-
2
-
-
33644945178
-
Structure and function of the nicotinic acetylcholine receptor
-
Dunn SMJ 1993 Structure and function of the nicotinic acetylcholine receptor Adv Struc Biol 2 225 244
-
(1993)
Adv Struc Biol
, vol.2
, pp. 225-244
-
-
Dunn, S.M.J.1
-
3
-
-
0032970174
-
International Union of Pharmacology. XXq5
-
. Current status of the nomenclature for nicotinic acetylcholine receptors and their subunits
-
Lukas RJ Changeux JP Le Novère N Albuquerque EX Balfour DJ Berg DK Bertrand D Chiappinelli VA Clarke PB Collins AC et al. 1999 International Union of Pharmacology. XXq5. Current status of the nomenclature for nicotinic acetylcholine receptors and their subunits Pharmacol Rev 51 397 401
-
(1999)
Pharmacol Rev
, vol.51
, pp. 397-401
-
-
Lukas, R.J.1
Changeux, J.P.2
Le Novère, N.3
Albuquerque, E.X.4
Balfour, D.J.5
Berg, D.K.6
Bertrand, D.7
Chiappinelli, V.A.8
Clarke, P.B.9
Collins, A.C.10
-
4
-
-
0024725677
-
Molecular basis of the two nonequivalent ligand binding sites of the muscle nicotinic acetylcholine receptor
-
Blount P Merlie JP 1989 Molecular basis of the two nonequivalent ligand binding sites of the muscle nicotinic acetylcholine receptor Neuron 3 349 357
-
(1989)
Neuron
, vol.3
, pp. 349-357
-
-
Blount, P.1
Merlie, J.P.2
-
5
-
-
0025308169
-
D-Tubocurarine binding sites are located at α-γ And α-δ subunit interfaces of the nicotinic acetylcholine receptor
-
Pederson SE Cohen JB 1990 d-Tubocurarine binding sites are located at α-γ and α-δ subunit interfaces of the nicotinic acetylcholine receptor Proc Natl Acad Sci USA 87 2785 2789
-
(1990)
Proc Natl Acad Sci USA
, vol.87
, pp. 2785-2789
-
-
Pederson, S.E.1
Cohen, J.B.2
-
8
-
-
0034212292
-
Localization of agonist and competitive antagonist binding sites on nicotinic acetylcholine receptor
-
Arias HR 2000 Localization of agonist and competitive antagonist binding sites on nicotinic acetylcholine receptor Neurochem Int 36 595 645
-
(2000)
Neurochem Int
, vol.36
, pp. 595-645
-
-
Arias, H.R.1
-
9
-
-
0036480194
-
Emerging structure of the nicotinic acetylcholine receptors
-
Karlin A 2002 Emerging structure of the nicotinic acetylcholine receptors Nat Neurosci 3 102 114
-
(2002)
Nat Neurosci
, vol.3
, pp. 102-114
-
-
Karlin, A.1
-
11
-
-
0021132711
-
Identification of the alpha subunit half-cysteine specifically labeled by an affinity reagent for the acetylcholine receptor binding site
-
Kao PN Dwork AJ Kaldany RR Silver ML Wideman J Stein S Karlin A 1984 Identification of the alpha subunit half-cysteine specifically labeled by an affinity reagent for the acetylcholine receptor binding site J Biol Chem 259 11662 11665
-
(1984)
J Biol Chem
, vol.259
, pp. 11662-11665
-
-
Kao, P.N.1
Dwork, A.J.2
Kaldany, R.R.3
Silver, M.L.4
Wideman, J.5
Stein, S.6
Karlin, A.7
-
12
-
-
0024278367
-
Amino acids of the Torpedo marmorata acetylcholine receptor alpha subunit labeled by a photoaffinity ligand for the acetylcholine binding site
-
Dennis M Giraudat J Kotzyba-Hibert F Goeldner M Hirth C Chang JY Lazure C Chretien M Changeux JP 1988 Amino acids of the Torpedo marmorata acetylcholine receptor alpha subunit labeled by a photoaffinity ligand for the acetylcholine binding site Biochem 27 2346 2357
-
(1988)
Biochem
, vol.27
, pp. 2346-2357
-
-
Dennis, M.1
Giraudat, J.2
Kotzyba-Hibert, F.3
Goeldner, M.4
Hirth, C.5
Chang, J.Y.6
Lazure, C.7
Chretien, M.8
Changeux, J.P.9
-
13
-
-
0025346780
-
Identification of a novel amino acid alpha-tyrosine 93 within the cholinergic ligands-binding sites of the acetylcholine receptor by photoaffinity labelling: Additional evidence for a three-loop model of the cholinergic ligands-binding sites
-
Galzi JL Revah F Black D Goeldner M Hirth C Changeux JP 1990 Identification of a novel amino acid alpha-tyrosine 93 within the cholinergic ligands-binding sites of the acetylcholine receptor by photoaffinity labelling: additional evidence for a three-loop model of the cholinergic ligands-binding sites J Biol Chem 265 10430 10437
-
(1990)
J Biol Chem
, vol.265
, pp. 10430-10437
-
-
Galzi, J.L.1
Revah, F.2
Black, D.3
Goeldner, M.4
Hirth, C.5
Changeux, J.P.6
-
14
-
-
0026344986
-
Structure of the agonist-binding site of the nicotinic acetylcholine receptor
-
Cohen JB Sharp SD Liu WS 1991 Structure of the agonist-binding site of the nicotinic acetylcholine receptor J Biol Chem 266 23354 23364
-
(1991)
J Biol Chem
, vol.266
, pp. 23354-23364
-
-
Cohen, J.B.1
Sharp, S.D.2
Liu, W.S.3
-
15
-
-
0031468619
-
Identification of amino acids contributing to high and low affinity d-tubocurarine sites in the Torpedo nicotinic acetylcholine receptor
-
Chiara DC Cohen JB 1997 Identification of amino acids contributing to high and low affinity d-tubocurarine sites in the Torpedo nicotinic acetylcholine receptor J Biol Chem 272 32940 32950
-
(1997)
J Biol Chem
, vol.272
, pp. 32940-32950
-
-
Chiara, D.C.1
Cohen, J.B.2
-
16
-
-
0032548783
-
3H]nicotine photoincorporation in the γ-subunit of the Torpedo nicotinic acetylcholine receptor
-
3H]nicotine photoincorporation in the γ-subunit of the Torpedo nicotinic acetylcholine receptor FEBS Lett 423 223 226
-
(1998)
FEBS Lett
, vol.423
, pp. 223-226
-
-
Chiara, D.C.1
Middleton, R.E.2
Cohen, J.B.3
-
17
-
-
0035951772
-
Contributions of Torpedo nicotinic acetylcholine receptor γtrp-55 and δtrp-57 to agonist and competitive antagonist function
-
Xie Y Cohen JB 2001 Contributions of Torpedo nicotinic acetylcholine receptor γTrp-55 and δTrp-57 to agonist and competitive antagonist function J Biol Chem 276 2417 2426
-
(2001)
J Biol Chem
, vol.276
, pp. 2417-2426
-
-
Xie, Y.1
Cohen, J.B.2
-
18
-
-
0036891560
-
The nicotinic receptor ligand binding domain
-
Sine SM 2002 The nicotinic receptor ligand binding domain J Neurobiol 53 431 446
-
(2002)
J Neurobiol
, vol.53
, pp. 431-446
-
-
Sine, S.M.1
-
19
-
-
0037047296
-
Lysine scanning mutagenesis delineates structural model of the nicotinic receptor ligand binding domain
-
Sine SM Wang HL Bren N 2002 Lysine scanning mutagenesis delineates structural model of the nicotinic receptor ligand binding domain J Biol Chem 277 29210 29223
-
(2002)
J Biol Chem
, vol.277
, pp. 29210-29223
-
-
Sine, S.M.1
Wang, H.L.2
Bren, N.3
-
20
-
-
0038112088
-
Structure and gating mechanism of the acetylcholine receptor pore
-
Miyazawa A Fujiyoshi Y Unwin N 2003 Structure and gating mechanism of the acetylcholine receptor pore Nature 423 949 955
-
(2003)
Nature
, vol.423
, pp. 949-955
-
-
Miyazawa, A.1
Fujiyoshi, Y.2
Unwin, N.3
-
21
-
-
27744438169
-
Principal pathway coupling agonist binding to channel gating in nicotinic receptors
-
Lee WY Sine SM 2005 Principal pathway coupling agonist binding to channel gating in nicotinic receptors Nature 438 243 247
-
(2005)
Nature
, vol.438
, pp. 243-247
-
-
Lee, W.Y.1
Sine, S.M.2
-
22
-
-
0028316086
-
Characterization of d-tubocurarine binding site of Torpedo acetylcholine receptor
-
O'leary ME Filatov GN White MM 1994 Characterization of d-tubocurarine binding site of Torpedo acetylcholine receptor Am J Physiol 266 C648 C653
-
(1994)
Am J Physiol
, vol.266
-
-
O'Leary, M.E.1
Filatov, G.N.2
White, M.M.3
-
23
-
-
0029078817
-
Identification of a new component of the agonist binding site of the nicotinic alpha 7 homooligomeric receptor
-
Corringer PJ Galzi JL Eisele JL Bertrand S Changeux JP Bertrand D 1995 Identification of a new component of the agonist binding site of the nicotinic alpha 7 homooligomeric receptor J Biol Chem 270 11749 11752
-
(1995)
J Biol Chem
, vol.270
, pp. 11749-11752
-
-
Corringer, P.J.1
Galzi, J.L.2
Eisele, J.L.3
Bertrand, S.4
Changeux, J.P.5
Bertrand, D.6
-
25
-
-
0030959309
-
Subtle changes in residue 77 of the gamma subunit of alpha1beta2gamma2 GABAA receptors drastically alter the affinity for ligands of the benzodiazepine binding site
-
Buhr A Baur R Sigel E 1997 Subtle changes in residue 77 of the gamma subunit of alpha1beta2gamma2 GABAA receptors drastically alter the affinity for ligands of the benzodiazepine binding site J Biol Chem 272 11799 11804
-
(1997)
J Biol Chem
, vol.272
, pp. 11799-11804
-
-
Buhr, A.1
Baur, R.2
Sigel, E.3
-
26
-
-
0034640418
-
Tyrosine 62 of the γ-aminobutyric acid type a receptor β2 subunit is an important determinant of high affinity agonist binding
-
Newell JG Davies M Bateson AN Dunn SMJ 2000 Tyrosine 62 of the γ-aminobutyric acid type A receptor β2 subunit is an important determinant of high affinity agonist binding J Biol Chem 275 14198 14204
-
(2000)
J Biol Chem
, vol.275
, pp. 14198-14204
-
-
Newell, J.G.1
Davies, M.2
Bateson, A.N.3
Dunn, S.M.J.4
-
27
-
-
0033605152
-
Structural features of the ligand-binding domain of the serotonin 5HT3 receptor
-
Yan D Schulte MK Bloom KE White MM 1999 Structural features of the ligand-binding domain of the serotonin 5HT3 receptor J Biol Chem 274 5537 5541
-
(1999)
J Biol Chem
, vol.274
, pp. 5537-5541
-
-
Yan, D.1
Schulte, M.K.2
Bloom, K.E.3
White, M.M.4
-
28
-
-
0026758178
-
Mutational analysis of ligand-induced activation of the Torpedo acetylcholine receptor
-
O'leary ME White MM 1992 Mutational analysis of ligand-induced activation of the Torpedo acetylcholine receptor J Biol Chem 267 8360 8365
-
(1992)
J Biol Chem
, vol.267
, pp. 8360-8365
-
-
O'Leary, M.E.1
White, M.M.2
-
29
-
-
0032199006
-
Binding, gating, affinity and efficacy: The interpretation of structure-activity relationships for agonists and of the effects of mutating receptors
-
Colquhoun D 1998 Binding, gating, affinity and efficacy: the interpretation of structure-activity relationships for agonists and of the effects of mutating receptors Br J Pharmacol 125 924 947
-
(1998)
Br J Pharmacol
, vol.125
, pp. 924-947
-
-
Colquhoun, D.1
-
30
-
-
0027287799
-
Amino acid residues within the sequence region α55-74 of Torpedo nicotinic acetylcholine receptor interacting with antibodies to the main immunogenic region and with snake α-neurotoxins
-
Wahlsten JL Lindstrom JM Conti-Tronconi BM 1993 Amino acid residues within the sequence region α55-74 of Torpedo nicotinic acetylcholine receptor interacting with antibodies to the main immunogenic region and with snake α-neurotoxins J Rec Res 13 989 1008
-
(1993)
J Rec Res
, vol.13
, pp. 989-1008
-
-
Wahlsten, J.L.1
Lindstrom, J.M.2
Conti-Tronconi, B.M.3
-
31
-
-
0028796540
-
Antagonist and partial agonist actions of d-tubocurarine at mammalian muscle acetylcholine receptors
-
Steinbach JH Chen Q 1995 Antagonist and partial agonist actions of d-tubocurarine at mammalian muscle acetylcholine receptors J Neurosci 15 230 240
-
(1995)
J Neurosci
, vol.15
, pp. 230-240
-
-
Steinbach, J.H.1
Chen, Q.2
-
32
-
-
13444271681
-
Refined structure of the nicotinic acetylcholine receptor at 4Å resolution
-
Unwin N 2005 Refined structure of the nicotinic acetylcholine receptor at 4Å resolution J Mol Biol 346 967 989
-
(2005)
J Mol Biol
, vol.346
, pp. 967-989
-
-
Unwin, N.1
-
33
-
-
0026732898
-
Preparation of RNA for injection into Xenopus oocytes
-
Goldin AL Sumikawa K 1992 Preparation of RNA for injection into Xenopus oocytes Methods Enzmol 207 279 297
-
(1992)
Methods Enzmol
, vol.207
, pp. 279-297
-
-
Goldin, A.L.1
Sumikawa, K.2
-
34
-
-
0019314914
-
Intracellular calcium and the desensitization of acetylcholine receptors
-
Miledi R 1980 Intracellular calcium and the desensitization of acetylcholine receptors Proc R Soc Lond B 209 447 452
-
(1980)
Proc R Soc Lond B
, vol.209
, pp. 447-452
-
-
Miledi, R.1
-
35
-
-
0019954796
-
Translation of exogenous messenger RNA coding for nicotinic acetylcholine receptors produces functional receptors in Xenopus oocytes
-
Barnard EA Miledi R Sumikawa K 1982 Translation of exogenous messenger RNA coding for nicotinic acetylcholine receptors produces functional receptors in Xenopus oocytes Proc R Soc Lond B 215 241 246
-
(1982)
Proc R Soc Lond B
, vol.215
, pp. 241-246
-
-
Barnard, E.A.1
Miledi, R.2
Sumikawa, K.3
-
36
-
-
0034724709
-
Mapping the agonist binding site of the nicotinic acetylcholine receptor: Orientation requirements for activation by covalent agonist
-
Sullivan DA Cohen JB 2000 Mapping the agonist binding site of the nicotinic acetylcholine receptor: orientation requirements for activation by covalent agonist J Biol Chem 275 12651 12660
-
(2000)
J Biol Chem
, vol.275
, pp. 12651-12660
-
-
Sullivan, D.A.1
Cohen, J.B.2
-
37
-
-
0034712698
-
Functional effects of periodic tryptophan substitutions in the α M4 transmembrane domain of the Torpedo californica nicotinic acetylcholine receptor
-
Tamamizu S Guzman GR Santiago J Rojas LV Mcnamee MG Lasalde-Dominicci JA 2000 Functional effects of periodic tryptophan substitutions in the α M4 transmembrane domain of the Torpedo californica nicotinic acetylcholine receptor Biochem 39 4666 4673
-
(2000)
Biochem
, vol.39
, pp. 4666-4673
-
-
Tamamizu, S.1
Guzman, G.R.2
Santiago, J.3
Rojas, L.V.4
McNamee, M.G.5
Lasalde-Dominicci, J.A.6
-
38
-
-
0015861774
-
Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction
-
Cheng Y Prusoff WH 1973 Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction Biochem Pharmacol 22 3099 3108
-
(1973)
Biochem Pharmacol
, vol.22
, pp. 3099-3108
-
-
Cheng, Y.1
Prusoff, W.H.2
|