogenesis deficiency and germ-cell apoptosis in CREM-mutant mice. Nature 380, 159-162 (1996).
8. Wolgemuth, D. J. & Watrin, F. List of cloned mouse genes with unique expression patterns during spermatogenesis. Mamm. Genome 1, 283-288 (1991).
9. Propst, F. et al. Genetic analysis and developmental regulation of testis-specific RNA expression of Mos, Abl, actin and Hox-1.4. Oncogene 2, 227-233 (1988).
10. Wolfes, H., Kogawa, K., Millette, C. F. & Cooper, G. M. Specific expression of nuclear proto-oncogenes before entry into meiotic prophase of spermatogenesis. Science 245, 740-743 (1989).
11. Ito, E. et al. Erythroid transcription factor GATA-1 is abundantly transcribed in mouse testis. Nature 362, 466-468 (1993).
12. Sorrentino, V., Giorgi, M., Geremia, R., Besmer, P. & Rossi, P. Expression of the c-kit proto-oncogene in the murine male germ cells. Oncogene 6, 149-151 (1991).
13. Chavrier, P. et al. A gene encoding a protien with zinc fingers is activated during G0/G1 transition in cultured cells. EMBO J. 7, 29-35 (1988).
14. Lemaire, P., Revelant, O., Bravo, R. & Charnay, P. Two mouse genes encoding potential transcription factors with identical DNA-binding domains are activated by growth factors in cultured cells. Proc. Natl Acad. Sci. Usa 85, 4691-4695 (1988).
15. Kaneko, Y. et al. Presence of alternative 5′ untranslated sequences and identification of cells expressing Natl Acad. Sci. Usa 85, 4691-4695 (1988).
16. Cohen, D. R., Vandermark, S. E., McGovern, J. D. & Bradley, M. P. Transcriptional regulation in the testis: a role for transcription factor AP-1 complexes at various stages of spermatogenesis. Oncogene 8, 443-455 (1993).
17. Rubin, M. R., Toth, L. E., Patel, M. D., D'Eustachio, P. & Nguyen-Huu, M. C. A mouse homeo box gene is expressed in spermatocytes and embryos. Science 233, 663-667 (1986).
18. Sun, Z., Sassone-Corsi, P. & Means, A. R. Calspermin gene transcription is regulated by two cyclic AMP response elements contained in an alternative promoter in the calmodulin kinase IV gene. Mol. Cell. Biol. 15, 561-571 (1995).
19. Baba, T. et al. An acrosomal protien, sp32, in mammalian sperm is a binding protein specific for two proacrosins and an acrosin intermediate. J. Biol. Chem. 269, 10133-10140 (1994).
20. Goto, M. et al. Transcription switch of two phosphoglycerate kinase genes during spermatogenesis as determined with mouse testis sections in situ. Exp. Cell Res. 183, 273-278 (1990).
21. Dix, D. J. et al. Developmentally regulated expression of Hsp70-2/lacZ transgene during spermatogenesis. Dev. Biol. 174, 310-321 (1996).
22. Dix, D. J. et al. Targeted gene disruption of Hsp70-2 results in failed meiosis, germ cell apoptosis, and male infertility. Proc. Natl Acad. Sci. USA 93, 3264-3268 (1996).
23. Blendy, J. A., Kaestner, K. H., Weinbauer, G. F., Nieschlag, E. & Schutz, G. Severe impairment of spermatogenesis in mice lacking the CREM gene. Nature 380, 162-165 (1996).
24. Howlett, A. R. & Bissell, M. J. The influence of tissue microenvironment (stroma and extracellular matrix) on the development and function of mammary epithelium. Epith. Cell Biol. 2, 79-89 (1993).
25. Wang, S., Counterman, L. J. & Haslam, S. Z. Progesterone action in normal mouse mammary gland. Endocrinology 127, 2183-2189 (1990).
26. Rosai. J. in Ackerman's Surgical Pathology (ed. Stamathis, G.) 949-982 (Mosby, St Louis, 1989).
27. Wong, T. W., Straus, F. H. & Warner, N. E. Testicular biopsy in the study of male infertility. I. Testicular causes of infertility. Arch. Pathol. 95, 151-159 (1973).
28. Sicinski, P. et al. Cyclin D1 provides a link between development and oncogenesis in the retina and breast. Cell 82, 621-630 (1995).