A Highly Selective and Potent PTP-MEG2 Inhibitor with Therapeutic Potential for Type 2 Diabetes

Journal of the American Chemical Society

Volumn 134, Issue 43, 2012, Pages 18116-18124

  Zhang, Sheng ^a   Liu, Sijiu ^a   Tao, Rongya ^a   Wei, Dan ^a   Chen, Lan ^a   Shen, Weihua ^a   Yu, Zhi Hong ^a   Wang, Lina ^a   Jones, David R ^a   Dong, Xiaocheng C ^a   Zhang, Zhong Yin ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; BINDING POCKETS; CELL-PERMEABLE; CELLULAR ACTIVITIES; CELLULAR LEVELS; GENERAL NATURE; GLUCOSE HOMEOSTASIS; IN-VIVO; INSULIN SENSITIVITY; INSULIN SIGNALING; MOLECULAR DIVERSITY; OBESE MICE; PATHOGENIC CONDITIONS; PROTEIN TYROSINE PHOSPHORYLATION; PROTEIN-TYROSINE PHOSPHATASE; SELECTIVE INHIBITORS; SMALL MOLECULES; THERAPEUTIC POTENTIALS; TYPE-2 DIABETES;

ENZYME INHIBITION; GLUCOSE; INSULIN; PHOSPHORYLATION; PHYSIOLOGY; PROTEINS;

AMINO ACIDS;

4 HYDROXYPHENYL ACETIC ACID DERIVATIVE; ACETIC ACID DERIVATIVE; ANTIDIABETIC AGENT; GLUCOSE; INSULIN; PHOSPHONODIFLUOROMETHYL PHENYLALANINE; PROTEIN TYROSINE PHOSPHATASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG ACTIVITY; DRUG BINDING; DRUG BLOOD LEVEL; DRUG SELECTIVITY; GLUCOSE HOMEOSTASIS; IN VIVO STUDY; INSULIN RESISTANCE; INSULIN SENSITIVITY; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; SIGNAL TRANSDUCTION;

ANIMALS; DIABETES MELLITUS, TYPE 2; DISEASE MODELS, ANIMAL; MICE; MICE, INBRED C57BL; MICE, OBESE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PHENYLALANINE; PROTEIN TYROSINE PHOSPHATASES, NON-RECEPTOR;

EID: 84868088782     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja308212y     Document Type: Article

References (35)

1. Hunter, T. Curr. Opin. Cell Biol. 2009, 21, 140-146
2. Jänne, P. A.; Gray, N.; Settleman, J. Nat. Rev. Drug Discov. 2009, 8, 709-723
3. Tonks, N. K. Nat. Rev. Mol. Cell Biol. 2006, 7, 833-846
4. Zhang, Z. Y. Curr. Opin. Chem. Biol. 2001, 5, 416-423
5. Julien, S. G.; Dubé, N.; Hardy, S.; Tremblay, M. L. Nat. Rev. Cancer 2011, 11, 35-49
6. Gu, M.; Warshawsky, I.; Majerus, P. W. Proc. Natl. Acad. Sci. U.S.A. 1992, 89, 2980-2984
7. Huynh, H.; Wang, X.; Li, W.; Bottini, N.; Williams, S.; Nika, K.; Ishihara, H.; Godzik, A.; Mustelin, T. J. Immunol. 2003, 171, 6661-6671
8. Kruger, J. M.; Fukushima, T.; Cherepanov, V.; Borregaard, N.; Loeve, C.; Shek, C.; Sharma, K.; Tanswell, A. K.; Chow, C. W.; Downey, G. P. J. Biol. Chem. 2002, 277, 2620-2628
9. Zhao, R.; Fu, X.; Li, Q.; Krantz, S. B.; Zhao, Z. J. J. Biol. Chem. 2003, 278, 22609-22614
10. Wang, X.; Huynh, H.; Gjorloff-Wingren, A.; Monosov, E.; Stridsberg, M.; Fukuda, M.; Mustelin, T. J. Immunol. 2002, 168, 4612-4619
11. Xu, M. J.; Sui, X.; Zhao, R.; Dai, C.; Krantz, S. B.; Zhao, Z. J. Blood 2003, 102, 4354-4360
12. Yuan, T.; Wang, Y.; Zhao, Z. J.; Gu, H. J. Biol. Chem. 2010, 285, 14861-14870
13. Cho, C. Y.; Koo, S. H.; Wang, Y.; Callaway, S.; Hedrick, S.; Mak, P. A.; Orth, A. P.; Peters, E. C.; Saez, E.; Montminy, M.; Schultz, P. G.; Chanda, S. K. Cell Metab. 2006, 3, 367-378
14. Zhang, Z. Y. Annu. Rev. Pharmacol. Toxicol. 2002, 42, 209-234
15. Puius, Y. A.; Zhao, Y.; Sullivan, M.; Lawrence, D. S.; Almo, S. C.; Zhang, Z. Y. Proc. Natl. Acad. Sci. U.S.A. 1997, 94, 13420-13245
16. Burke, T. R., Jr.; Kole, H. K.; Roller, P. P. Biochem. Biophys. Res. Commun. 1994, 204, 129-134
17. Chen, L.; Wu, L.; Otaka, A.; Smyth, M. S.; Roller, P. P.; Burke, T. R., Jr.; den Hertog, J.; Zhang, Z. Y. Biochem. Biophys. Res. Commun. 1995, 216, 976-984
18. Shen, K.; Keng, Y. F.; Wu, L.; Guo, X. L.; Lawrence, D. S.; Zhang, Z. Y. J. Biol. Chem. 2001, 276, 47311-47319
19. Sun, J. P.; Fedorov, A. A.; Lee, S. Y.; Guo, X. L.; Shen, K.; Lawrence, D. S.; Almo, S. C.; Zhang, Z. Y. J. Biol. Chem. 2003, 278, 12406-12414
20. Zhang, S.; Chen, L.; Luo, Y.; Gunawan, A.; Lawrence, D. S.; Zhang, Z. Y. J. Am. Chem. Soc. 2009, 131, 13072-13079
21. Barr, A. J.; Ugochukwu, E.; Lee, W. H.; King, O. N.; Filippakopoulos, P.; Alfano, I.; Savitsky, P.; Burgess-Brown, N. A.; Muller, S.; Knapp, S. Cell 2009, 136, 352-363
22. Elchelby, M.; Payette, P.; Michaliszyn, E.; Cromlish, W.; Collins, S.; Lee Loy, A.; Normandin, D.; Cheng, A.; Himms-Hagen, J.; Chan, C.-C.; Ramachandran, C.; Gresser, M. J.; Tremblay, M. L.; Kennedy, B. P. Science 1999, 283, 1544-1548
23. Klaman, L. D.; Boss, O.; Peroni, O. D.; Kim, J. K.; Martino, J. L.; Zabolotny, J. M.; Moghal, N.; Lubkin, M.; Kim, Y. B.; Sharpe, A. H.; Stricker-Krongrad, A.; Shulman, G. I.; Neel, B. G.; Kahn, B. B. Mol. Cell. Biol. 2000, 20, 5479-5489
24. Hruby, V. J. Nature Reviews Drug Discovery 2002, 1, 847-858
25. Weber, S. J.; Greene, D. L.; Sharma, S. D.; Yamamura, H. I.; Kramer, T. H.; Burks, T. F.; Hruby, V. J.; Hersh, L. B.; Davis, T. P. J. Pharmacol. Exp. Therap. 1991, 259, 1109-1117
26. Williams, S. A.; Abbruscato, T. J.; Hruby, V. J.; Davis, T. P. J. Neurochem. 1996, 66, 1289-1299
27. Dekan, Z.; Wang, C. I.; Andrews, R. K.; Lewis, R. J.; Alewood, P. F. Org. Biomol. Chem. 2012, 10, 5791-5794
28. Minor, W.; Cymborowski, M.; Otwinowski, Z.; Chruszcz, M. Acta. Crystallogr. D 2006, 62, 859-866
29. Navaza, J. Acta. Crystallogr. A 1994, 50, 157-163
30. Brünger, A. T.; Adams, P. D.; Clore, G. M.; DeLano, W. L.; Gros, P.; Grosse-Kunstleve, R. W.; Jiang, J. S.; Kuszewski, J.; Nilges, M.; Pannu, N. S.; Read, R. J.; Rice, L. M.; Simonson, T.; Warren, G. L. Acta. Crystallogr. D. Biol. Crystallogr. 1998, 54, 905-921
31. Brünger, A. T. Nature 1992, 355, 472-475
32. Jones, T. A.; Zou, J. Y.; Cowan, S. W.; Kjeldgaard, M. Acta. Crystallogr. A 1991, 47, 110-119
33. Dong, X. C.; Copps, K. D.; Guo, S.; Li, Y.; Kollipara, R.; DePinho, R. A.; White, M. F. Cell Metab. 2008, 8, 65-76
34. Wei, D.; Tao, R.; Zhang, Y.; White, M. F.; Dong, X. C. Am. J. Physiol. Endocrinol. Metab. 2011, 300, E312-320
35. Liu, H. Y.; Collins, Q. F.; Xiong, Y.; Moukdar, F.; Lupo, E. G., Jr.; Liu, Z.; Cao, W. J. Biol. Chem. 2007, 282, 14205-14212