Effects and action mechanisms of Korean pear (Pyrus pyrifolia cv. Shingo) on alcohol detoxification

Phytotherapy Research

Volumn 26, Issue 11, 2012, Pages 1753-1758

  Lee, Ho Sun ^a   Isse, Toyoshi ^b   Kawamoto, Toshihiro ^b   Woo, Hyun Su ^c   Kim, An Keun ^a   Park, Jong Y ^d   Yang, Mihi ^a  

^a Sookmyung Women's University   (South Korea)

^b UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

^c Kyung Hee University College of Medicine   (South Korea)

^d H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

Author keywords

ADH; alcohol; ALDH; detoxification; gene knockout mice; pear

Indexed keywords

ACETALDEHYDE; ALCOHOL; ALCOHOL DEHYDROGENASE; ALDEHYDE DEHYDROGENASE ISOENZYME 2; DRUGS USED IN THE TREATMENT OF ADDICTION; PLANT EXTRACT; PYRUS PYRIFOLIA EXTRACT; UNCLASSIFIED DRUG;

ALCOHOL BLOOD LEVEL; ALCOHOL METABOLISM; ALCOHOL WITHDRAWAL; ALCOHOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DETOXIFICATION; DRUG EFFICACY; DRUG MECHANISM; ENZYME ACTIVATION; GENETIC POLYMORPHISM; GENOTYPE; IN VITRO STUDY; IN VIVO STUDY; MALE; MASS FRAGMENTOGRAPHY; MAXIMUM PLASMA CONCENTRATION; MOUSE; NONHUMAN; PHARMACOGENETICS; PYRUS; PYRUS PYRIFOLIA; SOUTH KOREA; TIME TO MAXIMUM PLASMA CONCENTRATION;

ACETALDEHYDE; ALCOHOL DEHYDROGENASE; ALDEHYDE DEHYDROGENASE; ANIMALS; ETHANOL; GENOTYPE; MALE; METABOLIC DETOXICATION, DRUG; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PLANT EXTRACTS; PYRUS;

ANIMALIA; MUS; PYRUS; PYRUS PYRIFOLIA;

EID: 84867885245     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.4630     Document Type: Article

References (26)

1. Cho MH, Shim SM, Lee SR, Mar WC, Kim GH,. 2005. Effect of Evodiae fructus extracts on gene expressions related with alcohol metabolism and antioxidation in ethanol loaded mice. Food Chem Toxicol 43: 1365-1371.
2. Eng MY, Luczak SE, Wall TL,. 2007. ALDH2, ADH1B, and ADH1C genotypes in Asians: a literature review. Alcohol Res Health 30: 22-27.
3. Eriksson CJP, Saarenmaa TPS, Bykov IL, Heino PU,. 2007. Acceleration of ethanol and acetaldehyde oxidation by d -glycerate in rats. Metab Clin Exp 56: 895-898.
4. Hong SS,. 2005. Determination of functional compounds and physiological activity in fruit of apple (Malus spp.) and pear (Pyrus spp.) Doctoral Dissertation, Department of Horticultural Science, Graduate School, Korea University, Seoul, South Korea.
5. Isse T, Matsuno K, Oyama T, Kitagawa K, Kawamoto T,. 2005. Aldehyde dehydrogenase 2 gene targeting mouse lacking enzyme activity shows high acetaldehyde level in blood, brain, and liver after ethanol gavages. Alcohol Clin Exp Res 29: 1959-1964.
6. Isse T, Oyama T, Kitagawa K, et al,. 2002. Diminished alcohol preference in transgenic mice lacking aldehyde dehydrogenase activity. Pharmacogenetics 12: 621-626.
7. Itoh S, Matsuyama T, Kamataki T,. 1997. Low activity of aldehyde dehydrogenase (ALDH) in liver of Suncus murinus: possible explanation for high sensitivity to alcohol. J Toxicol Sci 22: 111-115.
8. Kim BY, Cui ZG, Lee SR, et al,. 2009. Effects of Asparagus officinalis extracts on liver cell toxicity and ethanol metabolism. J Food Sci 74: H204-H208.
9. Kitagawa K, Kawamoto T, Kunugita N, et al,. 2000. Aldehyde ehydrogenase (ALDH) 2 associates with oxidation of methoxyacetaldehyde; in vitro analysis with liver subcellular fraction derived from human and Aldh2 gene targeting mouse. FEBS Lett 476: 306-311.
10. Lee H,. 2009. Effects of the pears (Pyrus pyrifolia Nakai) on alcohol detoxification. Doctoral Dissertation, Department of Bio-Pharmacy, Graduate school, Sookmyung Women's University, Seoul, South Korea.
11. Li YG, Ji DF, Zhong S, Shi LG, Hu GY, Chen S,. 2010. Saponins from Panax japonicas protect against alcohol-induced hepatic injury in mice by up-regulating the expression of GPX3, SOD1 and SOD3. Alcohol Alcohol 45: 320-331.
12. Lin WT, Huang CC, Lin TJ, et al,. 2009. Effects of betacarotene on antioxidant status in rats with chronic alcohol consumption. Cell Biochem Funct 27: 344-350.
13. Matsuda H, Shimoda H, Ninomiya K, Yoshikawa M,. 2002. Inhibitory mechanism of costunolide, a sesquiterpene lactone isolated from Laurus nobilis, on blood ethanol elevation in rats: involvement of inhibition of gastric emptying and increase in gastric juice secretion. Alcohol Alcohol 37: 121-127.
14. Pittler MH, Verster JC, Ernst E,. 2005. Interventions for preventing or treating alcohol hangover: systematic review of randomized controlled trials. Br Med J 331: 1515-1518.
15. RDA (the Korean Rural Development Administration). 2011. http://koreanfood.rda.go.kr
16. Salaspuro V, Hietala J, Kaihovaara P, Pihlajarinne L, Marvola M, Salaspuro M,. 2002. Removal of acetaldehyde from saliva by a slow-release buccal tablet of l -cysteine. Int J Cancer 97: 361-364.
17. Sanaka M, Yamamoto T, Anjiki H, Nagasawa K, Kuyama Y,. 2007. Effects of agar and pectin on gastric emptying and post-prandial glycaemic profiles in healthy human volunteers. Clin Exp Pharmacol Physiol 34: 1151-1155.
18. Shin BS, Jun H, Lee DE, Lee KR, Eun SP, Sun DY,. 2005. Altered oral absorption of alcohol by combined aqueous extracts of four herbal plants in rats. J Toxicol Environ Health A 68: 2219-2226.
19. Swift R, Davidson D,. 1998. Alcohol hangover: mechanisms and mediators. Alcohol Health Res World 22: 54-60.
20. Thirunavukkarasu V, Anuradha CV, Viswanathan P,. 2003. Protective effect of fenugreek (Trigonella foenum graecum) seeds in experimental ethanol toxicity. Phytother Res 17: 737-743.
21. USDA (US Department of Agriculture). 2012. Nutrient data laboratory, Available from: http://www.nal.usda.gov/fnic/foodcomp
22. Uzuegbu UE, Onyesom I,. 2009. Fructose-induced increase in ethanol metabolism and the risk of syndrome x in man. C R Biol 332: 534-538.
23. Wiese J, McPherson S, Odden MC, Shlipak MG,. 2004. Effect of Opuntia ficus indica on symptoms of the alcohol hangover. Arch Intern Med 164: 1334-1340.
24. Wojciech L, Ewa Z, Elzbieta S,. 2010. Influence of green tea on erythrocytes antioxidant status of different age rats intoxicated with ethanol. Phytother Res 4: 424-428.
25. Yang M, Park JY,. 2010. Effects of Korean pears, Pyrus pyrifolia cv. Shingo, on alcohol detoxification. In Functional Foods in the Prevention and Management of Metabolic Syndrome, The Proceeding of the 7th International Conference of Functional Food: Dallas, TX; 193-194.
26. Zhang YB, Choi HJ, Han HS, et al,. 2003. Polyphenolic compounds from Korean pear and their biological activities. Food Sci Biotechnol. 12: 262-267.