Aldehyde dehydrogenase-2 deficiency aggravates cardiac dysfunction elicited by endoplasmic reticulum stress induction

Molecular Medicine

Volumn 18, Issue 5, 2012, Pages 785-793

  Liao, Jianquan ^a   Sun, Aijun ^a   Xie, Yeqing ^a   Isse, Toyoshi ^b   Kawamoto, Toshihiro ^b   Zou, Yunzeng ^a   Ge, Junbo ^a  

^a FUDAN UNIVERSITY   (China)

^b UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE DEHYDROGENASE; ALDEHYDE DEHYDROGENASE 2, MOUSE; NEUTROPHIL CYTOSOLIC FACTOR 1; PROTEIN KINASE B; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; TUNICAMYCIN;

ANIMAL; APOPTOSIS; ARTICLE; C57BL MOUSE; DRUG EFFECT; ENDOPLASMIC RETICULUM STRESS; GENETICS; HEART; HEART MUSCLE; HEART MUSCLE CELL; KNOCKOUT MOUSE; MALE; METABOLISM; MOUSE; PATHOPHYSIOLOGY; RAT; RNA INTERFERENCE; SPRAGUE DAWLEY RAT;

ALDEHYDE DEHYDROGENASE; ANIMALS; APOPTOSIS; ENDOPLASMIC RETICULUM STRESS; HEART; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYOCARDIUM; MYOCYTES, CARDIAC; NADPH OXIDASE; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; RNA INTERFERENCE; TUNICAMYCIN;

EID: 84867906320     PISSN: 10761551     EISSN: None     Source Type: Journal    
DOI: 10.2119/molmed.2011.00466     Document Type: Article

References (33)

1. Ron D, Walter P. (2007) Signal integration in the endoplasmic reticulum unfolded protein response. Nat. Rev. Mol. Cell. Biol. 8:519-29.
2. Kim I, Xu W, Reed JC. (2008) Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities. Nat. Rev. Drug. Discov. 7:1013-30.
3. Minamino T, Kitakaze M. (2010) ER stress in cardiovascular disease. J. Mol. Cell. Cardiol. 48:1105-10.
4. Minamino T, Komuro I, Kitakaze M. (2010) Endoplasmic reticulum stress as a therapeutic target in cardiovascular disease. Circ. Res. 107:1071-82.
5. Szegezdi E, Logue SE, Gorman AM, Samali A. (2006) Mediators of endoplasmic reticulum stress-induced apoptosis. EMBO Rep. 7:880-5.
6. Groenendyk J, Sreenivasaiah PK, Kim Do H, Agellon LB, Michalak M. (2010) Biology of endoplasmic reticulum stress in the heart. Circ. Res. 107:1185-97.
7. Tabas I. (2010) The role of endoplasmic reticulum stress in the progression of atherosclerosis. Circ. Res. 107:839-50.
8. Chen CH, et al. (2008) Activation of aldehyde dehydrogenase- 2 reduces ischemic damage to the heart. Science. 321:1493-5.
9. Ma H, Li J, Gao F, Ren J. (2009) Aldehyde dehydrogenase 2 ameliorates acute cardiac toxicity of ethanol: role of protein phosphatase and forkhead transcription factor. J. Am. Coll. Cardiol. 54:2187-96.
10. Ma H, et al. (2010) Aldehyde dehydrogenase 2 knockout accentuates ethanol-induced cardiac depression: role of protein phosphatases. J. Mol. Cell. Cardiol. 49:322-9.
11. Li SY, et al. (2006) Attenuation of acetaldehydeinduced cell injury by overexpression of aldehyde dehydrogenase-2 (ALDH2) transgene in human cardiac myocytes: role of MAP kinase signaling. J. Mol. Cell. Cardiol. 40:283-94.
12. Chen CH, Sun L, Mochly-Rosen D. (2010) Mitochondrial aldehyde dehydrogenase and cardiac diseases. Cardiovasc. Res. 88:51-7.
13. Wang J, et al. (2011) Inhibition of aldehyde dehydrogenase 2 by oxidative stress is associated with cardiac dysfunction in diabetic rats. Mol. Med. 17:172-9.
14. Zhang Y, Xia Z, La Cour KH, Ren J. (2011) Activation of Akt rescues endoplasmic reticulum stress-impaired murine cardiac contractile function via glycogen synthase kinase-3betamediated suppression of mitochondrial permeation pore opening. Antioxid. Redox. Signal. 15:2407-24.
15. Kitagawa K, et al. (2000) Aldehyde dehydrogenase (ALDH) 2 associates with oxidation of methoxyacetaldehyde; in vitro analysis with liver subcellular fraction derived from human and Aldh2 gene targeting mouse. FEBS Lett. 476:306-11.
16. Ohsawa I, Nishimaki K, Yasuda C, Kamino K, Ohta S. (2003) Deficiency in a mitochondrial aldehyde dehydrogenase increases vulnerability to oxidative stress in PC12 cells. J. Neurochem. 84:1110-7.
17. Zhang Y, Ren J. (2011) Thapsigargin triggers cardiac contractile dysfunction via NADPH oxidase- mediated mitochondrial dysfunction: role of Akt dephosphorylation. Free Radic. Biol. Med. 51:2172-84.
18. Datta SR, Brunet A, Greenberg ME. (1999) Cellular survival: a play in three Akts. Genes Dev. 13:2905-27.
19. Brunet A, et al. (1999) Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell. 96:857-68.
20. Malhotra JD, Kaufman RJ. (2007) Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword? Antioxid. Redox. Signal. 9:2277-93.
21. Zinszner H, et al. (1998) CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum. Genes Dev. 12:982-95.
22. Severino A, et al. (2007) Identification of protein disulfide isomerase as a cardiomyocyte survival factor in ischemic cardiomyopathy. J. Am. Coll. Cardiol. 50:1029-37.
23. Toldo S, et al. (2011) Altered oxido-reductive state in the diabetic heart: loss of cardioprotection due to protein disulfide isomerase. Mol. Med. 17:1012-21.
24. Budas GR, Disatnik MH, Mochly-Rosen D. (2009) Aldehyde dehydrogenase 2 in cardiac protection: a new therapeutic target? Trends ardiovasc. Med. 19:158-64.
25. Ma H, Guo R, Yu L, Zhang Y, Ren J. (2011) Aldehyde dehydrogenase 2 (ALDH2) rescues myocardial ischaemia/reperfusion injury: role of autophagy paradox and toxic aldehyde. Eur. Heart J. 32:1025-38.
26. Sanson M, et al. (2009) Oxidized low-density lipoproteins trigger endoplasmic reticulum stress in vascular cells: prevention by oxygen-regulated protein 150 expression. Circ. Res. 104:328-36.
27. Liu W, et al. (2003) Protein phosphatase 2Alinked and -unlinked caspase-dependent pathways for downregulation of Akt kinase triggered by 4-hydroxynonenal. Cell Death Differ. 10:772-81.
28. Clerk A, et al. (2003) Regulation of cardiac myocyte cell death. Pharmacol. Ther. 97:223-61.
29. Teng X, et al. (2011) Inhibition of endoplasmic eticulum stress by intermedin(1-53) protects against myocardial injury through a PI3 kinase- Akt signaling pathway. J. Mol. Med. (Berl.). 89:1195-205.
30. Malhotra JD, Kaufman RJ. (2007) Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword? Antioxid. Redox Signal. 9:2277-93.
31. Griendling KK, Sorescu D, Ushio-Fukai M. (2000) NAD(P)H oxidase: role in cardiovascular biology and disease. Circ. Res. 86:494-501.
32. Daiber A. (2010) Redox signaling (cross-talk) from and to mitochondria involves mitochondrial pores and reactive oxygen species. Biochim. Biophys. Acta. 1797:897-906.
33. Li G, Scull C, Ozcan L, Tabas I. (2010) NADPH oxidase links endoplasmic reticulum stress, oxidative stress, and PKR activation to induce apoptosis. J. Cell. Biol. 191:1113-25.