Protective effect of fenugreek (Trigonella foenum graecum) seeds in experimental ethanol toxicity

Phytotherapy Research

Volumn 17, Issue 7, 2003, Pages 737-743

  Thirunavukkarasu, V ^a   Anuradha, C V ^a   Viswanathan, P ^a  

^a ANNAMALAI UNIVERSITY   (India)

Author keywords

Antioxidants; Ethanol toxicity; Fenugreek seeds; Lipid peroxidation

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ALPHA TOCOPHEROL; ASCORBIC ACID; ASPARTATE AMINOTRANSFERASE; CATALASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; IRON; LIPID HYDROPEROXIDE; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TRIGONELLA FOENUM GRAECUM EXTRACT;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALCOHOL INTOXICATION; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; AQUEOUS SOLUTION; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BRAIN; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; FENUGREEK; HISTOPATHOLOGY; LIPID BLOOD LEVEL; LIPID PEROXIDATION; LIVER; MALE; NONHUMAN; PLANT SEED; PROTECTION; RAT; RAT STRAIN;

ALANINE TRANSAMINASE; ALKALINE PHOSPHATASE; ANIMALS; ANTIOXIDANTS; ASCORBIC ACID; ASPARTATE AMINOTRANSFERASES; BRAIN; ETHANOL; FERROUS COMPOUNDS; HEPATITIS, TOXIC; HUMANS; LIPID PEROXIDATION; LIVER; MALE; PHYTOTHERAPY; PLANT EXTRACTS; PROTECTIVE AGENTS; RATS; RATS, WISTAR; SEEDS; THIOBARBITURIC ACID REACTIVE SUBSTANCES; TRIGONELLA;

TRIGONELLA; TRIGONELLA FOENUM-GRAECUM;

EID: 0041510209     PISSN: 0951418X     EISSN: None     Source Type: Journal    
DOI: 10.1002/ptr.1198     Document Type: Article

References (29)

1. Akimoto K, Kitagawa YA, Kamatsu T, et al. 1993. Protective role of sesamin against liver damage caused by alcohol or carbon tetrachloride in rodents. Ann Nutr Metab 37(4): 218-224.
2. Asad SF, Singh S, Ahmad A, Hadi SM. 1998. Flavonoids: Antioxidants in diet and potential cancer agents. Med Sci Res 26: 723-728.
3. Baker H, Frank O, De Angelis B, Feingold S. 1980. Plasma tocopherol in man at various times after ingesting free or acetylated tocopherol. Nutr Rep Int 21: 531-536.
4. Cathin MC, Guizzetti M, Costa LG. 1999. Effects of ethanol on calcium homeostasis in the nervous system: Implications for astrocytes. Mol Neurobiol 19(1): 1-24.
5. D'Almedia V, Monteiro MG, Oliveira MG, et al. 1994. Long lasting effects of ethanol administration on the activity of antioxidant enzymes. J Biochem Toxicol 9(3): 141-143.
6. Ellman GL. 1959. Tissue sulphydryl groups. Arch Biochem Biophys 82: 70-77.
7. Gupta R, Nair S. 1999. Antioxidant flavonoids in Indian diet. South Asian J Prev Cardiol 3: 83-94.
8. Habig WH, Pabst MJ, Jakpoby WB. 1974. Glutathione transferase: A first enzymatic step in mercapturic acid and formation. J Biol Chem 249: 7130-7139.
9. Hjertan S, Pan H. 1983. Purification and characteristics of two forms of a low affinity calcium ion-ATPase from erythrocyte membrane. Biochem Biophys Acta 729: 281-288.
10. Horn HP, Burns FH. 1978. In Methods in Enzymology. Bergmeyer HV (ed.). Academic Press: New York; 877.
11. Howard BV, Kritchevsky D. 1997. Phytochemicals and cardiovascular disease. A statement for healthcare professionals from American Heart Association. Circulation 95: 2591-2593.
12. Jiang ZY, Hunt JV, Wolff SP. 1992. Detection of lipid hydroperoxides using the 'Fox method'. Anal Biochem 202: 384-389.
13. Kakkar P, Das B, Viswanathan PN. 1984. A modified spectrophotometric assay of superoxide dismutase. Ind J Biochem Biophys 21: 130-132.
14. Khosla P, Gupta DD, Nagpal RK. 1995. Effect of Trigonella foenum graecum (Fenugreek) on serum lipids in normal and diabetic rats. Int J Pharmacol 27: 89-93.
15. King E, Armstrong AR. 1934. Determination of serum and bile phosphatase activity. Canad Med Assoc J 31: 376.
16. Knekt P, Jarvinen R, Renuanen A, Maatela J. 1996. Flavonoid intake and coronary mortality in Finland: a cohort study. B M J 312: 478-481.
17. Kukielka E, Dicker E, Cederbaum AI. 1994. Increased production of reactive oxygen species by rat liver mitochondria after chronic ethanol treatment. Arch Biochem Biophy 2: 337-346.
18. Maher JJ. 1997. Exploring alcohol's effects on liver function. Alcohol Health and Research World 21: 5-12.
19. Mitchell JJ, Paiva M, Heaton MB. 1999. The antioxidants vitamin E and beta carotene protect against ethanol-induced neurotoxicity in embryonic rat hippocampal cultures. Alcohol 17(2): 163-168.
20. Nichans WG, Samuelson B. 1986. Formation of MDA from phospholipid arachidonate during microsomal lipid peroxidation. Eur J Biochem 6: 126-130.
21. Rashba-Step J, Turro NJ, Cederbaum AI. 1993. Increased NADPH- and NADH-dependent production of superoxide and hydroxyl radical by microsomes after chronic ethanol treatment. Arch Biochem Biophys 300: 401-408.
22. Ravikumar P, Anuradha CV. 1999. Effect of fenugreek seeds on blood lipid peroxidation and antioxidants in diabetic rats. Phytother Res 13: 1-5.
23. Reinke LA, Moore DR, McCay PB. 1997. Free radical formation in liver of rats treated acutely and chronically with ethanol. Alcohol Clin Exp Res 21(4): 642-646.
24. Reitman S, Frankel AS. 1957. A colorimetric method for the determination of serum glutamic oxaloacetate and glutamic pyruvic transminases. Am J Clin Pathol 28: 53-56.
25. Roe JH, Kuether CA. 1943. Detection of ascorbic acid in whole blood and urine through the 2,4-DNPH derivative of dehydro ascorbic acid. J Bio Chem 47: 399-407.
26. Rotruck JJ, Pope AL, Gantter HE, Swanson AB. 1973. Selenium: Biochemical role as a component of glutathione peroxidase. Science 179: 588-590.
27. Sergent O, Morel I, Cogrel P, et al. 1993. Simultaneous measurements of conjugated dienes and free malondialdehyde, used as micromethod for the evaluation of lipid peroxidation in rat hepatocyte cultures. Chem Phys Lip 65(2): 133-139.
28. Sharma RD, Rahuram TC, Sudhakar Rao N. 1990. Effect of fenugreek seeds on blood glucose and serum lipids in type 1 diabetes. Eur J Clin Nutr 44: 301-306.
29. Sinha AK. 1972. Colorimetric assay of catalase. Anal Biochem 47: 389-394.