The protease inhibitor, elafin, induces p53-dependent apoptosis in human melanoma cells

International Journal of Cancer

Volumn 127, Issue 6, 2010, Pages 1308-1320

  Yu, Kyung Sook ^a   Lee, Yangsoon ^a,b   Kim, Chung Mi ^a   Park, Eui Chul ^c   Choi, Juhyun ^b   Lim, Dae Sik ^b   Chung, Young Hwa ^d   Koh, Sang Seok ^a  

^a Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^b Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^c LG Chemical Ltd   (South Korea)

^d Pusan National University   (South Korea)

Author keywords

Apoptosis; Elafin; Melanoma; p53; Therapeutics

Indexed keywords

CASPASE 8; CASPASE 9; ELAFIN; PIFITHRIN ALPHA; PROTEIN BAX; PROTEIN NOXA; PROTEIN P21; PROTEIN P53; PUMA PROTEIN; SMALL INTERFERING RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER CELL; CANCER GROWTH; CONTROLLED STUDY; DRUG ACTIVITY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MELANOCYTE; MELANOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSCRIPTION INITIATION; TUMOR VOLUME; TUMOR XENOGRAFT;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL PROLIFERATION; DOWN-REGULATION; ELAFIN; HUMANS; IMMUNOHISTOCHEMISTRY; MELANOMA; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; PROTEASE INHIBITORS; RECOMBINANT PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; TUMOR SUPPRESSOR PROTEIN P53;

EID: 77955642515     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.25125     Document Type: Article

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