Effects of aqueous extracts of medicinal plants on MNNG-treated rat hepatocytes in primary cultures

Journal of Ethnopharmacology

Volumn 112, Issue 1, 2007, Pages 199-202

  Khader, M ^a   Eckl, P M ^a   Bresgen, N ^a  

^a UNIVERSITY OF SALZBURG   (Austria)

Author keywords

Genotoxicity; Hepatocytes; Nigella sativa; Teucrium polium; Traditional medicine; Trigonella foenum graecum

Indexed keywords

ANTIMUTAGENIC AGENT; METHYLNITRONITROSOGUANIDINE; NIGELLA SATIVA EXTRACT; PLANT EXTRACT; TEUCRIUM POLIUM EXTRACT; TRIGONELLA FOENUM GRAECUM EXTRACT;

ANIMAL CELL; APOPTOSIS; AQUEOUS SOLUTION; ARTICLE; CELL CULTURE; CONTROLLED STUDY; IN VITRO STUDY; LIVER CELL; MEDICINAL PLANT; NECROSIS; NONHUMAN; RAT;

ALKYLATING AGENTS; ANIMALS; ANTIMUTAGENIC AGENTS; APOPTOSIS; CELLS, CULTURED; CHROMOSOME ABERRATIONS; CYTOPROTECTION; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HEPATOCYTES; METHYLNITRONITROSOGUANIDINE; MUTAGENICITY TESTS; NECROSIS; NIGELLA SATIVA; PLANT EXTRACTS; PLANTS, MEDICINAL; RATS; RATS, INBRED F344; SOLVENTS; TEUCRIUM; TRIGONELLA; WATER;

FABACEAE; LAMIACEAE; NIGELLA SATIVA; RANUNCULACEAE; RATTUS; TEUCRIUM POLIUM; TRIGONELLA FOENUM-GRAECUM;

EID: 34247887324     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2007.01.027     Document Type: Article

References (21)

1. Abu-Irmaileh B.E., and Afifi F.U. Herbal medicine in Jordan with special emphasis on commonly used herbs. Journal of Ethnopharmacology 89 (2003) 193-197
2. Ali B.H., and Blunden G. Pharmacological and toxicological properties of Nigella sativa. Phytotherapy Research 17 (2003) 299-305
3. Bruno M., Maggio A.M., Piozzi F., Puech S., Rosselli S., and Simmonds M.S.J. Neoclerodane diterpenoids from Teucrium polium subsp. polium and their antifeedant activity. Biochemical Systematics and Ecology 31 (2003) 1051-1056
4. Burits M., and Bucar F. Antioxidant activity of Nigella sativa essential oil. Phytotherapy Research 14 (2000) 323-328
5. Eckl P.M., and Bresgen N. The cultured primary hepatocyte and its application in toxicology. Journal of Applied Biomedicine 1 (2003) 117-126
6. Eckl P.M., Strom S.C., Michalopoulos G., and Jirtle R.L. Induction of sister chromatid exchanges in cultured adult rat hepatocytes by directly and indirectly acting mutagens/carcinogens. Carcinogenesis 8 (1987) 1077-1083
7. El-Dakhakhny M., Madi N.J., Lembert N., and Ammon H.P.T. Nigella sativa oil, nigellone and derived thymoquinone inhibit synthesis of 5-lipoxygenase products in polymorphonuclear leukocytes from rats. Journal of Ethnopharmacology 81 (2002) 161-164
8. Kanter M., Coskun O., and Budancamanak M. Hepatoprotective effects of Nigella sativa L. and Urtica dioica L. on lipid peroxidation, antioxidant enzyme systems and liver enzymes in carbon tetrachloride-treated rats. World Journal of Gastroenterology 11 (2005) 6684-6688
9. Kawashty S.A., Gamal, El-Din E.M., and Saleh N.A.M. The flavonoid chemosystematics of two Teucrium species from Southern Sinai, Egypt. Biochemical Systematics and Ecology 27 (1999) 657-660
10. Lekehal M., Pessayre D., Lereau J.M., Moulis C., Fouraste I., and Fau D. Hepatotoxicity of the herbal medicine germander: metabolic activation of its furano diterpenoids by cytochrome P450 3A Depletes cytoskeleton-associated protein thiols and forms plasma membrane blebs in rat hepatocytes. Hepatology 24 (1996) 212-218
11. Madar Z., and Shomer I. Polysaccharide composition of a gel fraction derived from fenugreek and its effect on starch digestion and bile acid absorption in rats. Journal of Agriculture and Food Chemistry 38 (1990) 1535-1539
12. Michalopoulos G., Cianciulli H.D., Novotny A.R., Kligerman A.D., Strom S.C., and Jirtle R.L. Liver regeneration studies with rat hepatocytes in primary culture. Cancer Research 42 (1982) 4673-4682
13. Petit P.R., Sauvaire Y.D., Hillaire-Buys D.M., Leconte O.M., Baissac Y.G., Ponsin G.R., and Ribes G.R. Steroid saponins from fenugreek seeds: extraction, purification, and pharmacological investigation on feeding behavior and plasma cholesterol. Steroids 60 (1995) 674-680
14. Ravikumar P., and Anuradha C.V. Effect of fenugreek seeds on blood lipid peroxidation and antioxidants in diabetic rats. Phytotherapy Research 13 (1999) 197-201
15. Said O., Khalil K., Fulder S., and Azaizeh H. Ethnopharmacological survey of medicinal herbs in Israel, the Golan Heights and the West Bank region. Journal of Ethnopharmacology 83 (2002) 251-265
16. Salomi M.J., Nair S.C., and Panikkar K.R. Inhibitory effects of Nigella sativa and saffron (Crocus sativus) on chemical carcinogenesis in mice. Nutrition and Cancer 16 (1991) 67-72
17. Suboh S.M., Bilto Y.Y., and Aburjai T.A. Protective effects of selected medicinal plants against protein degradation, lipid peroxidation and deformability loss of oxidatively stressed human erythrocytes. Phytotherapy Research 18 (2004) 280-284
18. Sur P., Das M., Gomes A., Vedasiromoni J.R., Sahu N.P., Banerjee S., Sharma R.M., and Ganguly D.K. Trigonella foenum-graecum (fenugreek) seed extract as an antineoplastic agent. Phytotherapy Research 15 (2001) 257-259
19. Thirunavukkarasu V., Anuradha C.V., and Viswanathan P. Protective effect of fenugreek (Trigonella foenum-graecum) seeds in experimental ethanol toxicity. Phytotherapy Research 17 (2003) 737-743
20. World Health Organization. Traditional medicine-growing needs and potential. WHO Policy Perspectives on Medicines 2 (2002) 1-6
21. Wu X., Skog K., and Jagerstad M. Trigonelline, a naturally occurring constituent of green coffee beans behind the mutagenic activity of roasted coffee?. Mutation Research 391 (1997) 171-177