Intracellular delivery of the reactive oxygen species generating agent d -penicillamine upon conjugation to poly- l -glutamic acid

Molecular Pharmaceutics

Volumn 7, Issue 3, 2010, Pages 854-862

  Wadhwa, Saurabh ^a   Mumper, Russell J ^a,b  

^a UNC Hamner Institute for Drug Safety Sciences   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

Apoptosis; Copper; Leukemia; Polymer; Thiol

Indexed keywords

ANNEXIN; ETHYLAMINE; PENICILLAMINE; POLYGLUTAMIC ACID; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CELL STRAIN HL 60; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOTOXICITY; DISULFIDE BOND; DOSE RESPONSE; DRUG CONJUGATION; HUMAN; HUMAN CELL; IN VIVO STUDY; LEUKEMIA CELL; LEUKEMIA P 388; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; SURVIVAL;

ANIMALS; APOPTOSIS; CELL LINE, TUMOR; CHELATING AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HL-60 CELLS; HUMANS; MICE; MICROSCOPY, CONFOCAL; MOLECULAR STRUCTURE; NEOPLASMS; PENICILLAMINE; POLYGLUTAMIC ACID; REACTIVE OXYGEN SPECIES;

EID: 77953241893     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp1000058     Document Type: Article

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