Inhibitory effects of kale ingestion on metabolism by cytochrome P450 enzymes in rats

Biomedical Research (Japan)

Volumn 33, Issue 4, 2012, Pages 235-242

  Yamasaki, Izumi ^a   Yamada, Masayoshi ^a   Uotsu, Nobuo ^a   Teramoto, Sachiyuki ^a   Takayanagi, Risa ^b   Yamada, Yasuhiko ^b  

^a Central Research Development Laboratory Fancl Corporation   (Japan)

^b TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CAFFEINE; CHLORZOXAZONE; CYTOCHROME P450; CYTOCHROME P450 1A2; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 2E1; CYTOCHROME P450 3A4; DEXTROMETHORPHAN; HERBACEOUS AGENT; MESSENGER RNA; MIDAZOLAM MALEATE; OMEPRAZOLE; TOLBUTAMIDE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BRASSICA OLERACEA; CABBAGE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DOWN REGULATION; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG METABOLISM; DRUG POTENTIATION; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME LOCALIZATION; ENZYME METABOLISM; MALE; MAXIMUM PLASMA CONCENTRATION; METABOLIC INHIBITION; NONHUMAN; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION;

ADMINISTRATION, ORAL; ANIMALS; AREA UNDER CURVE; BRASSICA; CAFFEINE; CHLORZOXAZONE; CYTOCHROME P-450 CYP2D6; CYTOCHROME P-450 CYP2E1; CYTOCHROME P-450 ENZYME SYSTEM; CYTOCHROMES; DEXTROMETHORPHAN; ENZYME INHIBITORS; HERB-DRUG INTERACTIONS; LIVER; METABOLIC CLEARANCE RATE; MIDAZOLAM; OMEPRAZOLE; RATS; RNA, MESSENGER; TOLBUTAMIDE;

EID: 84867863973     PISSN: 03886107     EISSN: 1880313X     Source Type: Journal    
DOI: 10.2220/biomedres.33.235     Document Type: Article

References (22)

1. Block G, Patterson B and Subar A (1992) Fruit, vegetables, and cancer prevention: a review of the epidemiological evidence. Nutr Cancer 18, 1-29.
2. Dong H, Haining RL, Thummel KE, Rettie AE and Nelson SD (2000) Involvement of human cytochrome P450 2D6 in the bioactivation of acetaminophen. Drug Metab Dispos 28, 1397-1400.
3. Goosen TC, Kent UM, Brand L and Hollenberg PF (2000) Inactivation of cytochrome P450 2B1 by benzyl isothiocyanate, a chemopreventative agent from cruciferous vegetables. Chem Res Toxicol 13, 1349-1359.
4. Goosen TC, Mills DE and Hollenberg PF (2001) Effects of benzyl isothiocyanate on rat and human cytochromes P450: identification of metabolites formed by P450 2B1. J Pharmacol Exp Ther 296, 198-206.
5. Kurilich AC, Tsau GJ, Brown A, Howard L, Klein BP, Jeffery EH, Kushad M, Wallig MA and Juvik JA (1999) Carotene, tocopherol, and ascorbate contents in subspecies of Brassica oleracea. J Agric Food Chem 47, 1576-1581.
6. Laine JE, Auriola S, Pasanen M and Juvonen RO (2009) Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes. Xenobiotica 39, 11-21.
7. Moreno RL, Kent UM, Hodge K and Hollenberg PF (1999) Inactivation of cytochrome P450 2E1 by benzyl isothiocyanate. Chem Res Toxicol 12, 582-587.
8. Nakajima M, Yoshida R, Shimada N, Yamazaki H and Yokoi T (2001) Inhibition and inactivation of human cytochrome P450 isoforms by phenethyl isothiocyanate. Drug Metab Dispos 29, 1110-1113.
9. Patten CJ, Thomas PE, Guy RL, Lee M, Gonzalez FJ, Guengerich FP and Yang CS (1993) Cytochrome P450 enzymes involved in acetaminophen activation by rat and human liver microsomes and their kinetics. Chem Res Toxicol 6, 511-518.
10. Podsedek A (2005) Natural antioxidants and antioxidant capacity of Brassica vegetables: A review. LWT-Food Sci Technol 40, 1-11.
11. Raucy JL, Lasker JM, Lieber CS and Black M (1989) Acetaminophen activation by human liver cytochromes P450IIE1 and P450IA2. Arch Biochem Biophys 271, 270-283.
12. Riboli E and Norat T (2003) Epidemiologic evidence of the protective effect of fruit and vegetables on cancer risk. Am J Clin Nutr 78, 559S-569S.
13. Shapiro TA, Fahey JW, Wade KL, Stephenson KK and Talalay P (1998) Human metabolism and excretion of cancer chemoprotective glucosinolates and isothiocyanates of cruciferous vegetables. Cancer Epidemiol Biomarkers Prev 7, 1091-1100.
14. Shapiro TA, Fahey JW, Wade KL, Stephenson KK and Talalay P (2001) Chemoprotective glucosinolates and isothiocyanates of broccoli sprouts: metabolism and excretion in humans. Cancer Epidemiol Biomarkers Prev 10, 501-508.
15. Skupinska K, Misiewicz-Krzeminska I, Stypulkowski R, Lubelska K and Kasprzycka-Guttman T (2009) Sulforaphane and its analogues inhibit CYP1A1 and CYP1A2 activity induced by benzo[a]pyrene. J Biochem Mol Toxicol 23, 18-28.
16. Smith TJ, Guo Z, Guengerich FP and Yang CS (1996) Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) by human cytochrome P450 1A2 and its inhibition by phenethyl isothiocyanate. Carcinogenesis 17, 809-813.
17. Steinmetz KA and Potter JD (1991) Vegetables, fruit, and cancer. I. Epidemiology. Cancer Causes Control 2, 325-357.
18. Tan SC, New LS and Chan EC (2008) Prevention of acetaminophen (APAP)-induced hepatotoxicity by leflunomide via inhibition of APAP biotransformation to N-acetyl-p-benzoquinone imine. Toxicol Lett 180, 174-181.
19. Vainio H and Weiderpass E (2006) Fruit and vegetables in cancer prevention. Nutr Cancer 54, 111-142.
20. Verhoeven DT, Goldbohm RA, van Poppel G, Verhagen H and van den Brandt PA (1996) Epidemiological studies on brassica vegetables and cancer risk. Cancer Epidemiol Biomarkers Prev 5, 733-748.
21. Verhoeven DT, Verhagen H, Goldbohm RA, van den Brandt PA and van Poppel G (1997) A review of mechanisms underlying anticarcinogenicity by brassica vegetables. Chem Biol Interact 103, 79-129.
22. Yamasaki I, Uotsu N, Yamaguchi K, Takayanagi R and Yamada Y (2011) Effects of kale ingestion on pharmacokinetics of acetaminophen in rats. Biomed Res 32, 357-362.