Ex vivo evaluation of anti-GPVI antibody in Cynomolgus monkeys: Dissociation between anti-platelet aggregatory effect and bleeding time

Thrombosis and Haemostasis

Volumn 96, Issue 2, 2006, Pages 167-175

  Matsumoto, Yutaka ^a   Takizawa, Hisao ^a   Nakama, Kazuhiro ^b   Gong, Xiaoqi ^a   Yamada, Yoshihisa ^c   Tandon, Narendra N ^a   Kambayashi, Junichi ^a  

^a OTSUKA PHARMACEUTICAL DEVELOPMENT AND COMMERCIALIZATION INC   (United States)

^b SHIN NIPPON BIOMEDICAL LABORATORIES LTD   (Japan)

^c OTSUKA PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Antibody; GPVI; Platelet

Indexed keywords

ABCIXIMAB; COLLAGEN; FIBRINOGEN RECEPTOR; GLYCOPROTEIN VI; IMMUNOGLOBULIN F(AB) FRAGMENT; MONOCLONAL ANTIBODY;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BLEEDING TENDENCY; BLEEDING TIME; CONTROLLED STUDY; DOSE RESPONSE; DRUG HALF LIFE; EX VIVO STUDY; MONKEY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; SKIN BLEEDING; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOCYTE AGGREGATION INHIBITION; THROMBOCYTOPENIA; THROMBOGENESIS;

ANIMALS; ANTIBODIES; BLEEDING TIME; BLOTTING, WESTERN; COLLAGEN; IMMUNOGLOBULIN G; MACACA FASCICULARIS; PLATELET ADHESIVENESS; PLATELET AGGREGATION; PLATELET FUNCTION TESTS; PLATELET MEMBRANE GLYCOPROTEINS; TIME FACTORS;

EID: 32044458448     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1527/tjsai.21.167     Document Type: Article

References (44)

1. Fuster V, Badiman L, Badiman JJ, et al. The pathogenesis of coronary artery disease and die acute coronary syndrome. N Engl J Med 1992; 326: 310-8.
2. Conti CR, Mehta JL. Acute myocardial ischemia: role of atherosclerosis, thrombosis, platelet activation, coronary vasospasm and altered arachidonic acid metabolism. Circulation 1987; 75: V84-V95.
3. Baumgartner HR. Platelet interaction with collagen fibrils in flowing blood: reaction with human platelets with alpha chymotrypsin-digested subendothelium. Thromb Haemost 1977; 31: 1-16.
4. Hawiger J. Macromolecules that link platelets following vessel injury. Ann NY Acad Sci 1987; 509: 131-41.
5. Nieuwenhuis HK, Akkerman J, Houdljk WP, et al. Human platelets showing no response to collagen failed to express glycoprotein Ia. Nature 1985; 318: 470-2.
6. Kehrel B, Balleisen R, Kokott R, et al. Deficiency of intact thrombospondin and membrane glycoprotein Ia in platelets with defective collagen-induced aggregation and spontaneous loss of disorder. Blood 1988; 71: 1074-8.
7. 1 integrin) deficiency associated with a myeloproliferative disorder. Thromb Haemost 1995; 73: 521-8.
8. Sugiyama T, Okuma M, Ushikubi F, et al. A novel platelet aggregating factor found in a patient with defective collagen-induced platelet aggregation auto-immune thrombocytopenia. Blood 1987; 69: 1712-20.
9. Moroi M, Jung SM, Okuma M, et al. A patient with platelets deficient in glycoprotein VI that lack both collagen-induced platelet aggregation and adhesion. J Clin Invest 1989; 84: 1140-5.
10. Ryo R, Yoshida A, Sugano W, et al. Deficiency of P62, a putative collagen receptor, in platelets from a patient with defective collagen-induced platelet aggregation. Am J Hematol 1992; 39: 25-31.
11. Arai M, Yamamoto N, Moroi M, et al. Platelets with 10% of the normal amounts of glycoprotein VI have an impaired response to collagen that results in a mild bleeding tendency. Br J Haemtol 1995; 89: 124-30.
12. Takahashi H, Moroi M. Antibody against platelet membrane glycoprotein VI in a patient with systemic lupus erythematosus. Am J Hematol 2001; 67: 262-7.
13. Nurden P, Jandrot-Perrus M, Combrie R, et al. Severe deficiency of glycoprotein VI in a patient with gray platelet syndrome. Blood 2004; 104: 107-14.
14. Boylan B, Chen H, Rathore V, et al. Anti-GPVI-associated ITP: an acquired platelet disorder caused by autoantibody-mediated clearance of the GPVI/FcRgamma-chain complex from the human platelet surface. Blood 2004; 104: 1350-5.
15. Chen J, Diacovo TG, Grenache DG, et al. The α2 integrin sub-unit deficient mouse: A multifaceted phenotype including defects in branching morphogenesis and hemostasis. Am J Pathol 2002; 161: 337-44.
16. Kato, K, Kanaji T, Russell S, et al. The contribution of glycoprotein VI to stable platelet adhesion and thrombus formation illustrated by targeted gene deletion. Blood 2003; 102: 1701-7.
17. Lockyer S, Okuyama K, Begum S, et al. GPVI-deficient mice lack collagen responses and are protected against experimentally induced pulmonary thromboembolism. Thromb Res 2005; Epub ahead of print.
18. Neiswandt B, Watson SP. Platelet-collagen interaction: is GPVI the central receptor? Blood 2003; 102: 449-61.
19. Massburg S, Gawaz M, Gruner S, et al. A crucial role of glycoprotein VI for platelet recruitment to the injured arterial wall in vivo. J Exp Med 2003; 197: 41-9.
20. Munnix IC, Strehl A, Kuijpers MJ, et al. The glycoprotein VI-phospholipase Cgamma2 signaling pathway controls thrombus formation induced by collagen and tissue factor in vitro and in vivo. Arterioscler Thromb Vasc Biol 2005; 25: 2673-8.
21. Konishi H, Katoh Y, Takaya N, et al. Platelets activated by collagen through immunoreceptor tyrosine based activation motif play pivotal role in the initiation and generation of neointimal hyperplasia after vascular injury. Circulation 2002; 105: 912-6.
22. Jandrot-Perrus M, Lagrue AH, Okuma M, et al. Cloning, characterization, and functional studies of human and mouse glycoprotem VI: a platelet-specific collagen receptor from immunoglobulin superfamily. Blood 2000; 96: 1798-807.
23. Nieswandt B, Schulte V, Bergmeier W, et al. Long-term antithrombotic protection by in-vivo depletion of platelet glycoprotein GPVI in mice. J Exp Med 2001; 193: 459-69.
24. Lecut C, Feeney LA, Kingsbury G, et al. Human platelet glycoprotein VI function is antagonized by monoclonal antibody-derived Fab fragments. J Thromb Haemost 2003; 1: 2653-62.
25. Qian MD, Villeval J-L, Xiong X, et al. Anti GPVI human antibodies neutralizing collagen-induced platelet aggregation isolated from combinatorial phage display library. Human Antibodies 2002; 11: 97-105.
26. Smethurst PA, Joutsi-Korhonen L, O'Connor MN, et al. Identification of the primary collagen binding surface on human glycoprotein VI by site-directed mutagenesis and by a blocking phage antibody. Blood 2004; 103: 903-11.
27. Lecut C, Schoolmeester A, Kuijpers MJ, et al. Principal role of glycoprotein VI in alpha2beta1 and alphaIIbbeta3 activation during collagen-induced thrombus formation. Arterioscler Throm Vasc Biol 2004; 24: 1-7.
28. Siljander PRM, Munnix ICA, Smethurst PA, et al. Platelet receptor interplay regulates collagen-induced thrombus formation in flowing human blood. Blood 2004; 103: 1333-41.
29. Matsumoto Y, Takizawa H, Gong X, et al. Highly potent anti-human GPVI monoclonal antibodies derived from GPVI knockout mouse immunization. Thromb Res 2006; Epub ahead of print.
30. Morton LF, Hargreaves PG, Farndale RW, et al. Integrin alpha 2 beta 1-independent activation of platelets by simple collagen-like peptides: collagen tertiary (triple-helical) and quaternary (polymeric) structures are sufficient alone for alpha 2 beta 1-independent platelet reactivity. Biochem J 1995; 306: 337-44.
31. Polgar J, Clemetson JM, Kehrel BE, et al. Platelet activation and signal transduction by convulxin, a C-type lectin from Crotalus durissus terrificus (tropical rattlesnake) venom via the p62/GPVI collagen receptor. J Biol Chem 1997; 272: 13576-83.
32. Parham P, Androlewicz MJ, Brodsky FM, et al. Monoclonal antibodies: purification and application to structural functional studies of class I MHC antigens. J Immunol Meth 1982; 53: 133-73.
33. Clemetson KJ, Clemetson JM. Platelet collagen receptors. Thromb Haemost 200 1; 86: 189-97.
34. Watson SP, Asazuma N, Atkinson B, et al. The role of ITAM and ITIM-coupled receptors in platelet activation by collagen. Thromb Haemost 2001; 86: 276-88.
35. Kahn ML, Zheng YW, Huang W, et al. A dual thrombin receptor system for platelet activation. Nature 1998; 394: 690-4.
36. Marchese P, Kanaji T, Wagner DD, et al. Elevated threshold shear rate for the dependence of glycoprotein Ibα-mediated platelet thrombus formation onto immobilized von Willebrand factor in mouse blood. Blood 2004; 104: 996a.
37. Boylan B, Berndt MC, Kahn ML, et al. Activation-independent, antibody-mediated removal of GPVI from circulating human platelets: Development of a novel NOD/SCID mouse model to evaluate the in vivo effectiveness of anti-human platelet agents. Blood 2006; Epub ahead of print.
38. Buijs WC, Tibben JG, Boerman OC, et al. Dosimetric analysis of chimeric monoclonal antibody cMOv18 IgG in ovarian carcinoma patients after intraperitoneal and intravenous administration. Eur J Nucl Med 1998; 25: 1552-61.
39. 2, an effective antagonist of rat αIIβ3 and αvβ3, blocks in vivo thrombus formation and in vitro angiogenesis. Thromb Haemost 2001; 85: 896-902.
40. Li H, Lockyer S, Matsumoto Y, et al. A novel anti-GPVI monoclonal antibody OM4 reduces in vivo thrombosis with minimal bleeding risk in rats. Circulation 2005; 112: II-241.
41. Nguyen CM, Harrington RA. Glycoprotein IIb/IIIa receptor antagonists: a comparative review of their use in percutaneous coronary intervention. Am I Cardiovasc Drugs 2003; 3: 423-36.
42. The EPISTENT Investigators. Randomised placebo-controlled and balloon-angioplasty-controlled trial to assess safety of coronary stenting with use of platelet glycoprotein-IIb/IIIa blockade. Lancet 1998; 352: 87-92.
43. The GUSTO IV-ACS Investigators. Effect of glycoprotein IIb/IIIa receptor blocker abciximab on outcome in patients with acute coronary syndromes without early coronary revascularisation: the GUST IV-ACS randomised trial. Lancet 2001; 357: 1915-24.
44. The PURSUIT Trial Investigators. Inhibition of platelet glycoprotein IIb/ IIIa with eptifibatide in patients with acute coronary syndromes. New Engl J Med 1998; 339: 436-43.