Pentachlorophenol decreases ATP levels in human natural killer cells

Journal of Applied Toxicology

Volumn 28, Issue 8, 2008, Pages 1016-1020

  Nnodu, Ugochukwu ^a   Whalen, Margaret M ^a  

^a TENNESSEE STATE UNIVERSITY   (United States)

Author keywords

ATP levels; Glutathione; Lytic function; NK cells; Pentachlorophenol; Vitamin E

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALPHA TOCOPHEROL; GLUTATHIONE; PENTACHLOROPHENOL;

AEROBIC METABOLISM; ARTICLE; CELL LOSS; CELL VIABILITY; CYTOLYSIS; CYTOTOXICITY; DRUG EFFECT; FEMALE; HUMAN; HUMAN CELL; MALE; NATURAL KILLER CELL; NORMAL HUMAN; PRIORITY JOURNAL;

ADENOSINE TRIPHOSPHATE; ADULT; ANTIOXIDANTS; CELL SEPARATION; CELL SURVIVAL; CHROMIUM; ENVIRONMENTAL POLLUTANTS; FEMALE; GLUTATHIONE; HUMANS; KILLER CELLS, NATURAL; MALE; PENTACHLOROPHENOL; PHAGOCYTOSIS; VITAMIN E;

EID: 55549135043     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.1367     Document Type: Article

References (30)

1. Agency for Toxic Substances and Disease Registry. 2001. Toxicological Profile for Pentachlorophenol. Update. US Department of Health and Human Services, Public Health Service: Atlanta, GA.
2. Atuma SS, Okor DI. 1985. Gas chromatographic determination of pentachlorophenol in human blood and urine. Bull. Environ Contam. Toxicol. 35: 406-410.
3. Biron CA, Byron KS, Sullivan JL. 1989. Severe herpes virus infection in an adolescent without natural killer cells. New Engl. J. Med. 320: 1731-1735.
4. Cain K, Hyams RL, Griffiths DE. 1977. Studies on energy-linked reactions: inhibition of oxidative phosphorylation and energy-linked reactions by dibutyltin dichloride. FEBS Lett. 82: 23-28.
5. Centers for Disease Control and Prevention. 2005. 3rd National Report on Human Exposure to Environmental Chemicals.
6. Cirelli DP. 1978. Patterns of pentachlorophenol usage in the United States of America - an overview. In Pentachlorophenol, Chemistry, Pharmacology, and Environmental Toxicology, Rao KR (ed.). Plenum Press: New York; 13-18.
7. Cline RE, Hill RH Jr, Phillips DL, Needham LL. 1989. Pentachlorophenol measurements in body fluids of people in log homes and workplaces. Arch. Environ. Contam. Toxicol. 18: 475-481.
8. Demers PA, Davies HW, Friesen MC, Hertzman C, Ostry A, Hershler R, Teschke K. 2006. Cancer and occupational exposure to pentachlorophenol and tetrachlorophenol (Canada). Cancer Causes Control 17: 749-758.
9. Dorsey WC, Tchounwou PB, Ford BD. 2006. Neuregulin 1-Beta cytoprotective role in AML 12 mouse hepatocytes exposed to pentachlorophenol. Int. J. Environ. Res. Public Health 3: 11-22.
10. Dudimah FD, Gibson C, Whalen MM. 2007a. Effect of dibutyltin on ATP levels in human natural killer cells. Environ. Toxicol. 22: 117-123.
11. Dudimah FD, Odman-Ghazi SO, Hatcher F, Whalen MM. 2007b. Effect of tributyltin (TBT) on ATP levels in human natural killer (NK) cells: relationship to TBT-induced decreases in NK function. J. Appl. Toxicol. 27: 86-94.
12. Fleisher G, Starr S, Koven N, Kamiya H, Douglas SD, Henle W. 1982. A non-X-linked syndrome with susceptibility to severe Epstein-Barr virus infections. J. Pediatr. 100: 727-730.
13. Hanna N. 1980. Expression of metastatic potential of tumor cells in young nude mice is correlated with low levels of natural-killer-cell mediated cytotoxicity. Int. J. Cancer 26: 675-680.
14. Jones RD, Winter DP, Cooper AJ. 1986. Absorption study of pentachlorophenol in persons working with wood preservatives. Hum. Toxicol. 5: 189-194.
15. Juhl U, Witte I, Butte W. 1985. Metabolism of pentacholorphenol to tetrachorohydroquinone by human liver homogenate. Bull. Environ. Contam. Toxicol. 35: 596-601.
16. Kiessling R, Haller O. 1978. Natural killer cells in the mouse: An alternative surveillance mechanism? Contemp. Top. Immunobiol. 8: 171-201.
17. Reed A, Dzon L, Loganathan BG, Whalen MM. 2004. Immunomodulation of human natural killer cell cytotoxic function by organochlorine pesticides. Hum. Exp. Toxicol. 23: 463-471.
18. Thornton JW, McCally M, Houlihan J. 2002. Biomonitoring of industrial pollutants: health and policy implications of the chemical body burden. Public Health Rep. 117: 315-323; www.ewg.org/reports/bodyburden/ findings.php
19. Uhl S, Schmid P, Schlatter C. 1986. Pharmacokinetics of pentachlorophenol in man. Arch. Toxicol. 58: 182-186.
20. Umemura T, Kodama Y, Kanki K, Iatropoulas MJ, Nishikawa A, Hirose M, Williams GM. 2003. Pentachlorophenol (but not phenobarbital) promotes intrahepatic biliary cysts induced by diethylnitrosamine to cholangio cystic neoplasms in B6C3F1 mice possibly due to oxidative stress. Toxicol. Pathol. 31: 10-13.
21. Umemura T, Kuroiwa Y, Kitamura Y, Ishii Y, Kanki K, Kodama Y, Ito K, Yamamoto M, Nishikawa A, Hirose M. 2006. A crucial role of Nrf2 in in vivo defense against oxidative damage by an environmental pollutant, pentachlorophenol. Toxicol. Sci. 90: 111-119.
22. US Environmental Protection Agency (US EPA). Restricted use product file, 25 October 2001.
23. Vivier E, Nunès JA, Vely F. 2004. Natural killer cell signaling pathways. Science 306: 1517-1519.
24. Walzer T, Dalod M, robbins SH, Zitvogel L, Vivier E. 2005. Natural-killer cells and dendritic cells: 'l'union fait la force'. Blood 106: 2252-2258.
25. Wang YJ, Lee CC, Chang WC, Liou HB, Ho YS. 2001. Oxidative stress and liver toxicity in rats and human hepatoma cell line induced by pentachlorophenol and its major metabolite tetrachlorohydroquinone. Toxicol. Lett. 122: 157-169.
26. Weinbach EC. 1954. The effect of pentachlorophenol on oxidative phosphorylation. J. Biol. Chem. 210: 545-550.
27. Weinbach EC, Garbus J. 1965. The interaction of uncoupling phenols with mitochondria and with mitochondrial protein. J. Biol. Chem. 240: 1811-1819.
28. Whalen MM. 1997. Inhibition of human natural killer cell function in vitro by glucose concentrations seen in poorly controlled diabetes. Cell. Physiol. Biochem. 7: 53-60.
29. Whalen MM, Loganathan BG, Kannan K. 1999. Immunotoxicity of environmentally relevant concentrations of butyltins on human natural killer cells in vitro. Environ. Res. 81: 108-116.
30. Wu J, Lanier LL. 2003. Natural killer cells and cancer. Adv. Cancer Res. 90: 127-156.