Phytochemistry and medicinal properties of teucrium polium L. (Lamiaceae)

Phytotherapy Research

Volumn 26, Issue 11, 2012, Pages 1581-1593

  Bahramikia, Seifollah ^a   Yazdanparast, Razieh ^a  

^a UNIVERSITY OF TEHRAN   (Iran)

Author keywords

Lamiaceae; pharmacological effects; phytochemistry; T. polium

Indexed keywords

APIGENIN; BETA PINENE; BORNEOL; CAMPESTEROL; CARYOPHYLLENE OXIDE; ESSENTIAL OIL; EUPATORIN; FLAVONOID; GERMACRENE D; IRIDOID; LAURIC ACID; LINALOOL; LINOLENIC ACID; LUTEOLIN; LUTEOLIN 7 GLUCOSIDE; MYRCENE; NEROLIDOL; OCIMENE; PALMITIC ACID; PARA CYMENE; PINENE; PULEGONE; SABINENE; SALVIGENIN; SITOSTEROL; SPATHULENOL; STIGMASTEROL; TERPENOID DERIVATIVE; TEUCRIUM POLIUM EXTRACT; UNINDEXED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIDIABETIC ACTIVITY; ANTIFUNGAL ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTILIPEMIC ACTIVITY; ANTIMUTAGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTINOCICEPTION; ANTIOXIDANT ACTIVITY; ANTISPASMODIC ACTIVITY; ANTIULCER ACTIVITY; ANTIVIRAL ACTIVITY; DIABETES MELLITUS; DOSE RESPONSE; DRUG ISOLATION; DRUG MECHANISM; DRUG SCREENING; HEPATITIS; HUMAN; JAUNDICE; LIVER PROTECTION; LIVER TOXICITY; NONHUMAN; PAW EDEMA; PHYTOCHEMISTRY; REVIEW; SIDE EFFECT; STOMACH ULCER; TRADITIONAL MEDICINE;

ANIMALS; FLAVONOIDS; HUMANS; OILS, VOLATILE; PLANT EXTRACTS; PLANTS, MEDICINAL; TERPENES; TEUCRIUM;

LAMIACEAE; MAGNOLIOPHYTA; TEUCRIUM POLIUM;

EID: 84867892118     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.4617     Document Type: Review

References (96)

1. Abdollahi M, Karimpour H, Monsef-Esfehani HR,. 2003. Antinociceptive effects of Teucrium polium L. total extract and essential oil in mouse writhing test. Pharm Res 48: 31-35.
2. Aggelis G, Athanassopoulos N, Paliogianni A, Komaitis M,. 1998. Effect of a Teucrium polium L. extract on the growth and fatty acid composition of Saccharomyces cerevisiae and Yarrowia lipolytica. Antonie Van Leeuwenhoek 73: 195-198.
3. Aghazadeh S, Yazdanparast R,. 2010. Inhibitions of JNK along with activation of ERK1/2 MAPK pathways improve steatohepatitis among the rats. Clin Nutr 29: 381-385.
4. Alkofahi A, Atta AH,. 1999. Pharmacological screening of the anti-ulcerogenic effects of some Jordanian medicinal plants in rats. J Ethnopharmacol 67: 341-345.
5. Al-Mustafa AH, Al-Thunibat OY,. 2008. Antioxidant activity of some Jordanian medicinal plants used traditionally for treatment of diabetes. Pak J Biol Sci 11: 351-358.
6. Alwan AH, Abdul-Latif M, Jawad A, Albana S, Ali KF,. 1988. Antiviral activity of some Iraqi indigenous plants. Pharm Biol 26: 107-111.
7. Amini R, Nosrati N, Yazdanparast R, Molaei M,. 2009. Teucrium polium in prevention of steatohepatitis in rats. Liver Int 29: 1216-1221.
8. Amini R, Yazdanparast R,. 2009. Suppression of hepatic TNF-α and TGF-β gene expression in rats with induced nonalcoholic steatohepatitis. Pharmacologyonline 3: 340-350.
9. Amini R, Yazdanparast R, Aghazadeh S, Ghaffari SH,. 2011. Teucrium polium reversed the MCD diet-induced liver injury in rats. Hum Exp Toxicol 30: 1303-1312.
10. Aqel MB, Gharaibeh MN, Salhab AS,. 1990. The calcium antagonistic effect of the volatile oil of Teucrium polium. Pharm Biol 28: 201-207.
11. Ardestani A, Yazdanparast R,. 2007. Inhibitory effects of ethyl acetate extract of Teucrium polium on in vitro protein glycoxidation. Food Chem Toxicol 45: 2402-2411.
12. Ardestani A, Yazdanparast R, Jamshidi S,. 2008. Therapeutic effects of Teucrium polium extract on oxidative stress in pancreas of streptozotocin- induced diabetic rats. J Med Food 11: 525-532.
13. Autore G, Capasso F, De Fusco R, et al., 1984. Antipyretic and antibacterial actions of Teucrium polium. Pharmacol Res Commun 16: 21-29.
14. Bahramikia S, Ardestani A, Yazdanparast R,. 2009. Protective effects of four Iranian medicinal plants against free radical-mediated protein oxidation. Food Chem 115: 37-42.
15. Baluchnejadmojarada T, Mehrdad M, Roghani-Dehkordic F,. 2005. Antinociceptive effect of Teucrium polium leaf extract in the diabetic rat formalin test. J Ethnopharmacol 97: 207-210.
16. Bedir E, Tasdemir D, Calis I, Zerbe O, Sticher O,. 1999. Neo-clerodane diterpenoids from Teucrium polium. Phytochemistry 51: 921-925.
17. Boulila A, Béjaoui A, Messaoud C, Boussaid M,. 2008. Variation of volatiles in Tunisian populations of Teucrium polium L. (Lamiaceae). Chem Biodivers 5: 1385-1400.
18. Bruno M, Bondi ML, Rosselli S,. 2002. Neoclerodane diterpenoids from Teucrium montbretii subsp libanoticum and their absolute configuration. J Nat Prod 65: 142-146.
19. Bruno M, De la Torre MC, Rodríguez B, Omar AA,. 1993. Guaiane sesquiterpenes from Teucrium leucocladum. Phytochemistry 34: 245-247.
20. Bruno M, Maggio AM, Piozzi F, Puech S, Rosselli S, Simmonds MSJ,. 2003. Neoclerodane diterpenoids from Teucrium polium subsp. polium and their antifeedant activity. Biochem Syst Ecol 31: 1051-1056.
21. Cakir A, Duru ME, Harmandar M, Ciriminna R, Passannanti S,. 1998. Volatile constituents of Teucrium polium L. from Turkey. J Essent Oil Res 10: 113-115.
22. Capasso F, Cerri R, Morrica P, Senatore F,. 1983. Chemical composition and anti-inflammatory activity of an alcoholic extract of Teucrium polium L. Boll Soc Ital Bio Sper 59: 1639-1643.
23. Carreiras MC, Rodriguez B, Piozzi S, Savona G, Torres MR, Parales A,. 1989. A chlorine-containing and two 17β-neo-clerodane diterpenoids from Teucrium polium subsp. vincentinum. Phytochemistry 28: 1453-1461.
24. Carreiras MC, Rodriguez B, de la Torre MC, et al., 1990. Rearranged abietane diterpenoids from the root of Teucrium polium subsp. vincentinum. Tetrahedron 46: 847-860.
25. Couladis M, Tzakou O, Verykokidou E, Harvala C,. 2003. Screening of some Greek aromatic plants for antioxidant activity. Phytother Res 17: 194-195.
26. Cozzani S, Muselli A, Desjobert JM, Bernardini AF, Tomi F, Casanova J,. 2005. Chemical composition of essential oil of Teucrium polium subsp. capitatum (L.) from Corsica. Flav Fragr J 20: 436-441.
27. De la Torre MC, Piozzi F, Rizk AF, Rodriguez B, Savona G,. 1986. 19-Acetylteupolin IV, a neo-clerodane diterpenoid from Teucrium polium subsp. pilosum. Phytochemistry 25: 2239-2240.
28. Dehghani F, Talaee Khozani T, Panjehshahin MR, Karbalaedoost S,. 2005. Effect of Teucrium polium on histology and histochemistry in rat stomach. Indian J Gastroenterol 24: 126-127.
29. Eikani MH, Goodarznia L, Mirza M,. 1999. Comparison between the essential oil of supercritical carbon dioxide extract of Teucrium polium L. J Essent Oil Res 11: 470-472.
30. El Oualidi J, Verneau O, Puech S, Dubuisson JY,. 1999. Utility of rDNA ITS sequences in the systematics of Teucrium section Polium (Lamiaceae). Plant Syst Evol 215: 49-70.
31. Eskandary H, Rajabalian S, Yazdi T, Eskandari M, Fatehi K, Ganjooei NA,. 2007. Evaluation of cytotoxic effect of Teucrium polium on a new glioblastoma multiforme cell line (REYF-1) using MTT and soft agar clonogenic assays. Int J Pharmacol 3: 435-437.
32. Esmaeili MA, Yazdanparast R,. 2004. Hypoglycaemic effect of Teucrium polium: studies with rat pancreatic islets. J Ethnopharmacol 95: 27-30.
33. Esmaeili MA, Zoharil F, Sadeghi H,. 2009. Antioxidant and protective effects of major flavonoids from Teucrium polium on β-cell destruction in a model of streptozotocin-induced diabetes. Planta Med 75: 1418-1420.
34. Essawi T, Srour M,. 2000. Screening of some Palestinian medicinal plants for antibacterial activity. J Ethnopharmacol 70: 343-349.
35. Feinbrun-Dothan N,. 1978. Flora Palaestina, Part three. Israel Acad Sci Hum 3: 101-106.
36. Fernandez P, Rodriguez B, Savona G, Piozzi F,. 1986. Neo-clerodane diterpenoids from Teucrium polium subsp. capitatum. Phytochemistry 25: 181-184.
37. Galstyan AM, Shashkov AS, Oganesyan GB, Mnatsakanyan VA, Serebryakov ÉP,. 1992. Structures of two new diterpenoids from Teucrium polium. Chem Nat Comp 28: 439-443.
38. Gharaibeh MN, Elayan HH, Salhab AS,. 1988. Hypoglycemic effects of Teucrium polium. J Ethnopharmacol 24: 93-99.
39. Gharaibeh MN, Elayan HH, Salhab AS,. 1989. Anorexic effect of Teucrium polium in rats. Int J Crude Drug Res 27: 201-207.
40. Hachicha SF, Barrek S, Skanji T, Zarrouk H, Ghrabi ZG,. 2009. Fatty acid, tocopherol, and sterol content of three Teucrium species from Tunisia. Chem Nat Comp 45: 304-308.
41. Harborne JB, Tomas B, Williams GA, Gil MI,. 1986. A chemotaxonomic study of flavonoids from European Teucrium species. Phytochemistry 25: 2811-2816.
42. Hasani P, Yasa N, Vosough-Ghanbari S, Mohammadirad A, Dehghan G, Abdollahi M,. 2007. In vivo antioxidant potential of Teucrium polium, as compared to α-tocopherol. Acta Pharm 57: 123-129.
43. Hassan MM, Muhtadi FJ, Al-Badr AA,. 1979. Antispasmodic GLC-mass spectrometry of Teucrium polium oil. J Pharm Sci 68: 800-801.
44. Ilhami G, Metin U, Munir O, Suktru B, Irfan K,. 2003. Antioxidant and antimicrobial activities of Teucrium polium L. J Food Tech 1: 9-16.
45. Kabouche A, Kabouche Z, Ghannadi A, Sajjadi SE,. 2007. Analysis of the essential oil of Teucrium polium ssp. aurasiacum from Algeria. J Essent Oil Res 19: 44-46.
46. Kamel A, Sandra P,. 1994. Gas chromatography-mass spectrometry analysis of the volatile oils of two Teucrium polium varieties. Biochem Syst Ecol 22: 529-532.
47. Kandouz M, Alachkarb A, Zhang L, et al., 2010. Teucrium polium plant extract inhibits cell invasion and motility of human prostate cancer cells via the restoration of the E-cadherin/catenin complex. J Ethnopharmacol 129: 410-415.
48. Kawashty SA, Gamal El-Dinb EM, Saleh NAM,. 1999. The flavonoid chemosystematics of two Teucrium species from Southern Sinai, Egypt. Biochem Syst Ecol 27: 657-660.
49. Khader M, Bresgen N, Eckl PM,. 2010. Antimutagenic effects of ethanolic extracts from selected Palestinian medicinal plants. J Ethnopharmacol 127: 319-324.
50. Khader M, Eckl PM, Bresgen N,. 2007. Effects of aqueous extracts of medicinal plants on MNNG-treated rat hepatocytes in primary cultures. J Ethnopharmacol 112: 199-202.
51. Ladjei S, Laemara K, Al Hillo M, Pais MP,. 1994. Neo-clerodane diterpenoids from Teucrium polium ssp. Aurasianum. Phytochemistry 37: 1663-1666.
52. Litvinenko VI, Zoz IG, Sokolov VS,. 1970. Chemotaxonomische Untersuchungen zur Unterfamilie Ajugoideae Benth. der Lamiaceae Lindley. Planta Med 3: 243-253.
53. Ljubuncic P, Azaizeh H, Portnaya I, et al., 2005. Antioxidant activity and cytotoxicity of eight plants used in traditional Arab medicine in Israel. J Ethnopharmacol 99: 43-47.
54. Ljubuncic P, Dakwar S, Ortnaya I, Cogan U, Azaizeh H, Bomzon A,. 2006. Aqueous extracts of Teucrium polium possess remarkable antioxidant activity in vitro. Evid Based Complement Alternat Med 3: 329-338.
55. Malakov PY, Bonevaa IM, Papanov GY, Spassov SL,. 1988. Teulamifin B, a neo-clerodane diterpenoid from Teucrium lamiifolium and Teucrium polium. Phytochemistry 27: 1141-1143.
56. Malakov PY, Papanov GY,. 1983. Furanoid diterpenes from Teucrium polium. Phytochemistry 22: 2791-2793.
57. Malakov PY, Papanov GY, Ziesche J,. 1982. Teupolin III, a furanoid diterpene from Teucrium polium. Phytochemistry 21: 2597-2598.
58. 2-terminal kinase and Janus kinase/signal transducer and activator of transcription pathways. Endocrinology 146: 175-185.
59. Mattei A, Rucay P, Samuel D, Feray C, Reynes M, Bismuth H,. 1995. Liver transplantation for severe acute liver failure after herbal medicine (Teucrium polium) administration. J Hepatol 22: 597.
60. Mazokopakis E, Lazaridoul S, Tzardi M, Mixaki J, Diamantis I, Ganotakis E,. 2004. Acute cholestatic hepatitis caused by Teucrium polium L. Phytomedicine 11: 83-84.
61. Mehrabani D, Rezaee A, Azarpira N, et al., 2009. The healing effect of Teucrium polium in indomethacin-induced gastric ulcer in rats. Saudi Med J 30: 494-499.
62. Menichini F, Conforti F, Rigano D, Formisano C, Piozzi F, Senatore F,. 2009. Phytochemical composition, anti-inflammatory and antitumour activities of four Teucrium essential oils from Greece. Food Chem 115: 679-686.
63. Moghtader M,. 2009. Chemical composition of the essential oil of Teucrium polium L. from Iran. Am Euras J Agric Environ Sci 5: 843-846.
64. Mohseni Salehi Monfared SS, Pournourmohammadi S,. 2010. Teucrium polium complex with molybdate enhance cultured islets secretary function. Biol Trace Elem Res 133: 236-241.
65. Nematollahi-Mahani SN, Rezazadeh-Kermani M, Mehrabani M, Nakhaee N,. 2007. Cytotoxic effects of Teucrium polium on some established cell lines. Pharm Biol 45: 295-298.
66. Orhan I, Aslan M,. 2009. Appraisal of scopolamine-induced antiamnesic effect in mice and in vitro antiacetylcholinesterase and antioxidant activities of some traditionally used Lamiaceae plants. J Ethnopharmacol 122: 327-332.
67. Panovska TK, Kulevanova S, Gjorgoski I, Bogdanova M, Petrushevska G,. 2007. Hepatoprotective effect of the ethyl acetate extract of Teucrium polium L. against carbon tetrachloride-induced hepatic injury in rats. Acta Pharm 57: 241-248.
68. Panovska TK, Kulevanova S, Stefova M,. 2005. In vitro antioxidant activity of some Teucrium species (Lamiaceae). Acta Pharm 55: 207-214.
69. Parsaee H, Shafiee-Nick R,. 2006. Anti-spasmodic and anti-nociceptive effects of Teucrium polium aqueous extract. Iran Biomed J 10: 145-149.
70. Passos GF, Fernandes ES, da Cunha FM, Ferreira J, Pianowski LF, Campos MM,. 2007. Anti-inflammatory and anti-allergic properties of the essential oil and active compounds from Cordia verbenacea. J Ethnopharmacol 110: 323-333.
71. Pérez-Alonso MJ, Velasco-Negueruela A, Lopez-Saez JA,. 1993. The essential oils of two Iberian Teucrium species. J Essent Oil Res 5: 397-402.
72. Piozzi F., 1981. The diterpenoids of Teucrium species. Heterocycles 15: 1489-1503.
73. Piozzi F., 1994. Further researches on the furoclerodanes from Teucrium species. Heterocycles 37: 603-626.
74. Piozzi F, Bruno M, Rosselli S,. 1998. Further furoclerodanes from Teucrium genus. Heterocycles 48: 2185-2203.
75. Piozzi F, Bruno M, Rosselli S, Maggio A,. 2005. Advances on the chemistry of furano-diterpenoids from Teucrium genus. Heterocycles 65: 1221-1234.
76. Piozzi F, Rodríguez B, Savona G,. 1987. Advances in the chemistry of the furanoditerpenoids from Teucrium species. Heterocycles 25: 807-841.
77. Polymeros D, Kamberoglou D, Tzias V,. 2002. Acute cholestatic hepatitis caused by Teucrium polium (golden germander) with transient appearance of antimitochondrial antibody. J Clin Gastroenterol 34: 100-101.
78. Rajabalian S., 2008. Methanolic extract of Teucrium polium (Me-TP) potentiates the cytotoxic and apoptotic effects of anticancer drugs of vinblastine, vincristine and doxorubicin against a panel of cancerous cell lines. Exp Oncol 30: 133-138.
79. Rasekh HR, Khoshnood-Mansourkhani MJ, Kamalinejad M,. 2001. Hypolipidemic effects of Teucrium polium in rats. Fitoterapia 72: 937-939.
80. Rasik AM, Shukla A,. 2001. Antioxidant status in delayed healing type of wounds. Int J Exp Pathol 81: 257-263.
81. Rizk AM, Hammouda FM, Rimpler H, Kamel A,. 1986. Iridoids and flavonoids of Teucrium polium herb. Planta Med 2: 87-88.
82. Rojas A, Hernandez L, Pereda-Miranda R, Mata R,. 1992. Screening for antimicrobial activity of crude drug extracts and pure natural products from Mexican medicinal plants. J Ethnopharmacol 35: 275-283.
83. Sarac N, Ugur A,. 2007. Antimicrobial activities and usage in folkloric medicine of some Lamiaceae species growing in Mugla, Turkey. Eur Asian J BioSci 4: 28-37.
84. Sarer E, Konuklugll B, Eczaclllk F,. 1987. Investigation of the volatile oil of Teucrium polium L. Turkish Tipve Eczacillk Dergisi 11: 317-325.
85. Savvidou S, Goulis J, Giavazis I, Patsiaoura K, Hytiroglou P, Arvanitakis C,. 2007. Herb-induced hepatitis by Teucrium polium L.: report of two cases and review of the literature. Eur J Gastroenterol Hepatol 19: 507-511.
86. Shahraki MR, Arab MR, Mirimokaddam E, Palan MJ,. 2007. The effect of Teucrium polium (Calpoureh) on liver function, serum lipids and glucose in diabetic male rats. Iran Biomed J 11: 65-68.
87. Sharififar F, Dehghn-Nudeh G, Mirtajaldinic M,. 2009. Major flavonoids with antioxidant activity from Teucrium polium L. Food Chem 11: 885-888.
88. Suleiman MS, Abdul-Ghani AS, Al-Khalil S, Amin R,. 1988. Effect of Teucrium polium boiled leaf extract on intestinal motility and blood pressure. J Ethnopharmacol 22: 111-116.
89. Tariq M, Ageel AM, al-Yahya MA, Mossa JS, al-Said MS,. 1989. Anti-inflammatory activity of Teucrium polium. Int J Tissue React 11: 185-188.
90. Twaij HAA, Albadr AA, Abul-Khail A,. 1987. Anti-ulcer activity of Teucrium polium. Int J Crude Drug Res 25: 125-128.
91. Verykokidou-Vitsaropoulou E, Vajias C,. 1986. Methylated flavones from Teucrium polium. Planta Med 52: 401-402.
92. Vokou D, Bessiere JM,. 1985. Volatile constituents of Teucrium polium. J Nat Prod 48: 498-499.
93. Wassel GM, Ahmed SS,. 1974. On the essential oil of Teucrium polium L. Pharmazie 29: 351-352.
94. Yaniv Z, Dafni A, Friedman J, Palevitch D,. 1987. Plants used for the treatment of diabetes in Israel. J Ethnopharmacol 19: 145-151.
95. Yazdanparast R, Ardestani A,. 2009. Suppressive effect of ethyl acetate extract of Teucrium polium on cellular oxidative damages and apoptosis induced by 2-deoxy- d -ribose: role of de novo synthesis of glutathione. Food Chem 114: 1222-1230.
96. Yazdanparast R, Esmaeili MA, Ashrafi JH,. 2005. Teucrium polium extracts pancreatic function of streptozotocin diabetic rats: a histological examination. Iran Biomed J 9: 81-85.