Inhibition of cellular efflux pumps involved in multi xenobiotic resistance (MXR) in echinoid larvae as a possible mode of action for increased ecotoxicological risk of mixtures

Ecotoxicology

Volumn 21, Issue 8, 2012, Pages 2276-2287

  Anselmo, Henrique M R ^a   Van Den Berg, Johannes H J ^a   Rietjens, Ivonne M C M ^a   Murk, Alber Tinka J ^a  

^a WAGENINGEN UNIVERSITY   (Netherlands)

Author keywords

Cellular efflux pumps; Echinoids; Inhibition; Larvae; Mixture toxicity; MXR; Nanoparticles; Persistent organic pollutants; Potentiation

Indexed keywords

1,1,1 TRICHLORO 2 (2 CHLOROPHENYL) 2 (4 CHLOROPHENYL)ETHANE; 4,4' ISOPROPYLIDENEDIPHENOL; CALCEIN; HEPTADECAFLUOROOCTANE SULFONIC ACID; MULTIDRUG RESISTANCE PROTEIN; NANOPARTICLE; PENTACHLOROPHENOL; SULFONIC ACID DERIVATIVE; TRICLOSAN; UNCLASSIFIED DRUG; VALSPODAR; VERAPAMIL; VERLUKAST; VINBLASTINE;

ECHINODERM; ECOTOXICOLOGY; INHIBITION; LARVA; ORGANIC POLLUTANT; RISK ASSESSMENT; TOXICITY; XENOBIOTICS;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOASSAY; CELL LEVEL; CELLULAR EFFLUX PUMP; CONTROLLED STUDY; ECOTOXICITY; LARVA; MARINE ENVIRONMENT; MARINE SPECIES; MULTI XENOBIOTIC RESISTANCE; NONHUMAN; PHYSICAL SENSITIVITY; POLLUTANT; PRIORITY JOURNAL; PSAMMECHINUS MILIARIS; RISK ASSESSMENT; SEA URCHIN; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, MULTIPLE; FLUORESCEINS; LARVA; MICROSCOPY, FLUORESCENCE; SEA URCHINS; TOXICITY TESTS, ACUTE; XENOBIOTICS;

ECHINOIDA; PSAMMECHINUS MILIARIS;

EID: 84868126050     PISSN: 09639292     EISSN: 15733017     Source Type: Journal    
DOI: 10.1007/s10646-012-0984-2     Document Type: Article

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