16-Morpholino quaternary ammonium steroidal derivatives as neuromuscular blocking agents: Synthesis, biological evaluation and in silico probe of ligand-receptor interaction

European Journal of Medicinal Chemistry

Volumn 56, Issue , 2012, Pages 332-347

  Hu, Hao ^a   Rao, Zhigang ^a   Xu, Jianrong ^b   Zhu, Qingfu ^a   Altenbach, Hans Josef ^c   Chen, Hongzhuan ^b   Zhou, Dingshan ^a   Xiao, Yuling ^a   Ke, Xianbing ^a   Guo, Hao ^a   Wu, Zhongyuan ^a   Liu, Peng ^a   Hu, Xianming ^a  

^a WUHAN UNIVERSITY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c UNIVERSITY OF WUPPERTAL   (Germany)

Author keywords

Muscle relaxant; nAChR; Neuromuscular blocking agent; Non depolarizing agent; Steroid

Indexed keywords

16BETA MORPHOLINO 3BETA PIPERIDINO 5ALPHA ANDROSTAN 17BETA YL ACETATE DIMETHIODIDE; 3BETA N METHYLBENZYLAMINO 16BETA MORPHOLINO 5ALPHA ANDROSTAN 17BETA YL ACETATE DIMETHIODIDE; AMMONIUM DERIVATIVE; BENZYLAMINE DERIVATIVE; BINDING PROTEIN; BUNGAROTOXIN RECEPTOR; MORPHOLINE DERIVATIVE; NEUROMUSCULAR BLOCKING AGENT; PANCURONIUM; PIPERIDINE DERIVATIVE; ROCURONIUM; STEROID; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG DESIGN; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SYNTHESIS; HEMIDIAPHRAGM; IC 50; LIGAND BINDING; MALE; MOLECULAR DOCKING; MOLECULAR MODEL; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; DIAPHRAGM; DOSE-RESPONSE RELATIONSHIP, DRUG; LIGANDS; MALE; MICE; MOLECULAR PROBES; MOLECULAR STRUCTURE; MORPHOLINES; MUSCLE, SKELETAL; NEUROMUSCULAR BLOCKING AGENTS; NEURONS; QUATERNARY AMMONIUM COMPOUNDS; RECEPTORS, NICOTINIC; STEROIDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84867989340     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.07.048     Document Type: Article

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