메뉴 건너뛰기




Volumn 11, Issue , 2012, Pages

Antihyperglycemic and hypolipidemic effects of α,β-amyrin, a triterpenoid mixture from Protium heptaphyllum in mice

Author keywords

, amyrin; Antihyperglycemic and hypolipidemic effects; Mice; Pentacyclic triterpene; Protium heptaphyllum

Indexed keywords

ALPHA AMYRIN; ALPHA,BETA AMYRIN; ANTIDIABETIC AGENT; ANTILIPEMIC AGENT; BETA AMYRIN; CHOLESTEROL; FENOFIBRATE; GLIBENCLAMIDE; GLUCOSE; INSULIN; TRIACYLGLYCEROL; TRITERPENOID; UNCLASSIFIED DRUG;

EID: 84868112333     PISSN: None     EISSN: 1476511X     Source Type: Journal    
DOI: 10.1186/1476-511X-11-98     Document Type: Article
Times cited : (163)

References (41)
  • 1
    • 0036581966 scopus 로고    scopus 로고
    • Diabetic dyslipidemia
    • DOI 10.1016/S1567-5688(01)00006-X, PII S156756880100006X
    • Diabetic dyslipidemia. Taskinen MR, Atheroscler Suppl 2002 3 47 51 10.1016/S1567-5688(01)00006-X 12044586 (Pubitemid 38234478)
    • (2002) Atherosclerosis Supplements , vol.3 , Issue.1 , pp. 47-51
    • Taskinen, M.-R.1
  • 3
    • 33646526072 scopus 로고    scopus 로고
    • I want a new drug: G-protein-coupled receptors in drug development
    • 10.1016/j.drudis.2006.04.008 16713899
    • I want a new drug: G-protein-coupled receptors in drug development. Schlyer S, Horuk R, Drug Discov Today 2006 11 481 493 10.1016/j.drudis.2006.04. 008 16713899
    • (2006) Drug Discov Today , vol.11 , pp. 481-493
    • Schlyer, S.1    Horuk, R.2
  • 4
    • 69749127035 scopus 로고    scopus 로고
    • Antidiabetic and antioxidant effects of oleanolic acid from Ligustrum lucidum Ait in alloxan-induced diabetic rats
    • 10.1002/ptr.2603 19274687
    • Antidiabetic and antioxidant effects of oleanolic acid from Ligustrum lucidum Ait in alloxan-induced diabetic rats. Gao D, Li Q, Li Y, Liu Z, Fan Y, Liu Z, Zhao H, Li J, Han Z, Phytother Res 2009 23 1257 1262 10.1002/ptr.2603 19274687
    • (2009) Phytother Res , vol.23 , pp. 1257-1262
    • Gao, D.1    Li, Q.2    Li, Y.3    Liu, Z.4    Fan, Y.5    Liu, Z.6    Zhao, H.7    Li, J.8    Han, Z.9
  • 5
    • 77954997237 scopus 로고    scopus 로고
    • Glycyrrhizic acid improved lipoprotein lipase expression, insulin sensitivity, serum lipid and lipid deposition in high-fat diet-induced obese rats
    • 10.1186/1476-511X-9-81 20670429
    • Glycyrrhizic acid improved lipoprotein lipase expression, insulin sensitivity, serum lipid and lipid deposition in high-fat diet-induced obese rats. Eu CH, Lim WY, Ton SH, bin Abdul Kadir K, Lipids Health Dis 2010 9 81 90 10.1186/1476-511X-9-81 20670429
    • (2010) Lipids Health Dis , vol.9 , pp. 81-90
    • Eu, C.H.1    Lim, W.Y.2    Ton, S.H.3    Bin Abdul Kadir, K.4
  • 6
    • 77957737171 scopus 로고    scopus 로고
    • Effect of corosolic acid on dietary hypercholesterolemia and hepatic steatosis in KK-Ay diabetic mice
    • 10.2220/biomedres.31.213 20834178
    • Effect of corosolic acid on dietary hypercholesterolemia and hepatic steatosis in KK-Ay diabetic mice. Takagi S, Miura T, Ishihara E, Ishida T, Chinzei Y, Biomedical Research 2010 31 213 218 10.2220/biomedres.31.213 20834178
    • (2010) Biomedical Research , vol.31 , pp. 213-218
    • Takagi, S.1    Miura, T.2    Ishihara, E.3    Ishida, T.4    Chinzei, Y.5
  • 7
    • 79952026605 scopus 로고    scopus 로고
    • Synthesis, biology and clinical significance of pentacyclic triterpenes: A multi-target approach to prevention and treatment of metabolic and vascular diseases
    • 10.1039/c0np00059k 21290067
    • Synthesis, biology and clinical significance of pentacyclic triterpenes: a multi-target approach to prevention and treatment of metabolic and vascular diseases. Sheng H, Sun H, Nat Prod Rep 2011 28 543 593 10.1039/c0np00059k 21290067
    • (2011) Nat Prod Rep , vol.28 , pp. 543-593
    • Sheng, H.1    Sun, H.2
  • 9
    • 80051664374 scopus 로고    scopus 로고
    • Anti-inflammatory effect of α,β-amyrin, a triterpene from Protium heptaphyllum, on cerulein-induced acute pancreatitis in mice
    • 10.1007/s00011-011-0321-x 21400110
    • Anti-inflammatory effect ofα,β-amyrin, a triterpene from Protium heptaphyllum, on cerulein-induced acute pancreatitis in mice. Melo CM, Morais TC, Tomé AR, Brito GA, Chaves MH, Rao VS, Santos FA, Inflamm Res 2011 60 673 681 10.1007/s00011-011-0321-x 21400110
    • (2011) Inflamm Res , vol.60 , pp. 673-681
    • Melo, C.M.1    Morais, T.C.2    Tomé, A.R.3    Brito, G.A.4    Chaves, M.H.5    Rao, V.S.6    Santos, F.A.7
  • 10
    • 39149117712 scopus 로고    scopus 로고
    • Anti-inflammatory effect of alpha, beta-amyrin, a pentacyclic triterpene from Protium heptaphyllum in rat model of acute periodontitis
    • 10.1007/s10787-007-1609-x 18046512
    • Anti-inflammatory effect of alpha, beta-amyrin, a pentacyclic triterpene from Protium heptaphyllum in rat model of acute periodontitis. Holanda Pinto SA, Pinto LM, Cunha GM, Chaves MH, Santos FA, Rao VS, Inflammopharmacology 2008 16 48 52 10.1007/s10787-007-1609-x 18046512
    • (2008) Inflammopharmacology , vol.16 , pp. 48-52
    • Holanda Pinto, S.A.1    Pinto, L.M.2    Cunha, G.M.3    Chaves, M.H.4    Santos, F.A.5    Rao, V.S.6
  • 11
    • 70350339816 scopus 로고    scopus 로고
    • Therapeutic action and underlying mechanisms of a combination of two pentacyclic triterpenes, alpha- and beta-amyrin, in a mouse model of colitis
    • 10.1111/j.1476-5381.2009.00271.x 19508397
    • Therapeutic action and underlying mechanisms of a combination of two pentacyclic triterpenes, alpha- and beta-amyrin, in a mouse model of colitis. Vitor CE, Figueiredo CP, Hara DB, Bento AF, Mazzuco TL, Calixto JB, Br J Pharmacol 2009 157 1034 1044 10.1111/j.1476-5381.2009.00271.x 19508397
    • (2009) Br J Pharmacol , vol.157 , pp. 1034-1044
    • Vitor, C.E.1    Figueiredo, C.P.2    Hara, D.B.3    Bento, A.F.4    Mazzuco, T.L.5    Calixto, J.B.6
  • 12
    • 79960473402 scopus 로고    scopus 로고
    • Activation of cannabinoid receptors by the pentacyclic triterpene α,β-amyrin inhibits inflammatory and neuropathic persistent pain in mice
    • 10.1016/j.pain.2011.04.005 21620566
    • Activation of cannabinoid receptors by the pentacyclic triterpeneα,β-amyrin inhibits inflammatory and neuropathic persistent pain in mice. da Silva KA, Paszcuk AF, Passos GF, Silva ES, Bento AF, Meotti FC, Calixto JB, Pain 2011 152 1872 1887 10.1016/j.pain.2011.04.005 21620566
    • (2011) Pain , vol.152 , pp. 1872-1887
    • Da Silva, K.A.1    Paszcuk, A.F.2    Passos, G.F.3    Silva, E.S.4    Bento, A.F.5    Meotti, F.C.6    Calixto, J.B.7
  • 13
    • 84867386846 scopus 로고    scopus 로고
    • The antinociceptive triterpene -amyrin inhibits 2-arachidonoylglycerol (2-AG) hydrolysis without directly targeting CB receptors
    • press 10.1111/j.1476-5381.2012.02059.x
    • The antinociceptive triterpene -amyrin inhibits 2-arachidonoylglycerol (2-AG) hydrolysis without directly targeting CB receptors. Chicca A, Marazzi J, Gertsch J, Br J Pharmacol 2012 in press 10.1111/j.1476-5381.2012.02059.x
    • (2012) Br J Pharmacol
    • Chicca, A.1    Marazzi, J.2    Gertsch, J.3
  • 15
    • 4444261144 scopus 로고    scopus 로고
    • Gastroprotective effect of the mixture of alpha- and beta-amyrin from Protium heptaphyllum: Role of capsaicin-sensitive primary afferent neurons
    • DOI 10.1055/s-2004-827212
    • Gastroprotective effect of the mixture of alpha- and beta-amyrin from Protium heptaphyllum: role of capsaicin-sensitive primary afferent neurons. Oliveira FA, Vieira-Júnior GM, Chaves MH, Almeida FR, Santos KA, Martins FS, Silva RM, Santos FA, Rao VS, Planta Med 2004 70 780 782 15368675 (Pubitemid 39178942)
    • (2004) Planta Medica , vol.70 , Issue.8 , pp. 780-782
    • Oliveira, F.A.1    Vieira Jr., G.M.2    Chaves, M.H.3    Almeida, F.R.C.4    Santos, K.A.5    Martins, F.S.6    Silva, R.M.7    Santos, F.A.8    Rao, V.S.N.9
  • 16
    • 14844310290 scopus 로고    scopus 로고
    • Protective effect of alpha- And beta-amyrin, a triterpene mixture from Protium heptaphyllum (Aubl.) March. trunk wood resin, against acetaminophen-induced liver injury in mice
    • DOI 10.1016/j.jep.2005.01.036
    • Protective effect of alpha- and beta-amyrin, a triterpene mixture from Protium heptaphyllum (Aubl.) March. trunk wood resin, against acetaminophen-induced liver injury in mice. Oliveira FA, Chaves MH, Almeida FR, Lima RC, Silva RM, Maia JL, Brito GA, Santos FA, Rao VS, J Ethnopharmacol 2005 98 103 108 10.1016/j.jep.2005.01.036 15763370 (Pubitemid 40349174)
    • (2005) Journal of Ethnopharmacology , vol.98 , Issue.1-2 , pp. 103-108
    • Oliveira, F.A.1    Chaves, M.H.2    Almeida, F.R.C.3    Lima Jr., R.C.P.4    Silva, R.M.5    Maia, J.L.6    Brito, G.A.A.C.7    Santos, F.A.8    Rao, V.S.9
  • 17
    • 79953242026 scopus 로고    scopus 로고
    • New synthetic triterpenoids: Potent agents for prevention and treatment of tissue injury caused by inflammatory and oxidative stress
    • 10.1021/np100826q 21309592
    • New synthetic triterpenoids: potent agents for prevention and treatment of tissue injury caused by inflammatory and oxidative stress. Sporn MB, Liby KT, Yore MM, Fu L, Lopchuk JM, Gribble GW, J Nat Prod 2011 74 537 45 10.1021/np100826q 21309592
    • (2011) J Nat Prod , vol.74 , pp. 537-545
    • Sporn, M.B.1    Liby, K.T.2    Yore, M.M.3    Fu, L.4    Lopchuk, J.M.5    Gribble, G.W.6
  • 18
    • 0043166481 scopus 로고    scopus 로고
    • Diabetes-induced oxidative stress and low-grade inflammation in porcine coronary arteries
    • DOI 10.1161/01.CIR.0000080378.96063.23
    • Diabetes-Induced Oxidative Stress and Low-Grade Inflammation in Porcine Coronary Arteries. Zhang L, Zalewski A, Liu Y, Mazurek T, Cowan S, Martin JL, Hofmann SM, Vlassara H, Shi Y, Circulation 2003 108 472 478 10.1161/01.CIR. 0000080378.96063.23 12860917 (Pubitemid 36935542)
    • (2003) Circulation , vol.108 , Issue.4 , pp. 472-478
    • Zhang, L.1    Zalewski, A.2    Liu, Y.3    Mazurek, T.4    Cowan, S.5    Martin, J.L.6    Hofmann, S.M.7    Vlassara, H.8    Shi, Y.9
  • 19
    • 67650938870 scopus 로고    scopus 로고
    • Antihyperglycaemic activity of alpha-amyrin acetate in rats and db/db mice
    • 10.1080/14786410802420416 19488928
    • Antihyperglycaemic activity of alpha-amyrin acetate in rats and db/db mice. Singh AB, Yadav DK, Maurya R, Srivastava AK, Nat Prod Res 2009 23 876 882 10.1080/14786410802420416 19488928
    • (2009) Nat Prod Res , vol.23 , pp. 876-882
    • Singh, A.B.1    Yadav, D.K.2    Maurya, R.3    Srivastava, A.K.4
  • 20
    • 18244404049 scopus 로고    scopus 로고
    • Resina de Protium heptaphyllum: Isolamento, caracterização estrutural e avaliação das propriedades térmicas
    • Resina de Protium heptaphyllum: isolamento, caracterização estrutural e avaliação das propriedades térmicas. Vieira-Junior GM, Souza CML, Chaves MH, Química Nova 2005 28 183 187 23100143 (Pubitemid 40627577)
    • (2005) Quimica Nova , vol.28 , Issue.2 , pp. 183-187
    • Vieira Jr., G.M.1    Leite De Souza, C.M.2    Chaves, M.H.3
  • 21
    • 0001372524 scopus 로고
    • Análise de misturas de triterpenos por 13C NMR
    • 23100143
    • Análise de misturas de triterpenos por 13C NMR. Gallegos RS, Roque NE, Química Nova 1990 13 278 281 23100143
    • (1990) Química Nova , vol.13 , pp. 278-281
    • Gallegos, R.S.1    Roque, N.E.2
  • 22
    • 0031127508 scopus 로고    scopus 로고
    • Advances in triterpenoid research, 1990-1994
    • Advances in triterpenoid research, 1990-1994. Mahato SB, Sen S, Phytochemistry 1997 44 1165 1236
    • (1997) Phytochemistry , vol.44 , pp. 1165-1236
    • Mahato, S.B.1    Sen, S.2
  • 23
    • 0042882849 scopus 로고    scopus 로고
    • Protein kinase C beta inhibition and aorta and corpus cavernosum function in streptozotocin-diabetic mice
    • DOI 10.1016/S0014-2999(03)02113-7
    • Protein kinase C beta inhibition and aorta and corpus cavernosum function in streptozotocin-diabetic mice. Nangle MR, Cotter MA, Cameron NE, Eur J pharmacol 2003 475 99 106 10.1016/S0014-2999(03)02113-7 12954365 (Pubitemid 37088012)
    • (2003) European Journal of Pharmacology , vol.475 , Issue.1-3 , pp. 99-106
    • Nangle, M.R.1    Cotter, M.A.2    Cameron, N.E.3
  • 24
    • 0019940467 scopus 로고
    • Effects of stilbene components of the roots of Polygonum cuspidatum Sieb. et Zucc. on lipid metabolism
    • Effects of stilbene components of the roots of Polygonum cuspidatum Sieb. et Zucc. on lipid metabolism. Arichi H, Kimura Y, Okuda H, Baba K, Kozawa M, Arichi S, Chem Pharm Bull 1982 30 1766 1770 10.1248/cpb.30.1766 7116511 (Pubitemid 12029652)
    • (1982) Chemical and Pharmaceutical Bulletin , vol.30 , Issue.5 , pp. 1766-1770
    • Arichi, H.1    Kimura, Y.2    Okuda, H.3
  • 25
    • 0015348189 scopus 로고
    • Estimation of the Concentration of Low-Density Lipoprotein Cholesterol in Plasma, Without Use of the Preparative Ultracentrifuge
    • 4337382
    • Estimation of the Concentration of Low-Density Lipoprotein Cholesterol in Plasma, Without Use of the Preparative Ultracentrifuge. Friedewald WT, Levy RI, Fredrickson DS, Clinical Chemistry 1972 18 499 502 4337382
    • (1972) Clinical Chemistry , vol.18 , pp. 499-502
    • Friedewald, W.T.1    Levy, R.I.2    Fredrickson, D.S.3
  • 26
    • 73649197648 scopus 로고
    • Studies on the diabetogenic action of streptozotocin (NSC-37917)
    • 13990586
    • Studies on the diabetogenic action of streptozotocin (NSC-37917). Rakieten N, Rakieten ML, Nadkarni MV, Cancer Chemother Rep 1963 29 91 98 13990586
    • (1963) Cancer Chemother Rep , vol.29 , pp. 91-98
    • Rakieten, N.1    Rakieten, M.L.2    Nadkarni, M.V.3
  • 27
    • 84864508209 scopus 로고    scopus 로고
    • Antidiabetic, antihyperlipidemic and antioxidant effects of the flavonoid rich fraction of Pilea microphylla (L.) in high fat diet/streptozotocin-induced diabetes in mice
    • press 10.1016/j.etp.2010.12.009
    • Antidiabetic, antihyperlipidemic and antioxidant effects of the flavonoid rich fraction of Pilea microphylla (L.) in high fat diet/streptozotocin-induced diabetes in mice. Bansal P, Paul P, Mudgal J, Nayak PG, Thomas Pannakal S, Priyadarsini KI, Unnikrishnan MK, Exp Toxicol Pathol 2011 in press 10.1016/j.etp.2010.12.009
    • (2011) Exp Toxicol Pathol
    • Bansal, P.1    Paul, P.2    Mudgal, J.3    Nayak, P.G.4    Thomas Pannakal, S.5    Priyadarsini, K.I.6    Unnikrishnan, M.K.7
  • 29
    • 77950955698 scopus 로고    scopus 로고
    • Oleanolic acid, a natural triterpenoid improves blood glucose tolerance in normal mice and ameliorates visceral obesity in mice fed a high-fat diet
    • 10.1016/j.cbi.2010.02.028 20188082
    • Oleanolic acid, a natural triterpenoid improves blood glucose tolerance in normal mice and ameliorates visceral obesity in mice fed a high-fat diet. de Melo CL, Queiroz MG, Fonseca SG, Bizerra AM, Lemos TL, Melo TS, Santos FA, Rao VS, Chem Biol Interact 2010 185 59 65 10.1016/j.cbi.2010.02.028 20188082
    • (2010) Chem Biol Interact , vol.185 , pp. 59-65
    • De Melo, C.L.1    Queiroz, M.G.2    Fonseca, S.G.3    Bizerra, A.M.4    Lemos, T.L.5    Melo, T.S.6    Santos, F.A.7    Rao, V.S.8
  • 30
    • 80755175244 scopus 로고    scopus 로고
    • Ursolic acid, A pentacyclic triterpene from Sambucus australis, prevents abdominal adiposity in mice fed a high-fat diet
    • Ursolic acid, A pentacyclic triterpene from Sambucus australis, prevents abdominal adiposity in mice fed a high-fat diet. Rao VS, Melo CL, Queiroz MG, Lemos TL, Menezes DB, Melo TS, Santos FA, J Med Food 2001 14 1375 1382
    • (2001) J Med Food , vol.14 , pp. 1375-1382
    • Rao, V.S.1    Melo, C.L.2    Queiroz, M.G.3    Lemos, T.L.4    Menezes, D.B.5    Melo, T.S.6    Santos, F.A.7
  • 31
    • 79952379869 scopus 로고    scopus 로고
    • Protective effect of cyclo (his-pro) on streptozotocin-induced cytotoxicity and apoptosis in vitro
    • 10.4014/jmb.1012.12003 21364307
    • Protective effect of cyclo (his-pro) on streptozotocin-induced cytotoxicity and apoptosis in vitro. Koo KB, Suh HJ, Ra KS, Choi JW, J Microbiol Biotechnol 2011 21 218 227 10.4014/jmb.1012.12003 21364307
    • (2011) J Microbiol Biotechnol , vol.21 , pp. 218-227
    • Koo, K.B.1    Suh, H.J.2    Ra, K.S.3    Choi, J.W.4
  • 32
    • 84856348064 scopus 로고    scopus 로고
    • Central and peripheral cannabinoid receptors as therapeutic targets in the control of food intake and body weight
    • 10.1007/978-3-642-24716-3-17 22249824
    • Central and peripheral cannabinoid receptors as therapeutic targets in the control of food intake and body weight. Engeli S, Handb Exp Pharmacol 2012 209 357 381 10.1007/978-3-642-24716-3-17 22249824
    • (2012) Handb Exp Pharmacol , vol.209 , pp. 357-381
    • Engeli, S.1
  • 35
    • 79954529440 scopus 로고    scopus 로고
    • Quantification of - And -amyrin in rat plasma by gas chromatography-mass spectrometry: Application to preclinical pharmacokinetic study
    • 10.1002/jms.1912 21500304
    • Quantification of - and -amyrin in rat plasma by gas chromatography-mass spectrometry: application to preclinical pharmacokinetic study. Ching J, Lin HS, Tan CH, Koh HL, J Mass Spectrom 2011 46 457 64 10.1002/jms.1912 21500304
    • (2011) J Mass Spectrom , vol.46 , pp. 457-464
    • Ching, J.1    Lin, H.S.2    Tan, C.H.3    Koh, H.L.4
  • 37
    • 34848840575 scopus 로고    scopus 로고
    • Lipids behavior and adverse effects for oral antidiabetic agents in patients with type2 diabetes treated with sulfonylureas alone based on systematic review
    • DOI 10.1248/yakushi.127.1747
    • Lipids behavior and adverse effects for oral antidiabetic agents in patients with Type 2 diabetes treated with sulfonylureas alone based on systematic review. Mukai J, Tada H, Watanabe Y, Miura M, Katsuyama S, Shoji T, Mouri K, Eto M, Suzuki T, Yakugaku Zasshi 2007 127 1747 1756 10.1248/yakushi.127.1747 17917433 (Pubitemid 47511081)
    • (2007) Yakugaku Zasshi , vol.127 , Issue.10 , pp. 1747-1756
    • Mukai, J.1    Tada, H.2    Watanabe, Y.3    Miura, M.4    Katsuyama, S.5    Shoji, T.6    Mouri, K.7    Masaaki, E.T.O.8    Suzuki, T.9
  • 39
    • 74249084094 scopus 로고    scopus 로고
    • Stimulation of glucose uptake by triterpenoids from Weigela subsessilis
    • 10.1002/ptr.2865 19548274
    • Stimulation of glucose uptake by triterpenoids from Weigela subsessilis. Ms L, Thoung PT, Phytother Res 2010 24 49 53 10.1002/ptr.2865 19548274
    • (2010) Phytother Res , vol.24 , pp. 49-53
    • Ms, L.1    Thoung, P.T.2
  • 40
    • 65649116215 scopus 로고    scopus 로고
    • Alpha-glucosidase inhibitors from Luculia pinciana
    • 19459300
    • Alpha-glucosidase inhibitors from Luculia pinciana. Kang W, Zhang L, Song Y, Zhongguo Zhong Yao Za Zhi 2009 34 406 409 19459300
    • (2009) Zhongguo Zhong Yao Za Zhi , vol.34 , pp. 406-409
    • Kang, W.1    Zhang, L.2    Song, Y.3
  • 41
    • 80052388637 scopus 로고    scopus 로고
    • Increased very low density lipoprotein (VLDL) secretion, hepatic steatosis, and insulin resistance
    • 10.1016/j.tem.2011.04.007 21616678
    • Increased very low density lipoprotein (VLDL) secretion, hepatic steatosis, and insulin resistance. Choi SH, Ginsberg HN, Trends Endocrinol Metab 2011 22 353 363 10.1016/j.tem.2011.04.007 21616678
    • (2011) Trends Endocrinol Metab , vol.22 , pp. 353-363
    • Choi, S.H.1    Ginsberg, H.N.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.