P2X7 receptor activation mediates organic cation uptake into human myeloid leukaemic KG-1 cells

Purinergic Signalling

Volumn 8, Issue 4, 2012, Pages 669-676

  Gadeock, Safina ^a,b   Pupovac, Aleta ^a,b   Sluyter, Vanessa ^a,b   Spildrejorde, Mari ^a,b   Sluyter, Ronald ^a,b  

^a UNIVERSITY OF WOLLONGONG   (Australia)

^b ILLAWARRA HEALTH AND MEDICAL RESEARCH INSTITUTE   (Australia)

Author keywords

Acute myelogenous leukaemia; Cation channel; Extracellular ATP; Purinergic receptor; Single nucleotide polymorphism

Indexed keywords

3 [[5 (2,3 DICHLOROPHENYL) 1H TETRAZOL 1 YL]METHYL]PYRIDINE; ADENOSINE TRIPHOSPHATE; AZ 10606120; CARBENOXOLONE; COMPLEMENTARY DNA; ETHIDIUM; MESSENGER RNA; POTASSIUM CHLORIDE; PROBENECID; PROPIDIUM IODIDE; PURINERGIC P2X RECEPTOR ANTAGONIST; PURINERGIC P2X7 RECEPTOR; REAGENT; SODIUM CHLORIDE; SUCROSE; UNCLASSIFIED DRUG; YO PRO 1;

ANTIBODY LABELING; ARTICLE; CATION TRANSPORT; CONTROLLED STUDY; DNA SEQUENCE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOCHEMISTRY; MYELOID LEUKEMIA; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SINGLE NUCLEOTIDE POLYMORPHISM;

ADENOSINE TRIPHOSPHATE; CATIONS; CELL LINE; HUMANS; MYELOID CELLS; POLYMORPHISM, SINGLE NUCLEOTIDE; PURINERGIC P2X RECEPTOR ANTAGONISTS; RECEPTORS, PURINERGIC P2X7;

EID: 84867883658     PISSN: 15739538     EISSN: 15739546     Source Type: Journal    
DOI: 10.1007/s11302-012-9320-9     Document Type: Article

References (45)

1. Wiley JS, Sluyter R, Gu BJ, Stokes L, Fuller SJ (2011) The human P2X7 receptor and its role in innate immunity. Tissue Antigens 78: 321-332.
2. Lenertz LY, Gavala ML, Zhu Y, Bertics PJ (2011) Transcriptional control mechanisms associated with the nucleotide receptor P2X7, a critical regulator of immunologic, osteogenic, and neurologic functions. Immunol Res 50: 22-38.
3. Sluyter R, Stokes L (2011) Significance of P2X7 receptor variants to human health and disease. Recent Pat DNA Gene Seq 5: 41-54.
4. Gorodeski GI (2009) P2X7-mediated chemoprevention of epithelial cancers. Expert Opin Ther Targets 13: 1313-1332.
5. Roger S, Pelegrin P (2011) P2X7 receptor antagonism in the treatment of cancers. Expert Opin Investig Drugs 20: 875-880.
6. Feng YH, Li X, Zeng R, Gorodeski GI (2006) Endogenously expressed truncated P2X7 receptor lacking the C-terminus is preferentially upregulated in epithelial cancer cells and fails to mediate ligand-induced pore formation and apoptosis. Nucleosides Nucleotides Nucleic Acids 25: 1271-1276.
7. 7: a growth-promoting receptor-implications for cancer. Purinergic Sig 5: 251-256.
8. Adinolfi E, Raffaghello L, Giuliani AL, Cavazzini L, Capece M, Chiozzi P, Bianchi G, Kroemer G, Pistoia V, Di Virgilio F (2012) Expression of the P2X7 receptor increases in vivo tumor growth. Cancer Res. doi: 10. 1158/0008-5472. CAN-11-1947.
9. Ren S, Zhang Y, Wang Y, Lui Y, Wei W, Huang X, Mao W, Zuo Y (2010) Targeting P2X7 receptor inhibits the metastasis of murine P388D1 lymphoid neoplasm cells to lymph nodes. Cell Biol Int 34: 1205-1211.
10. Gu BJ, Wiley JS (2006) Rapid ATP-induced release of matrix metalloproteinase 9 is mediated by the P2X7 receptor. Blood 107: 4946-4953.
11. Jelassi B, Chantôme A, Alcaraz-Pérez F, Baroja-Mazo A, Cayuela ML, Pelegrin P, Surprenant A, Roger S (2011) P2X7 receptor activation enhances SK3 channels- and cystein cathepsin-dependent cancer cells invasiveness. Oncogene 30: 2108-2122.
12. Jamieson GP, Snook MB, Thurlow PJ, Wiley JS (1996) Extracellular ATP causes of loss of L-selectin from human lymphocytes via occupancy of P2Z purinocepters. J Cell Physiol 166: 637-642.
13. Lin C, Ren S, Zhang L, Jin H, Sun J, Zuo Y (2011) Extracellular ATP induces CD44 shedding from macrophage-like P388D1 cells via the P2X7 receptor. Hematol Oncol. doi: 10. 1002/hon. 1008.
14. Farrell AW, Gadeock S, Pupovac A, Wang B, Jalilian I, Ranson M, Sluyter R (2010) P2X7 receptor activation induces cell death and CD23 shedding in human RPMI 8226 multiple myeloma cells. Biochim Biophys Acta 1800: 1173-1182.
15. Deli T, Csernoch L (2008) Extracellular ATP and cancer-an overview with special reference to P2 purinergic receptors. Pathol Oncol Res 14: 219-231.
16. White N, Burnstock G (2006) P2 receptors and cancer. Trends Pharmacol Sci 27: 211-217.
17. Koeffler HP, Golde DW (1978) Acute myelogenous leukemia: a human cell line responsive to colony-stimulating activity. Science 200: 1153-1154.
18. Gadeock S, Tran JN, Georgiou JG, Jalilian I, Taylor RM, Wiley JS, Sluyter R (2010) TGF-β1 prevents up-regulation of the P2X7 receptor by IFN-γ and LPS in leukemic THP-1 monocytes. Biochim Biophys Acta 1798: 2058-2066.
19. Michel AD, Chessell IP, Humphrey PP (1999) Ionic effects on human recombinant P2X7 receptor function. Naunyn Schmiedebergs Arch Pharmacol 359: 102-109.
20. 7 receptor function in leucocyte subsets by two-colour time-resolved flow cytometry. J Immunol Methods 325: 67-77.
21. 7 receptor. EMBO J 25: 5071-5082.
22. Silverman WR, de Rivero Vaccari JP, Locovei S, Qiu F, Carlsson SK, Scemes E, Keane RW, Dahl G (2009) The pannexin 1 channel activates the inflammasome in neurons and astrocytes. J Biol Chem 284: 18143-18151.
23. 7 function and function impairs ATP-induced mycobacterial killing by macrophages. J Biol Chem 281: 2079-2086.
24. Cabrini G, Falzoni S, Forchap SL, Pellegatti P, Balboni A, Agostini P, Cuneo A, Castoldi G, Baricordi OR, Di Virgilio F (2005) A His-155 to Tyr polymorphism confers gain-of-function to the human P2X7 receptor of human leukemic lymphocytes. J Immunol 175: 82-89.
25. Roger S, Mei ZZ, Baldwin JM, Dong L, Bradley H, Baldwin SA, Surprenant A, Jiang LH (2010) Single nucleotide polymorphisms that were identified in affective mood disorders affect ATP-activated P2X7 receptor functions. J Psychiatr Res 44: 347-355.
26. Stokes L, Fuller SJ, Sluyter R, Skarratt KK, Gu BJ, Wiley JS (2010) Two haplotypes of the P2X7 receptor containing the Ala-348 to Thr polymorphism exhibit gain-of-function effect and enhanced interleukin-1β secretion. FASEB J 24: 2916-2927.
27. Constantinescu P, Wang B, Kovacevic K, Jalilian I, Bosman GJ, Wiley JS, Sluyter R (2010) P2X7 receptor activation induces cell death and microparticle release in murine erythroleukemia cells. Biochim Biophys Acta 1798: 1797-1804.
28. Smart ML, Gu B, Panchel RG, Wiley JS, Cromer B, Williams DA, Petrou S (2003) P2X7 receptor cell surface expression and cytolytic pore formation are regulated by a distal C-terminal region. J Biol Chem 278: 8853-8860.
29. Hattori M, Gouaux E (2012) Molecular mechanism of ATP binding and ion channel activation in P2X receptors. Nature 485: 207-212.
30. 7 receptor pharmacology in two human ostoblast-like cell lines. Br J Pharmacol 156: 1124-1135.
31. Pojoga LH, Haghiac ML, Moose JE, Hilderman RH (2004) Determination of ATP impurity in adenine dinucleotides. Nucleosides Nucleotides Nucleic Acids 23: 581-598.
32. Sun C, Chu J, Singh S, Salter RD (2010) Identification and characterization of a novel variant of the human P2X7 receptor resulting in gain of function. Purinergic Sig 6: 31-45.
33. Chong JH, Zheng GG, Ma YY, Zhang HY, Nie K, Lin YM, Wu KF (2010) The hyposensitive N187D P2X7 mutant promotes malignant progression in nude mice. J Biol Chem 285: 36179-36187.
34. + uptake-inhibition of fluxes by suramin. Arch Biochem Biophys 305: 54-60.
35. 7 receptors. Int Immunol 14: 1415-1421.
36. Panupinthu N, Rogers JT, Zhao L, Solano-Flores LP, Possmayer F, Sims SM, Dixon SJ (2008) P2X7 receptors on osteoblasts couple to production of lysophosphatidic acid: a signaling axis promoting osteogenesis. J Cell Biol 181: 859-871.
37. Milius D, Gröger-Arndt H, Stanchev D, Lange-Dohna C, Rossner S, Sperlagh B, Wirkner K, Illes P (2007) Oxygen/glucose deprivation increases the integration of recombinant P2X7 receptors into the plasma membrane of HEK293 cells. Toxicology 238: 60-69.
38. Di Virgilio F, Steinberg TH, Silverstein SC (1990) Inhibition of Fura-2 sequestration and secretion with organic anion transport blockers. Cell Calcium 11: 57-62.
39. Qu Y, Misaghi S, Newton K, Gilmour LL, Louie S, Cupp JE, Dubyak GR, Hackos D, Dixit VM (2011) Pannexin-1 is required for ATP release during apoptosis but not for inflammasome activation. J Immunol Methods 186: 6553-6561.
40. 7 receptor expression in evolutive and indolent forms of chronic B lymphocytic leukemia. Blood 99: 706-708.
41. Chong JH, Zheng GG, Zhu XF, Guo Y, Wang L, Ma CH, Liu SY, Xu LL, Lin YM, Wu KF (2010) Abnormal expression of P2X family receptors in Chinese pediatric acute leukemias. Biochem Biophys Res Commun 391: 498-504.
42. 7 receptor stimulated phospholipase D activity in chronic lymphocytic leukaemia B-lymphocytes. Immunol Cell Biol 85: 68-72.
43. Wiley JS, Dubyak GR (1989) Extracellular adenosine triphosphate increases cation permeability of chronic lymphocytic leukemia lymphocytes. Blood 73: 1316-1323.
44. Zhang XJ, Zheng GG, Ma XT, Yang YH, Li G, Rao Q, Nie K, Wu KF (2004) Expression of P2X7 in human hematopoietic cell lines and leukemia patients. Leuk Res 28: 1313-1322.
45. Janiak M, Hashmi HR, Janowska-Wieczorek A (1994) Use of the Matrigel-based assay to measure the invasiveness of leukemic cells. Exp Hematol 22: 559-565.