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Volumn 21, Issue 7, 2012, Pages 1841-1856

Atorvastatin up-regulate toxicologically relevant genes in rainbow trout gills

Author keywords

Atorvastatin; Gene expression; Gill; Na+ K + ATPase; Rainbow trout

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ATORVASTATIN; CASPASE 7; CYTOCHROME P450 3A; GERANYLTRANSFERASE; GLUCURONOSYLTRANSFERASE; GLUTAMATE CYSTEINE LIGASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; LACTONE; METALLOTHIONEIN; MULTIDRUG RESISTANCE PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PROTEIN BAX; SULFOTRANSFERASE; SUPEROXIDE DISMUTASE;

EID: 84868123241     PISSN: 09639292     EISSN: 15733017     Source Type: Journal    
DOI: 10.1007/s10646-012-0918-z     Document Type: Article
Times cited : (21)

References (104)
  • 1
    • 48649107502 scopus 로고    scopus 로고
    • Characterization of branchial na,k-Atpase from three freshwater fish species (oreochromis niloticus, cyprinus carpio, and oncorhynchus mykiss)
    • Atli G, Canli M (2008) Characterization of branchial Na,K-ATPase from three freshwater fish species (Oreochromis niloticus, Cyprinus carpio, and Oncorhynchus mykiss). Turk J Zool 32(3):299-304
    • (2008) Turk J Zool , vol.32 , Issue.3 , pp. 299-304
    • Atli, G.1    Canli, M.2
  • 3
    • 0030801725 scopus 로고    scopus 로고
    • 12th meeting of the scientific group on methodologies for the safety evaluation of chemicals: Susceptibility to environmental hazards
    • Barrett JC, Vainio H, Peakall D, Goldstein BD (1997) 12th Meeting of the Scientific Group on Methodologies for the Safety Evaluation of Chemicals: Susceptibility to environmental hazards. Environ Health Perspect 105:699-737
    • (1997) Environ Health Perspect , vol.105 , pp. 699-737
    • Barrett, J.C.1    Vainio, H.2    Peakall, D.3    Goldstein, B.D.4
  • 4
    • 0020698434 scopus 로고
    • Distribution and some properties of the glutathione s-Transferase and [gamma] glutamyl transpeptidase activities of rainbow trout
    • doi101016/0742-89-93 do84138390155
    • Bauermeister A, Lewendon A, Ramage PIN, Nimmo IA (1983) Distribution and some properties of the glutathione s-Transferase and [gamma]-glutamyl transpeptidase activities of rainbow trout. Comp Biochem Physiol C 74(1):89-93. doi:10.1016/0742-8413(83)90155-x
    • (1983) Comp Biochem Physiol C , vol.74 , Issue.1 , pp. 89-93
    • Bauermeister, A.1    Lewendon, A.2    Ramage, P.I.N.3    Nimmo, I.A.4
  • 7
    • 0032988573 scopus 로고    scopus 로고
    • Synthesis of procaspases-3 and-7 during apoptosis in prostate cancer cells
    • Bowen C, Voeller HJ, Kikly K, Gelmann EP (1999) Synthesis of procaspases-3 and-7 during apoptosis in prostate cancer cells. Cell Death Differ 6(5):394-401
    • (1999) Cell Death Differ , vol.6 , Issue.5 , pp. 394-401
    • Bowen, C.1    Voeller, H.J.2    Kikly, K.3    Gelmann, E.P.4
  • 8
    • 0031770433 scopus 로고    scopus 로고
    • Rainbow trout cytochrome p450s: Purification, molecular aspects, metabolic activity, induction and role in environmental monitoring
    • Buhler DR, Wang-Buhler J-L (1998) Rainbow trout cytochrome P450s: Purification, molecular aspects, metabolic activity, induction and role in environmental monitoring. Comp Biochem Physiol C 121(1-3):107-137
    • (1998) Comp Biochem Physiol C , vol.121 , Issue.1-3 , pp. 107-137
    • Buhler, D.R.1    Wang-Buhler, J.-L.2
  • 10
    • 76349085164 scopus 로고    scopus 로고
    • Atorvastatin-induced cell toxicity in yeast is linked to disruption of protein isoprenylation
    • doi: 101111/j1567-188-198 doi: 101111/j1364-2009.00593
    • Callegari S, McKinnon RA, Andrews S, De Barros Lopes MA (2010) Atorvastatin-induced cell toxicity in yeast is linked to disruption of protein isoprenylation. FEMS Yeast Res 10(2):188-198. doi: 10.1111/j.1567-1364.2009. 00593.x
    • (2010) FEMS Yeast Res , vol.10 , Issue.2 , pp. 188-198
    • Callegari, S.1    McKinnon, R.A.2    Andrews, S.3    De Barros Lopes, M.A.4
  • 11
    • 84954358093 scopus 로고    scopus 로고
    • Human pharmaceuticals modulate p-gp1 (abcb1) transport activity in the fish cell line plhc-1
    • Caminada D, Zaja R, Smital T, Fent K (2008) Human pharmaceuticals modulate P-gp1 (ABCB1) transport activity in the fish cell line PLHC-1. Aquat Toxicol 90(3):214-222
    • (2008) Aquat Toxicol , vol.90 , Issue.3 , pp. 214-222
    • Caminada, D.1    Zaja, R.2    Smital, T.3    Fent, K.4
  • 12
    • 58949087260 scopus 로고    scopus 로고
    • Characterization of 22 novel single nucleotide polymorphism markers in steelhead and rainbow trout
    • doi101111/j1755-0998.200802376x
    • Campbell NR, Overturf KEN, Narum SR (2009) Characterization of 22 novel single nucleotide polymorphism markers in steelhead and rainbow trout. Mol Ecol Resour 9(1):318-322. doi:10.1111/j.1755-0998.2008.02376.x
    • (2009) Mol Ecol Resour , vol.9 , Issue.1 , pp. 318-322
    • Campbell, N.R.1    Overturf, K.E.N.2    Narum, S.R.3
  • 13
    • 70349323604 scopus 로고    scopus 로고
    • Statin-induced muscle damage and atrogin-1 induction is the result of a geranylgeranylation defect
    • doi101096/fj08-2844-2854 doi10109128843
    • Cao P, Hanai J-I, Tanksale P, Imamura S, Sukhatme VP, Lecker SH (2009) Statin-induced muscle damage and atrogin-1 induction is the result of a geranylgeranylation defect. FASEB J 23(9): 2844-2854. doi:10.1096/fj.08-128843
    • (2009) FASEB J , vol.23 , Issue.9 , pp. 2844-2854
    • Cao, P.1    Hanai, J.-I.2    Tanksale, P.3    Imamura, S.4    Sukhatme, V.P.5    Lecker, S.H.6
  • 14
    • 15344341734 scopus 로고    scopus 로고
    • Differential interaction of 3-hydroxy-3-methylglutaryl-coa reductase inhibitors with abcb1, abcc2 and oatp1b1
    • Chen C, Mireles RJ, Campbell SD, Lin J, Mills JB, Xu JJ, Smolarek TA (2005) Differential interaction of 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors with ABCB1, ABCC2 and OATP1B1. Drug Metab Dispos 33(4):537-546
    • (2005) Drug Metab Dispos , vol.33 , Issue.4 , pp. 537-546
    • Chen, C.1    Mireles, R.J.2    Campbell, S.D.3    Lin, J.4    Mills, J.B.5    Xu, J.J.6    Smolarek, T.A.7
  • 15
    • 77957750790 scopus 로고    scopus 로고
    • Induction of oxidative stress and apoptosis by silver nanoparticles in the liver of adult zebrafish
    • doi101016/jaquatox.2009-12012
    • Choi JE, Kim S, Ahn JH, Youn P, Kang JS, Park K, Yi J, Ryu D-Y (2010) Induction of oxidative stress and apoptosis by silver nanoparticles in the liver of adult zebrafish. Aquat Toxicol 100(2):151-159. doi:10.1016/j.aquatox.2009. 12.012
    • (2010) Aquat Toxicol , vol.100 , Issue.2 , pp. 151-159
    • Choi, J.E.1    Kim, S.2    Ahn, J.H.3    Youn, P.4    Kang, J.S.5    Park, K.6    Yi, J.7    Ryu, D.-Y.8
  • 16
    • 0025878799 scopus 로고
    • Glucuronidation in fish
    • doi:10.1016/0166-445x(91) 90040-g
    • Clarke DJ, George SG, Burchell B (1991) Glucuronidation in fish. Aquat Toxicol 20(1-2):35-56. doi:10.1016/0166-445x(91) 90040-g
    • (1991) Aquat Toxicol , vol.20 , Issue.1-2 , pp. 35-56
    • Clarke, D.J.1    George, S.G.2    Burchell, B.3
  • 17
    • 33745982529 scopus 로고    scopus 로고
    • Cholesterol function in plasma membranes from ectotherms: Membrane-specific roles in adaptation to temperature
    • Crockett EL (1998) Cholesterol function in plasma membranes from ectotherms: Membrane-specific roles in adaptation to temperature. Am Zool 38(2):291-304
    • (1998) Am Zool , vol.38 , Issue.2 , pp. 291-304
    • Crockett, E.L.1
  • 18
    • 0030800240 scopus 로고    scopus 로고
    • Cholesterol affects physical properties and (na,k)-Atpase in basolateral membranes of renal and intestinal epithelia from thermally acclimated rainbow trout
    • doi101007/s003600050083
    • Crockett EL, Hazel JR (1997) Cholesterol affects physical properties and (Na,K)-ATPase in basolateral membranes of renal and intestinal epithelia from thermally acclimated rainbow trout. J Comp Physiol B 167(5):344-351. doi:10.1007/s003600050083
    • (1997) J Comp Physiol B , vol.167 , Issue.5 , pp. 344-351
    • Crockett, E.L.1    Hazel, J.R.2
  • 19
    • 0030589044 scopus 로고    scopus 로고
    • Genetic ecotoxicology: An overview
    • doi:10.1016/s0022-0981(96)02639-1
    • Depledge MH (1996) Genetic ecotoxicology: An overview. J Exp Mar Biol Ecol 200(1-2):57-66. doi:10.1016/s0022-0981(96)02639-1
    • (1996) J Exp Mar Biol Ecol , vol.200 , Issue.1-2 , pp. 57-66
    • Depledge, M.H.1
  • 20
    • 33845306820 scopus 로고    scopus 로고
    • Statin-induced apoptosis and skeletal myopathy
    • Dirks AJ, Jones KM (2006) Statin-induced apoptosis and skeletal myopathy. Am J Physiol Cell Physiol 291:C1208-C1212
    • (2006) Am J Physiol Cell Physiol , vol.291
    • Dirks, A.J.1    Jones, K.M.2
  • 21
    • 41149099433 scopus 로고    scopus 로고
    • Role of multi-drug resistance-Associated protein-1 transporter in statin-induced myopathy
    • doi:10.1016/j.lfs.2008.01021
    • Dorajoo RSO, Pereira BP, Yu Z, Gopalakrishnakone P, Leong CC, Wee A, Lee E (2008) Role of multi-drug resistance-Associated protein-1 transporter in statin-induced myopathy. Life Sci 82(15-16):823-830. doi:10.1016/j.lfs.2008.01. 021
    • (2008) Life Sci , vol.82 , Issue.15-16 , pp. 823-830
    • Dorajoo, R.S.O.1    Pereira, B.P.2    Yu, Z.3    Gopalakrishnakone, P.4    Leong, C.C.5    Wee, A.6    Lee, E.7
  • 22
    • 77956171133 scopus 로고    scopus 로고
    • Cytotoxicity of atorvastatin and simvastatin on primary rainbow trout (oncorhynchus mykiss) hepatocytes
    • doi:10.1016/j.tiv.2010.06.006
    • Ellesat KS, Tollefsen KE, A ° sberg A, Thomas KV, Hylland K (2010) Cytotoxicity of atorvastatin and simvastatin on primary rainbow trout (Oncorhynchus mykiss) hepatocytes. Toxicol In Vitro 24(6):1610-1618. doi:10.1016/j.tiv.2010.06.006
    • (2010) Toxicol In Vitro , vol.24 , Issue.6 , pp. 1610-1618
    • Ellesat, K.S.1    Tollefsen, K.E.2    Asberg, A.3    Thomas, K.V.4    Hylland, K.5
  • 23
    • 0017043554 scopus 로고
    • Competitive inhibition of 3-hydroxy-3-methylglutaryl coenzyme a reductase by ml-236a and ml-236b fungal metabolites, having hypercholesterolemic activity
    • Endo A, Kuroda M, Tanzawa K (1976) Competitive inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase by ML-236A and ML-236B fungal metabolites, having hypercholesterolemic activity. FEBS Lett 72(2):323-326
    • (1976) FEBS Lett , vol.72 , Issue.2 , pp. 323-326
    • Endo, A.1    Kuroda, M.2    Tanzawa, K.3
  • 24
    • 39749086163 scopus 로고    scopus 로고
    • 3-Hydroxy-3-methylglutaryl coenzyme A reductase in rainbow trout: Effects of fasting and statin drugs on activities and mRNA transcripts
    • Estey C, Chen X, Moon TW (2008) 3-Hydroxy-3-methylglutaryl coenzyme A reductase in rainbow trout: Effects of fasting and statin drugs on activities and mRNA transcripts. Comp Biochem Physiol C 147(3):386-398
    • (2008) Comp Biochem Physiol C , vol.147 , Issue.3 , pp. 386-398
    • Estey, C.1    Chen, X.2    Moon, T.W.3
  • 25
    • 0036326155 scopus 로고    scopus 로고
    • The myotoxicity of statins
    • Evans M, Rees A (2002) The myotoxicity of statins. Curr Opin Lipidol 13(4):415-420
    • (2002) Curr Opin Lipidol , vol.13 , Issue.4 , pp. 415-420
    • Evans, M.1    Rees, A.2
  • 26
    • 33847078849 scopus 로고    scopus 로고
    • Toxicogenomic responses in rainbow trout (oncorhynchus mykiss) hepatocytes exposed to model chemicals and a synthetic mixture
    • Finne EF, Cooper GA, Koop BF, Hylland K, Tollefsen KE (2007) Toxicogenomic responses in rainbow trout (Oncorhynchus mykiss) hepatocytes exposed to model chemicals and a synthetic mixture. Aquat Toxicol 81:293-303
    • (2007) Aquat Toxicol , vol.81 , pp. 293-303
    • Finne, E.F.1    Cooper, G.A.2    Koop, B.F.3    Hylland, K.4    Tollefsen, K.E.5
  • 27
    • 77957751477 scopus 로고    scopus 로고
    • Identification of multi-drug resistance associated proteins mrp1 (abcc1) and mrp3 (abcc3) from rainbow trout (oncorhynchus mykiss
    • doi:10.1016/j.marenvres.2009.11.003
    • Fischer S, Pietsch M, Schirmer K, Luckenbach T (2010) Identification of multi-drug resistance associated proteins MRP1 (ABCC1) and MRP3 (ABCC3) from rainbow trout (Oncorhynchus mykiss). Mar Environ Res 69(Supplement 1):S7-S10. doi:10.1016/j.marenvres.2009.11.003
    • (2010) Mar Environ Res , vol.69 , Issue.SUPPL. 1
    • Fischer, S.1    Pietsch, M.2    Schirmer, K.3    Luckenbach, T.4
  • 28
    • 33644975004 scopus 로고    scopus 로고
    • Rna integrity and the effect on the realtime qrt-pcr performance
    • doi:10.1016/j.mam. 2005.12003
    • Fleige S, Pfaffl MW (2006) RNA integrity and the effect on the realtime qRT-PCR performance. Mol Aspects Med 27(2-3): 126-139. doi:10.1016/j.mam.2005. 12.003
    • (2006) Mol Aspects Med , vol.27 , Issue.2-3 , pp. 126-139
    • Fleige, S.1    Pfaffl, M.W.2
  • 29
    • 0030952937 scopus 로고    scopus 로고
    • Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-Activated receptors a and d
    • Forman BM, Chen J, Evans RM (1997) Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-Activated receptors a and d. Proc Natl Acad Sci USA 94(9):4312-4317
    • (1997) Proc Natl Acad Sci USA , vol.94 , Issue.9 , pp. 4312-4317
    • Forman, B.M.1    Chen, J.2    Evans, R.M.3
  • 30
    • 19744382332 scopus 로고    scopus 로고
    • The 3-hydroxy-3-methylglutaryl coenzyme-A (hmg-coa) reductases
    • doi:10.1186/gb-2004-5-11-248
    • Friesen JA, Rodwell VW (2004) The 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductases. Genome Biol 5(11):248. doi:10.1186/gb-2004-5-11-248
    • (2004) Genome Biol , vol.5 , Issue.11 , pp. 248
    • Friesen, J.A.1    Rodwell, V.W.2
  • 31
    • 12344260689 scopus 로고    scopus 로고
    • Molecular markers for animal biotechnology: Sea bass (dicentrarchus labrax, l.) hmg-coa reductase mrna
    • doi:10.1016/j.gene.2004.11007
    • Gornati R, Papis E, Rimoldi S, Chini V, Terova G, Prati M, Saroglia M, Bernardini G (2005) Molecular markers for animal biotechnology: Sea bass (Dicentrarchus labrax, L.) HMG-CoA reductase mRNA. Gene 344:299-305. doi:10.1016/j.gene.2004.11.007
    • (2005) Gene , vol.344 , pp. 299-305
    • Gornati, R.1    Papis, E.2    Rimoldi, S.3    Chini, V.4    Terova, G.5    Prati, M.6    Saroglia, M.7    Bernardini, G.8
  • 32
    • 73249123089 scopus 로고    scopus 로고
    • Simultaneous determination of acidic, neutral and basic pharmaceuticals in urban wastewater by ultra high-pressure liquid chromatography-Tandem mass spectrometry
    • doi 101016/jchroma.2009.11090
    • Gracia-Lor E, Sancho JV, Hernández F (2010) Simultaneous determination of acidic, neutral and basic pharmaceuticals in urban wastewater by ultra high-pressure liquid chromatography-Tandem mass spectrometry. J Chromatogr A 1217(5):622-632. doi: 10.1016/j.chroma.2009.11.090
    • (2010) J Chromatogr A , vol.1217 , Issue.5 , pp. 622-632
    • Gracia-Lor, E.1    Sancho, J.V.2    Hernández, F.3
  • 34
    • 77955558573 scopus 로고    scopus 로고
    • Estrogen responses in killifish (fundulus heteroclitus) from polluted and unpolluted environments are site-And gene-specific
    • doi:10.1016/j.aquatox.2010. 05.009
    • Greytak SR, Tarrant AM, Nacci D, Hahn ME, Callard GV (2010) Estrogen responses in killifish (Fundulus heteroclitus) from polluted and unpolluted environments are site-And gene-specific. Aquat Toxicol 99(2):291-299. doi:10.1016/j.aquatox.2010. 05.009
    • (2010) Aquat Toxicol , vol.99 , Issue.2 , pp. 291-299
    • Greytak, S.R.1    Tarrant, A.M.2    Nacci, D.3    Hahn, M.E.4    Callard, G.V.5
  • 36
    • 33846864008 scopus 로고    scopus 로고
    • Lc-ms analysis and environmental risk of lipid regulators
    • Hernando M, Aguera A, Fernández-Alba A (2007) LC-MS analysis and environmental risk of lipid regulators. Anal Bioanal Chem 387(4):1269-1285
    • (2007) Anal Bioanal Chem , vol.387 , Issue.4 , pp. 1269-1285
    • Hernando, M.1    Aguera, A.2    Fernández-Alba, A.3
  • 37
    • 33750731687 scopus 로고    scopus 로고
    • Role of p-glycoprotein in statin drug interaction
    • Holtzman CW, Wiggins BS, Spinler SA (2006) Role of P-glycoprotein in statin drug interaction. Pharmacotherapy 26(11): 1601-1607
    • (2006) Pharmacotherapy , vol.26 , Issue.11 , pp. 1601-1607
    • Holtzman, C.W.1    Wiggins, B.S.2    Spinler, S.A.3
  • 38
    • 77955555305 scopus 로고    scopus 로고
    • Temporal patterns in the transcriptomic response of rainbow trout, oncorhynchus mykiss, to crude oil
    • doi:10.1016/j.aquatox.2010.05.011
    • Hook SE, Lampi MA, Febbo EJ, Ward JA, Parkerton TF (2010) Temporal patterns in the transcriptomic response of rainbow trout, Oncorhynchus mykiss, to crude oil. Aquat Toxicol 99(3):320-329. doi:10.1016/j.aquatox.2010.05.011
    • (2010) Aquat Toxicol , vol.99 , Issue.3 , pp. 320-329
    • Hook, S.E.1    Lampi, M.A.2    Febbo, E.J.3    Ward, J.A.4    Parkerton, T.F.5
  • 39
    • 39149140706 scopus 로고    scopus 로고
    • Statin-induced heme oxygenase-1 increases nf-kappa b activation and oxygen radical production in cultured neuronal cells exposed to lipopolysaccharide
    • doi101093/toxsci/kfm298
    • Hsieh CH, Jeng SF, Hsieh MW, Chen YC, Rau CS, Lu TH, Chen SS (2008) Statin-induced heme oxygenase-1 increases NF-kappa B activation and oxygen radical production in cultured neuronal cells exposed to lipopolysaccharide. Toxicol Sci 102(1): 150-159. doi:10.1093/toxsci/kfm298
    • (2008) Toxicol Sci , vol.102 , Issue.1 , pp. 150-159
    • Hsieh, C.H.1    Jeng, S.F.2    Hsieh, M.W.3    Chen, Y.C.4    Rau, C.S.5    Lu, T.H.6    Chen, S.S.7
  • 40
    • 33645830172 scopus 로고
    • Surface glycoprotein modulating drug permeability in chinese-hamster ovary cell mutants
    • Juliano RL, Ling V (1976) Surface glycoprotein modulating drug permeability in Chinese-hamster ovary cell mutants. Biochim Biophys Acta 455(1):152-162
    • (1976) Biochim Biophys Acta , vol.455 , Issue.1 , pp. 152-162
    • Juliano, R.L.1    Ling, V.2
  • 41
    • 0035997378 scopus 로고    scopus 로고
    • Biochemistry of na,k-Atpase
    • doi101146/annurevbiochem71 102201141218
    • Kaplan JH (2002) Biochemistry of Na,K-ATPase. Annu Rev Biochem 71(1):511-535. doi:10.1146/annurev.biochem.71. 102201.141218
    • (2002) Annu Rev Biochem , vol.71 , Issue.1 , pp. 511-535
    • Kaplan, J.H.1
  • 42
    • 0027434229 scopus 로고
    • The interconversion kinetics, equilibrium, and solubilities of the lactone and hydroxyacid forms of the hmg-coa reductase inhibitor, ci-981
    • Kearney AS, Crawford LF, Mehta SC, Radebaugh GW (1993) The interconversion kinetics, equilibrium, and solubilities of the lactone and hydroxyacid forms of the HMG-CoA reductase inhibitor, CI-981. Pharm Res 10(10):1461-1465
    • (1993) Pharm Res , vol.10 , Issue.10 , pp. 1461-1465
    • Kearney, A.S.1    Crawford, L.F.2    Mehta, S.C.3    Radebaugh, G.W.4
  • 43
    • 34447102604 scopus 로고    scopus 로고
    • Human pharmaceuticals in the aquatic environment: A challenge to green chemistry
    • doi101021/cr020441w
    • Khetan SK, Collins TJ (2007) Human pharmaceuticals in the aquatic environment: A challenge to green chemistry. Chem Rev 107(6):2319-2364. doi:10.1021/cr020441w
    • (2007) Chem Rev , vol.107 , Issue.6 , pp. 2319-2364
    • Khetan, S.K.1    Collins, T.J.2
  • 44
    • 34547126880 scopus 로고    scopus 로고
    • Salmonid microarrays identify intestinal genes that reliably monitor p deficiency in rainbow trout aquaculture
    • Kirchner S, McDaniel N, Suguira S, Scoteropoulos P, Tian B, Fletcher J, Ferraris R (2007) Salmonid microarrays identify intestinal genes that reliably monitor P deficiency in rainbow trout aquaculture. Animal Genet 38:319-331
    • (2007) Animal Genet , vol.38 , pp. 319-331
    • Kirchner, S.1    McDaniel, N.2    Suguira, S.3    Scoteropoulos, P.4    Tian, B.5    Fletcher, J.6    Ferraris, R.7
  • 45
    • 0036799870 scopus 로고    scopus 로고
    • The nuclear pregnane x receptor: A key regulator of xenobiotic metabolism
    • doi101210/er2001-0038
    • Kliewer SA, Goodwin B, Willson TM (2002) The nuclear pregnane X receptor: A key regulator of xenobiotic metabolism. Endocr Rev 23(5):687-702. doi:10.1210/er.2001-0038
    • (2002) Endocr Rev 23 , vol.5 , pp. 687-702
    • Kliewer, S.A.1    Goodwin, B.2    Willson, T.M.3
  • 46
    • 76349092662 scopus 로고    scopus 로고
    • Human skeletal muscle drug transporters determine local exposure and toxicity of statins
    • doi:10.1161/circresaha.109.203596
    • Knauer MJ, Urquhart BL, Schwabedissen H, Schwarz UI, Lemke CJ, Leake BF, Kim RB, Tirona RG (2010) Human skeletal muscle drug transporters determine local exposure and toxicity of statins. Circ Res 106(2):297-306. doi:10.1161/ circresaha.109.203596
    • (2010) Circ Res , vol.106 , Issue.2 , pp. 297-306
    • Knauer, M.J.1    Urquhart, B.L.2    Schwabedissen, H.3    Schwarz, U.I.4    Lemke, C.J.5    Leake, B.F.6    Kim, R.B.7    Tirona, R.G.8
  • 47
    • 84868137110 scopus 로고    scopus 로고
    • Gene expression analysis for statin-induced cytotoxicity from rat primary hepatocytes
    • Ko M-J, Ahn J-I, Shin HJ, Kim HS, Chung HJ, Jeong H-S (2010) Gene expression analysis for statin-induced cytotoxicity from rat primary hepatocytes. Genome Inform 8(1):41-49
    • (2010) Genome Inform , vol.8 , Issue.1 , pp. 41-49
    • Ko, M.-J.1    Ahn, J.-I.2    Shin, H.J.3    Kim, H.S.4    Chung, H.J.5    Jeong, H.-S.6
  • 48
    • 0027319127 scopus 로고
    • Regulation of phenobarbital-inducible cytochrome-p450 2b1/2 mrna by lovastatin and oxysterols in primary cultures of adult rat hepatocytes
    • doi 101006/taap1993.1115
    • Kocarek TA, Schuetz EG, Guzelian PS (1993) Regulation of phenobarbital-inducible cytochrome-P450 2B1/2 mRNA by lovastatin and oxysterols in primary cultures of adult rat hepatocytes. Toxicol Appl Pharmacol 120(2):298-307. doi: 10.1006/taap.1993.1115
    • (1993) Toxicol Appl Pharmacol , vol.120 , Issue.2 , pp. 298-307
    • Kocarek, T.A.1    Schuetz, E.G.2    Guzelian, P.S.3
  • 49
    • 41749119661 scopus 로고    scopus 로고
    • Liver and muscle metabolic changes induced by dietary energy content and genetic selection in rainbow trout (oncorhynchus mykiss)
    • doi:10.1152/ajpregu.00766.2007
    • Kolditz C, Borthaire M, Richard N, Corraze G, Panserat S, Vachot C, Lefevre F, Medale F (2008) Liver and muscle metabolic changes induced by dietary energy content and genetic selection in rainbow trout (Oncorhynchus mykiss). Am J Physiol Regul Integr Comp Physiol 294(4):R1154-R1164. doi:10.1152/ajpregu. 00766.2007
    • (2008) Am J Physiol Regul Integr Comp Physiol , vol.294 , Issue.4
    • Kolditz, C.1    Borthaire, M.2    Richard, N.3    Corraze, G.4    Panserat, S.5    Vachot, C.6    Lefevre, F.7    Medale, F.8
  • 50
    • 22544444514 scopus 로고    scopus 로고
    • Caspase-independent cell death
    • doi101038/nm1263
    • Kroemer G, Martin SJ (2005) Caspase-independent cell death. Nat Med 11(7):725-730. doi:10.1038/nm1263
    • (2005) Nat Med , vol.11 , Issue.7 , pp. 725-730
    • Kroemer, G.1    Martin, S.J.2
  • 51
    • 2442434564 scopus 로고    scopus 로고
    • Apoptotic injury in cultured human hepatocytes induced by hmg-coa reductase inhibitors
    • doi101016/jbcp2004.02037
    • Kubota T, Fujisaki K, Itoh Y, Yano T, Sendo T, Oishi R (2004) Apoptotic injury in cultured human hepatocytes induced by HMG-CoA reductase inhibitors. Biochem Pharmacol 67(12): 2175-2186. doi:10.1016/j.bcp.2004.02.037
    • (2004) Biochem Pharmacol , vol.67 , Issue.12 , pp. 2175-2186
    • Kubota, T.1    Fujisaki, K.2    Itoh, Y.3    Yano, T.4    Sendo, T.5    Oishi, R.6
  • 52
    • 79955728799 scopus 로고    scopus 로고
    • Uptake from water, biotransformation, and biliary excretion of pharmaceuticals by rainbow trout
    • doi:10.1002/etc.501
    • Lahti M, Brozinski J-M, Jylha A, Kronberg L, Oikari A (2011) Uptake from water, biotransformation, and biliary excretion of pharmaceuticals by rainbow trout. Environ Toxicol Chem 30(6):1403-1411. doi:10.1002/etc.501
    • (2011) Environ Toxicol Chem , vol.30 , Issue.6 , pp. 1403-1411
    • Lahti, M.1    Brozinski, J.-M.2    Jylha, A.3    Kronberg, L.4    Oikari, A.5
  • 54
    • 79951496270 scopus 로고    scopus 로고
    • Input of selected human pharmaceutical metabolites into the norwegian aquatic environment
    • doi:10.1039/c0em00342e
    • Langford K, Thomas KV (2011) Input of selected human pharmaceutical metabolites into the Norwegian aquatic environment. J Environ Monit 13(2):416-421. doi:10.1039/c0em00342e
    • (2011) J Environ Monit , vol.13 , Issue.2 , pp. 416-421
    • Langford, K.1    Thomas, K.V.2
  • 55
    • 0035025428 scopus 로고    scopus 로고
    • Responses of chub (leuciscus cephalus) populations to chemical stress, assessed by genetic markers, dna damage and cytochrome p4501a induction
    • doi 101023/a1016637809483
    • Larno V, Laroche J, Launey S, Flammarion P, Devaux A (2001) Responses of chub (Leuciscus cephalus) populations to chemical stress, assessed by genetic markers, DNA damage and cytochrome P4501A induction. Ecotoxicology 10(3):145-158. doi: 10.1023/a:1016637809483
    • (2001) Ecotoxicology , vol.10 , Issue.3 , pp. 145-158
    • Larno, V.1    Laroche, J.2    Launey, S.3    Flammarion, P.4    Devaux, A.5
  • 56
    • 76849108262 scopus 로고    scopus 로고
    • Hmgcoa reductase inhibitors (statins) activate expression of ppara/pparc and abca1 in cultured gallbladder epithelial cells
    • Lee J, Hong E, Koh D, Choi M, Jang H, Kae S, Choi H (2010) HMGCoA reductase inhibitors (statins) activate expression of PPARa/PPARc and ABCA1 in cultured gallbladder epithelial cells. Dig Dis Sci 55(2):292-299
    • (2010) Dig Dis Sci , vol.55 , Issue.2 , pp. 292-299
    • Lee, J.1    Hong, E.2    Koh, D.3    Choi, M.4    Jang, H.5    Kae, S.6    Choi, H.7
  • 57
    • 0242383181 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of atorvastatin
    • Lennernas H (2003) Clinical pharmacokinetics of atorvastatin. Clin Pharmacokinet 42(13):1141-1160
    • (2003) Clin Pharmacokinet , vol.42 , Issue.13 , pp. 1141-1160
    • Lennernas, H.1
  • 58
    • 0032773242 scopus 로고    scopus 로고
    • Cyp1a expression in liver and gill of rainbow trout following waterborne exposure: Implications for biomarker determination
    • doi: 10.1016/s0166-445x(98)00124-6
    • Levine SL, Oris JT (1999) CYP1A expression in liver and gill of rainbow trout following waterborne exposure: Implications for biomarker determination. Aquat Toxicol 46(3-4):279-287. doi: 10.1016/s0166-445x(98)00124-6
    • (1999) Aquat Toxicol , vol.46 , Issue.3-4 , pp. 279-287
    • Levine, S.L.1    Oris, J.T.2
  • 59
    • 23944501996 scopus 로고    scopus 로고
    • A teleost in vitro reporter gene assay to screen for agonists of the peroxisome proliferator-Activated receptors
    • Liu G, Moon TW, Metcalfe CD, Lee LEJ, Trudeau VL (2005) A teleost in vitro reporter gene assay to screen for agonists of the peroxisome proliferator-Activated receptors. Environ Toxicol Chem 24(9):2260-2266
    • (2005) Environ Toxicol Chem , vol.24 , Issue.9 , pp. 2260-2266
    • Liu, G.1    Moon, T.W.2    Metcalfe, C.D.3    Lee, L.E.J.4    Trudeau, V.L.5
  • 60
    • 72049101172 scopus 로고    scopus 로고
    • Gene expression analysis of the abc efflux transporters in rainbow trout (oncorhynchus mykiss)
    • doi101016/jcbpc.2009.10009
    • Loncar J, Popovic M, Zaja R, Smital T (2010) Gene expression analysis of the ABC efflux transporters in rainbow trout (Oncorhynchus mykiss). Comp Biochem Physiol C 151(2):209-215. doi:10.1016/j.cbpc.2009.10.009
    • (2010) Comp Biochem Physiol C , vol.151 , Issue.2 , pp. 209-215
    • Loncar, J.1    Popovic, M.2    Zaja, R.3    Smital, T.4
  • 63
    • 0024580571 scopus 로고
    • In vitro stimulation of na-k-Atpase activity and ouabain binding by cortisol in coho salmon gill
    • McCormick SD, Bern HA (1989) In vitro stimulation of Na-K-ATPase activity and ouabain binding by cortisol in coho salmon gill. Am J Physiol Regul Integr Comp Physiol 256(3):R707-R715
    • (1989) Am J Physiol Regul Integr Comp Physiol , vol.256 , Issue.3
    • McCormick, S.D.1    Bern, H.A.2
  • 65
    • 0345305721 scopus 로고    scopus 로고
    • Distribution of acidic and neutral drugs in surface waters near sewage treatment plants in the lower great lakes, canada
    • Metcalfe CD, Miao XS, Koenig BG, Struger J (2003) Distribution of acidic and neutral drugs in surface waters near sewage treatment plants in the lower Great Lakes, Canada. Environ Toxicol Chem 22(12):2881-2889
    • (2003) Environ Toxicol Chem , vol.22 , Issue.12 , pp. 2881-2889
    • Metcalfe, C.D.1    Miao, X.S.2    Koenig, B.G.3    Struger, J.4
  • 66
    • 78751648416 scopus 로고    scopus 로고
    • Ranscriptional control mechanisms of genes of lipid and fatty acid metabolism in the atlantic salmon (salmo salar l.) established cell line, shk-1
    • doi:10.1016/j.bbalip.2010.12.008
    • Minghetti M, Leaver MJ, Tocher DR (2011) Transcriptional control mechanisms of genes of lipid and fatty acid metabolism in the Atlantic salmon (Salmo salar L.) established cell line, SHK-1. Biochim Biophys Acta Mol Cell Biol Lipids 1811(3):194-202. doi:10.1016/j.bbalip.2010.12.008
    • (2011) Biochim Biophys Acta Mol Cell Biol Lipids , vol.1811 , Issue.3 , pp. 194-202
    • Minghetti, M.1    Leaver, M.J.2    Tocher, D.R.3
  • 68
    • 0034093374 scopus 로고    scopus 로고
    • Feedback and hormonal regulation of hepatic 3-hydroxy-3-methylglutaryl coenzyme a reductase: The concept of cholesterol buffering capacity
    • doi101111/j1525-1373.200022359x
    • Ness GC, Chambers CM (2000) Feedback and hormonal regulation of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase: The concept of cholesterol buffering capacity. Proc Soc Exp Biol Med 224(1):8-19. doi:10.1111/j.1525-1373. 2000.22359.x
    • (2000) Proc Soc Exp Biol Med , vol.224 , Issue.1 , pp. 8-19
    • Ness, G.C.1    Chambers, C.M.2
  • 69
    • 72849141790 scopus 로고    scopus 로고
    • Transporter pharmacogenetics and statin toxicity
    • doi101038/clpt2009.197
    • Niemi M (2009) Transporter pharmacogenetics and statin toxicity. Clin Pharmacol Ther 87(1):130-133. doi:10.1038/clpt.2009.197
    • (2009) Clin Pharmacol Ther , vol.87 , Issue.1 , pp. 130-133
    • Niemi, M.1
  • 70
    • 79953901458 scopus 로고    scopus 로고
    • Organic anion transporting polypeptide 1b1: A genetically polymorphic transporter of major importance for hepatic drug uptake
    • doi:10.1124/pr.110.002857
    • Niemi M, Pasanen MK, Neuvonen PJ (2011) Organic anion transporting polypeptide 1B1: A genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev 63(1):157-181. doi:10.1124/pr.110.002857
    • (2011) Pharmacol Rev , vol.63 , Issue.1 , pp. 157-181
    • Niemi, M.1    Pasanen, M.K.2    Neuvonen, P.J.3
  • 71
    • 0036789519 scopus 로고    scopus 로고
    • Variation in gene expression within and among natural populations
    • Oleksiak MF, Churchill GA, Crawford DL (2002) Variation in gene expression within and among natural populations. Nat Genet 32(2):261-266
    • (2002) Nat Genet , vol.32 , Issue.2 , pp. 261-266
    • Oleksiak, M.F.1    Churchill, G.A.2    Crawford, D.L.3
  • 72
    • 18044392731 scopus 로고    scopus 로고
    • Drug-induced myopathies. An overview of the possible mechanisms
    • Owaczarek J, Jasinska M, Orszulak-Michalak D (2005) Drug-induced myopathies. An overview of the possible mechanisms. Pharm Represent 57:23-34
    • (2005) Pharm Represent , vol.57 , pp. 23-34
    • Owaczarek, J.1    Jasinska, M.2    Orszulak-Michalak, D.3
  • 73
    • 0036137131 scopus 로고    scopus 로고
    • Role of bcl-2 family members in caspaseindependent apoptosis during chlamydia infection
    • doi101128/iai70155-61.2002
    • Perfettini J-L, Reed JC, Israel N, Martinou J-C, Dautry-Varsat A, Ojcius DM (2002) Role of Bcl-2 family members in caspaseindependent apoptosis during chlamydia infection. Infect Immun 70(1):55-61. doi:10.1128/iai.70.1.55-61.2002
    • (2002) Infect Immun , vol.70 , Issue.1 , pp. 55-61
    • Perfettini, J.-L.1    Reed, J.C.2    Israel, N.3    Martinou, J.-C.4    Dautry-Varsat, A.5    Ojcius, D.M.6
  • 74
    • 0036581160 scopus 로고    scopus 로고
    • Relative expression software tool (rest-) for group-wise comparison and statistical analysis of relative expression results in real-Time pcr
    • doi:10.1093/nar/30.9.e36
    • Pfaffl MW, Horgan GW, Dempfle L (2002) Relative expression software tool (REST-) for group-wise comparison and statistical analysis of relative expression results in real-Time PCR. Nucleic Acids Res 30(9):e36. doi:10.1093/nar/30.9.e36
    • (2002) Nucleic Acids Res , vol.30 , Issue.9
    • Pfaffl, M.W.1    Horgan, G.W.2    Dempfle, L.3
  • 75
    • 77952583657 scopus 로고    scopus 로고
    • Stability studies of cholesterol lowering statin drugs in aqueous samples using hplc and lc-ms
    • doi 101007/s10311-009-0207-0210
    • Piecha M, Sarakha M, Trebse P, Kocar D (2009) Stability studies of cholesterol lowering statin drugs in aqueous samples using HPLC and LC-MS. Environ Chem Lett 8(2):185-191. doi: 10.1007/s10311-009-0207-0
    • (2009) Environ Chem Lett , vol.8 , Issue.2 , pp. 185-191
    • Piecha, M.1    Sarakha, M.2    Trebse, P.3    Kocar, D.4
  • 76
    • 79952002831 scopus 로고    scopus 로고
    • The fibrate drug gemfibrozil disrupts lipoprotein metabolism in rainbow trout
    • doi:10.1016/j.taap.2010.12.013
    • Prindiville JS, Mennigen JA, Zamora JM, Moon TW, Weber J-M (2011) The fibrate drug gemfibrozil disrupts lipoprotein metabolism in rainbow trout. Toxicol Appl Pharmacol 251(3): 201-208. doi:10.1016/j.taap.2010.12.013
    • (2011) Toxicol Appl Pharmacol , vol.251 , Issue.3 , pp. 201-208
    • Prindiville, J.S.1    Mennigen, J.A.2    Zamora, J.M.3    Moon, T.W.4    Weber, J.-M.5
  • 78
    • 34548318655 scopus 로고    scopus 로고
    • Reduction of protein synthesis and statin-induced cardiomyocyte cell death
    • doi101007/s12012-007-0003-0007
    • Rabkin S, Lodha P, Kong J (2007) Reduction of protein synthesis and statin-induced cardiomyocyte cell death. Cardiovasc Toxicol 7(1):1-9. doi:10.1007/s12012-007-0003-7
    • (2007) Cardiovasc Toxicol , vol.7 , Issue.1 , pp. 1-9
    • Rabkin, S.1    Lodha, P.2    Kong, J.3
  • 79
    • 3242809022 scopus 로고    scopus 로고
    • Cadmium-induced apoptosis through the mitochondrial pathway in rainbow trout hepatocytes: Involvement of oxidative stress
    • Risso-de Faverney C, Orsini N, de Sousa G, Rahmani R (2004) Cadmium-induced apoptosis through the mitochondrial pathway in rainbow trout hepatocytes: Involvement of oxidative stress. Aquat Toxicol 69(3):247-258
    • (2004) Aquat Toxicol , vol.69 , Issue.3 , pp. 247-258
    • Risso-De Faverney, C.1    Orsini, N.2    De Sousa, G.3    Rahmani, R.4
  • 80
    • 77951269333 scopus 로고    scopus 로고
    • Efflux and uptake transporters as determinants of statin response
    • doi:10.1517/17425251003713519
    • Rodrigues AC (2010) Efflux and uptake transporters as determinants of statin response. Expert Opin Drug Metab Toxicol 6(5): 621-632. doi:10.1517/17425251003713519
    • (2010) Expert Opin Drug Metab Toxicol , vol.6 , Issue.5 , pp. 621-632
    • Rodrigues, A.C.1
  • 81
    • 0033990048 scopus 로고    scopus 로고
    • Primer3 on the www for general users and for biologist programmers
    • In: Krawetz S, Misener S (eds), Humana Press, Totowa
    • Rozen S, Skaletsky H (2000) Primer3 on the WWW for general users and for biologist programmers. In: Krawetz S, Misener S (eds) Bioinformatics methods and protocols: Methods in molecular biology, vol 132. Humana Press, Totowa, pp 365-386
    • (2000) Bioinformatics Methods and Protocols: Methods in Molecular Biology , vol.132 , pp. 365-386
    • Rozen, S.1    Skaletsky, H.2
  • 82
    • 0036738444 scopus 로고    scopus 로고
    • Regulation of hepatic lowdensity lipoprotein receptor, 3-hydroxy-3-methylglutaryl coenzyme a reductase, and cholesterol 7alpha-hydroxylase mrnas in human liver
    • doi 101210/jc.2002-012041
    • Rudling M, Angelin B, Stahle L, Reihner E, Sahlin S, Olivecrona H, Bjorkhem I, Einarsson C (2002) Regulation of hepatic lowdensity lipoprotein receptor, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and cholesterol 7alpha-hydroxylase mRNAs in human liver. J Clin Endocrinol Metab 87(9):4307-4313. doi: 10.1210/jc.2002-012041
    • (2002) J Clin Endocrinol Metab , vol.87 , Issue.9 , pp. 4307-4313
    • Rudling, M.1    Angelin, B.2    Stahle, L.3    Reihner, E.4    Sahlin, S.5    Olivecrona, H.6    Bjorkhem, I.7    Einarsson, C.8
  • 83
    • 23944515089 scopus 로고    scopus 로고
    • Delineation of myotoxicity induced by 3-hydroxy-3-methylglutaryl coa reductase inhibitors in human skeletal muscle cells
    • Sacher J, Weigl L, Werner M, Szegedi C, Hohenegger M (2005) Delineation of myotoxicity induced by 3-hydroxy-3-methylglutaryl CoA reductase inhibitors in human skeletal muscle cells. J Pharmacol Exp Ther 314:1032-1041
    • (2005) J Pharmacol Exp Ther , vol.314 , pp. 1032-1041
    • Sacher, J.1    Weigl, L.2    Werner, M.3    Szegedi, C.4    Hohenegger, M.5
  • 85
    • 48249083431 scopus 로고    scopus 로고
    • Statin-induced inhibition of mcf-7 breast cancer cell proliferation is related to cell cycle arrest and apoptotic and necrotic cell death mediated by an enhanced oxidative stress
    • doi 101080/07357900701874658
    • Sanchez CA, Rodriguez E, Varela E, Zapata E, Paez A, Masso FA, Montano LF, Lopez-Marure R (2008) Statin-induced inhibition of MCF-7 breast cancer cell proliferation is related to cell cycle arrest and apoptotic and necrotic cell death mediated by an enhanced oxidative stress. Cancer Invest 26(7):698-707. doi: 10.1080/07357900701874658
    • (2008) Cancer Invest , vol.26 , Issue.7 , pp. 698-707
    • Sanchez, C.A.1    Rodriguez, E.2    Varela, E.3    Zapata, E.4    Paez, A.5    Masso, F.A.6    Montano, L.F.7    Lopez-Marure, R.8
  • 86
    • 33947097991 scopus 로고    scopus 로고
    • Pharmacogenetics and pharmacogenomics of cholesterol-lowering therapy
    • Schmitz G, Schmitz-Madry A, Ugocsai P (2007) Pharmacogenetics and pharmacogenomics of cholesterol-lowering therapy. Curr Opin Lipidol 18:164-173
    • (2007) Curr Opin Lipidol , vol.18 , pp. 164-173
    • Schmitz, G.1    Schmitz-Madry, A.2    Ugocsai, P.3
  • 87
    • 14844327531 scopus 로고    scopus 로고
    • Simvastatin triggers mitochondria-induced ca2 signaling alteration in skeletal muscle
    • Sirvent P, Mercier J, Vassort G, Lacampagne A (2005) Simvastatin triggers mitochondria-induced Ca2 signaling alteration in skeletal muscle. Biochem Biophys Res Commun 329(3): 1067-1075
    • (2005) Biochem Biophys Res Commun , vol.329 , Issue.3 , pp. 1067-1075
    • Sirvent, P.1    Mercier, J.2    Vassort, G.3    Lacampagne, A.4
  • 88
    • 44649143800 scopus 로고    scopus 로고
    • New insights into mechanisms of statin-Associated myotoxicity
    • Sirvent P, Mercier J, Lacampagne A (2008) New insights into mechanisms of statin-Associated myotoxicity. Curr Opin Pharmacol 8(3):333-338
    • (2008) Curr Opin Pharmacol , vol.8 , Issue.3 , pp. 333-338
    • Sirvent, P.1    Mercier, J.2    Lacampagne, A.3
  • 89
    • 70449686372 scopus 로고    scopus 로고
    • Rainbow trout genetically selected for greater muscle fat content display increased activation of liver tor signaling and lipogenic gene expression
    • doi:10.1152/ajpregu.00312.2009
    • Skiba-Cassy S, Lansard M, Panserat S, Medale F (2009) Rainbow trout genetically selected for greater muscle fat content display increased activation of liver TOR signaling and lipogenic gene expression. Am J Physiol Regul Integr Comp Physiol 297(5):R1421-R1429. doi:10.1152/ajpregu.00312.2009
    • (2009) Am J Physiol Regul Integr Comp Physiol , vol.297 , Issue.5
    • Skiba-Cassy, S.1    Lansard, M.2    Panserat, S.3    Medale, F.4
  • 90
    • 41349113141 scopus 로고    scopus 로고
    • Statin induced myotoxicity: The lactone forms are more potent than the acid forms in human skeletal muscle cells in vitro
    • Skottheim IB, Gedde-Dahl A, Hejazifar S, Hoel K, A ° sberg A (2008) Statin induced myotoxicity: The lactone forms are more potent than the acid forms in human skeletal muscle cells in vitro. Eur J Pharm Sci 33(4-5):317-325
    • (2008) Eur J Pharm Sci , vol.33 , Issue.4-5 , pp. 317-325
    • Skottheim, I.B.1    Gedde-Dahl, A.2    Hejazifar, S.3    Hoel, K.4    Asberg, A.5
  • 91
    • 77957068574 scopus 로고    scopus 로고
    • P-glycoproteins and xenobiotic efflux transport in fish
    • In: Mommsen TP, Hochachka PW (eds), Elsevier, Amsterdam
    • Sturm A, Segner H (2005) P-glycoproteins and xenobiotic efflux transport in fish. In: Mommsen TP, Hochachka PW (eds) Biochemistry and molecular biology of fishes, vol 6. Elsevier, Amsterdam, pp 495-533
    • (2005) Biochemistry and Molecular Biology of Fishes , vol.6 , pp. 495-533
    • Sturm, A.1    Segner, H.2
  • 92
    • 0034791497 scopus 로고    scopus 로고
    • Expression and functional activity of p-glycoprotein in cultured hepatocytes from oncorhynchus mykiss
    • Sturm A, Ziemann C, Hirsch-Ernst KI, Segner H (2001) Expression and functional activity of P-glycoprotein in cultured hepatocytes from Oncorhynchus mykiss. Am J Physiol Regul Integr Comp Physiol 281(4):R1119-R1126
    • (2001) Am J Physiol Regul Integr Comp Physiol , vol.281 , Issue.4
    • Sturm, A.1    Ziemann, C.2    Hirsch-Ernst, K.I.3    Segner, H.4
  • 93
    • 36549069768 scopus 로고    scopus 로고
    • Caspases and apoptosis in fish
    • (sc
    • Takle H, Andersen Ø (2007) Caspases and apoptosis in fish. J Fish Biol 71(sc):326-349
    • (2007) J Fish Biol , vol.71 , pp. 326-349
    • Takle, H.1    Andersen, O.2
  • 94
    • 0442294188 scopus 로고    scopus 로고
    • Germ cell migration in zebrafish is dependent on hmgcoa reductase activity and prenylation
    • Thorpe JL, Doitsidou M, Ho S-Y, Raz E, Farber SA (2004) Germ cell migration in zebrafish is dependent on HMGCoA reductase activity and prenylation. Dev Cell 6(2):295-302
    • (2004) Dev Cell , vol.6 , Issue.2 , pp. 295-302
    • Thorpe, J.L.1    Doitsidou, M.2    Ho, S.-Y.3    Raz, E.4    Farber, S.A.5
  • 95
    • 0037129827 scopus 로고    scopus 로고
    • Accurate normalization of real-Time quantitative rt-pcr data by geometric averaging of multiple internal control genes
    • research0034.1-research0034.11
    • Vandesompele J, Preter KD, Pattyn F, Poppe B, Roy NV, Paepe AD, Speleman F (2001) Accurate normalization of real-Time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol 3(7):research0034.1-research0034.11
    • (2001) Genome Biol , vol.3 , pp. 7
    • Vandesompele, J.1    Preter, K.D.2    Pattyn, F.3    Poppe, B.4    Roy, N.V.5    Paepe, A.D.6    Speleman, F.7
  • 96
    • 0343048978 scopus 로고    scopus 로고
    • Improvement of nitric oxide-dependent vasodilatation by hmgcoa reductase inhibitors through attenuation of endothelial superoxide anion formation
    • Wagner AH, Kohler T, Ruckschloss U, Just I, Hecker M (2000) Improvement of nitric oxide-dependent vasodilatation by HMGCoA reductase inhibitors through attenuation of endothelial superoxide anion formation. Arterioscler Thromb Vasc Biol 20(1):61-69
    • (2000) Arterioscler Thromb Vasc Biol , vol.20 , Issue.1 , pp. 61-69
    • Wagner, A.H.1    Kohler, T.2    Ruckschloss, U.3    Just, I.4    Hecker, M.5
  • 97
    • 23044436687 scopus 로고    scopus 로고
    • Car and pxr agonists stimulate hepatic bile acid and bilirubin detoxification and elimination pathways in mice
    • doi101002/he20784
    • Wagner M, Halilbasic E, Marschall HU, Zollner G, Fickert P, Langner C, Zatloukal K, Denk H, Trauner M (2005) CAR and PXR agonists stimulate hepatic bile acid and bilirubin detoxification and elimination pathways in mice. Hepatology 42(2):420-430. doi:10.1002/hep.20784
    • (2005) Hepatology , vol.42 , Issue.2 , pp. 420-430
    • Wagner, M.1    Halilbasic, E.2    Marschall, H.U.3    Zollner, G.4    Fickert, P.5    Langner, C.6    Zatloukal, K.7    Denk, H.8    Trauner, M.9
  • 98
    • 0034866642 scopus 로고    scopus 로고
    • Hmg-coa reductase inhibitors (statins) characterized as direct inhibitors of p-glycoprotein
    • Wang E, Casciano CN, Clement RP, Johnson WW (2001) HMG-CoA reductase inhibitors (statins) characterized as direct inhibitors of P-glycoprotein. Pharm Res 18(6):800-806
    • (2001) Pharm Res , vol.18 , Issue.6 , pp. 800-806
    • Wang, E.1    Casciano, C.N.2    Clement, R.P.3    Johnson, W.W.4
  • 99
    • 77957591569 scopus 로고    scopus 로고
    • Interactions of pharmaceuticals and other xenobiotics on hepatic pregnane x receptor and cytochrome p450 3a signaling pathway in rainbow trout (oncorhynchus mykiss
    • doi: 10.1016/j.aquatox.2010.07.013
    • Wassmur B, Grans J, Kling P, Celander MC (2010) Interactions of pharmaceuticals and other xenobiotics on hepatic pregnane X receptor and cytochrome P450 3A signaling pathway in rainbow trout (Oncorhynchus mykiss). Aquat Toxicol 100(1):91-100. doi: 10.1016/j.aquatox.2010.07.013
    • (2010) Aquat Toxicol , vol.100 , Issue.1 , pp. 91-100
    • Wassmur, B.1    Grans, J.2    Kling, P.3    Celander, M.C.4
  • 101
    • 62649141791 scopus 로고    scopus 로고
    • Effects of acid and lactone forms of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors on the induction of mdr1 expression and function in ls180 cells
    • Yamasaki D, Nakamura T, Okamura N, Kokudai M, Inui N, Takeuchi K, Watanabe H, Hirai M, Okumura K, Sakaeda T (2009) Effects of acid and lactone forms of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on the induction of MDR1 expression and function in LS180 cells. Eur J Pharm Sci 37(2): 126-132
    • (2009) Eur J Pharm Sci , vol.37 , Issue.2 , pp. 126-132
    • Yamasaki, D.1    Nakamura, T.2    Okamura, N.3    Kokudai, M.4    Inui, N.5    Takeuchi, K.6    Watanabe, H.7    Hirai, M.8    Okumura, K.9    Sakaeda, T.10
  • 102
    • 0004252445 scopus 로고    scopus 로고
    • 4th edn. Prentice Hall, Upper Saddle River
    • Zar JH (1999) Biostatistical analysis, 4th edn. Prentice Hall, Upper Saddle River
    • (1999) Biostatistical Analysis
    • Zar, J.H.1
  • 103
    • 77951855300 scopus 로고    scopus 로고
    • Tissue-specific in vivo bioconcentration of pharmaceuticals in rainbow trout (oncorhynchus mykiss) using space-resolved solid-phase microextraction
    • doi:10.1021/es903064t
    • Zhang X, Oakes KD, Cui S, Bragg L, Servos MR, Pawliszyn J (2010) Tissue-specific in vivo bioconcentration of pharmaceuticals in rainbow trout (Oncorhynchus mykiss) using space-resolved solid-phase microextraction. Environ Sci Technol 44(9): 3417-3422. doi:10.1021/es903064t
    • (2010) Environ Sci Technol , vol.44 , Issue.9 , pp. 3417-3422
    • Zhang, X.1    Oakes, K.D.2    Cui, S.3    Bragg, L.4    Servos, M.R.5    Pawliszyn, J.6
  • 104
    • 33846169366 scopus 로고    scopus 로고
    • Toxicological effects of the lipid regulator gemfibrozil in four aquatic systems
    • doi101016/jaquatox2006.11007
    • Zurita JL, Repetto G, Jos A, Salguero M, Lopez-Artiguez M, Camean AM (2007) Toxicological effects of the lipid regulator gemfibrozil in four aquatic systems. Aquat Toxicol 81(1):106-115. doi:10.1016/j.aquatox.2006.11.007
    • (2007) Aquat Toxicol , vol.81 , Issue.1 , pp. 106-115
    • Zurita, J.L.1    Repetto, G.2    Jos, A.3    Salguero, M.4    Lopez-Artiguez, M.5    Camean, A.M.6


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