Gastroprotective effect of the mixture of α- and β-amyrin from Protium heptaphyllum: Role of capsaicin-sensitive primary afferent neurons

Planta Medica

Volumn 70, Issue 8, 2004, Pages 780-782

  Oliveira, Francisco A ^a   Vieira Jr , Gerardo M ^b   Chaves, Mariana H ^b   Almeida, Fernanda R C ^b   Santos, Kelcyana A ^a   Martins, Fabrício S ^a   Silva, Regilane M ^a   Santos, Flavia A ^a   Rao, Vietla S N ^a  

^a FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

^b FEDERAL UNIVERSITY OF PIAUÍ   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; ALPHA AMYRIN; BETA AMYRIN; CAPSAICIN; PLANT EXTRACT; PROTIUM HEPTAPHYLLUM EXTRACT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BURSERACEAE; COMPARATIVE STUDY; CONTROLLED STUDY; GASTROINTESTINAL DISEASE; MALE; MOUSE; MUSCLE SPINDLE AFFERENT NERVE; NONHUMAN; PEPPER; PROTIUM HEPTAPHYLLUM; SENSITIVITY ANALYSIS; STOMACH MUCOSA LESION;

ADMINISTRATION, ORAL; ANIMALS; BURSERACEAE; CAPSAICIN; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG THERAPY, COMBINATION; ETHANOL; GASTRITIS; GASTROINTESTINAL AGENTS; MALE; MICE; NEURONS, AFFERENT; OLEANOLIC ACID; PHYTOTHERAPY; WOOD;

ANIMALIA; BURSERACEAE; CAPSICUM; CAPSICUM FRUTESCENS; PROTIUM; PROTIUM HEPTAPHYLLUM;

EID: 4444261144     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2004-827212     Document Type: Article

References (13)

1. Farina C, Pinza M, Pifferi G. Synthesis and antiulcer activity of new derivatives of glycyrrhetic, oleanolic and ursolic acids. II Farmaco 1998; 5: 22-32
2. Arrieta J, Benitez J, Flores E, Castillo C, Navarete A. Purification of gastroprotective triterpenoids from the stem bark of Amphipterygium adstringens; role of prostaglandins, sulfhydryls, nitric oxide and capsaicin-sensitive neurons. Planta Med 2003; 69: 905-9
3. Siani AC, Ramos MFS, de Lima MO, Santos R, Ferreira FE, Soares EC, Susunaga GS, Guimarães AC, Zoghbi MGB, Henriques MGMO. Evaluation of anti-inflammatory-related activity of essential oils from the leaves and resin of species of Protium. J Ethnopharmacol 1999; 66: 57-69
4. Bandeira PN, Pessoa ODL, Trevisan MTS, Lemos TLG. Metabólitos secundários de Protium heptaphyllum March. Quim Nova 2002; 25: 1078-80
5. Oliveira FA, Vieira-Junior GM, Chaves MH, Almeida FRC, Lima Junior RCP, Santos FA, Rao VSN. Gastroprotective and anti-inflammatory effects of resin from Protium heptaphyllum in mice and rats. Pharmacol Res 2004; 49: 05-11
6. Szolesányi J, Bartó L. Capsaicin-sensitive afferents and their role in gastroprotection: an update. J Physiol 2001; 95: 181-8
7. Park J-S, Choi M-A, Kim B-S, Han I-S, Kurata T, Yu R. Capsaicin protects against ethanol-induced oxidative injury in the gastric mucosa of rats. Life Sci, 2000: 3087-93
8. Kato S, Aihara E, Nakamura A, Xin H, Matsui H, Kohama K, Takeuchi K. Expression of vanilloid receptors in rat gastric epithelial cells: role in cellular protection. Biochem Pharmacol 2003; 66: 1115-21
9. 13C NMR. Quim Nova 1990; 13: 278-81
10. 13C NMR spectra of triterpenoids - A compilation and some salient features. Phytochemistry 1994; 37: 1517-75
11. Robert A, Nezamis JE, Lancaster C, Hanchar AJ. Cytoprotection by prostaglandins in rats. Prevention of gastric necrosis produced by alcohol, HCl, NaOH, Hypertonie NaCl and thermal injury. Gastroenterology 1979; 77: 433-43
12. Szabo S, Trier JS, Brown A, Schnoor J, Homan HD, Bradford JC. A quantification method for assessing the extent of experimental erosions and ulcers. J Pharmacol Meth 1985; 13: 59-66
13. Matsuda H, Li Y, Yoshikawa M. Roles of capsaicin-sensitive sensory nerves, endogenous nitric oxide, sulfhydrils, and prostaglandins in gastroprotection by momordin k, an oleanolic acid oligoglycoside, on ethanol-induced gastric mucosal lesions in rats. Life Sci 1999; 65: 27-32