Endogenously expressed truncated P2X7 receptor lacking the C-terminus is preferentially upregulated in epithelial cancer cells and fails to mediate ligand-induced pore formation and apoptosis

Nucleosides, Nucleotides and Nucleic Acids

Volumn 25, Issue 9-11, 2006, Pages 1271-1276

  Feng, Y H ^a   Li, X ^b   Zeng, R ^b   Gorodeski, George I ^b,c  

^a UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY HOSPITALS OF CLEVELAND   (United States)

Author keywords

Apoptosis; Cervix; Epithelium; P2X7; Receptor; Truncated; Variant

Indexed keywords

AMINO ACID; PURINE P2X7 RECEPTOR;

APOPTOSIS; ARTICLE; CANCER CELL; CHANNEL GATING; CONTROLLED STUDY; EPITHELIUM CELL; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; UTERINE CERVIX EPITHELIUM;

ANIMALS; APOPTOSIS; CELL LINE; DOGS; EPITHELIAL CELLS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HELA CELLS; HUMANS; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, PURINERGIC P2; SKIN NEOPLASMS; UP-REGULATION; UTERINE CERVICAL NEOPLASMS;

EID: 33750475253     PISSN: 15257770     EISSN: 15322335     Source Type: Journal    
DOI: 10.1080/15257770600890921     Document Type: Article

References (3)

1. Wang, Q.; Wang, L.; Feng, Y.H.; Li, X.; Zeng, R.; Gorodeski, G.I. P2X7-receptor mediated apoptosis of human cervical epithelial cells. Am. J. Physiol. 2004, 287, C1349-C1358.
2. Khakh, B.S.; Burnstock, G.; Kennedy, C.; King, B.F.; North, R.A.; Seguela, P.; Voigt, M.; Humphrey, P.P.A. Current status of the nomenclature and properties of P2X receptors and their subunits. Pharmacol. Rev. 2001, 53, 107-118.
3. Feng, Y.H.; Wang, L.; Wang, Q.; Li, X.; Zeng, R.; Gorodeski, G.I. ATP ligation stimulates GRK-3-mediated phosphorylation and β-arrestin-2- and dynamin-dependent internalization of the P2X7-receptor. Am. J. Physiol. 2005, 288, C1342-C1356.